Nur, Rahime Burcu | Ulkur, Feyza | Nalbantgil, Didem

Other | 2015 | Turkish Journal of Orthodontics28 ( 1 ) , pp.31 - 37

Cleidocranial dysplasia (CCD) is a rare congenital deformity inherited as an autosomal genetic trait with the prevalence of1:1,000,000. It is characterized by dental defomities such as retained primary teeth, presence of supernumerary teeth, skeletaldicrepancy, malocclusion and retarded/absence of eruption of permanent teeth. The orthodontist take part in the team for patientswith CCD to resolve the eruption delay of permanent teeth and correct skeletal discrepancies. The aim of this review is to discussthe history, genetic backgrounds, clinical and dental features, different dental treatment approaches and orthodonticmanagement of . . .CCD. (Turkish J Orthod 2015;28:31–37 Daha fazlası Daha az

Çelikmen, Mustafa Ferudun | Sarıkaya, Sezgin | Özüçelik, Doğaç Niyazi | Sever, Mehmet Şükrü | Açıksarı, Kurtuluş | Yazıcıoğlu, Mustafa | Sadıllıoğlu, Sıla

Other | 2016 | Ulusal Travma ve Acil Cerrahi Dergisi22 ( 4 ) , pp.305 - 314

AMAÇ: Bu çalışmada, mekanik ezilme yaralanması oluşturulan sıçanlarda, asetaminofen ve mannitolün böbrek fonksiyonu ve histopatolojisi üzerine etkileri araştırıldı.GEREÇ VE YÖNTEM: Çalışmada 370-400 gram ağırlığında 36 sıçan kullanıldı. Kontrol amaçlı birinci gruba bir işlem uygulanmadı. Diğer beş gruba ikişer saat süresince her iki bacak gastroknemius kası bölgesine mekanik ezilme işlemi uygulandı. Sonra dördüncü gruba asetaminofen 100 mg/kg; beşinci gruba mannitol 1 gr/kg; altıncı gruba asetaminofen 100 mg/kg ve mannitol 1 gr/kg intraperitoneal verildi. Herhangi bir tedavi uygulanmayan ikinci grup iki saat sonra, üçüncü grup ve te . . .davi grupları ise 24 saat sonra sakrifiye edilerek kan ve doku örnekleri alındı.BULGULAR: Sodyum, potasyum, alanin aminotranferaz, kreatinin, ortalama kreatinin klirensi değerleri açısından asetaminofen ve mannitol tedavi grupları arasında istatistiksel olarak anlamlı fark bulunmadı. Histopatolojik olarak hidropik dejenerasyon, tübüler nekroz, enflamasyon, tubulus lü-meninde immünoperoksidaz ve miyoglobin varlığı, tubulus epitel hücre dejenerasyonu, tubulus lümeninde PAS boyanan materyel varlığı bulgularının mannitol uygulanan grupta azaldığı, asetaminofen uygulanan grupta mannitol uygulanan gruptan daha fazla azaldığı, asetaminofenle mannitol birlikte uygulandığında ise bulguların tek başına mannitol uygulamasından daha iyi, ancak tek başına asetaminofen uygulamasından daha iyi olmadığı görüldü.TARTIŞMA: Ezilme yaralanmalarında oluşan böbrek hasarında asetaminofen histopatolojik olarak mannitolden daha etkilidir. Asetamniofen manni-tolle birlikte kullanıldığında ise karaciğere olan toksik etkisi daha az olmaktadır BACKGROUND: The present objective was to evaluate effects of acetaminophen and mannitol on renal function and histopathology in crush injuries.METHODS: Thirty-six rats weighing 370-400 g each were used. No surgery was performed on the first (control) group. The gastrocnemius muscle regions of each rat in the remaining 5 groups were compressed for 2 or 24 hours. In the 4th group, 100 mg/kg acetaminophen was intraperitoneally administered. In the 5th group, 1 g/kg mannitol was administered. In the 6th group, 100 mg/kg acetaminophen and 1 g/kg mannitol were administered.RESULTS: No statistically significant differences were observed among the treatment groups in terms of sodium, potassium, alanine aminotransferase (ALT), and average creatinine clearance values. Hydropic degeneration, tubular necrosis, presence of immunoperoxidase and myoglobin, tubulus epithelial cell degeneration, and presence of PAS-dyed material in tubular lumen was more prominently decreased in the acetaminophen group than the mannitol group. Improvement was observed in the group that was administered both drugs, compared to the mannitol-only group, though findings were still worse than those of the group administered acetaminophen only.CONCLUSION: In crush injuries, acetaminophen improves histopathological renal damage better than mannitol. When used in conjunction with mannitol, the toxic effect of acetaminophen on the liver is decrease Daha fazlası Daha az

