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Diffusion coefficients of carbon dioxide—ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) system at temperatures of 313 K and 323 K and pressures of 5 MPa and 8 MPa

Emek, O.B. | Yildiz, E.E. | Sekerci-Cetin, M. | Unlusu, B.

Article | 2019 | Chemical Engineering Communications

This work reports the mutual diffusion coefficients of carbon dioxide - 1-Butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) system at different temperatures (313.15 and 323.15 K) and pressures (5 and 8 MPa). We have determined the time-dependent solubility of carbon dioxide in the ionic liquid and then, fit a computational fluid dynamics (CFD) model to the experimental data to obtain the diffusion coefficients. The increase in the molar density and the expansion of the liquid phase during the dissolution of carbon dioxide are taken into account in the transport model. The results show that the mutual diffusion coefficients i . . .ncrease with carbon dioxide mole fraction and the values obtained at thermodynamic phase equilibrium compare well with those calculated using different correlations. © 2019, © 2019 Taylor & Francis Group, LLC Daha fazlası Daha az

Botulinum toxin for the treatment of bruxism

Tinastepe, N. | Küçük, B.B. | Oral, K.

Article | 2015 | Cranio - Journal of Craniomandibular Practice33 ( 4 ) , pp.292 - 299

Aims: Botulinum toxin, the most potent biological toxin, has been shown to be effective for a variety of disorders in several medical conditions, when used both therapeutically and cosmetically. In recent years, there has been a rising trend in the use of this pharmacological agent to control bruxing activity, despite its reported adverse effects. The aim of this review was to provide a brief overview to clarify the underlying essential ideas for the use of botulinum toxin in bruxism based on available scientific papers. Methodology: An electronic literature search was performed to identify publications related to botulinum toxin an . . .d its use for bruxism in PubMed. Hand searching of relevant articles was also made to identify additional studies. Results: Of the eleven identified studies, only two were randomized controlled trials, compared with the effectiveness of botulinum toxins on the reduction in the frequency of bruxism events and myofascial pain after injection. The authors of these studies concluded that botulinum toxin could be used as an effective treatment for reducing nocturnal bruxism and myofascial pain in patients with bruxism. Conclusion: Evidence-based research was limited on this topic. More randomized controlled studies are needed to confirm that botulinum toxin is safe and reliable for routine clinical use in bruxism. © W. S. Maney & Son Ltd Daha fazlası Daha az

Classical and Bayesian estimation of P(Y < X) for Kumaraswamy's distribution

Nadar, M. | Kizilaslan, F. | Papadopoulos, A.

Article | 2014 | Journal of Statistical Computation and Simulation84 ( 7 ) , pp.1505 - 1529

The aim of this paper is to study the estimation of the reliability R=P(Y

Sensitivity of muscle and intervertebral disc force computations to variations in muscle attachment sites

Bayoglu, R. | Guldeniz, O. | Verdonschot, N. | Koopman, B. | Homminga, J.

Article | 2019 | Computer Methods in Biomechanics and Biomedical Engineering22 ( 14 ) , pp.1135 - 1143

The current paper aims at assessing the sensitivity of muscle and intervertebral disc force computations against potential errors in modeling muscle attachment sites. We perturbed each attachment location in a complete and coherent musculoskeletal model of the human spine and quantified the changes in muscle and disc forces during standing upright, flexion, lateral bending, and axial rotation of the trunk. Although the majority of the muscles caused minor changes (less than 5%) in the disc forces, certain muscle groups, for example, quadratus lumborum, altered the shear and compressive forces as high as 353% and 17%, respectively. F . . .urthermore, percent changes were higher in the shear forces than in the compressive forces. Our analyses identified certain muscles in the rib cage (intercostales interni and intercostales externi) and lumbar spine (quadratus lumborum and longissimus thoracis) as being more influential for computing muscle and disc forces. Furthermore, the disc forces at the L4/L5 joint were the most sensitive against muscle attachment sites, followed by T6/T7 and T12/L1 joints. Presented findings suggest that modeling muscle attachment sites based on solely anatomical illustrations might lead to erroneous evaluation of internal forces and promote using anatomical datasets where these locations were accurately measured. When developing a personalized model of the spine, certain care should also be paid especially for the muscles indicated in this work. © 2019, © 2019 University of Twente. Published by Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Amygdalin in bitter and sweet seeds of apricots

Karsavuran, N. | Charehsaz, M. | Celik, H. | Asma, B.M. | Yakıncı, C. | Aydın, A.

