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Knowledge management, innovation, and competitive advantage: is the relationship in the eye of the beholder?

Aydin, S. | Dube, M.

Article | 2018 | Knowledge Management Research and Practice16 ( 3 ) , pp.402 - 413

As countries like Turkey rapidly develop their technology sectors, there is significant interest in whether knowledge management (KM) can help companies gain competitive advantages. However, individual perceptions as to the effectiveness of KM or information systems, which ultimately determine company-wide usage, may vary by individual preferences, as well as by tasks and department. This study compares a sample of 61 survey responses from 61 firms operating in Turkey, to an auxiliary sample of 34 responses from a single firm. The populations of the responses for the two surveys were statistically the same. Furthermore, the response . . .s in the auxiliary survey provided similar relationships between the regression factors as the cross-company responses. This suggests a potential reinterpretation of cross-company survey results, and furthermore that KM and information technology measures for firms could be treated as distributions instead of single values. Perceptions also varied by employee turnover and workforce size. © 2018, © Operational Research Society 2018 Daha fazlası Daha az

Efficacy of multi-mode adhesive systems on dentin wettability and microtensile bond strength of resin composite

Arhun, N. | Halacoglu, D.M. | Ozduman, Z.C. | Tuncer, D.

Article | 2018 | Journal of Adhesion Science and Technology32 ( 21 ) , pp.2405 - 2418

Purpose: To evaluate the wetting ability and the microtensile bond strength of adhesive systems in various depths of dentin. Materials and Method: 48 extracted human molars cut in half in buccolingual direction. Buccal and lingual surfaces were used to obtain deep (n = 48) and superficial (n = 48) dentin. Groups were divided into 4 subgroups: Self-etch (CSE), etch&rinse (SB), multi-mode self-etch (SAU) and multimode etch&rinse (EAU) adhesive systems. 3 consecutive contact-angle measurements were obtained: T0- 3 µl drop of distilled water on dentin; T1-Droplet of the adhesive; T2- Distilled water after polymerization of the adhesive. . . . After composite build-ups, microtensile measurements were performed. Contact angle data were analysed with analysis of variance for repeated measures. Bond strength data were analyzed by repeated measures analysis of variance, comparisons were made according to the logarithmic values (p Daha fazlası Daha az

Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation

G. Renda | B. Korkmaz | M. Kılıç | M.K. Duman | H. Kırmızıbekmez

Article | 2018 | Natural Product Research32 ( 16 ) , pp.1902 - 1910

The present study was undertaken to evaluate the in vivo analgesic activities of the extracts prepared from the aerial parts and roots of Scrophularia kotscyhana and to isolate the bioactive metabolites from the most active extract. Analgesic activities of all extracts and subextracts at the doses of 5, 10 and 30 mg/kg (i.p.) were examined using hot plate test in mice. Among the tested extracts, MeOH extract prepared from the aerial parts and the n-butanol subextract prepared thereof displayed the best analgesic activity at all doses. Phytochemical studies on n-butanol subextract led to the isolation of two new iridoid glycosides as . . . an inseparable mixture, 8-O-acetyl-4'-O-(E)-(p-coumaroyl)-harpagide (1) and 8-O-acetyl-4'-O-(Z)-(p-coumaroyl)-harpagide (2) along with five known secondary metabolites, ß-sitosterol 3-O-ß-glucopyranoside (3), apigenin 7-O-ß-glucopyranoside (4), apigenin 7-O-rutinoside (5), luteolin 7-O-ß-glucopyranoside (6) and luteolin 7-O-rutinoside (7). The iridoid mixture (1 and 2), 3 and 4 elicited significant inhibition of pain at 5 mg/kg dose. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Ground filtering and DTM generation from DSM data using probabilistic voting and segmentation

Özcan, A.H. | Ünsalan, Cem | Reinartz, P.

