Yencilek, F. | Kalkan, M. | Uzun, H. | Akkuş, E. | Öner, A. | Solok, V.

Article | 2003 | Turk Uroloji Dergisi29 ( 2 ) , pp.126 - 132

Introduction: Glycosaminogylicans (GAG) play as a promotor and inhibitor in some phases of stone formation. Sialic acid (SA) is a low-molecular weight aminosaccaride and found in the molecular structure of GAG and on the surface of many cells. Plasma SA level increases in inflamatory diseases, glomerulonephritis and metabolic abnormalities. Unfortunately, there are only a few studies investigating the relationship between SA level in urine and urological diseases. In this study, the relationship between calcium oxalate crystalization and free, total and complex sialic acid levels in urine and plasma has been investigated. Additional . . .ly, possible effect of potassium citrate on this relationship was also studied. Material and Methods: Thirty wistar female rats were included in this study. They were randomly divided in three groups. 0.12 ml of %5 ethylene glycole was dissolved in water and given to the rats in group 1 by feeding tube two times a day and every other day 0.5 microgram vitamin D3 was added to their drinking water to expose them hyperoxlacuric and hypercalciuric, respectively. Rats in group 2 were exposed to the same procedure as group1. Additionally, 5 mg/day K-Citrat was added to their diet. No special diet program was applied in group 3 (control group). At the end of 30 days, 24 hours urine samples were collected by using metabolic cages and blood samples were taken from each rat. Free and total SA levels were calculated by the technique of measuring thiobarbituric acid as mmol/liter (Warren's method). One way ANOVA test was applied for statistical analysis. Result: Calcium levels measured in plasma and urine were higher in group 1 and 2 than the control group. Similarly, oxalate levels in urine were also higher in group 1 and group 2., The differences were statistically significant when compared with the control group ( Daha fazlası Daha az

Koyuncu, H. | Yencilek, F. | Kalkan, M. | Bastug, Y. | Yencilek, E. | Ozdemir, A.T.

Article | 2015 | International Braz J Urol41 ( 2 ) , pp.245 - 251

Purpose: To compare the efficacy of RIRS and PNL in lower pole stones ?2 cm. Materials and and Methods: A total of 109 patients who underwent PNL or RIRS for solitary lower pole stone between April 2009 and December 2012, were retrospectively analyzed. Lower pole stone was diagnosed with CT scan. Stone size was assessed as the longest axis of the stone. All patients were informed about the advantages, disadvantages and probable complications of both PNL and RIRS before the selection of the procedure. Patients decided the surgery type by themselves without being under any influences and written informed consent was obtained from all . . .patients prior to the surgery. Patients were divided into two groups according to the patients' preference of surgery type. Group 1 consisted of 77 patients who underwent PNL and Group 2 consisted of 32 patients treated with RIRS. Stone free statuses, postoperative complications, operative time and hospitalization time were compared in both groups. Results: There was no statistical significance between the two groups in mean age, stone size, stone laterality, mean follow-up periods and mean operative times. In PNL group, stone-free rate was 96.1% at first session and 100% after the additional procedure. In Group 2, stone-free rate was 90.6% at the first procedure and 100% after the additional procedure. The final stone-free rates and operative times were similar in both groups. Conclusions: RIRS should be an effective treatment alternative to PNL in lower pole stones larger than 2 cm, especially in selected patients Daha fazlası Daha az

Koyuncu, H. | Serefoglu, E.C. | Karacay, S. | Ozdemir, A.T. | Kalkan, M. | Yencilek, F.

Article | 2014 | Central European Journal of Urology67 ( 1 ) , pp.74 - 78

Introduction Premature ejaculation (PE) is the most common male sexual dysfunction. Monosymptomatic enuresis (ME) is nocturnal bed wetting, without any daytime symptoms. Recent clinical studies report an association between lifelong PE and ME. The purpose of this study was to compare the intravaginal ejaculatory time (IELT) between lifelong PE in men with and without ME. The goal was to determine if there is an association between the severity of ME and of IELT. Material and methods A total of 137 men with lifelong PE were included in this study. Subjects were asked if they had childhood ME. The characteristics and mean IELTs of pat . . .ients with and without ME were compared using the student's t-test, and the correlation between severity of ME and IELT was assessed with trend test. Results Of the 137 lifelong PE patients, 57 reported ME. There was a strong negative correlation in patients with ME between the severity of enuresis and IELT, with IELT being shorter in patients with severe ME. Conclusions A strong correlation between IELT and the severity of ME suggests a common underlying mechanism. Further studies are required to confirm these findings and elucidate the exact pathophysiology Daha fazlası Daha az

Kalkan, M. | Uzun, H. | Turkan, S. | Sahin, C. | Fatma, F. | Yencilek, F. | Koyuncu, H.