Article | 2014 | Toxicological and Environmental Chemistry96 ( 10 ) , pp.1564 - 1570

Hydrogen cyanide (HCN) poisoning due to amygdalin (AMY) in apricot seeds is one of the public health issues in Turkey. The aim of this study was to investigate the AMY content of 13 different apricot seeds including bitter and sweet ones, and which are either sulfurized or roasted. The AMY content was determined by a high-performance liquid chromatography. Release of HCN was predicted and total amount of seeds which can cause poisoning was calculated. The mean AMY content of bitter seeds was 26 ± 14 mg g-1 and that of sweet seeds was 0.16 ± 0.09 mg g-1. The consumption of small amounts of bitter seeds may cause cyanide poisoning. © . . .2015 Taylor & Francis Daha fazlası Daha az

Synthesis and characterization of new thiosemicarbazonato molybdenum(VI) complexes and their in vitro antimicrobial activities

Çelen, Ş. | Eğlence-Bakır, S. | Şahin, M. | Deniz, I. | Celik, H. | Kizilcikli, I.

Article | 2019 | Journal of Coordination Chemistry72 ( 10 ) , pp.1747 - 1758

Eight new mixed ligand complexes of dioxomolybdenum(VI) with 2-hydroxy-3-methoxy/3,5-dibromo benzaldehyde 4-phenyl/ethyl-S-methyl/butyl thiosemicarbazones (L) were synthesized. The complexes of general formula [MoO2LD] (D: methanol, pyridine) were characterized by elemental analysis, IR, UV, and 1H-NMR spectroscopy. The structure of 3a was also determined by X-ray single-crystal diffraction. The thiosemicarbazone ligands are coordinated to dioxomolybdenum(VI) center through ONN set and the sixth coordinated site of the molybdenum is occupied by the second ligand (D). The in vitro antimicrobial activities of all thiosemicarbazones an . . .d their dioxomolybdenum(VI) complexes were tested against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Mesenchymal stem cell therapy for the streptozotocin-induced neurodegeneration in rats

Isik, A.T. | Celik, T. | Ural, A.U. | Tosun, M. | Ulusoy, G. | Elibol, B.

Article | 2016 | Neurological Research38 ( 4 ) , pp.364 - 372

Background and Aim: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are one of the sources of adult stem cells being explored for potential use in repairing neurodegenerative disorders. In this study, it was aimed to investigate the useful effects of BM-MSCs therapy on the streptozotocin-induced neurodegeneration in rats. Materials and Methods: Adult female Wistar rats were bilaterally injected intra-cerebroventricularly with streptozotocin (3 mg/kg) for neurodegeneration. Water maze tests were used to monitor spatial learning and memory. One or two intravenous injections of BM-MSCs were administrated to rat via the tail veins. . . . At the end of the study, all rats were sacrificed for histological evaluation and immunohistochemistry. Results: Streptozotocin group demonstrated a significant increase in escape latency in comparison with both control groups (Sham and Saline), whereas rats treated with BM-MSCs exhibited a decrease in escape latency in comparison with streptozotocin group. The percentage of time spent in the target quadrant and the mean number of platform crossings did not change in all the groups. BM-MSCs administration improved spatial learning but not memory. However, improvement in neuronal cells in hippocampal CA1 region was only observed in the rats treated with BM-MSCs twice as opposed to the rats treated with BM-MSCs once or with saline. Conclusions: In this study, mesenchymal stem cells therapy failed to improve the streptozotocin-induced neurodegeneration like Alzheimer’s disease in rats. © 2016 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Çapar, G.D. | Sapmaz-Metin, M. | Kütan, E. | Tomruk, C.O. | Yalcin, G.M. | Er, N. | Ozfidan, G.K.

Article | 2016 | Biotechnology and Biotechnological Equipment30 ( 4 ) , pp.752 - 761

The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Grou . . .p III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels’ analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats. © 2016 The Author(s). Published by Taylor & Francis Daha fazlası Daha az

Karyomorphology and nuclear DNA content of sixteen Ophrys L. taxa from Turkey

Deniz, İ.G. | Genç, İ. | Yücel, G. | Sümbül, H. | Sezik, E. | Tuna, M.

