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Effects of Chlorine Stress on Pseudomonas aeruginosa Biofilm and Analysis of Related Gene Expressions

Kekeç, Ö. | Gökalsın, B. | Karaltı, İ. | Kayhan, F.E. | Sesal, N.C.

Article | 2016 | Current Microbiology73 ( 2 ) , pp.228 - 235

Chlorine is deployed worldwide to clean waters and prevent water-originated illnesses. However, chlorine has a limited disinfection capacity against biofilms. Microorganisms form biofilms to protect themselves from biological threats such as disinfectant chemicals. Pseudomonasaeruginosa is an opportunistic pathogen and its biofilm form attaches to surfaces, living buried into exopolysaccharides, can be present in all watery environments including tap water and drinking water. This research aimed to study the biofilm trigger mechanism of the opportunistic pathogen P.aeruginosa PAO1 strain, which is known to form biofilm in water supp . . .ly systems and human body, under chlorine stress levels. In addition to biofilm staining, certain genes that are relevant to the stress condition were selected for gene expression analysis. The bacteria cultures were grown under chlorine stress with concentrations of 0.5, 0.7 and 1 mg/l. Six gene regions were determined related to biofilm and stress response: rpoS,bifA,migA,katB,soxR, and algC. Biofilm formation was analyzed by basic fuchsin staining, and gene expressions were quantified by quantitative real-time PCR. According to the results, highest biofilm production was observed in P.aeruginosa PAO1 wild strain under no stress conditions. Higher biofilm amounts were observed for bacteria under 0.5 and 0.7 mg/l chlorine stress compared to 1 mg/l chlorine stress. © 2016, Springer Science+Business Media New York Daha fazlası Daha az

Intra-arterial Ultra-low-Dose CT Angiography of Lower Extremity in Diabetic Patients

Özgen, A. | Sanioğlu, S. | Bingöl, U.A.

Article | 2016 | CardioVascular and Interventional Radiology39 ( 8 ) , pp.1165 - 1169

Purpose: To image lower extremity arteries by CT angiography using a very low-dose intra-arterial contrast medium in patients with high risk of developing contrast-induced nephropathy (CIN). Materials and Methods: Three cases with long-standing diabetes mellitus and signs of lower extremity atherosclerotic disease were evaluated by CT angiography using 0.1 ml/kg of the body weight of contrast medium given via 10-cm-long 4F introducer by puncturing the CFA. Images were evaluated by an interventional radiologist and a cardiovascular surgeon. Density values of the lower extremity arteries were also calculated. Findings in two cases wer . . .e compared with digital subtraction angiography images performed for percutaneous revascularization. Blood creatinine levels were followed for possible CIN. Results: Intra-arterial CT angiography images were considered diagnostic in all patients and optimal in one patient. No patient developed CIN after intra-arterial CT angiography, while one patient developed CIN after percutaneous intervention. Conclusion: Intra-arterial CT angiography of lower extremity might be performed in selected patients with high risk of developing CIN. Our limited experience suggests that as low as of 0.1 ml/kg of the body weight of contrast medium may result in adequate diagnostic imaging. © 2016, Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Daha fazlası Daha az

Styles and style-stretching: How are they related to successful learning?

Griffiths, C. | İnceçay, G.

Article | 2016 | Journal of Psycholinguistic Research45 ( 3 ) , pp.599 - 613

Although the learning style construct has aroused much interest over the years, questions remain regarding basic issues such as definition, the validity and/or reliability of various measurement instruments, and the relationship between learning style and successful learning. Furthermore, although maintaining stylistic flexibility is recommended by many authors, few studies have attempted to relate the style-stretching concept to successful learning. This study therefore attempted to address these questions. According to results, conducted among 106 Turkish university students, using an original instrument constructed using elements . . . from established questionnaires, a small group of styles was significantly correlated with exam results, accounting for about a quarter of the variance (considered a large effect size in social science). In addition, higher-scoring students reported a more eclectic range of styles, suggesting more willingness to style-stretch, while lower-scoring students reported a more limited range. Pedagogical implications as well as areas for ongoing research are suggested. © Springer Science+Business Media New York 2015 Daha fazlası Daha az

Management of blood donation system: Literature review and research perspectives

Baş, S. | Carello, G. | Lanzarone, E. | Ocak, Z. | Yalçındağ, S.