Article | 2018 | International Journal of Remote Sensing39 ( 9 ) , pp.2860 - 2883

Automated digital terrain model (DTM) generation from remotely sensed data has gained wide application areas due to increased sensor resolution. In this study, a novel ground filtering and segmentation method is proposed for digital surface model (DSM) data. The proposed method starts with extracting DSM feature points. These are used in a probabilistic framework to generate a non-ground object probability map in spatial domain. Modes of this map are used as seed points in a novel segmentation method based on morphological operations. This leads to ground filtering and DTM generation. The method is tested on three different data set . . .s. Two of these originate from light detection and ranging (lidar) sensors, where resulting kappa coefficient (?) range mostly higher than 95% for differently structured urban areas. Also, the visual appearance of the generated DTM exhibits obvious improvements over all other investigated methods. The third data set is a DSM obtained from WorldView-2 stereo image pairs. Also here, we compare our results with three different methods in the literature. Although the DSM quality is much lower, more than 85% of ? can be reached by the proposed method, showing its superiority over other methods. Overall experimental results show that the proposed method can be used reliably for DTM generation. The results also indicate that the method has prominent advantages in comparison to established methodologies in terms of robustness in handling urban areas of different properties. Moreover, there are only few parameters to adjust in the proposed method, and these are independent of the object size in DSM data. © 2018 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Optimisation of micro-arc oxidation electrolyte for fabrication of antibacterial coating on titanium

Teker Aydogan, D. | Muhaffel, F. | Menekse Kilic, M. | Karabiyik Acar, O. | Cempura, G. | Baydogan, M. | Cimenoglu, H.

Article | 2018 | Materials Technology33 ( 2 ) , pp.119 - 126

This study has been carried out to optimise the silver (Ag) content of the coating synthesised on commercially pure titanium (Cp–Ti, Grade 4) for biomedical applications by micro-arc oxidation (MAO) process. The MAO process has been conducted in electrolytes containing silver acetate (AgC2H3O2) at different concentrations between 0 and 0·002 mol L-1. When compared to the base electrolyte, coatings synthesised in ?0·001 mol L-1 AgC2H3O2 added electrolytes exhibited an antibacterial efficiency of 99·98% against Staphylococcus aureus (S. aureus). Detailed examination revealed that the presence of 0·001 mol L-1 AgC2H3O2 in the electroly . . .te resulted in incorporation of 1·14 wt-% Ag into fabricated coating consisting mainly of outer hydroxyapatite (HA) and inner titanium oxide (TiO2) layers. In comparison to the Ag-free coating, 1·14 wt-% Ag in the coating lowered the proliferation of SAOS-2 cells, which still tended to grow at a relatively low rate with increasing culturing time. © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Unaddressed problems and research perspectives in scheduling blood collection from donors

Baş Güre, S. | Carello, G. | Lanzarone, E. | Yalçındağ, S.

Note | 2018 | Production Planning and Control29 ( 1 ) , pp.84 - 90

Many optimisation problems arise in managing the Blood Donation (BD) supply chain. Most of them have been addressed in the literature, while other problems, e.g. donation scheduling, have not been sufficiently addressed so far. However, blood collection from donors may have a disruptive impact on the entire BD supply chain if not properly managed. For example, scheduling donation appointments based on some system metrics may improve the flow of blood units through the BD supply chain and increase the quality of service perceived by donors. In this short communication, we present the donation scheduling problem and highlight the lack . . . of work in the literature that deals with this problem. Then, we analyse the impact of an unbalanced flow of blood units on the BD system and the benefits that may derive from a suitable appointment scheduling. Finally, we propose suggestions for future research in BD collection scheduling that may improve the BD process. © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Karyomorphology and nuclear DNA content of sixteen Ophrys L. taxa from Turkey

Deniz, İ.G. | Genç, İ. | Yücel, G. | Sümbül, H. | Sezik, E. | Tuna, M.

