Nur, R.B. | Cakan, D.G. | Noyan, A.
Article | 2016 | Journal of Craniofacial Surgery27 ( 2 )
Objective: The aim of the study was to evaluate the changes in oxygen saturation and heart pulse during intraoral impression taking from infants with cleft lip and palate (CLP) at onset of presurgical orthopedic therapy. Subjects and Methods: In our study, 21 uni-and bilateral infants with CLP (9 female, 12 males, mean age 5.90±2.46 days) were monitored and heart pulse and oxygen saturation were measured under operating conditions before any intervention (T1), after delivery of 50% supplemental oxygen (T2), during impression taking with oxygen support (T3), and immediately before the discharge from the operating room (T4). Results: . . .Statistically significant differences were found in the average oxygen saturation levels (P0.05) between T1, T2, T3, and T4. Decreases in the oxygen levels from T2 to T3 were noted ( Daha fazlası Daha az
E. Demirci | L. Kabasakal | T. Toklu | M. Ocak | O.E. Şahin | N. Alan-Selcuk | A. Araman
Article | 2018 | Nuclear Medicine Communications39 ( 8 ) , pp.789 - 796
Purpose Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. 177Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively investigated its efficacy and effect on the survival in patients with both well-differentiated and grade III NETs who had high uptake in pretherapeutic 68Ga-DOTATATE PET/computed tomography scans. Patients and methods Patients with metastatic NETs treated with 177Lu-DOTATATE between January 2010 and November 2015 in ou . . .r department were included in this retrospective cohort. Toxicity and adverse effects were evaluated according to SWOG criteria. Progression-free survival (PFS) and overall survival (OS) rates were calculated considering the first date of treatment. Response was evaluated according to RECIST criteria. Potential predictors of survival and response were analysed. Results Patients (n=186) with metastatic NETs originating from various primary sites (bronchial, pancreatic, nonpancreatic gastroenteropancreatic-NETs, pheochromocytoma-paraganglioma and unknown primary) were treated with 1107 courses of 177Lu-DOTATATE treatment (median: 6; range: 3-12). Among 160 patients whose responses to treatment could be evaluated according to the RECIST criteria, 28.1% (n=45) had a progressive disease, 21.9% (n=35) had a stable disease, 46.9% (n=75) had a partial response and 3.1% (n=5) had a complete response. Median follow-up was 30.6 months. The Kaplan-Meier estimated median PFS was 36.4 months, mean PFS was 38 months and the mean OS was 55 months. The disease control rates in patients with WHO grades I, II and III were 74, 73 and 60%, respectively, and the OS rates were 61.9, 52.2 and 38.4 months, respectively. We observed no major renal toxicity except a minor increase (11.1%) in average serum creatinine levels. In 33.9% (n=56) of the patients, grade I toxicity; in 9.1% (n=15), grade II; and in 1.2% (n=2), grade III toxicity were observed. Conclusion 177Lu-DOTATATE therapy is an important treatment option in somatostatin receptor type-2-positive pancreatic, nonpancreatic gastroenteropancreatic-NETs, and lung NETs including metastatic NETs with an unknown primary site and significantly contributed to patients' OS. Additionally, peptide receptor radionuclide therapy may have a role in a selected subgroup of patients with grade III NET with high somatostatin receptor type-2 expression. Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc Daha fazlası Daha az
Celebi, S. | Köner, Ö. | Menda, F. | Omay, O. | Günay, I. | Suzer, K. | Cakar, N.