Conference Object | 2016 | Springer Proceedings in Mathematics and Statistics169 , pp.121 - 132

2nd International Conference on Health Care Systems Engineering, HCSE 2015 -- 27 May 2015 through 29 May 2015 -- -- 181519

Boron promotes streptozotocin-induced diabetic wound healing: roles in cell proliferation and migration, growth factor expression, and inflammation

Demirci, S. | Doğan, A. | Aydın, S. | Dülger, E.Ç. | Şahin, Fikrettin

Article | 2016 | Molecular and Cellular Biochemistry417 ( 01.02.2020 ) , pp.119 - 133

Acute wounds do not generally require professional treatment modalities and heal in a predictable fashion, but chronic wounds are mainly accompanied with infection and prolonged inflammation, leading to healing impairments and continuous tissue degradation. Although a vast amount of products have been introduced in the market, claiming to provide a better optimization of local and systemic conditions of patients, they do not meet the expectations due to being expensive and not easily accessible, requiring wound care facilities, having patient-specific response, low efficiency, and severe side-effects. In this sense, developing new, . . .safe, self-applicable, effective, and cheap wound care products with broad-range antimicrobial activity is still an attractive area of international research. In the present work, boron derivatives [boric acid and sodium pentaborate pentahydrate (NaB)] were evaluated for their antimicrobial activity, proliferation, migratory, angiogenesis, gene, and growth factor expression promoting effects on dermal cells in vitro. In addition, boron-containing hydrogel formulation was examined for its wound healing promoting potential using full-thickness wound model in streptozotocin-induced diabetic rats. The results revealed that while both boron compounds significantly increased proliferation, migration, vital growth factor, and gene expression levels of dermal cells along with displaying remarkable antimicrobial effects against bacteria, yeast, and fungi, NaB displayed greater antimicrobial properties as well as gene and growth factor expression inductive effects. Animal studies proved that NaB-containing gel formulation enhanced wound healing rate of diabetic animals and histopathological scores. Overall data suggest a potential promising therapeutic option for the management of chronic wounds but further studies are highly warranted to determine signaling pathways and target metabolisms in which boron is involved to elucidate the limitations and extend its use in clinics. © 2016, Springer Science+Business Media New York Daha fazlası Daha az

Blow up of solutions of second order semilinear parabolic equations under robin boundary conditions

Kalantarova, J. | Polat, M.

Conference Object | 2016 | Springer Proceedings in Mathematics and Statistics155 , pp.211 - 224

We considered initial boundary value problems for semilinear heat equation with a nonlinear source term under the Robin boundary conditions. Sufficient conditions for the finite-time blow up of solutions with negative initial energy and arbitrary positive initial energy are obtained. © Springer International Publishing Switzerland 2016.

Memory Partitioning in the Limit

Kültürsay, E. | Ebcioğlu, K. | Küçük, G. | Kandemir, M.T.

Article | 2016 | International Journal of Parallel Programming44 ( 2 ) , pp.337 - 380

