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Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats

Kilinc, E. | Dagistan, Y. | Kukner, A. | Yılmaz, B. | Agus, S. | Soyler, G. | Tore, F.

Article | 2018 | Clinical and Experimental Pharmacology and Physiology45 ( 6 ) , pp.536 - 546

The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature of migraine pain. Salmon calcitonin (SC) exhibits antinociceptive effects in the treatment of various pain conditions. In this study, we explored the mechanisms underlying the analgesic effect of salmon calcitonin on migrane pain using glyceryltrinitrate (GTN)-induced model of migraine and ex vivo meningeal preparations in rats. Rats were intraperitoneally administered saline, GTN (10 mg/kg), vehicle, saline + GTN, SC (50 µg/kg) + GTN, and SC alone. Also, ex vivo meningeal preparations were applied topically 100 µmol/L GTN, 50 µmol/L SC, . . .and SC + GTN. Calcitonin gene-related peptide (CGRP) contents of plasma, trigeminal neurons and superfusates were measured using enzyme-immunoassays. Dural mast cells were stained with toluidine blue. c-fos neuronal activity in trigeminal nucleus caudalis (TNC) sections were determined by immunohistochemical staining. The results showed that GTN triggered the increase in CGRP levels in plasma, trigeminal ganglion neurons and ex vivo meningeal preparations. Likewise, GTN-induced c-fos expression in TNC. In in vivo experiments, GTN caused dural mast cell degranulation, but similar effects were not seen in ex vivo experiments. Salmon calcitonin administration ameliorated GTN-induced migraine pain by reversing the increases induced by GTN. Our findings suggested that salmon calcitonin could alleviate the migraine-like pain by modulating CGRP release at different levels including the generation and conduction sites of migraine pain and mast cell behaviour in the dura mater. Therefore salmon calcitonin may be a new therapeutic choice in migraine pain relief. © 2018 John Wiley & Sons Australia, Lt Daha fazlası Daha az

Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects

Ozcelik, O. | Algul, S. | Yılmaz, B.

Article | 2018 | Cellular and molecular biology (Noisy-le-Grand, France)64 ( 10 ) , pp.130 - 133

This study aimed to investigate the potential effects of acute soccer matches performed in morning, afternoon and at night on both nesfatin-1 and irisin levels in trained subjects. Total of 20 male subjects performed in soccer matches at three different times of day: morning, afternoon, and night. Pre- and post-match venous blood samples were taken, and levels of both nesfatin-1 and irisin were analysed using the enzyme-linked immunosorbent assay (ELISA). Following all matches, the subjects' irisin levels increased significantly in all subjects (p < 0.0001). Nesfatin-1 levels were also increased after the matches; however, the in . . .crease was statistically significant for morning (P=0.01) and night-time (p=0.009). The subjects' nesfatin-1 levels did not increase in all subjects and decrease of nesfatin-1 levels observed in some subjects after matches. This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin levels in all subjects but nesfatin-1 response varied among the subjects and it did not change significantly in afternoon match Daha fazlası Daha az

Neuronal Energy Production

Hazal Yalçinkaya, B. | Genç, S. | Özilgen, M. | Yılmaz, B.

Book Part | 2018 | Comprehensive Energy Systems03.05.2020 , pp.638 - 672

The voluntary and involuntary communication within the body occurs through the nervous system. The building blocks of the nervous system are electrically excitable neurons and neuroglia. They require large amount of ATP in a very short period of time to be able to reestablish resting membrane conditions after transmitting signals as electric current; entropy generation accompanies this process. Generally, a single neuron cannot provide the sufficient energy to achieve this and will need the support of neuroglia. This chapter includes theories of signal transmission along the neurons parallel with the basic thermodynamic knowledge to . . . describe energy supply and consumption. © 2018 Elsevier Inc. All rights reserved Daha fazlası Daha az

Assessment of the work efficiency with exergy method in ageing muscles and healthy and enlarged hearts

Çlatak, J. | Özilgen, M. | Olcay, A.B. | Yılmaz, B.