Article | 2008 | Anesthesia and Analgesia107 ( 2 ) , pp.614 - 619
BACKGROUND: The aim of our study was to evaluate the pulmonary effects of noninvasive ventilation (NIV) with or without recruitment maneuver (RM) after open heart surgery. METHODS: One-hundred patients undergoing coronary artery bypass surgery were randomized into four groups after the operation: 1) RM with sustained inflation during mechanical ventilation postoperatively (RM group, n = 25); 2) RM combined with NIV applied for 1/2-h periods every 6 h in the first postoperative day after tracheal extubation (RM-NIV group, n = 25); 3) NIV after tracheal extubation (NIV group, n = 25); and 4) a control group consisting of patients rece . . .iving neither RM nor NIV (control group, n = 25). Pulmonary function tests, oxygenation index, and atelectasis on chest radiograph were evaluated and compared among the groups. RESULTS: RM provided higher arterial oxygen levels during mechanical ventilation and after tracheal extubation compared to other interventions. Oxygenation was better in the RM-NIV and NIV groups than in the control group (P = 0.02 and P = 0.008, respectively) at the end of the study. The postoperative atelectasis score of the control group (median: 1) was higher than those of the RM (1; P = 0.03), RM-NIV (0; P < 0.01) and NIV (0; P < 0.01) groups. Pulmonary function of the NIV groups on postoperative day 2 was better than in the other groups, whereas the tests were similar among the groups on postoperative day 7. CONCLUSIONS: NIV associated with RM provided better oxygenation both during and after the mechanical ventilation period. NIV either alone or in combination with RM provided lower atelectasis scores and better early pulmonary function tests compared to the control group, without a significant difference regarding the duration of mechanical ventilation, intensive care unit stay, and the length of hospitalization. NIV combined with RM is recommended after open heart surgery to prevent postoperative atelectasis and hypoxemia. © 2008 International Anesthesia Research Society Daha fazlası Daha az
Ozturk, M.A. | Erdik, B. | Eren, O.O.
Letter | 2016 | American Journal of Therapeutics23 ( 1 ) , pp.614 - 619
[No abstract available]
Buyukguclu, G. | Ozkurt-Kayahan, Z. | Kazazoglu, E.
Article | 2018 | Implant Dentistry27 ( 4 ) , pp.429 - 433
Purpose: To evaluate the reliability of the Osstell implant stability quotient (ISQ) and Penguin resonance frequency analysis (RFA) devices in measuring implant stability. Materials and Methods: Forty implants were embedded in self-curing acrylic resin, soft-lining material, polyvinyl siloxane impression material, and polycarboxylate cement (n ¼ 10). After the initial setting times were completed, the stability of each implant was measured with Osstell ISQ and Penguin RFA with 3 repeated measurements. The “intraclass correlation coefficient” evaluated the correspondence between the measurements (P, 0.05). Results: Polyvinyl siloxane . . . impression material had lower ISQ values than soft-lining material, self-curing acrylic resin, and polycarboxylate cement in both devices (P, 0.05). The intraclass correlation was 1.00 in self-curing acrylic resin and 0.48 in polycarboxylate cement (P, 0.05) for Osstell. This value was 0.95 in self-curing acrylic resin and 0.38 in polycarboxylate cement (P, 0.05) for Penguin. There was no correlation between the repeated measurements in soft-lining material and polyvinyl siloxane impression material for both devices (P . 0.05). The repeatability was 0.90 for Osstell and 0.60 for Penguin (P, 0.05). Conclusions: Osstell ISQ and Penguin RFA are reliable only when the implants are embedded in stiff materials. Osstell ISQ is more reliable than Penguin RFA. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved Daha fazlası Daha az
Satana, B. | Yalvac, I.S. | Sungur, G. | Eksioglu, U. | Basarir, B. | Altan, C. | Duman, S.
