The effects of rhBMP-2 on bone healing in ovariectomized rats treated with zoledronic acid and dexamethasone

Atalay, B. | Cabbar, F. | Guler, N. | Sencift, K.

Article | 2018 | Biomedical Research (India)29 ( 17 ) , pp.3362 - 3369

Background/aim: The aim is to determine the histological findings of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone healing after zoledronic acid (ZOL) treatment in ovariectomized rats. Materials and methods: The study was performed on 42 female Sprague-Dawley rats untreated for 4 w after ovariectomy. Fourteen rats were injected with 7.5 µg/kg ZOL once a week, and 1 mg/kg dexamethasone per day served as control. Two groups of 14 rats were injected with the same dosage as a control group for once a week for two weeks (group A) and three weeks (group B). The molar teeth in both jaws were extracted two weeks after the . . . first injection for the control group and group A and three weeks for group B. Collagen carriers with rhBMP-2 were implanted into the extraction sockets in groups A and B. The histological findings of new bone formation, and necrotic bone were recorded. Results: The new bone formation was observed in 71.4% of group A and 28.6% of group B (P=0.017). Necrotic bone was observed in 14.3% of both the control group and group A and 71.4% of group B (P=0.032). Conclusion: An increased rhBMP-2 dosage on bone healing after ZOL treatment in ovariectomized rats could lead to new bone formation. © 2018, Scientific Publishers of India. All rights reserved Daha fazlası Daha az

Volumetric Muscle Measurements Indicate Significant Muscle Degeneration in Single-Level Disc Herniation Patients

Yaltırık, K. | Güdü, B.O. | Işık, Y. | Altunok, Ç. | Tipi, U. | Atalay, B.

Article | 2018 | World Neurosurgery116 , pp.3362 - 3369

Background: There is a strong relationship between lower back pain and paraspinal muscle atrophy. In this study, we aimed to investigate the prevalence of lumbar paravertebral muscle atrophy in patients with and without single-level disc herniation. Methods: The 110 retrospectively analyzed patients in this study were divided into 2 groups. Group A included 55 patients with radiologically confirmed single-level disc herniation with back pain and radiculopathy. Group B included 55 patients with back pain without radiologic lumbar disc herniation. The paravertebral muscle cross-sectional areas were measured in both groups by 2 indepen . . .dent observers. Results: In total, 68 women and 42 men were examined. Their mean age was 40.85 years old. The mean ages of groups A and B were 42.49 and 39.22 years, respectively. The cross-sectional areas of the multifidus muscles (MM) and erector spinae muscles were significantly greater in group B than in group A (P < 0.0001). However, there were no statistically significant differences in the psoas major cross-sectional areas, disc heights, and perpendicular distances between the MM and the laminae. Conclusions: The MM and erector spinae muscle groups are innervated by the dorsal root of the spinal nerve arising from the same level; therefore, long-term pressure on the root caused by disc herniation can cause atrophy and degeneration of that muscle group. © 2018 Elsevier Inc Daha fazlası Daha az

Spinal tuberculosis mimicking failed back surgery

Özdoğan, S. | Yaltırık, C.K. | Düzkalır, A.H. | Demirel, N. | Kaya, M. | Atalay, B.

Article | 2018 | American Journal of Case Reports19 , pp.249 - 253

Objective: Challenging differential diagnosis Background: The aim of this study was to draw attention to rare spinal infections in recurrent failed spinal surgeries. Case Report: A 59-year-old female was admitted to the hospital for back pain, which was assessed as a 9 on the visual analogue scale (VAS); the patient reported tiredness and night sweats. She had an operation for L3–4 far lateral disc herniation four years ago. Then another operation for L4–5 disc herniation six months ago and immediately three months later she has an operation with L3–4–5 fixation again. She had hypothyroidism, diabetes mellitus, and hypertension. Her . . . daughter was cured of pulmonary tuberculosis 20 years ago. We performed an operation by L4–5 discectomy; all granulation formation with inflammatory processes were debrided and irrigated with antibiotics at levels of L3–5. The old fixation was controlled and replaced. Her back pain improved immediately after surgery; she had a score of 2 on the VAS. Two days after her surgery, our Infection Disease Department reported acid resistant bacillus (ARB+) in samples and began anti-tuberculosis medication. Conclusions: Spinal infections should always be taken into consideration in recurrent failed back surgeries. © Am J Case Rep, 2018 Daha fazlası Daha az

What is the survival rate of dental implants in Turkey? A systematic review

Cabbar, F. | Burdurlu, M.Ç. | Işiksaçan, N.S. | Atalay, B. | Çapar, G.D.

Review | 2018 | Biomedical Research (India)29 ( 3 ) , pp.485 - 495

Objectives: The purpose of this study was to examine the failures of dental implants in Turkey and to investigate the complications, which may lead to implant loss. Study Design: The Systematic review was performed in accordance with PRISMA statement and Cochrane guidelines. PubMed, Google Scholar, Cochrane Library, TUBITAK ULAKBIM databases were searched for both in English and Turkish up to 2015. Data on implant failure, demographic variables and outcomes were included. Nonclinical and animal reports were excluded. Search was conducted by two authors and conflicts were resolved by a third reader. Results: Seventeen reports were sa . . .tisfied the inclusion criteria. In total, 1764 (51.19% female and 48.81% male) participants were included. A total of 4487 implants were used. Total implant success was 97.48% (61 early and 52 late failures) in a follow-up period for 42.71 ± 33.78 months. The failure reasons were infection (38.9%), lack of osseointegration (44.4%), implant fractures (5.8%), periimplantitis (1.76%), sensory disturbances (2.65%). Conclusion: Immediate and late implantation has similar failure rates and failure rates may increase with time. Implants have similar survival rates with the literature in Turkey region as well. It was observed that few reports with limited data were reported considering the high number of implants placed in the Turkey. © 2018, Scientific Publishers of India. All rights reserved Daha fazlası Daha az

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