Cinar, EN | Vatanoglu-Lutz, E

Other | 2018 | NOBEL MEDICUS14 ( 1 ) , pp.55 - 57

Prof. Dr. Sureyya Tahsin Aygun has a story of dedication, success and professional loneliness.. Although he was found as odd and not being understood by medical authorities due to the inadequacy in medical technology and poor opportunities in medicine those days; the great importance of his scientific work has been started to be understood during the last few decades. As the Turkish Medical Society we cannot thank and be proud of him enough. Because he is the first scientist in the world who has started both practical and clinical research on stem cell.

Bastas, KK | Şahin, Fikrettin

Other | 2014 | PLANT DISEASE98 ( 1 ) , pp.153 - 153

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Eroglu, S | Ozbek, H | Şahin, Fikrettin

Other | 2010 | PLANT DISEASE94 ( 11 ) , pp.1374 - 1374

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Vatanoğlu, Emine Elif Lutz | Ataman, Ahmet Doğan

Other | 2016 | Türk Biyokimya Dergisi41 ( 1 ) , pp.58 - 62

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Tatlı, Özge | Nikerel, Emrah | Soğutmaz, Bahar Özdemir

Other | 2015 | Turkish Journal of Botany39 ( 6 ) , pp.1042 - 1050

Metabolomics aims to systematically gather (quantitative) information on metabolites in the cell and is commonly viewed as the missing link between genomics, transcriptomics, and physiology. Typical metabolomics platforms consist of two main steps, the quenching and extraction of metabolites from plant material and the (un)targeted quantification of the extracted metabolites. Brachypodium distachyon, a native grass species of the Mediterranean region, is an attractive model plant to study temperate crops. In recent years, despite an increasing interest in genomic and transcriptomic studies, metabolomics studies for B. distachyon are . . . still in their infancy. Drought, an abiotic stress factor, causes severe loss in plant productivity and it is therefore crucial to understand its effect on plant metabolism, in particular its metabolome. The objective of this study is to set up a quantitative plant metabolomics platform for B. distachyon to evaluate and optimize alternative metabolite extraction protocols (methanol and methanol-chloroform extraction). Focusing on three reporter metabolites (ATP, glucose, and starch) for metabolite quantification and two extraction protocols, we compared the drought stress response of 2 different genotypes from different geographical regions of Turkey. Results revealed that there is no one-protocol-fits-all, pointing to significant differences in metabolite recoveries upon different extraction protocols, though methanol extraction generally yielded higher recoveries. Drought stress resulted in higher glucose levels while ATP and starch levels did not show statistically significant or consistent changes. In conclusion, the impact of drought stress on B. distachyon metabolism was significant and this study could be the basis for further metabolomics studies on plant stress response Daha fazlası Daha az

Servet, Erkan | Bekler, Halil | Kılınçoğlu, Volkan | Özler, Turhan | Özkut, Afşar

Other | 2016 | Acta Orthopaedica et Traumatologica Turcica50 ( 2 ) , pp.234 - 241

Objective: Epineural scar formation is one of the most significant negative factors affecting surgical repair after peripheral nerve injury. The scar tissue mechanically hinders axonal regeneration and causes adhesions between nerves and surrounding tissues. A hemostatic agent Ankaferd Blood Stopper (ABS; İmmun Gıda İlaç Kozmetik San. ve Tic. Ltd. Şti., Istanbul, Turkey) has not been previously used. Decreasing the postoperative bleeding and adhesions between nerve and surrounding tissues will prevent the formation of scar tissue, as well as corresponding compressive neuropathy and/or deceleration of axonal regeneration. The . . .purpose of this experimental study was to investigate the effects of bleeding on nerve healing and scar tissue after repair of peripheral nerve injuries.Methods: The right sciatic nerve of 30 Sprague-Dawley male rats (weighing 260-330 g) was cut 1.5 cm proximal to the trifurcation and repaired primarily with 8/0 sutures using epineural technique. The rats were then divided into 3 groups. Saline was applied in Group 1 (n10), ABS in Group 2 (n10), and heparin in Group 3 (n10) for 5 minutes to the repair site and surrounding tissues. In each group, electrophysiological measurements were performed with electromyography (EMG) at postoperative week 12. Magnetic resonance diffusion tensor imaging was used at week 12. Macroscopical and histopathological evaluations were conducted after sacrificing the rats at week 24 with total excision of the repaired sciatic nerves and surrounding tissues.Results: The ABS and saline groups showed better healing than the heparin group. The ABS and saline groups were better in the histopathologic evaluations, but there was no statistically significant difference between the 2 groups.Conclusion: Statistically significant differences were not found between the 3 groups. Significant results may be obtained with larger studie Daha fazlası Daha az