Article | 2018 | International Journal of Exergy25 ( 1 ) , pp.1 - 33

Thermodynamic aspects of skeletal and cardiac muscle work performance are assessed with the data obtained from the literature. Since the second law muscle work efficiency decreases with declining metabolic energy conversion efficiency in the mitochondria, followed by structural failure of the muscles during ageing, the thermodynamic aspects of the muscle work ageing process were simulated by incorporating the decreasing second law muscle work efficiency with the exercise data obtained with the healthy young adults. Within limits of the data analysed here, glucose utilisation ability of the cardiac muscle appears to be the most criti . . .cal factor determining its work performance. The left and the right ventricles of the enlarged heart had the ability of utilising approximately 3.5 and 2.7 times less glucose, respectively, than their healthy counterparts. The work performance and the entropy generation by the enlarged and the healthy hearts maintained the same ratios. Copyright © 2018 Inderscience Enterprises Ltd Daha fazlası Daha az

Entropy generation behaviour of the lean and obese rats shows the effect of the diet on the wasted life span work

Semerciöz, A.S. | Yılmaz, B. | Özilgen, M.

Article | 2018 | International Journal of Exergy26 ( 3 ) , pp.359 - 391

Entropy generation behaviour of the rats is affected by their diet and nature of being lean or obese. Thermodynamic analyses showed that the obese Zucker rats may generate 22,092 kJ/K of life span entropy when fed soybean oil diet and 38,718 kJ/K of entropy when fed with butter fat. Their lean counterparts may generate 15,314 kJ/K of life span entropy when fed with soybean oil diet and 47,657 kJ/K of entropy and when fed with butter fat diet. The lean Zucker rats fed with butter fat diet had 92%, while the obese Zucker rats fed with soybean oil diet had 72%, wasted life-time work potential. Obese Zucker rats fed with butter fat diet . . . performed approximately 48% more total physical work and generated 48% more muscular heat through their life span than the lean rats fed with soybean oil diet. Copyright © 2018 Inderscience Enterprises Ltd Daha fazlası Daha az

Bioenergy Conversion

Çatak, J. | Semerciöz, A.S. | Yalçinkaya, B.H. | Yılmaz, B. | Özilgen, M.

Book Part | 2018 | Comprehensive Energy Systems04.05.2020 , pp.1131 - 1158

The major energy source in the world is solar energy. Only a small fraction of this energy is absorbed by plants to produce starch, for example, a glucose polymer, via photosynthesis. Glucose molecules are employed to produce adenosine triphosphate (ATP) in energy metabolism, which may be utilized to synthesize new plant cells. Herbivore animals survive on plants; carnivores prey on the herbivores. Both plant and animal cells store the chemical energy in their structures in the form of high-energy molecules. The raw material of fossil fuels is fossilized biological structures, for example, plant and animal cells. A similar conversio . . .n may be achieved by direct conversion, by skipping the fossil formation step, in biodiesel factories. The fossil fuel-rich areas of the world once housed rich ecosystems, before their inhabitants were fossilized. The age of the organisms and their resulting fossil fuels is typically millions of years. In biological structures, growth and reproduction and muscle work performance are achieved with ATP expenditure. In all of these processes substantial amounts of entropy are generated. Hormonal control of this energy uptake and utilization regulates functioning of anabolism and catabolism; the brain provides the balance between them. Imposing energy (calorie) restriction on the body may cause substantial changes in numerous body functions. © 2018 Elsevier Inc. All rights reserved Daha fazlası Daha az

Mitochondrial Energy Production

Hazal Yalçinkaya, B. | Genç, S. | Çatak, J. | Özilgen, M. | Yılmaz, B.

Book Part | 2018 | Comprehensive Energy Systems03.05.2020 , pp.95 - 125

The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review

Günalan, E. | Yaba, A. | Yılmaz, B.

Article | 2018 | Journal of the Turkish German Gynecology Association19 ( 4 ) , pp.220 - 232

Polycystic ovary syndrome (PCOS) is complex heterogeneous disorder that has several aspects in terms of pathology such as metabolic, endocrine, reproductive, and psychological. However, the etiology of PCOS remains poorly understood. Several studies suggest that insulin resistance and hyperandrogenism play a central role in the progression of PCOS pathophysiology. Therefore, common treatment strategies of PCOS are based on lifestyle modification, which include exercise, diet, and nutrient supplementation therapy. Recent studies have recommended some nutrients such as vitamins, minerals, and vitamin-like nutrients for the therapy of . . .PCOS because each has at least one functional property in PCOS-induced pathways. Therefore, it is claimed that the cause of PCOS could be vitamin or mineral deficiency. This review aims to provide a critical literature survey on nutritional supplementation for the treatment of PCOS-associated endocrine and metabolic dysfunctions and discuss the role of nutrients in the management of PCOS in view of the clinical trials and experimental studies. © 2018 by the Turkish-German Gynecological Education and Research Foundation Daha fazlası Daha az

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