The key difficulties in designing memory hierarchies for future computing systems with extreme scale parallelism include (1) overcoming the design complexity of system-wide memory coherence, (2) achieving low power, and (3) achieving fast access times within such a memory hierarchy. Towards addressing these difficulties, in this paper we propose an automatic memory partitioning method to generate a customized, application-specific, energy-efficient, low latency memory hierarchy, tailored to particular application programs. Given a software program to accelerate, our method automatically partitions the memory of the original program, . . . creates a new customized application-specific multi-level memory hierarchy for the program, and modifies the original program to use the new memory hierarchy. This new memory hierarchy and modified program are then used as the basis to create a customized, application-specific, highly parallel hardware accelerator, which is functionally equivalent to the original, unmodified program. Using dependence analysis and fine grain valid/dirty bits, the memories in the generated hierarchy can operate in parallel without the need for maintaining coherence and can be independently initialized/flushed from/to their parent memories in the hierarchy, enabling a scalable memory design. The generated memories are fully compatible with the memory addressing in the original software program; this compatibility feature enables the translation of general software applications to application-specific accelerators. We also provide a compiler analysis method to perform accurate dependence analysis for memory partitioning based on symbolic execution, and a profiler-based futuristic limit study to identify the maximum gains that can be achieved by memory partitioning. © 2015, Springer Science+Business Media New York Daha fazlası Daha az

WiSEGATE: Wireless Sensor Network Gateway framework for internet of things

Serdaroglu, K.C. | Baydere, S.

Article | 2016 | Wireless Networks22 ( 5 ) , pp.1475 - 1491

With internet of things vision, computing systems get the ubiquity of real world. Wireless Sensor Network (WSN) technology plays a critical role for the construction of this paradigm. Hence, WSN technology should be adapted to support interoperability with the commodity internet entities. Since technological background of WSN and IP networks do not fit each other, this effort is not a straightforward process. In this paper, we introduce WiSEGATE which addresses end-to-end reliable interconnection problem between multiple internet entities and sensor nodes. WiSEGATE is a prototype of a new web server which supports three tier service . . . scheme with a data acquisition mechanism of WSN to access the physical data in particular locations in the real world. In WiSEGATE, an interconnection gateway handles operations required for the interoperability. Since this gateway maintains reliable TCP/IP connections of the interconnected entities, the resource constraint sensor nodes on WSN do not require a TCP/IP stack for handling end-to-end connections. A lightweight service layer is implemented on a sensor node for operations required by the interconnection. The strength and novelty of the model lies in the fact that this lightweight service layer relieves extra memory usage for end-to-end connection management. For determining limits of the proposed model, firstly, we examined the steps for request/response mechanism and modeled the gateway as a queueing system. By doing this, we derive a definition of the request traffic. For proof of concept, we performed comprehensive tests in simulation and real testbed environments for WLAN connection. WiSEGATE can achieve reasonable response times up to 80 simultaneous connections from remote entities to WSN when WLAN PER is less than 0.2. © 2015, Springer Science+Business Media New York Daha fazlası Daha az

A Genome-Wide Analysis of mRNA Expression in Human Tooth Germ Stem Cells Treated with Pluronic P85

Ataei, A. | Solovyeva, V.V. | Poorebrahim, M. | Blatt, N.L. | Salafutdinov, I.I. | Şahin, Fikrettin | Rizvanov, A.A.

Article | 2016 | BioNanoScience6 ( 4 ) , pp.392 - 402

Human tooth germ stem cells (hTGSCs) originate from the neural crest and have a great potential to be used in stem cell therapies. Our group has previously shown that Pluronics interact with stem cells and affect their biological function. Pluronics block copolymer (P85), a potential drug delivery agent in the micelle form, which was shown to improve stem cell expansion. However, it is not known how P85 treatment affects the transcription profile of hTGSCs. In the present study, we found substantial changes in the expression of 252 genes in response to P85 treatment by using Illumina microarray. The gene enrichment was carried out u . . .sing database for annotation, visualization, and integrated discovery (DAVID) and the results classified in several biologically meaningful clusters. Using bioinformatics tools, we constructed a global regulatory network of P85-modulated genes associated with stem cell differentiation pathways and multi-drug resistance (MDR) processes. In conclusion, our results were compatible with many of the P85-mediated biological processes and may help us to gain a better molecular understanding of P85 biological function. © 2016, Springer Science+Business Media New York Daha fazlası Daha az

Most-favored-nation clauses in commercial contracts: legal and economic analysis and proposal for a guideline

Gürkaynak, G. | Güner, A. | Diniz, S. | Filson, J.