Mercanoğlu, Olguner Güldem | Pamukçu, Burak | Safran, Nurhas | Mercanoğlu, Fehmi | Fıcı, Francesco | Güngör, Mehmet

Other | 2010 | Anadolu Kardiyoloji Dergisi10 ( 1 ) , pp.18 - 27

Amaç: Miyokard infarktüsü (MI) sonrası gelişen ventriküler yeniden şekillenme (VR) ilerleyici sol ventrikül disfonksiyonunda önemli bir role sahiptir. Çalışmada sıçan iskemi-reperfüzyon modelinde MI sonrası nebivolol tedavisinin VR üzerine etkisini incelemeyi amaçladık. Yöntemler: Sıçanlar her grupta 12 hayvan olacak şekilde 3 gruba ayrıldı; operasyonel kontrol (sham-kontrol), MI kontrol (MI-kontrol) ve nebivolol uygulanmış MI (MI-nebivolol). Sol ventrikül (LV) çapları, hacimleri ve diyastolik dolum parametreleri ekokardiyografi ile incelendi. Yirmi sekiz günlük periyodun sonunda sistemik ve LV basınçları kaydedildi, plazma nitrik o . . .ksit (NO), peroksinitrit (ONOO-) düzeyleri ölçüldü, vücut (BW), kalp (HW) ve LV (LVW) ağırlıkları ile infarkt alanları belirlendi. Istatistiksel değerlendirme tekrarlı ölçümler varyans analizi ve ikili karşılaştırmalar Bonferroni testi ile yapıldı. Bulgular: İnfarktüs sonrası MI-kontrol grubunda belirgin VR parametreleri (LV çap ve hacminde artış, EF, FS ve arka duvar % kalınlık değişimde azalma) saptanırken (bütün karşılaştırmalar için p0.05); bu değişiklikler MI-nebivolol grubunda MI-kontrol grubu ile karşılaştırıldığında kısıtlanmıştı (EF ve FS için sırası ile p0.08 ve p0.06). Sol ventrikül diyastol sonu basıncı (LVEDP) MI-nebivolol grubunda daha düşüktü (p0.005). Yine bu grupta ?dp/dt değerleri daha yüksekti (p0.05). İnfarktüs oluşturulmuş gruplarda infarkt alanları benzer olmasına rağmen (p0.79); LVW/HW ve HW/BW değerleri MI-kontrol grubunda sham-kontrol grubuna göre daha yüksekti (bütün karşılaştırmalar için p0.01). Bu değerler MI-nebivolol grubunda istatistiksel olarak anlamlı değildi. Plazma NO ve ONOO- düzeylerindeki artış da MI-nebivolol grubunda önlenmişti. Sonuç: Nebivolol tedavisi sıçanlarda MI sonrası gelişen VR'i azaltmıştır. Bu etki nebivololün kalp hızı ve kan basıncı düşürücü etkilerine bağlanamamıştır. Molekülün NO düzenleyici etkisi MI sonrası gelişen VR'de nebivololün yaralı etkilerinden sorumlu olabilir. Ob­jec­ti­ve: Ventricular remodeling (VR) which develops after myocardial infarction (MI) plays an important role in progressive left ventricular dysfunction. We aimed to investigate the role of nebivolol treatment on VR after a MI in a rat ischemia-reperfusion model. Methods: Rats were divided into 3 groups of 12 each: sham operated (sham-control), MI-induced (MI-control) and nebivolol treated (MI-nebivolol). Left ventricular (LV) diameters, volumes, and diastolic filling parameters were evaluated by echocardiography. On the 28th day, after recording the systemic and LV pressures and determining the plasma nitric oxide (NO) and peroxynitrite (ONOO-) levels , animals were sacrificed and heart, body and LV weights (HW, BW, LVW) were measured and infarct sizes were determined. Results were evaluated statistically by ANOVA for repeated measurements 3x3 factorial design with post-hoc Bonferroni test. Results: After MI, while VR (an increase in LV diameters and volumes associated with a decrease in EF, FS and posterior wall thickness change (LWPc) was significant in MI-control rats (p<0.05 for; all comparisons) these changes were significantly less in MI-nebivolol group (p0.08 and p0.06 for EF and FS respectively). LV end diastolic pres-sure (LVEDP) was lower (p<0.005) and &#916;±dp/dt&#8217;s (p<0.05) were higher in MI-nebivolol group compared to MI-control animals. Although infarct sizes were similar in MI-induced groups (p0.79); LVW/HW and HW/BW&#8217;s were significantly greater in the MI-control group compared to sham-control (p<0.01 for all comparisons), these changes were not statistically significant in MI-nebivolol group. The increase in plasma NO and ONOO- levels were also prevented with nebivolol. Conclusion: Nebivolol therapy reduced the effects of VR in rats after MI. These beneficial effects were not related to its heart rate and blood pressure reducing effects. Nitric oxide regulatory action of this compound may contribute these beneficial effects on VR developed after MI Daha fazlası Daha az