Article | 2018 | Plant Biosystems152 ( 4 ) , pp.711 - 719

Karyotypes in 16 representative taxa of the Ophrys genus are compared, based on Feulgen-stained somatic metaphase chromosomes. The karyotypes of O. omegaifera subsp. israelitica, O. ulupinara, O. lycia, O. argolica subsp. lucis, O. argolica subsp. lesbis, O. climacis and O. reinholdii subsp. reinholdii are described for the first time. Karyological analyses indicate relationships among the species with respect to their asymmetry indices. All Ophrys taxa studied were diploid with 2n = 2x = 36 chromosomes. One B chromosome has been detected among the chromosomes of O. argolica subsp. lucis. All karyotypes are symmetrical, consisting o . . .f metacentric and submetacentric chromosomes. The longest chromosomes of all the investigated specimens contain a secondary constriction. It is determined that there is a correlation between the total number of chromosomes having secondary constrictions and the evolutionary development order of the taxa. Based on nuclear DNA content, analysis was carried out by flow cytometer using propodium iodide as fluorochrome, 2C nuclear DNA content of 16 Ophrys species varying between 20.80 pg (O. argolica subsp. lucis) and 23.11 pg (O. omegaifera subsp. israelitica). Karyotype asymmetry relationships are discussed according to the bidimensional scatter plots of A1–A2, CVCL–CVCI, CVCL–MCA and CVCI–MCA. © 2017 Società Botanica Italiana Daha fazlası Daha az

Effect of orthognathic surgery on masticatory performance and muscle activity in skeletal Class III patients

Celakil, D. | Ozdemir, F. | Eraydin, F. | Celakil, T.

Article | 2018 | Cranio - Journal of Craniomandibular Practice36 ( 3 ) , pp.174 - 180

Objective: To evaluate the effect of double jaw orthognathic surgery (OGS) on masticatory performance and electromyographic activity of the masseter and anterior temporal muscles in skeletal Class III patients. Methods: Individuals were instructed to chew standardized round tablets of silicone impression material. The cumulative weight percentage was calculated using sieve analysis. The bilateral surface electromyographic activity of the muscles was evaluated. Following the orthodontic treatment, a stabilization splint was fabricated. Patients were instructed to wear it full-time until the surgical procedure occurred. Recordings wer . . .e performed before the splint application (T0), after the splint application (T1), 1 month after the OGS (T2), and 6–8 months after the OGS (T3). Results: Median particle size of the chewed silicone material did not differ from T0 to T1 with the use of an occlusal splint (p > 0.05). However, it decreased from 9.46 to 6.92 cm from T2 to T3. From T0 to T3, a statistically significant decrease was found, following the surgical intervention (p Daha fazlası Daha az

Comparative approach to analyse the effects of different surface treatments on CAD/CAM resin nanoceramics–resin composite repair bond strength

Tinastepe, N. | Turkes, E. | Kazazoglu, E.

Article | 2018 | Biotechnology and Biotechnological Equipment32 ( 1 ) , pp.142 - 149

Limited data are available on the repair bond strength between computer-aided design and manufacturing (CAD/CAM) resin nanoceramics and composite repair materials. Therefore, the purpose of this study was to test the influence of several different surface treatment modalities, intermediate agents and phosphoric acid on the shear bond strength (SBS) of repair composites with water-aged CAD/CAM resin nanoceramics. Three pretreatment and four conditioning methods comprised 12 different groups. A universal testing machine was used to test the SBS. Specimens were examined with a stereomicroscope and scanning electron microscope to determ . . .ine the fracture mode. The results showed that a combination of the pretreatment and conditioning methods significantly enhanced the SBS of the resin nanoceramic (p:0.001; p < 0.01), while etching with phosphoric acid did not affect the SBS (p:0.841; p > 0.05). This study showed that surface pretreatment in combination with a conditioning method should be used in the repair of CAD/CAM nanoceramics. The highest SBS values were achieved by grinding the surface with a diamond bur followed by silane and adhesive application, whereas the lowest values were obtained in the non-conditioned non-pretreated group. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Histopathologic evaluation of the effects of local simvastatin application and photobiomodulation by light-emitting diode on bone healing of rat calvarial defects

Burdurlu, C. | Deniz, E. | Olgac, V.