Article | 2018 | Plant Biosystems152 ( 4 ) , pp.711 - 719

Karyotypes in 16 representative taxa of the Ophrys genus are compared, based on Feulgen-stained somatic metaphase chromosomes. The karyotypes of O. omegaifera subsp. israelitica, O. ulupinara, O. lycia, O. argolica subsp. lucis, O. argolica subsp. lesbis, O. climacis and O. reinholdii subsp. reinholdii are described for the first time. Karyological analyses indicate relationships among the species with respect to their asymmetry indices. All Ophrys taxa studied were diploid with 2n = 2x = 36 chromosomes. One B chromosome has been detected among the chromosomes of O. argolica subsp. lucis. All karyotypes are symmetrical, consisting o . . .f metacentric and submetacentric chromosomes. The longest chromosomes of all the investigated specimens contain a secondary constriction. It is determined that there is a correlation between the total number of chromosomes having secondary constrictions and the evolutionary development order of the taxa. Based on nuclear DNA content, analysis was carried out by flow cytometer using propodium iodide as fluorochrome, 2C nuclear DNA content of 16 Ophrys species varying between 20.80 pg (O. argolica subsp. lucis) and 23.11 pg (O. omegaifera subsp. israelitica). Karyotype asymmetry relationships are discussed according to the bidimensional scatter plots of A1–A2, CVCL–CVCI, CVCL–MCA and CVCI–MCA. © 2017 Società Botanica Italiana Daha fazlası Daha az

Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation

G. Renda | B. Korkmaz | M. Kılıç | M.K. Duman | H. Kırmızıbekmez

Article | 2018 | Natural Product Research32 ( 16 ) , pp.1902 - 1910

The present study was undertaken to evaluate the in vivo analgesic activities of the extracts prepared from the aerial parts and roots of Scrophularia kotscyhana and to isolate the bioactive metabolites from the most active extract. Analgesic activities of all extracts and subextracts at the doses of 5, 10 and 30 mg/kg (i.p.) were examined using hot plate test in mice. Among the tested extracts, MeOH extract prepared from the aerial parts and the n-butanol subextract prepared thereof displayed the best analgesic activity at all doses. Phytochemical studies on n-butanol subextract led to the isolation of two new iridoid glycosides as . . . an inseparable mixture, 8-O-acetyl-4'-O-(E)-(p-coumaroyl)-harpagide (1) and 8-O-acetyl-4'-O-(Z)-(p-coumaroyl)-harpagide (2) along with five known secondary metabolites, ß-sitosterol 3-O-ß-glucopyranoside (3), apigenin 7-O-ß-glucopyranoside (4), apigenin 7-O-rutinoside (5), luteolin 7-O-ß-glucopyranoside (6) and luteolin 7-O-rutinoside (7). The iridoid mixture (1 and 2), 3 and 4 elicited significant inhibition of pain at 5 mg/kg dose. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Dynamic programming and mixed integer programming based algorithms for the online glass cutting problem with defects and production targets

Durak, B. | Aksu, D.T.

Article | 2017 | International Journal of Production Research55 ( 24 ) , pp.7398 - 7411

In flat glass manufacturing, glass products of various dimensions are cut from a glass ribbon that runs continuously on a conveyor belt. Placement of glass products on the glass ribbon is restricted by the defects of varying severity located on the ribbon as well as the quality grades of the products to be cut. In addition to cutting products, a common practice is to remove defective parts of the glass ribbon as scrap glass. As the glass ribbon moves continuously, cutting decisions need to be made within seconds, which makes this online problem very challenging. A simplifying assumption is to limit scrap cuts to those made immediate . . .ly behind a defect (a cut-behind-fault or CBF). We propose an online algorithm for the glass cutting problem that solves a series of static cutting problems over a rolling horizon. We solve the static problem using two methods: a dynamic programming algorithm (DP) that utilises the CBF assumption and a mixed integer programming (MIP) formulation with no CBF restriction. While both methods improve the process yield substantially, the results indicate that MIP significantly outperforms DP, which suggests that the computational benefit of the CBF assumption comes at a cost of inferior solution quality. © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Polyharmonic robin problem for complex linear partial differential equations

Aksoy, Ü. | Çelebi, A.O.

Article | 2014 | Complex Variables and Elliptic Equations59 ( 12 ) , pp.1679 - 1695

In this article, generalized polyharmonic Robin functions are introduced together with some of their properties. A hierarchy of integral operators with relevant kernel functions are investigated. These operators are used to transform the Robin problem for a 2nth order linear partial complex differential equation with polyharmonic leading term (generalized n-Poisson equation) into a singular integral equation having Fredholm property. © 2014 Taylor & Francis.

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