Article | 2015 | Journal of Glaucoma24 ( 8 ) , pp.607 - 612
Purpose: To evaluate outcomes of patients with uveitic glaucoma secondary to Behçet disease (BD) who underwent Ahmed glaucoma valve (AGV) implantation. Patients and Methods: A retrospective chart review of 14 eyes of 10 patients with uveitic glaucoma associated with BD who underwent AGV implantation at a tertiary referral center. Treatment success was defined as intraocular pressure (IOP) between 6 and 21mm Hg with or without antiglaucoma medication, without further additional glaucoma surgery or loss of light perception. The main outcome measures were IOP, best-corrected visual acuity measured with Snellen charts, and number of gla . . .ucoma medications. Results: Mean duration of postoperative follow-up was 18.2±6.6 months (range, 6 to 31 mo). Of the 14 eyes, 10 (71.4%) were pseudophakic and 5 (35.7%) had primary AGV implantation without a history of previous glaucoma surgery. At the most recent follow-up visit, 13 of the 14 eyes had an IOP between 6 and 21mm Hg. Mean IOP was significantly reduced during follow-up, as compared with preoperative values (Pr0.005). The cumulative probability of surgical success rate was 90.9% at 18 months based on Kaplan-Meier survival analysis. The mean number of antiglaucoma medications required to achieve the desired IOP decreased from 3.4±0.5 preoperatively to 1.0±1.1 postoperatively (Pr0.05). Visual acuity loss of >2 lines occurred in 4 eyes (28.5%) due to optic atrophy associated with retinal vasculitis. Temporary hypotony developed during follow-up in 4 eyes (28.5%) at first postoperative week. Conclusions: For the management of uveitic glaucoma associated with BD, AGV implantation is a successful method for glaucoma control but requires additional surgical interventions for high early hypotony rates. © 2014 Wolters Kluwer Health, Inc. All rights reserved Daha fazlası Daha az
Aslanger, E. | Assous, B. | Bihry, N. | Beauvais, F. | Logear, D. | Cohen-Sola, A.
Article | 2016 | Journal of Cardiopulmonary Rehabilitation and Prevention36 ( 4 ) , pp.240 - 249
Purpose: Despite being repeatedly shown that exercise training (ET) increases exercise capacity and decreases mortality in many cardiac conditions, not all patients enjoy the benefits of ET programs. We hypothesized that baseline cardiovascular mechanic properties, including cardiac systolic and diastolic functions, arterial mechanics and ventriculoarterial interaction, may have a role in predicting response to ET. Methods: Full left ventricular pressure-volume loops were constructed and arterial mechanics were evaluated using echocardiographic and tonometric measurements. A cardiopulmonary exercise (CPX) test was performed before a . . .nd after the ET program. Result: Sixty of the 75 patients with coronary artery disease or heart failure diagnoses completed the study. All of the CPX parameters showed a significant improvement with ET. The change in oxygen uptake correlated only with arterial parameters, such as compliance (r=0.399, P=.002), end-systolic arterial elastance (r=- 0.293, P=.02), aortic pulse pressure (r=- 0.302, P=.02), and brachial pulse pressure (r=- 0.312, P=.01). Receiver-operating characteristics analysis demonstrated that baseline arterial compliance and brachial pulse pressure predicted a significantly positive ET result with reasonable sensitivity and specificity. Conclusions: Patients with a more compliant arterial system improved their exercise capacity more with ET. Evaluation of baseline arterial compliance may facilitate proper patient selection and may define patients who need optimizing measures for the arterial system before commencing ET. Even a simple blood pressure measurement may give clues in this regard. © Copyright 2016 Wolters Kluwer Health Daha fazlası Daha az
Ugutmen, E. | Ozkan, K. | Ozkan, F.U. | Eceviz, E. | Altintas, F. | Unay, K.
Article | 2010 | Journal of Pediatric Orthopaedics Part B19 ( 4 ) , pp.289 - 293
In radius neck fractures, reduction manipulations applied on the radial head with percutaneous K-wires may lead to epiphysis or physis damage. In this study, 16 cases were evaluated without using any percutaneous manipulations upon the displaced radius head. Rather, an Ender-pin-like, curve-tipped K-wire was inserted intramedullarly (Metaizeau technique) after a certain amount of reduction by manual manipulation under fluoroscopic guidance. Complete reduction was obtained with wire rotations in 16 patients. A total of 16 patients with open growth plates with an average age of 8 years were enrolled within the scope of the study. Thir . . .teen patients (81.25%) showed excellent clinical results, two patients (12.5%) showed good results, and one patient (6.25%) showed average results. None of the cases exhibited poor results. A single K-wire was used in nine cases, whereas two K-wires were used for fixation rigidity in seven cases with larger medullas. No sign of neurovascular deficit, synostosis, or infection was observed in any of the cases. In conclusion, the use of two wires in patients with larger medullas and emphasis on the importance of closed reduction, even without percutaneous K-wire manipulation, might lead to the development of a new treatment approach for pediatric patients with radial head fractures. © 2010 Wolters Kluwer Health | Lippincott Daha fazlası Daha az
Bingol, U.A. | Ulucay, C. | Ozler, T.
