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Epicardial fat thickness is associated with impaired coronary flow reserve in hemodialysis patients

A. Atakan | B. Macunluoglu | Y. Kaya | E. Ari | H. Demir | E. Asicioglu | C. Kaspar

Article | 2014 | Hemodialysis International18 ( 1 ) , pp.62 - 69

Cardiovascular disease (CVD) is the main cause of mortality in hemodialysis (HD) patients. Epicardial fat tissue (EFT) is a new risk factor in CVD. The aim of this study was to evaluate the association between EFT and coronary artery flow reserve (CFR), which is an early indicator of endothelial dysfunction in coronary vessels of HD patients. We performed a cross-sectional study including 71 chronic HD patients and 65 age- and sex-matched healthy controls. Epicardial fat tissue was significantly higher in HD patients when compared to healthy controls (6.53±1.01mm vs. 5.79±1.06mm, respectively, P

Gender, Nationalism, and War: Conflict on the Movie Screen

Dincsahin, S

Review | 2014 | POLITICAL STUDIES REVIEW12 ( 1 ) , pp.125 - 126

Opinion of pharmacists towards accessibility of physically disabled people to pharmacy

Culduz, A. | Şencan, N. | İğnec, D. | Kaspar, Ç. | Özgören, R. | Çelİk, E.

Article | 2014 | Marmara Pharmaceutical Journal18 ( 2 ) , pp.73 - 78

AIM: This study aims to determine, the accessibility of physically disabled persons to community pharmacy. Other objectives are understanding the sensitivity of pharmacists to disability and pharmacists’ desire to change. METHOD: A web survey is used to collect the data. Survey questions are prepared by the researchers which includes demographic information and 14 open and/or closed ended questions related to pharmacy size, location, suitability of pharmacy placement and pharmacists knowledge on disabled laws and etc. In 2011 a priliminary face to face survey had been performed in Kayışdağı-Atasehir region. Then in 2012 wider spread . . . survey was performed via web, through all pharmacies of İstanbul and the data of web survey was collected in two months at January-March, 2012. RESULTS: The survey applied to community pharmacists; over 50% of the pharmacists have declared that their pharmacies are not suitable for access by disabled people. 91% of pharmacies’ placement area found to be satisfactory as meter square. Pharmacists believe that necessary arrangements are needed and the responsibility belongs to the government agencies. However, only 41% of pharmacists are aware of the legal arrangements for disabled citizens. 27% of community pharmacists stated that, their pharmacies have fully compatible and 54% of them pointed out that their pharmacy have some deficiencies in habitat. CONCLUSION: It has been found that community pharmacies are partly accesible for phsically disabled people. This condition is not only pharmacy related, but also caused by many architectural problems in the neighbourhood of pharmacy. It appears that, presence of legislations could not solve the architectural problems itself. Primarily standard measurements should be implemented by government authorities. However, legislation implementions may not enough for and education is needed to improve the thoughts and behaviours of public and health professionals. © 2014, Marmara University. All rights reserved Daha fazlası Daha az

Saccharomyces cerevisiae Fungemia in an elderly patient following probiotic treatment

Eren, Z. | Gürol, Y. | Sönmezoglu, M. | Eren, H.Š. | Çelik, G. | Kantarci, G.

Article | 2014 | Mikrobiyoloji Bulteni48 ( 2 ) , pp.351 - 355

Saccharomyces cerevisiae, known as baker's yeast, is also used as a probiotic agent to treat gastroenteritis by modulating the endogenous flora and immune system. However, since there have been increasing reports of fungemia due to S.cerevisiae and its subspecies S.boulardii, it is recommended that probiotics should be cautiously used in immunosuppressed patients, people with underlying diseases and low-birth weight babies. To emphasize this phenomenon, in this report, a case of S.cerevisiae fungemia developed in a patient given probiotic treatment for antibiotic-associated diarrhea, was presented. An 88-year-old female patient was . . .admitted to our hospital with left hip pain, hypotension, and confusion. Her medical history included hypertension, chronic renal failure, left knee replacement surgery, and recurrent urinary tract infections due to neurogenic bladder. She was transferred to the intensive care unit with the diagnosis of urosepsis. After obtaining blood and urine samples for culture, empirical meropenem (2 × 500 mg) and linezolid (1 × 600 mg) treatment were administered. A central venous catheter (CVC) was inserted and after one day of inotropic support, her hemodynamic parameters were stabilized. The urine culture obtained on admission yielded extended-spectrum betalactamase-producing Klebsiella pneumoniae and Escherichia coli. Urine culture was repeated after three days and no bacteria were isolated. On the 4th day of admission she developed diarrhea. Toxin A/B tests for Clostridium difficile were negative. To releive diarrhea, S.boulardii (Reflor 250 mg capsules, Sanofi Aventis, Turkey) was administered twice a day, without opening capsules. Two days later, her C-reactive protein (CRP) level increased from 23.2 mg/L to 100 mg/L without fever. Her blood culture taken from the CVC yielded S.cerevisiae. Linezolid and meropenem therapies were stopped on the 13th and 14th days, respectively, while prophylactic fluconazole therapy was replaced with caspofungin 1 × 50 mg on the fifth day. After seven days of therapy CRP and serum creatinine levels decreased to 9.1 mg/L and 1.2 mg/dl, respectively; and she was discharged from the hospital with improvement. The probiotic capsules were used unopen, thus, it was proposed that S.cerevisiae fungemia originated from translocation from the intestinal mucosa. Since it was not possible to investigate the molecular genetics of the strain isolated from the blood culture and the strain present in the probiotic, a definite conclusion about the origin of the strain could not be reached. It was thought that old age and underlying disease of the patient were the related predisposing factors for S.cerevisiae fungemia. This case emphasized that clinicians should be cautious in case of probiotic application eventhough in encapsulated form, even in immunocompetent patients with a history of long-term hospital stay and use of broad-spectrum antimicrobials since there may be a risk of S.cerevisiae fungemia development Daha fazlası Daha az

An alternative method for cementing laminate restorations with a micropulse toothbrush

Kursoglu, P. | Karagoz Motro, P.F.

