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A Novel Electrophysiological Method in the Diagnosis of Pudendal Neuropathy: Position-related Changes in Pudendal Sensory Evoked Potentials

Örmeci, B. | Avcı, E. | Kaspar, Ç. | Terim, Ö.E. | Erdoğru, T. | Öge, A.E.

Article | 2017 | Urology99 , pp.2880 - 2880000000

Objective To examine the diagnostic value of pudendal somatosensory evoked potentials (SEPs) in pudendal nerve entrapment (PNE) neuropathy by stimulating the 2 sides separately after provocation by a standard sitting position. Routine pudendal SEPs performed in the supine position with bilateral simultaneous stimulation may fail to show the abnormality because the complaints of PNE appear or worsen in the sitting position. Methods Forty-nine patients with PNE and 16 controls were included. SEP recordings were performed by stimulating the dorsal nerve of penis or clitoris on either side. The recordings were performed at the initial s . . .upine position, at the beginning and end of the provocation by sitting position, and at the second supine position. Results Amplitude loss in the SEP responses after prolonged sitting was significantly more pronounced on the symptomatic sides of the patients. Approximately 45% decrease in the SEP amplitude or an amplitude value less than 1.5?µV at the end of sitting are the parameters to be used with high selectivity. Conclusion The dynamic pudendal SEP study described herein seems to be more helpful in PNE diagnosis than in conventional SEPs. © 2016 Elsevier Inc Daha fazlası Daha az

Phenolipids as New Antioxidants: Production, Activity, and Potential Applications

Kahveci, D. | Laguerre, M. | Villeneuve, P.

Book Part | 2015 | Polar Lipids: Biology, Chemistry, and Technology , pp.185 - 214

Phenolics are secondary metabolites widely found in plants; they have several biological roles and they contribute to the defense system of the host. Among them, the phenolic acid family is one of the most important classes and is mainly composed of the cinnamic and benzoic acid derivatives. The interest in these compounds from a nutritional point of view has risen due to their potential properties, including antioxidant, anti-inflammatory, antiallergic, antimicrobial, antiviral, and anti carcinogenic. As phenolic acids have a rather low solubility in oils, improvement of hydrophopicity of these compounds by chemical or enzymatic li . . .pophilization has been applied extensively to render these functionalized compounds, so-called phenolipids, active in the oil-water interphase. This chapter focuses on the synthesis of phenolipids derived from phenolic acids, their physicochemical and biological activity, and their potential applications. It also discusses the production technology of phenolipids. One of the most reliable methods to improve antioxidant activity of phenolics is to incorporate properly positioned lipophilic groups to obtain phenolipids. Phenolipids show greater miscibility and incorporation into lipid phases and lipocarriers, offering an advantage for their use in drug delivery systems, pharmaceuticals, nutraceuticals, foods, and cosmetic formulations. © 2015 by AOCS Press. All rights reserved Daha fazlası Daha az

Linking technology foresight and entrepreneurship

Öner, M.A. | Kunday, Ö.

Editorial | 2016 | Technological Forecasting and Social Change102 , pp.185 - 214

[No abstract available]

Atrium Advanta V12 Large Diameter Stent-Graft Applications for Infrarenal Abdominal Aortic Pseudoaneurysms (due to Behcet Disease): Safety and Efficacy

Altay, Ç.M. | Alpar, A. | Topcuoglu, O.M. | Kucukay, M.B. | Cansu, D.U. | Temel, T. | Kucukay, F.

Article | 2017 | Annals of Vascular Surgery44 , pp.197 - 202

Background The aim of the study was to determine the safety and effectiveness of Atrium Advanta V12 large diameter stent-graft applications for infrarenal abdominal aortic pseudoaneurysms (due to Behcet disease [BD]). Methods Data of Advanta V12™ (Atrium Europe B.V, Mijdrecht, the Netherlands) applied 12 female patients (mean age 30.5 ± 6.3, range 26–44) with infrarenal abdominal aortic pseudoaneurysms were analyzed retrospectively. All Advanta V12 large diameter stent grafts were implemented from right or left sided 12F femoral sheaths. Stent grafts with 12–16 mm in size and 29–61 mm in length were utilized. Technical success rate, . . . procedure-related mortality and morbidity, and primary patency rate at 4 years were evaluated. Results Technical success rate was 100%. Neither procedure-related mortality nor morbidity was determined. The mean aortic diameter was 14.0 ± 0.8 mm for pseudoaneurysmatic abdominal aortas. The mean follow-up period was 46.5 ± 40.3 months (range 18–75). During follow-ups, only one recurrent aneurysm has evolved at the stenting site due to patients' withdrawal of immunosuppressive treatment. The advent of a new aneurysm proximal or distal to the stent-graft region or at the femoral access localization was not observed. There were no stent occlusions. Primary patency rate at 4 years was 100%. Complete aneurysm exclusion was achieved 100% at 48 months. Conclusions The use of Advanta V12 large diameter stent grafts for infrarenal abdominal aortic pseudoaneurysms (due to BD), especially in female patients with small aortic diameter, is safe and efficient. Primary patency rate of the stent grafts at 4 years is excellent. © 2017 Elsevier Inc Daha fazlası Daha az

Oxidative Stability of Enzymatically Processed Oils and Fats

Kahveci, D. | Guo, Z. | Cheong, L.-Z. | Falkeborg, M. | Panpipat, W. | Xu, X.

