Aslanger, Emre | Sezer, Murat | Umman, Sabahattin

Other | 2016 | The Anatolian Journal of Cardiology16 ( 9 ) , pp.713 - 719

High blood pressure (BP) has been identified as a major risk factor for cardiovascular complications. Although two-way association between BP and hypertensive complications makes hypertension a near-ideal biomarker, BP as "the cause" for the complications of HT per se still needs more evidence. Another entirely possible hemodynamic candidate for causing hypertensive cardiovascular adverse events can be flow or its iterations, which might have escaped the attention because of its perfect correlation with pressure and harder technical measurement. In this article, we analyze the evidence in hand to compare flow- and pressure . . .-related phenomena to delineate which of the two is the dominant mediator of complications related to hypertension and should be the target for therapy. A "flow-" rather than a "pressure-" based factor, as the causative or major driving mediator of common hypertensive complications, may change our understanding of hypertension pathophysiology Daha fazlası Daha az

Bayrakdar, Mehmet

Other | 2016 | Diyanet İlmi Dergi52 ( 1 ) , pp.11 - 16

Bu makalede Fârâbînin felsefesinde tümel kavramların varlıkla ilişkilerinin birisi olan öncelik, beraberlik ve sonralık ilişkisi, kısa ve sistematik bir biçimde tanıtılacaktır. Bu tür ilişkiyi ilk defa kuranın Fârâbî olduğuna da işaret edilecektir. The purpose of this article is to present, in a brief and systematic way, one of the aspects of universals relations to existence, in the philosophy of al-Fârâbî, in terms of time, e.i. ante rem, inre and post rem. And it shall be pointed out that al-Fârâbî was the first philosopher to formulate such a kind of relationship.

Çelikmen, Mustafa Ferudun | Sarıkaya, Sezgin | Özüçelik, Doğaç Niyazi | Sever, Mehmet Şükrü | Açıksarı, Kurtuluş | Yazıcıoğlu, Mustafa | Sadıllıoğlu, Sıla

Other | 2016 | Ulusal Travma ve Acil Cerrahi Dergisi22 ( 4 ) , pp.305 - 314

AMAÇ: Bu çalışmada, mekanik ezilme yaralanması oluşturulan sıçanlarda, asetaminofen ve mannitolün böbrek fonksiyonu ve histopatolojisi üzerine etkileri araştırıldı.GEREÇ VE YÖNTEM: Çalışmada 370-400 gram ağırlığında 36 sıçan kullanıldı. Kontrol amaçlı birinci gruba bir işlem uygulanmadı. Diğer beş gruba ikişer saat süresince her iki bacak gastroknemius kası bölgesine mekanik ezilme işlemi uygulandı. Sonra dördüncü gruba asetaminofen 100 mg/kg; beşinci gruba mannitol 1 gr/kg; altıncı gruba asetaminofen 100 mg/kg ve mannitol 1 gr/kg intraperitoneal verildi. Herhangi bir tedavi uygulanmayan ikinci grup iki saat sonra, üçüncü grup ve te . . .davi grupları ise 24 saat sonra sakrifiye edilerek kan ve doku örnekleri alındı.BULGULAR: Sodyum, potasyum, alanin aminotranferaz, kreatinin, ortalama kreatinin klirensi değerleri açısından asetaminofen ve mannitol tedavi grupları arasında istatistiksel olarak anlamlı fark bulunmadı. Histopatolojik olarak hidropik dejenerasyon, tübüler nekroz, enflamasyon, tubulus lü-meninde immünoperoksidaz ve miyoglobin varlığı, tubulus epitel hücre dejenerasyonu, tubulus lümeninde PAS boyanan materyel varlığı bulgularının mannitol uygulanan grupta azaldığı, asetaminofen uygulanan grupta mannitol uygulanan gruptan daha fazla azaldığı, asetaminofenle mannitol birlikte uygulandığında ise bulguların tek başına mannitol uygulamasından daha iyi, ancak tek başına asetaminofen uygulamasından daha iyi olmadığı görüldü.TARTIŞMA: Ezilme yaralanmalarında oluşan böbrek hasarında asetaminofen histopatolojik olarak mannitolden daha etkilidir. Asetamniofen manni-tolle birlikte kullanıldığında ise karaciğere olan toksik etkisi daha az olmaktadır BACKGROUND: The present objective was to evaluate effects of acetaminophen and mannitol on renal function and histopathology in crush injuries.METHODS: Thirty-six rats weighing 370-400 g each were used. No surgery was performed on the first (control) group. The gastrocnemius muscle regions of each rat in the remaining 5 groups were compressed for 2 or 24 hours. In the 4th group, 100 mg/kg acetaminophen was intraperitoneally administered. In the 5th group, 1 g/kg mannitol was administered. In the 6th group, 100 mg/kg acetaminophen and 1 g/kg mannitol were administered.RESULTS: No statistically significant differences were observed among the treatment groups in terms of sodium, potassium, alanine aminotransferase (ALT), and average creatinine clearance values. Hydropic degeneration, tubular necrosis, presence of immunoperoxidase and myoglobin, tubulus epithelial cell degeneration, and presence of PAS-dyed material in tubular lumen was more prominently decreased in the acetaminophen group than the mannitol group. Improvement was observed in the group that was administered both drugs, compared to the mannitol-only group, though findings were still worse than those of the group administered acetaminophen only.CONCLUSION: In crush injuries, acetaminophen improves histopathological renal damage better than mannitol. When used in conjunction with mannitol, the toxic effect of acetaminophen on the liver is decrease Daha fazlası Daha az