Article | 2015 | European Journal of General Medicine12 ( 2 ) , pp.101 - 103

To assess the impact of a diagnosis of bladder cancer on smoking behavior and to analyze the role of the physician in smoking cessation. Nonmuscle-invasive bladder cancer patients completed a phone survey of their smoking habits. They were asked about smoking behavior before and after the diagnosis of cancer and whether they had been informed by their physician about the relation between smoking and bladder cancer. Two hundred-twelve patients responded to the survey. The mean age was 60.03±6.36 years. Ninety-three of the 135 current smokers (68.9%) were advised to quit smoking, whereas nine of 20 nonsmokers (45%) were not commented . . .about the future risks of smoking. The results showed that 13% of the current smokers and 35% of the current nonsmokers were not warned about the relation of bladder cancer with smoking. Statistical significance was not seen in terms of sex, disease stage, and tumor grade at diagnosis. The relation between smoking and bladder cancer has been well established. However, some patients are not informed to quit smoking by their physicians. © 2015, TIP ARASTIRMALARI DERNEGI. All rights reserved Daha fazlası Daha az

Yencilek, F. | Kalkan, M. | Uzun, H. | Akkuş, E. | Öner, A. | Solok, V.

Article | 2003 | Türk Üroloji Dergisi/Turkish Journal of Urology29 ( 2 ) , pp.126 - 132

Glikozaminoglikanlar taş oluşumunun bazı aşamalarında promoter, bazı aşamalarında ise inhibitor gibi davranmaktadır. Düşük molekül ağırlıklı bir aminosakkarid olan sialik asit (SA) glikozaminoglikanlanın yapısında bulunur. Kontrollü deney grupları oluşturarak kalsiyum-okzalat kristalizasyonu ile idrarda serbest ve bağlı SA ilişkisini ve potasyum sitratm bu ilişki üzerine etkisini araştırdık. Çalışmamızda Wistar cinsi dişi sıçanlardan 10'arlı 3 ayrı grup oluşturuldu. Grup l 'e 0.12 mi %5 etilen glikol l mi normal çeşme suyunda çözündürülerek 2x1 feeding tüple verilip hiperoksalürik ve günaşırı 0.5 mikrogram vitamin ds sularına karışt . . .ırılıp hiperkalsiürik hale getirildi. Grup 2, Grup l'den farklı olarak sularına 5mg/gün K-Sitrat eklendi. Grup 3'e normal beslemne yapıldı. Bütün sıçanlardan 30. günde metabolik kafesler kullanılarak 24 saatlik idrar ve kan örnekleri alındı. İdrarda serbest ve total SA düzeyleri Warren'in tarif ettiği tiobarbüritik asit tekniği ile standart eğrilere göre mmol/litre cinsinden hesaplandı. İstatistiksel analizde One way ANOVA test'i kullanıldı.Seram ve idrar kalsiyum, idrar okzalat düzeyleri grup l ve 2'de grup 3'e göre artmış olup istatistiksel anlamlı bulundu. Serum total ve bağlı SA düzeyi üç grupta normal sınırlar içerisinde fakat serbest SA grup l ve 2'de kontrol grubuna göre düşük bulundu ve bu istatistiksel anlamlı idi. İdrar total ve bağlı SA düzeyleri grup l ve 2'de grup 3'e göre azalmış bulundu ve bu istatistiksel anlamlı iken kendi aralarında istatistiksel anlamlılık yoktu. Her üç grup idrar serbest SA düzeyi arasında istatistiksel anlamlılık bulunmadı. Kristalüri ile idrar ve serum SA düzeyleri arasında anlamlı ilişki vardır. Potasyum sitrat'ın seram ve idrar SA üzerine anlamlı bir etkisi yoktur. Introduction: Glycosaminogylicans (GAG) play as a promoter and inhibitor in some phases of stone formation. Sialic acid (SA) is a low-molecular weight aminosaccaride and found in the molecular, structure of GAG and on the surface of many cells. Plasma SA level increases in inflammatory diseases, glomerulonephritis and metabolic abnormalities. Unfortunately, there are only a few studies investigating the relationship between SA level in urine and urological diseases. In this study, the relationship between calcium oxalate crystalization and free, total and complex sialic acid levels in urine and plasma has been investigated. Additionally, possible effect of potassium citrate on this relationship was also studied. Material and Methods: Thirty Wistar female rats were included in this study. They were randomly divided in three groups. 0.12 ml of %5 ethylene glycole was dissolved in water and given to the rats in group 1 by feeding tube two times a day and every other day 0.5 microgram vitamin D3 was added to their drinking water to expose them hypcroxlacuric and hypercalciuric, respectively. Rats in group 2 were exposed to the same procedure as group l Additionally, 5 mg/day K-Citrat was added to their diet. No special diet program was applied in group 3 (control group). At the end of 30 days, 24 hours urine samples were collected by using metabolic cages and blood samples were taken from each rat. Free and total SA levels were calculated by the technique of measuring thiobarbituric acid as mmol/liter (Warren's method). One way ANOVA test was applied for statistical analysis. Result: Calcium levels measured in plasma and urine were higher in group 1 and 2 than the control group. Similarly, oxalate levels in urine were also higher in group 1 and group 2., The differences were statistically significant when compared with the control group (p<0.05). Phisma complex and total SA levels were almost the same in all groups but free SA was significantly lower in group 1 and 2 than the controls (p<0.05). Low levels of total and complex SA in the urine were statistically significant in group 1 and 2 compared to the controls (p<0.05). In contrary, there was no significant difference between group 1 and 2. There was no statistical significance in urine free SA levels among 3 groups. Conclusion: In this experimental study, significant correlation is found between crystaluria and urine and plasma SA levels. In our opinion, SA can make a complex with crystals in urine and acts as a promoter in stone formation. Consequently, urine levels of SA can change in crystalluric cases. However, potassium citrate has not any significant effect on urine and plasma SA levels Daha fazlası Daha az