Book Part | 2013 | Lipid Oxidation: Challenges in Food Systems , pp.211 - 242

Fats and oils with modified functional and nutritional properties are in high demand in the food industry. The physical characteristics of fats and oils-for instance, those related to their melting and crystallization profiles-are important for food technologists to consider because nutritionists and consumers display great interest in their nutritional properties, based on their composition. The fats and oils industry has extensively used chemical interesterification to alter the physical and/or nutritional properties of fats and oils. However, the random end products of chemical interesterification cannot meet the demand for lipid . . .s with specific structures and compositions. The enzymatic process, on the other hand, requires mild reaction temperature and pressure, which is vital for handling unsaturated Fatty Acids (FAs), and has some other advantages as well. Therefore, the enzymatic modification of fats and oils has been a popular topic for the past few decades. However, information on the oxidative stability of such products remains limited. This chapter reviews the newest developments regarding the oxidative stability of enzymatically processed fats and oils. Many researchers have noted that the reduced oxidative stability of fats and oils produced by enzyme-involving steps presents a disadvantage. Many explanations exist for the low oxidative stability of these products. One of them is that a change in lipid structure affects stability by increasing or decreasing the exposure of unsaturated FAs to oxygen as well as the oxygen solubility or diffusivity of sensitive FAs. Moreover, structural change may alter the state of metal ions in the system. © 2013 AOCS Press Published by Elsevier Inc. All rights reserved Daha fazlası Daha az

Magnetic nanoparticles and cancer

Bucak, S. | Altan, C.L.

Book Part | 2017 | Nanotechnology in Cancer , pp.105 - 137

Cancer, being the number one cause of death, is a disease that becomes even more widespread as the population's life expectancy increases. Chemotherapy drugs that are designed to destroy the cancer cells, inevitably kill also the healthy cells. Without being targeted or controlled release, these drugs are administered in high doses which make them highly toxic. Magnetic nanoparticles (MNPs) are currently being investigated for their versatile use in drug targeting, therapy, and diagnostics. In this chapter the toxicity of magnetic particles and types of MNPs and their synthesis methods are shortly summarized. As different types of M . . .NPs are employed in this research field, we focused the chapter to magnetite (Fe3O4) nanoparticles. Research in the field of magnetic drug delivery is summarized based on the type of magnetic carrier. Hyperthermia, which is the destruction or reduction of tumor by procuring heat at the tumor site, can be achieved by the application of an external magnetic field, inducing heat generation around the MNPs. This makes MNPs invaluable in cancer therapy, and the type of MNPs along with suitable coatings and targeting ligands used in hyperthermia are summarized. Cancer diagnostics is another field where MNPs find diverse use. MNPs are employed as contrast agents in magnetic resonance imaging (MRI), not only to image the existing tumors but also for post therapy monitoring in stem cell transplantation. By summarizing the work done in this field, MNPs, with ease of surface modification, low toxicity, and magnetic properties are shown to have great potential in novel therapies against cancer. © 2017 Elsevier Inc. All rights reserved Daha fazlası Daha az

Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma

Erdem, M. | Erdem, S. | Sanli, O. | Sak, H. | Kilicaslan, I. | Şahin, Fikrettin | Telci, D.

Article | 2014 | Urologic Oncology: Seminars and Original Investigations32 ( 1 ) , pp.105 - 137

Objective: Tissue transglutaminase (TGM2) up-regulation is involved in the progression and dissemination of carcinomas through ß1 integrin (ITGB1) association. Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we investigated the roles of TGM2, ITGB1, and SDC4 in the development and metastasis of renal cell carcinoma (RCC). Material and methods: Expression levels of TGM2, ITGB1, and SDC4 mRNA were analyzed in primary tumor samples (n = 95) and their healthy counterparts in addition to control and RCC epithelial cell lines. TGM2 cat . . .alytic activity in 60 randomly selected patient samples was measured by enzyme-linked sorbent plate assay. Results: TGM2 expression ratio showed a significant 2.9-fold decrease in 67 (70.5%) of the primary RCC tumors (P Daha fazlası Daha az

Functional Biopolymers in Food Manufacturing

Ozilgen, S. | Bucak, S.