Özgen, Ali

Other | 2016 | Solunum18 ( 1 ) , pp.46 - 49

Objective: Malignant pleural effusion (MPE) is a frequent and disturbing complication of metastatic disease. Talc pleurodesis via percutaneosly placed 12-18F catheters is an effective procedure to treat recurrent MPE. We aimed to determine the efficiency of talc pleurodesis through very-small-bore catheters in the treatment of recurrent malignant pleural effusion. Methods: We performed 13 talc pleurodesis procedures in 10 patients with recurrent MPE via pre-existing 7F (6 patients) and 8F (4 patients) pig-tail catheters. We analyzed technical and clinical success of the procedure.Results: All procedures were performed successfully. . . .Complete or partial clinical success was achieved in 8 out of 10 patients. No major complication was observed. Conclusion: Talc pleurodesis through 7F or 8F catheters may be performed in selected patients with reduced patient discomfort, and similar success rates that was obtained using higher caliber catheters in the treatment of recurrent MP Daha fazlası Daha az

Göncü, Emek Kocatürk | Aktan, Şebnem | Atakan, Nilgün | Başkan, Emel Bülbül | Erdem, Teoman | Koca, Rafet | Utaş, Serap

Other | 2016 | Türkderm-Deri Hastalıkları ve Frengi Arşivi50 ( 3 ) , pp.82 - 98

http://www.trdizin.gov.tr/publication/paper/detail/TWpBek5qTTVPUT09 https://hdl.handle.net/20.500.11831/5960

Yaşargil, M. Gazi | Yaşargil, Dianne C. H.

Other | 2016 | Anatomy10 ( 1 ) , pp.78 - 84

Magnus Gustaf Retzius, 1842-1919, was a prolific researcher, honored and respected at home and abroad during his lifetime. His achievements are many and varied. He established pivotal and essential foundations in human anatomy and natural sciences on which, even today, research, teaching, medicine and surgery are founded. He paved the way for future scientists to advance and progress in these fields. The precise portrayal and superb presentation of his studies bear witness toa man obsessed with revealing the absolute reality. The text of all his anatomic publications is in German. Regretfully noEnglish translations exist. The high p . . .oints of Retzius' research will be presented, and a representation of his lesser-knownpursuits described. This paper aspires to arouse reflection on Retzius' philosophy, principles, standards and sources of inspiratio Daha fazlası Daha az

Servet, Erkan | Bekler, Halil | Kılınçoğlu, Volkan | Özler, Turhan | Özkut, Afşar

Other | 2016 | Acta Orthopaedica et Traumatologica Turcica50 ( 2 ) , pp.234 - 241

Objective: Epineural scar formation is one of the most significant negative factors affecting surgical repair after peripheral nerve injury. The scar tissue mechanically hinders axonal regeneration and causes adhesions between nerves and surrounding tissues. A hemostatic agent Ankaferd Blood Stopper (ABS; İmmun Gıda İlaç Kozmetik San. ve Tic. Ltd. Şti., Istanbul, Turkey) has not been previously used. Decreasing the postoperative bleeding and adhesions between nerve and surrounding tissues will prevent the formation of scar tissue, as well as corresponding compressive neuropathy and/or deceleration of axonal regeneration. The . . .purpose of this experimental study was to investigate the effects of bleeding on nerve healing and scar tissue after repair of peripheral nerve injuries.Methods: The right sciatic nerve of 30 Sprague-Dawley male rats (weighing 260-330 g) was cut 1.5 cm proximal to the trifurcation and repaired primarily with 8/0 sutures using epineural technique. The rats were then divided into 3 groups. Saline was applied in Group 1 (n10), ABS in Group 2 (n10), and heparin in Group 3 (n10) for 5 minutes to the repair site and surrounding tissues. In each group, electrophysiological measurements were performed with electromyography (EMG) at postoperative week 12. Magnetic resonance diffusion tensor imaging was used at week 12. Macroscopical and histopathological evaluations were conducted after sacrificing the rats at week 24 with total excision of the repaired sciatic nerves and surrounding tissues.Results: The ABS and saline groups showed better healing than the heparin group. The ABS and saline groups were better in the histopathologic evaluations, but there was no statistically significant difference between the 2 groups.Conclusion: Statistically significant differences were not found between the 3 groups. Significant results may be obtained with larger studie Daha fazlası Daha az

Vatanoğlu, Emine Elif Lutz | Ataman, Ahmet Doğan

Other | 2016 | Türk Biyokimya Dergisi41 ( 1 ) , pp.58 - 62

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