Eren, Zehra | Koyuncu, Hakan

Other | 2019 | Balkan Medical Journal36 ( 5 ) , pp.290 - 291

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Tansug, F

Other | 2009 | YEARBOOK FOR TRADITIONAL MUSIC41 , pp.199 - 220

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Karlıkaya, Geysu | Yüksel, Gülbin | Yıldırım, Banu | Örken, Cihat | Tireli, Hülya

Other | 2007 | Journal of Neurological Sciences (Turkish)24 ( 2 ) , pp.104 - 108

Intravenous Immunglobulin (IVIg), an important immunomodulatory treatment for various neurological disorders. In previous studies IVIg treatment has been associated with thromboembolic events such as stroke or myocardial infarction due to an increase in serum viscosity. The aim of this study was to investigate hematological and biochemical changes in patients receiving IVIg treatment. Six female and 5 male patients who were treated with a standard IVIg treatment regimen were inclueded in this study. Different serum parameters were evaluated before treatment and on the 1’st, 5’th, 10’th days and after 1 month of IVIg treatment. Stati . . .stical analysis revealed a significant increase in the ESR, total protein and Ig G levels lasting up to one month following treatment. IVIg treatment may cause remarkable biochemical and hematological changes. Such changes should not be confused with a serious medical problem such as disease reactivity; and caution should be taken for patients with previous risk factors (such as elderly patients or patients with advanced atherosclerosis) for thromboembolic events since increase in serum viscosity may cause serious complications. İntravenöz İmmünglobülin (IVIg) tedavisi pek çok nörolojik hastalıkta uygulanan bir immün modülatuvar tedavi olup, daha önce yapılan çalışmalarda inme ve miyokard enfarktüsü gibi tromboembolik olaylarla ilişkilendirilmiştir. Bu çalışma IVIg tedavisi sonucu ortaya çıkan hematolojik ve biokimyasal değişiklikleri araştırmak amacıyla yapılmıştır. IVIg tedavisi uygulanmış 6 kadın 5 erkek hasta bu çalışmaya dahil edilimiştir. Farklı serum parametreleri IVIg tedavisi öncesi ve sonrası 1. , 5., 10. ve 30. günlerde incelenmiştir. İstatistiksel değerlendirme sonucunda eritrosit sedimantasyon hızı, total protein ve serum Ig G düzeylerinde tedavi öncesine göre 1 aya kadar uzayabilen belirgin artış saptanmıştır. IVIg tedavisinin belirgin hematolojik ve biokimyasal değişikliklere sebep olabildiği bildirilmiştir. Bu değişikliklerin iyi bilinmesi hastalık reaktivasyonu gibi bir durumla karıştırılmaması ve tromboembolik olaylar açısından riskli hasta gruplarında (ileri yaş, belirgin ateroskleroz) hiperviskosite ile ilişkili komplikasyonlardan kaçınılabilmesi bakımından önemlidir Daha fazlası Daha az