A. Kumar | I.A. Ince | A. Kati | R. Chakraborty

Article | 2013 | International Journal of Systematic and Evolutionary Microbiology63 ( PART2 ) , pp.511 - 515

A Gram-positive-staining, rod-shaped, facultatively oligotrophic bacterial strain, designated MB18T, was isolated from a water sample collected from the River Mahananda at Siliguri (26° 44' 23.20' N, 88° 25' 22.89' E), West-Bengal, India. On the basis of 16S rRNA gene sequence similarity, the closest relative of this strain was Brevibacterium epidermidis NCDO 2286T (96% similarity). The DNA G+C content of strain MB18T was 64.6 mol%. Chemotaxonomic data [MK-8(H2) as the major menaquinone, galactose as the sole cell-wall sugar, meso-diaminopimelic acid as the diagnostic cell-wall diamino acid, phosphatidylglycerol and diphosphatidylgl . . .ycerol as constituents of the polar lipids, anteiso-C15: 0, anteiso-C17: 0 and iso-C15: 0 as the major fatty acids] supported the affiliation of strain MB18T to the genus Brevibacterium. The results of DNA G+C content, 16S rRNA gene sequence analysis and biochemical and physiological analyses allowed genotypic and phenotypic differentiation of strain MB18T from its nearest neighbour B. epidermidis. The isolate therefore represents a novel species, for which the name Brevibacterium siliguriense sp. nov. is proposed; the type strain is MB18T (=DSM 23676T=LMG 25772T). © 2013 IUMS Daha fazlası Daha az

Yükselici, H. | Allahverdi, C. | Aşikoglu, A. | Ünlü, H. | Baysal, A. | Çulha, Mustafa | Athalin, H.

Article | 2013 | NanoScience and Technology77 , pp.101 - 117

Optical absorption (ABS), steady-state photoluminescence (PL), resonant Raman, and photoabsorption (PA) spectroscopies are employed to study quantumsize effects in II-VI semiconductor quantum dots (QDs) grown in glass samples. We observe a size-dependent shift in the energetic position of the first exciton peak and have examined the photoinduced evolution of the differential absorption spectra. The Raman shifts of the phonon modes are employed to monitor stoichiometric changes in the composition of the QDs during growth. Two sets of glass samples were prepared from color filters doped with CdSxSe1-xand ZnxCd1-xTe. We analyze the opt . . .ical properties of QDs through the ABS, PL, resonant Raman, and PA spectroscopies. The glass samples were prepared from commercially available semiconductor doped filters by a two-step thermal treatment. The average size of QDs is estimated from the energetic position of the first exciton peak in the ABS spectrum. A calculation based on a quantized-state effective mass model in the strong confinement regime predicts that the average radius of QDs in the glass samples ranges from 2.9 to 4.9 nm for CdTe and from 2.2 to 9.3 nm for CdS0:08Se0:92. We have also studied the nonlinear optical properties of QDs by reviewing the results of size-dependent photoinduced modulations in the first exciton band of CdTe QDs studied by PA spectroscopy. © Springer-Verlag Berlin Heidelberg 2013 Daha fazlası Daha az

Sencan, N. | Yegenoglu, S. | Aydintan, B.

Review | 2013 | Marmara Pharmaceutical Journal17 ( 2 ) , pp.104 - 112

Employees' individual and social management behavior is a subject of organizational behavior discipline. Organisational commitment and job satisfaction concepts are widely studied items of organisational behavior researchers. The factors and results of job satisfaction and organization behaviour are related to each other. The services given by the health professionals are also affected by organizational commitment and job satisfaction and needed to be measured, impoved and searched. This review summarises the factors of job satisfaction, organizational commitment and researches conducted on health care givers including pharmacists.

Bilgic, M.M. | Yegin, K.

Erratum | 2013 | Microwave and Optical Technology Letters55 ( 8 ) , pp.104 - 112

[No abstract available]

Dalan, A.B. | Toptaş, B. | Buğra, Z. | Polat, N. | Yılmaz-Aydoğan, H. | Çimen, A. | İsbir, T.

