Reply by the Authors

Sarica, K. | Yencilek, F. | Eryildirim, B. | Kuyumcuoglu, U.

Letter | 2009 | Urology74 ( 6 ) , pp.1378 - 1379

[No abstract available]

Role of Overweight Status on Stone-forming Risk Factors in Children: A Prospective Study

Sarica, K. | Eryildirim, B. | Yencilek, F. | Kuyumcuoglu, U.

Article | 2009 | Urology73 ( 5 ) , pp.1003 - 1007

Objectives: To evaluate the possible role of being overweight on stone-forming risk factors in children. Methods: A total of 94 children (43 boys and 51 girls, male/female ratio 1:1.8) who were taking no medication or dietary modifications before treatment were included in the study. After a detailed stone disease history, the systolic and diastolic blood pressures were precisely measured and recorded for all patients. The body mass index, 24-hour urine values, and serum stone-forming risk parameters were evaluated in 44 overweight (17 boys and 27 girls; group 1) and 50 normal (26 boys and 24 girls; group 2) children. The results of . . . each group were compared using the Wilcoxon rank sum test. Results: The evaluation of the stone-forming risk factors in both groups revealed that the overweight status might be responsible for the increased excretion of these substances in such children. Most of the children in group 1 demonstrated hypocitraturia and hyperoxaluria (9/44, 20.5%) compared with the patients in group 2. Although the mean urinary oxalate level was 0.74 ± 0.81 mg/kg/24 h for boys and 0.69 ± 0.72 mg/kg/24 h for girls in group 1, relatively lower values were noted in group 2 (0.42 ± 0.52 and 0.45 ± 0.57 mg/kg/24 h for the boys and girls, respectively). Similarly, the children in group 1 had elevated mean urinary calcium and lower citrate excretion compared with the group 2 patients. Conclusions: Overweight status in children might be associated with an elevated risk of stone formation in both sexes owing to the alterations in urine composition. Obese children could be more prone to stone formation, and they should be evaluated and followed up for this aspect. Crown Copyright © 2009 Daha fazlası Daha az

Hyperoxaluria-induced tubular ischemia: The effect of verapamil on the limitation of tissue HIF-1 alpha levels in renal parenchyma

Yencilek, F. | Sarica, K. | Eryildirim, B. | Erturhan, S. | Karakok, M. | Kuyumcuoglu, U.

Article | 2010 | International Urology and Nephrology42 ( 2 ) , pp.361 - 367

Objectives The effect of verapamil on tubular ischemia that is demonstrated by HIF-1a positivity in tubular cells following hyperoxaluria was evaluated in a rabbit model. Methods Thirty-six healthy male rabbits were randomly divided into three groups. Animals in the hyperoxaluric group were fed with 0.75% ethylene glycol. The verapamil group was fed identically to the hyperoxaluric group. Additionally, the verapamil group received verapamil orally (0.1 mg/kg). The control group received no special diet. Six animals in each group were killed on the 7th day of the experiment and the remaining six at the 28th day. Kidneys of the rabbit . . .s were examined by histopathologic and immunohistochemical analysis to detect the presence and degree of HIF-1a positivity. Results On the 7th day analysis, severe and moderate degree staining for HIF-1a in hyperoxaluric group were shown in four and two, respectively. In the verapamil group, however, three of six specimens showed nuclear staining (moderate in two and severe in one). Two of six specimens in the control group had minimal staining. The 28th day evaluation showed that two of the hyperoxaluric group had minimal degree nuclear staining but not in the remaining four. No staining was shown in the verapamil and control group animals. Conclusions Hyperoxaluria-related ischemia formation may be responsible for subsequent alterations in renal tubules. As a protective agent, verapamil was found to limit the presence of hypoxic changes as documented by HIF-1 alpha positivity in this study. These data also support the presence ischemic insult after hyperoxaluria induction in animal model. © Springer Science+Business Media, B.V. 2009 Daha fazlası Daha az

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