Gulec-Yilmaz, S. | Gulec, H. | Ogut, D.B. | Cetin, B. | Gormus, U. | İşbir, Turgay

Article | 2018 | Nordic Journal of Psychiatry72 ( 7 ) , pp.477 - 483

Aim: In this study, we aimed to investigate possible interactions among the apolipoprotein E (ApoE) and panic disorder (PD), taking into account serum cholesterol levels and subfractions. Methods: ApoE genotyping was performed by real-time polymerase chain reaction in DNA samples of PD patient group (n = 45) and healthy control group (n = 50). The serum lipid levels, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) subfraction analysis were examined. Results: There was a significant difference of ApoE genotypes in patient and control groups. The E3/E3 genotypes lower whereas E4 allele carriers were significantly hig . . .her in PD group ApoE4allele carriers had 3.2-fold higher risk of PD. PD group had significantly lower LDL and HDL levels. In spite of the decreased levels of total LDL, antiatherogenic large LDL subgroup was significantly lower in a patient with PD. Antiatherogenic large HDL and Intermediate HDL levels were lower, while atherogenic small HDL subfraction was significantly higher in PD group. Furthermore, Apo E3/E3 genotype carriers had significantly higher large LDL, HDL, large HDL, intermediate HDL level, and also had highest HDL between all the groups. ApoE4 allele carriers while they had highest atherogenic small HDL level. Conclusion: E4 allele can be associated with PD as an eligible risk factor, the E3/E3 could be a risk-reducing factor for PD. Patients with PD not only had lower LDL and HDL levels but also they have higher atherogenic LDL and HDL subfractions. Also, E3/E3 genotype carriers had convenient but ApoE4 carriers had atherogenic plasma cholesterol levels and subfractions. © 2018, © 2018 The Nordic Psychiatric Association Daha fazlası Daha az

Kuran, S.B. | Iplik, E.S. | Cakmakoglu, B. | Kahraman, O.T. | Iyibozkurt, A.C. | Koc, A. | İşbir, Turgay

Article | 2018 | Cellular and Molecular Biology64 ( 4 ) , pp.78 - 82

Reactive oxygen species (ROS) have been shown to be responsible for inducing DNA damage leading to mutagenesis, carcinogenesis, and cell death if the capacity of the protective antioxidant system is impaired. Endometrial carcinoma is the primary cancer type in the female genital system. The enhanced cell lipid peroxidation and impaired antioxidant enzyme activities observed in patients with endometrial cancer indicate the potential for oxidative injury to cells and cell membranes in such patients. The aim of the study was to investigate the possible association between gene variants of superoxide dismutase (SOD), myeloperoxidase (MP . . .O), and NADPH quinone oxido reductase (NQO1), and their possible role in endometrial cancer in Turkish patients. According to results, MPO G+ genotype and AG genotype were significantly increased in patients compared with controls ( Daha fazlası Daha az

Yılmaz, Seda Güleç | Gül, Tuğçe | Attar, Rukset | Yıldırım, Gazi | İşbir, Turgay

Article | 2018 | Journal of the Turkish-German Gynecological Association19 ( 3 ) , pp.128 - 131

Objective: The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.Material and Methods: For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performedon blood samples of uterine leiomyoma (n27) and control (n33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL,USA) was used.Results: A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and controlgroups, and the frequencies of the T allele in the uterine leiomyoma groups were significan . . .tly higher than in the control group.Conclusion: The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developinguterine leiomyoma. (J Turk Ger Gynecol Assoc 2018; 19: 128-31 Daha fazlası Daha az

Ozdogan, S | Yaltirik, CK | Yılmaz, SG | Kaya, M | Duzkalir, AH | Demirel, N | İşbir, Turgay

Article | 2018 | IN VIVO32 ( 2 ) , pp.287 - 289

Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligo-dendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-alpha -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There . . . were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities Daha fazlası Daha az