Article | 2013 | Molecular Biology Reports40 ( 8 ) , pp.5143 - 5149

Atherosclerosis is a major pathological process related with several important adverse vascular events including coronary artery disease, stroke, and peripheral arterial disease. Endothelial lipase is an enzyme the activity of which affects all of lipoproteins, whereas HDL is the main substrate. The purpose of our study was to investigate the effects of endothelial lipase gene polymorphism and inflammation markers (CRP, IL-1ß, IL-6, IL-8 and TNF-?) in the atherosclerosis. 104 patients with atherosclerosis and 76 healthy individuals were included in the study. LIPG -584C/T polymorphism gene polymorphisms were assessed with PCR-RFLP m . . .ethod. The serum CRP levels were measured by turbidimetric method using a biochemistry autoanalyzer, whereas serum IL-1ß, IL-6, IL-8, TNF-? levels were determined by enzyme-linked immunosorbent assay. In this study, we found that the frequencies of TC genotype are more prevalent in patients than controls. We found a statistically significant difference of IL-6 levels between patient and control group. Our findings suggest that T allele might play a potential role in the susceptibility to atherogenesis in the Turkish population. © 2013 Springer Science+Business Media Dordrecht Daha fazlası Daha az

Vatanoglu-Lutz, E.E. | Çoban, M. | Izgi, M.C.

Article | 2013 | Omega (United States)68 ( 4 ) , pp.367 - 382

https://hdl.handle.net/20.500.11831/1165

Sancak, S. | Altun, H. | Aydin, H. | Tukun, A. | Mantoglu, B. | Ender, O. | Memisoglu, K.

Article | 2013 | Acta Endocrinologica9 ( 1 ) , pp.109 - 119

Increased frequency of adrenal tumours and adrenal myelolipoma has been reported in patients with 21-hydroxylase deficiency (21-OHD). Adrenal myelolipoma is an uncommon, benign, biochemically nonfunctioning tumor and occasionally reported in association with endocrine disorders. Diagnosis of myelolipomas is based on imaging with ultrasonography, CT or MRI being effective in more than 90% of cases. We present a 34-year-old man with massive bilateral adrenal masses which was detected on computed tomography and was diagnosed as 21-hydroxylase deficiency (21-OHD) based on biochemical findings. Computerized tomography of the abdomen demo . . .nstrated bilaterally very low-density adrenal masses (16x28 mm on the right side and 91x88 and 33x30 mm on the left side) consistent with adrenal myelolipomas. Since myelolipomas are considered as benign tumors, he was not operated. Tumor size did not increase during two year follow-up periods. It is recommended to the physicians to be aware of increased frequency of benign adrenal tumors that occur frequently in patients with 21-OHD. Untreated Congenital Adrenal Hyperplasia CAH with prolonged excessive ACTH stimulation might contribute to the growth of adrenal masses. CAH should always be ruled out in incidentally detected adrenal masses to avoid unnecessary surgical procedures Daha fazlası Daha az

Tatlipinar, S. | Yenerel, N.M.

Article | 2013 | Retinal Cases and Brief Reports7 ( 2 ) , pp.150 - 151

Purpose: To present a failed macular hole surgery with gas microbubble retention within the hole. Methods: A 68-year-old female patient with a Stage 2 macular hole underwent vitrectomy with removal of posterior hyaloid and 12% C3F8 gas injection. Because the macular hole was Stage 2 and posterior hyaloid was observed to be firmly attached over the macular area, no attempt was made for peeling of internal limiting membrane. Postoperatively, the patient was instructed to keep a facedown posture for 1 week. At 1-month visit, ophthalmoscopy revealed a tiny gas bubble filling the macular hole that failed to close. Results: The patient un . . .derwent a repeat vitrectomy in which internal limiting membrane was peeled, and the eye was filled with 20% SF6. At 2-week follow-up visit, the hole was observed to be closed. Conclusion: The reason for the macular hole nonclosure in this case may be the lack of internal limiting membrane peeling in the first operation. However, the authors believe that microbubble localized within the hole might have contributed to the failure. © (c) 2000-2012 Ovid Technologies, Inc Daha fazlası Daha az

Ray, A. | Barreto, S.C. | Armstrong, E. | Dogan, S.