Book Part | 2018 | Biopolymers for Food Design , pp.157 - 189

Food hydrocolloids are high molecular weight long-chain biopolymers. They are made of high molecular weight polysaccharides and proteins. Hydrocolloids are widely used as functional food additives in many food products to keep or improve the sensory attributes of the foods and drinks, to improve the shelf life of the food products, to make the production processes easier and more efficient, and to produce functional food products. The key focus of this chapter is the hydrocolloids themselves, including the fundamental discussion of the research findings and their significance. The main areas of the interest are chemical and physicoc . . .hemical characterization of hydrocolloids, their rheological properties including viscosity, viscoelastic properties and gelation behavior, their interfacial properties, including stabilization of food colloids, their influence on sensory properties of food products, their film-forming properties with application to edible films and active packaging, their encapsulation properties, and their applications in the food industry as food additives and health promoters. Functional properties and the relation between the functional properties and the nanostructures of bacterial polysaccharides (e.g., xanthan, cellulose), plant/algal polysaccharides (e.g., starch, agar, alginate, pectin), and animal polysaccharides (e.g., chitosan), and their primary applications in the food industry are covered in this chapter. © 2018 Elsevier Inc. All rights reserved Daha fazlası Daha az

Social dynamics of university intellectual capital

Öner, M.A.

Editorial | 2017 | Technological Forecasting and Social Change123 , pp.120 - 121

[No abstract available]

Evaluation of the root canal configurations of the mandibular and maxillary permanent teeth by gender in the Turkish population

Sert, S. | Bayirli, G.S.

Article | 2004 | Journal of Endodontics30 ( 6 ) , pp.391 - 398

A key objective of successful nonsurgical endodontic treatment is obturation of the root canal systems. One factor in achieving this goal is the knowledge of possible root canal morphologies. Root canal morphology may exhibit variation as a result of many factors, including ethnic origin. In this study, 1400 male and 1400 female extracted mandibular and maxillary permanent teeth were evaluated for patterns in root canal morphology. The mandibular and maxillary teeth were divided into seven groups of tooth type (e.g. centrals, laterals, canines, first premolars, second premolars, first molars, and second molars), subdivided into gend . . .er, and classified by root canal morphologies. Vertucci's classification was taken as a reference during the evaluation. Although a majority of the specimens corresponded to this classification scheme, the analysis of this large data set revealed 14 additional root canal morphologies Daha fazlası Daha az

Non-linear volatility dynamics and risk management of precious metals

Demiralay, S. | Ulusoy, V.

Article | 2014 | North American Journal of Economics and Finance30 , pp.183 - 202

In this paper, we investigate the value-at-risk predictions of four major precious metals (gold, silver, platinum, and palladium) with non-linear long memory volatility models, namely FIGARCH, FIAPARCH and HYGARCH, under normal and Student-t innovations' distributions. For these analyses, we consider both long and short trading positions. Overall, our results reveal that long memory volatility models under Student-t distribution perform well in forecasting a one-day-ahead VaR for both long and short positions. In addition, we find that FIAPARCH model with Student-t distribution, which jointly captures long memory and asymmetry, as w . . .ell as fat-tails, outperforms other models in VaR forecasting. Our results have potential implications for portfolio managers, producers, and policy makers. © 2014 Elsevier Inc Daha fazlası Daha az

Familial Chiari Type 1: A Molecular Karyotyping Study in a Turkish Family and Review of the Literature

Keser, N. | Kuskucu, A. | Is, M. | Celikoglu, E.

Article | 2019 | World Neurosurgery121 , pp.183 - 202

Background: The etiology of Chiari I malformation (CMI) has not been fully elucidated. Therefore, we performed a genetic study of a Turkish family in which 3 sisters had a diagnosis of CMI with or without syringomyelia. Methods: In a family with 7 children, 4 daughters complained of occipital headaches. In 2 of these daughters, CMI had been diagnosed during their 30s, and CMI plus syrinx had been diagnosed in the other daughter in her 40s. Cranial magnetic resonance imaging of the fourth daughter who had developed headaches during her 30s showed normal findings. Because the other siblings in the family were asymptomatic, radiologica . . .l examinations were not performed. The family had a history of distant consanguineous marriage between parents. Additionally, the father had died, and the mother was asymptomatic, with radiologically normal findings. Array comparative genome hybridization studies were performed for 12 persons from 3 generations of this family. Results: None of the 12 cases examined harbored copy number variations. Conclusions: This family with 3 sisters having CMI suggested a possible autosomal recessive single-gene etiology. Cases of familial CMI are unusual but important to study because they could reveal the specific genes involved in posterior fossa/foramen magnum structure and function and provide insights into the cause of sporadic cases. © 2018 Elsevier Inc Daha fazlası Daha az

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