Article | 2018 | Biotechnology and Biotechnological Equipment32 ( 2 ) , pp.442 - 450

The purpose of this study was to evaluate the effect of photombiomodulation (PBM) and locally applied simvastatin on bone formation in critical size defects of the experimental rat model calvarium. A total of 28 Spraque-Dawley male rats, mean age of 18 weeks, were used. Bilateral 5 mm critical sized calvarial defects were created. Then 0.5 mg/mL simvastatin solution was inoculated into gelatin sponge and locally applied on one side. The other side served as control. Half of the animals were subjected to PBM treatment and the remaining half were left for spontaneous healing. The animals were sacrificed by guillotine at days 8 and 15. . . . The specimens were histopathologically analysed. The histopathologic evaluation revealed that the new bone formation levels were significantly higher at the 15th day compared to the 8th day. The bone formation levels with PBM and simvastatin treatment either combined or applied individually were significantly higher than the control ones. PBM and local simvastatin applications had favourable effects on the early phase of new bone formation and reduced the bone healing period in the rat model. Further human trials must be performed for evaluation of the reliability of this protocol. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Role of STRO-1 sorting of porcine dental germ stem cells in dental stem cell-mediated bone tissue engineering

Gurel Pekozer, G. | Ramazanoglu, M. | Schlegel, K.A. | Kok, F.N. | Torun Kose, G.

Article | 2018 | Artificial Cells, Nanomedicine and Biotechnology46 ( 3 ) , pp.607 - 618

Stem cells of dental origin emerged as a new source for the regeneration of tissues with advantages mainly including non-invasive collection procedures and lack of ethical contraversies with their harvest or use. In this study, porcine TGSCs (pTGSCs) were isolated from mandibular third molar tooth germs of 6-month-old domestic pigs. This is the first study that reports the isolation and characterization of TGSCs from porcine third molars and their differentiation depending on STRO-1 expression. PTGSCs were sorted according to their STRO-1 expression as STRO-1(+) and STRO-1(-). Sorted and unsorted heterogenous cells (US) were charact . . .erized by their osteogenic, chondrogenic and adipogenic differentiation capabilities. STRO-1(+) cells exhibited a higher proliferation rate owing to their clonogenic properties. All three groups of cells were found differentiated into osteogenic lineage as shown by ALP activity, calcium deposition assay, detection of osteogenic mRNAs and, proteins and mineralization staining. According to differentiation analysis, STRO-1(+) cells did not show a better performance for osteogenesis compared to STRO-1(-) and US cells. This might indicate that STRO-1(+) cells might require a heterogeneous population of cells including STRO-1(-) in their niche to perform their proposed role in osteogenesis. © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Development of novel self-assembled polymeric micelles from partially hydrolysed poly(2-ethyl-2-oxazoline)-co-PEI-b-PCL block copolymer as non-viral vectors for plasmid DNA in vitro transfection

Kara, A. | Ozturk, N. | Esendagli, G. | Ozkose, U.U. | Gulyuz, S. | Yilmaz, O. | Vural, I.

Article | 2018 | Artificial Cells, Nanomedicine and Biotechnology46 ( sup3 ) , pp.607 - 618

A new efficient, non-viral gene delivery cationic polymeric micellar system was developed by partial hydrolysis of poly(2-ethyl-2-oxazoline) (PEtOx) with two different hydrolysis percentages of PEtOx (30% and 60%) to reduce the disadvantages of the PEI. These self-assemble amphiphilic cationic micelles prepared from poly(2-ethyl-2-oxazoline)30%-co-poly(ethyleneimine)-block-poly(?-caprolactone) (PEtOx30%-co-PEI-b-PCL) (PPP30) and poly(2-ethyl-2-oxazoline) 60%-co-poly(ethyleneimine)-block-poly(?-caprolactone) (PEtOx60%-co-PEI-b-PCL) (PPP60) block copolymers were successfully condensed with pEGFP-C3 plasmid DNA via electrostatic intera . . .ctions to form micelle/DNA complexes with desirable particle sizes. All formulations showed low critical micelle concentration (CMC) values that means highly stable in serum containing medium. Polymeric micelles were also evaluated for their stability in the presence of serum and nuclease as well as cytotoxicity and transfection efficiency. All our results proved that our novel polymeric micellar system prepared by PPP60 block copolymer offer to be an efficient promising carrier for gene delivery applications. Moreover, these findings contribute to design and development of novel gene vectors with tunable and functionality features and also to reduce the cytotoxicity of PEI by partial hydrolysis of PEtOx an alternative synthesis method to produce linear PEI. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

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