Article | 2016 | European Journal of Law and Economics42 ( 1 ) , pp.129 - 155

The prevalent use of “most favored nation” (MFN) clauses in commercial agreements has garnered significant attention in the economics and legal literature and by practitioners and enforcement agencies. From an antitrust standpoint, there is a strong consensus that while MFN provisions can lead to procompetitive outcomes or at least play a competitively neutral role, they may also result in competitive harm and a loss of consumer welfare. Therefore, US and EU enforcement agencies and courts have held that MFNs should be reviewed on a case-by-case basis, considering the specific characteristics of both the contractual provision and th . . .e industry. While a case-by-case approach is valid, it is not ideal from a variety of standpoints: that of the competition authorities seeking to make best use of their limited resources and that of practitioners seeking to advise their clients. Accordingly, published guidelines on the use of MFNs, containing presumptions and safe harbors, would be both efficient and useful. The paper argues that it would increase the efficiency and accuracy of antitrust enforcement if one of the leading competition authorities issued MFN guidelines. The paper suggests a set of presumptions and safe harbors that should be included in any such guidelines. © 2015, The Author(s) Daha fazlası Daha az

Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?

Özcan, P. | Fıçıcıoğlu, C. | Kizilkale, O. | Yesiladali, M. | Tok, O.E. | Ozkan, F. | Esrefoglu, M.

Article | 2016 | Journal of Assisted Reproduction and Genetics33 ( 9 ) , pp.1223 - 1230

Purpose: We investigated antioxidant effects of CoQ10 supplementation on the prevention of OS-induced ovarian damage and to evaluate the protective effect of such supplementation against OS-related DNA damage. Methods: Twenty-four adult female Sprague–Dawley rats were randomly divided into three groups (8 rats per group): group 1 (control): saline, ip, and orally; group 2 (cisplatin group): cisplatin, 4.5 mg/kg ip, two times with an interval of 7 days; and group 3 (cisplatin + CoQ10 group): cisplatin, 4.5 mg/kg ip, two times with an interval of 7 days, and 24 h before cisplatin, 150 mg/kg/day orally in 1 mL of saline daily for 14 da . . .ys. Serum concentrations of anti-Mullerian hormone (AMH), number of AMH-positive follicles, the assessment of the intensity of 8'OHdG immunoreactivity, the primordial, antral and atretic follicle counts in the ovary were assessed. Result(s): The mean serum AMH concentrations were 1.3 ± 0.19, 0.16 ± 0.03, and 0.27 ± 0.20 ng/mL in groups 1, 2, and 3, respectively (p < 0.01). Serum AMH levels were significantly higher in group 1 compared to groups 2 and 3 (p < 0.01 and p = 0.01, respectively). There was a statistically significant difference in AMH-positive follicle count between the groups (p < 0.01). Group 1 showed higher numbers of AMH-positive granulosa cells compared to group 2 (p = 0.01). A significant difference was found in the primordial, the atretic, and antral follicle counts between the three groups (p < 0.01, p < 0.01, and p < 0.01, respectively). The atretic follicle count was significantly lower in the cisplatin plus CoQ10 group compared to the cisplatin group (p < 0.01). The antral follicle counts were significantly higher in the cisplatin plus CoQ10 group compared with the cisplatin group (p < 0.01). There was a statistically significant difference in the intensity of staining of the follicles that were positive for anti-8'OHdG between the groups (p = 0.02). Group 1 showed a significant lower intensity of staining of the follicles positive for anti-8'OHdG compared with group 2 (p = 0.03). Conclusion(s): CoQ10 supplementation may protect ovarian reserve by counteracting both mitochondrial ovarian ageing and physiological programmed ovarian ageing although the certain effect of OS in female infertility is not clearly known. © 2016, Springer Science+Business Media New York Daha fazlası Daha az

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