Article | 2014 | Plastic and Reconstructive Surgery - Global Open2 ( 12 ) , pp.289 - 293
Summary: Streptococcus mitis is a commensal organism of the human oropharynx that rarely causes infection in healthy individuals. Herein, we describe a previously healthy 35-year-old woman who presented with acute pyogenic flexor tenosynovitis of the left index finger due to S. mitis infection. The patient’s infection was treated successfully via surgical and medical interventions, and during follow-up, it was determined that she was complement component C3 deficient. Tenosynovitis is an emergent clinical syndrome that can result in permanent disability or amputation. To the best of our knowledge, this case report is the first to de . . .scribe tenosynovitis due to S. mitis; in addition, it highlights the importance of initiating therapy with antibiotics that are effective against this rare pathogen. Copyright © 2014 The Authors. Published by Lippincott Williams & Wilkins on behalf of The American Society of Plastic Surgeons Daha fazlası Daha az
Öksüz, S. | Ülkür, E. | Öncül, O. | Köse, G.T. | Küçükodac, Z. | Urhan, M.
Article | 2013 | Plastic and Reconstructive Surgery131 ( 3 ) , pp.463 - 471
Bingol, U.A. | Cinar, C. | Tasdelen, N.
Article | 2015 | Plastic and Reconstructive Surgery - Global Open3 ( 3 ) , pp.463 - 471
Ganglions are the most frequently seen soft-tissue tumors in the hand. Nerve compression due to ganglion cysts at the wrist is rare. We report 2 ganglion cysts arising from triangular fibrocartilage complex, one of which caused ulnar nerve compression proximal to the Guyon's canal, leading to ulnar neuropathy. Ganglion cysts seem unimportant, and many surgeons refrain from performing a general hand examination. Copyright © 2015 The Authors.
Avsar Abdik, E. | Kaleagasioglu, F. | Abdik, H. | Şahin, Fikrettin | Berger, M.R.
Article | 2019 | Anti-Cancer Drugs30 ( 4 ) , pp.383 - 393
A deeper understanding of the molecular basis of castration-resistant prostate cancer (CRPC) paved the way for the rational design and development of targeted therapies, which yielded promising preclinical results. However, translation of these potentially promising agents into clinics has usually failed, partly because of tumor heterogeneity. In this study, anticancer activities of the Bcl-2 inhibitor ABT-737 and the Akt-inhibitor erufosine (ErPC3) alone and in combination were compared between CRPC (PC-3 and DU-145) and healthy (PNT-1A) cell lines. The combination of ABT-737 and ErPC3 showed synergistic antiproliferative, antimigr . . .atory, and apoptotic effects in PC-3 cells. In DU-145 cells, ErPC3 showed a resistant profile, with half-maximal inhibitory concentration (IC 50) values more than two-fold of PC-3, and combining ErPC3 with ABT-737 yielded no added benefit for all the incubation periods compared with ErPC3 alone. In PNT-1A cells, ABT-737 and ErPC3 alone and in combination reduced cell survival slightly and only at the highest concentrations. Apoptosis analysis showed that ABT-737 induced increased Akt expression and ErPC3 induced increased Mcl-1 expression in DU-145 cells. In conclusion, the ABT-737 and ErPC3 combination seems to be promising against CRPC, with a favorable safety profile in healthy cells. However, CRPC cell-type-specific resistance may be induced by enhancement of antiapoptotic signaling. © Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved Daha fazlası Daha az