Kirac, D | Erdem, A | Gezmis, H | Yesilcimen, K | Altunok, EC | İşbir, Turgay

Article | 2018 | CLINICAL AND EXPERIMENTAL HEALTH SCIENCES8 ( 1 ) , pp.1 - 8

Objective: This study aimed to investigate the relationship between genetic and environmental factors that are believed to have an effect on stent thrombosis (ST) in coronary artery disease (CAD) patients after stent implantation. Methods: Seventy-three CAD patients who were implanted with stents by surgical intervention were enrolled. Thirty-seven patients with ST were included in the patient group, and 36 patients without ST were included in the control group. After obtaining necessary information from the patients, DNA was isolated from blood. Rs2228570 and rs1544410 mutations in the vitamin D receptor (VDR) gene as well as rs458 . . .8 and rs7041 mutations in the vitamin D-binding protein (VDBP) gene were investigated by performing real-time polymerase chain reaction. Biochemical measurements, such as those of vitamin D and lipid levels, were performed using appropriate kits. Results were evaluated using statistical methods. Results: The number of individuals who carry homozygous or heterozygous alleles of the rs4588 mutation in the VDBP gene was found to be statistically high in the patient group (p=0.027). Vitamin D and hemoglobin levels were significantly low and C-reactive protein levels were significantly high, while the occurrence of vitamin D deficiency, hypertension, and familial history of CAD as well as the current status of smoking were significantly high in the patient group ( Daha fazlası Daha az

Kafadar, D. | Yaylim, I. | Kafadar, A.M. | Cacina, C. | Ergen, A. | Kaynar, M.Y. | İşbir, Turgay

Article | 2018 | Anticancer Research38 ( 10 ) , pp.5991 - 5998

Background/Aim: The single nucleotide polymorphism-31C/G identified in the survivin gene promoter seems to be associated with over-expression of survivin, an anti-apoptotic protein. In gliomas, increased survivin expression correlated with decreased survival. The aim of the study was to investigate whether survivin gene polymorphism associates with benign and malignant brain tumors and whether it affects survivin serum levels. Patients and Methods: Survivin polymorphism-31C>G was genotyped in 82 patients with brain tumors and 65 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sur . . .vivin levels were evaluated by enzyme-linked immuno sorbent assay (ELISA) in patients and controls. Results: Serum survivin levels in patients with malignant tumors were higher than patients with benign tumors (pG did not differ between patients and controls. Conclusion: Survivin promoter-31C>G gene polymorphism seems to be associated with serum survivin levels in brain tumors of different grades and histologies. © 2018 International Institute of Anticancer Research. All rights reserved Daha fazlası Daha az

Yilmaz, S.G. | Isbir, S. | Kunt, A.T. | İşbir, Turgay

Article | 2018 | In Vivo32 ( 3 ) , pp.561 - 565

Background/Aim: In this study, we determined the expression of selected circulating microRNAs (miRNA) and their potential roles as biomarkers in patients with atherosclerosis and a control group. Materials and Methods: In order to obtain insight into miRNA expression levels in atherosclerosis, we analyzed miRNA expression levels by real-time polymerase chain reaction (RT-PCR) in case (n=89) and healthy control (n=93) groups. Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of miRNAs. Results: miRNA221 and miRNA221 expression levels were significantly lower in patients than controls ( . . .p=0.011 and p=0.004, respectively). Receiver operator curve analysis demonstrated that expression levels of miRNA221 [area under curve (AUC)=0.623, p=0.0086) and miRNA222 (AUC=0.654, p=0.0006) were significantly different between groups. There were positive correlations between miRNA122a and triglyceride (p=0.046) and very-low-density lipoprotein (p=0.029) levels. Conclusion: miRNA221 and miRNA222 could be convenient biomarkers for diagnosis of atherosclerosis Daha fazlası Daha az

Atalan, N. | Acar, L. | Yapici, N. | Kudsioglu, T. | Ergen, A. | Yilmaz, S.G. | İşbir, Turgay

Article | 2018 | In Vivo32 ( 6 ) , pp.1653 - 1658

Background/Aim: Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels. Materials and Methods: The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded. Results: TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group. It was also seen that when the lactate level was >5 mmol/l in patients in the sepsis group, the serum TLR-9 levels were substantially higher. Conclusion: There is a relationshi . . .p between sepsis-induced immunosuppression and serum TLR-9 levels. The host immunity system can be activated by means of TLR-9-related systems, while hyperlactatemia may play a stimulating role in the re-activation of the immune system. © 2018 Institute of Electrical and Electronics Engineers Inc. All rights reserved Daha fazlası Daha az

Ozdogan, S. | Yaltirik, C.K. | Yilmaz, S.G. | Kaya, M. | Duzkalir, A.H. | Demirel, N. | İşbir, Turgay

Article | 2018 | In Vivo32 ( 2 ) , pp.287 - 289

Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligodendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-? -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were . . . no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities. © 2018 International Institute of Anticancer Research. All Rights Reserved Daha fazlası Daha az

Kirac, D | Eraydin, F | Avcilar, T | Ulucan, K | Ozdemir, F | Guney, AI | İşbir, Turgay

Conference Object | 2018 | EUROPEAN JOURNAL OF HUMAN GENETICS26 , pp.476 - 476

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