Review | 2013 | Journal of Pediatric Biochemistry3 ( 4 ) , pp.187 - 201

Early diagnosis of cancer clearly reduces morbidity and mortality, and a sizable number of cancers could be prevented at the secondary level with appropriate diagnostic tools. In early detection, biochemical analyses are highly supportive of the cytological and/or histopathological assessments. Among children, cancers probably originate from altered signaling pathways attributable to developmental genetic disorders. In adults, generally preventable risk factors, e.g., cigarette smoking, infections, unhealthy lifestyle and obesity, create a state of inflammation and associated oxidative imbalance, which may progress to malignancy. Pa . . .thological mechanisms of cancer are associated with abnormal expressions of various endogenous molecules that can be used as tumor biomarkers. Evaluation of such markers in different phases along the disease course plays a crucial role in clinical management and prognosis. Definitely, the current trend of active research on neoplastic mechanisms will help the clinical biochemistry laboratories to provide a better service. © 2013 - IOS Press and the authors. All rights reserved Daha fazlası Daha az

Muter, I. | Ilker Birbil, Ş. | Bülbül, K. | Şahin, G. | Yenigün, H. | Taş, D. | Tüzün, D.

Article | 2013 | Computers and Operations Research40 ( 3 ) , pp.815 - 830

In this study, we solve a robust version of the airline crew pairing problem. Our concept of robustness was partially shaped during our discussions with small local airlines in Turkey which may have to add a set of extra flights into their schedule at short notice during operation. Thus, robustness in this case is related to the ability of accommodating these extra flights at the time of operation by disrupting the original plans as minimally as possible. We focus on the crew pairing aspect of robustness and prescribe that the planned crew pairings incorporate a number of predefined recovery solutions for each potential extra flight . . .. These solutions are implemented only if necessary for recovery purposes and involve either inserting an extra flight into an existing pairing or partially swapping the flights in two existing pairings in order to cover an extra flight. The resulting mathematical programming model follows the conventional set covering formulation of the airline crew pairing problem typically solved by column generation with an additional complication. The model includes constraints that depend on the columns due to the robustness consideration and grows not only column-wise but also row-wise as new columns are generated. To solve this difficult model, we propose a row and column generation approach. This approach requires a set of modifications to the multi-label shortest path problem for pricing out new columns (pairings) and various mechanisms to handle the simultaneous increase in the number of rows and columns in the restricted master problem during column generation. We conduct computational experiments on a set of real instances compiled from local airlines in Turkey. © 2010 Elsevier Ltd Daha fazlası Daha az

Kilic, U. | Yılmaz, B. | Reiter, R.J. | Yüksel, A. | Kilic, E.

Article | 2013 | Neuroscience237 , pp.268 - 276

Because of their favorable action profiles in humans, both memantine and melatonin are particularly interesting candidates as neuroprotectants in acute ischemic stroke. Until now, the signaling mechanisms mediating memantine's neuroprotective actions remained essentially uninvestigated. In addition, we have combined memantine with melatonin, which is a well-known neuroprotective molecule. Herein, we examined the effects of memantine (20. mg/kg, i.p.) administered alone or in combination with melatonin (4. mg/kg, i.p.) on the activation of signaling transduction pathways, IgG extravasation and ischemic injury in mice submitted to 90. . . . min of intraluminal middle cerebral artery occlusion, followed by 24. h of reperfusion. In these studies, both agents reduced ischemic injury and the density of DNA-fragmentation. Notably, melatonin/memantine combination reduced ischemic injury further as compared with memantine treatment, which was associated with reduced IgG extravasation, indicating vascular leakage in the brain. Animals receiving memantine exhibited elevated ERK-1/2 and decreased p21 and p38/MAPK activations, while it had no significant effect on phosphorylated Akt and SAPK/JNK1/2 in the ischemic brain. However, melatonin increased the activation of Akt and reduced the activations of ERK-1/2, p21, p38/MAPK and SAPK/JNK1/2 significantly. Synergistic effects of memantine and melatonin were observed in the inactivation of p21, p38/MAPK and SAPK/JNK1/2 pathways. Moreover, memantine reversed the effects of melatonin on the activation of ERK-1/2 pathway. Here, we provide evidence that free radical scavenger melatonin potentiates the effects of memantine on ischemic brain injury via inactivations of p21 and stress kinases p38/MAPK and SAPK/JNK1/2 pathways. © 2013 IBRO Daha fazlası Daha az

Yildirim, D. | Tamam, M.O. | Sahin, M. | Ekci, B. | Gurses, B.

Article | 2013 | Revista Espanola de Medicina Nuclear e Imagen Molecular32 ( 2 ) , pp.86 - 91

https://hdl.handle.net/20.500.11831/1608