Article | 2014 | Journal of Prosthetic Dentistry112 ( 6 ) , pp.1595 - 1596

Because porcelain laminate veneers are fragile and thin, seating should be handled carefully, but complete seating is essential for a successful restoration. When a high-viscosity luting resin is chosen, high pressure will be needed to seat the veneer, which makes it possible to fracture the material with finger pressure. This technical report describes a straightforward and safe cementation technique for porcelain laminate veneers as well as for complete crown, inlay, and onlay restorations. © 2014 Editorial Council for the Journal of Prosthetic Dentistry.

3D bioprinting of aortic structures with HDF cells

Koc, B | Ozer, SB | Kucukgul, C | Altunbek, M | Sen, O | Culha, M


The effect of vascular endothelial growth factor overexpression in experimental necrotizing enterocolitis

Karatepe, H.O. | Kilincaslan, H. | Berber, M. | Ozen, A. | Saricoban, H.E. | Ustek, D. | Bakar, F.

Article | 2014 | Pediatric Surgery International30 ( 3 ) , pp.327 - 332

Purpose: Necrotizing enterocolitis (NEC) is a serious condition, predominantly observed in premature infants. We used an experimental NEC model to investigate the effects of vascular endothelial growth factor (VEGF) cloned into a plasmid. Materials and methods: Twenty-four newborn Wistar albino rats were randomized equally into three groups as follows: control, NEC and NEC+VEGF. NEC was induced by hyperosmolar enteral formula feeding, exposure to hypoxia/reoxygenation and cold stress. In the NEC+VEGF group, VEGF (1 µg) incorporated into plasmid (2 µg) was administered subcutaneously once daily for a total of 3 days starting on the f . . .irst day of the NEC procedure. All rats were sacrificed on the 4th day of life, and the specimens were harvested for histopathological and biochemical examinations [including tissue oxidative stress (malondialdehyde and nitric oxide), inflammation (myeloperoxidase, interleukin-6 and tumor necrosis factor alpha) and apoptosis (caspase-3 activity) parameters]. Results: In the NEC+VEGF group, tissue malondialdehyde, nitric oxide, interleukin-6, tumor necrosis factor alpha levels and caspase-3 activity were significantly decreased. In addition, the myeloperoxidase level was increased compared to that of the NEC group (p < 0.05). Histopathologically, VEGF overexpression enhanced angiogenesis, alleviated villous atrophy and tissue edema (p < 0.05). Conclusion: VEGF overexpression with plasmids seems to be a promising approach in the management of NEC. © 2013 Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

Is there a correlation between intravaginal ejaculatory latency time and enuresis? An exploratory study

Koyuncu, H. | Serefoglu, E.C. | Karacay, S. | Ozdemir, A.T. | Kalkan, M. | Yencilek, F.

Article | 2014 | Central European Journal of Urology67 ( 1 ) , pp.74 - 78

Introduction Premature ejaculation (PE) is the most common male sexual dysfunction. Monosymptomatic enuresis (ME) is nocturnal bed wetting, without any daytime symptoms. Recent clinical studies report an association between lifelong PE and ME. The purpose of this study was to compare the intravaginal ejaculatory time (IELT) between lifelong PE in men with and without ME. The goal was to determine if there is an association between the severity of ME and of IELT. Material and methods A total of 137 men with lifelong PE were included in this study. Subjects were asked if they had childhood ME. The characteristics and mean IELTs of pat . . .ients with and without ME were compared using the student's t-test, and the correlation between severity of ME and IELT was assessed with trend test. Results Of the 137 lifelong PE patients, 57 reported ME. There was a strong negative correlation in patients with ME between the severity of enuresis and IELT, with IELT being shorter in patients with severe ME. Conclusions A strong correlation between IELT and the severity of ME suggests a common underlying mechanism. Further studies are required to confirm these findings and elucidate the exact pathophysiology Daha fazlası Daha az

A qualitative study on menopause described from the man's perspective

Hidiroglu, S. | Tanriover, O. | Ay, P. | Karavus, M.

Article | 2014 | Journal of the Pakistan Medical Association64 ( 9 ) , pp.1031 - 1036

Objective: To look at menopause from men's point of view and to provide a better understanding of this phase to improve the care delivered to menopausal women. Methods: The study was conducted at the health centre of a single district of Istanbul, from April 2013 to June 2013, which serves as the research and training area of the Marmara University and which receives migrations from mainly southern and eastern regions of Turkey. The study sample included 33 married men. Qualitative in-depth interviews were performed individually and main themes were noted down for analysis. Results: The age range of the study population was 40-77 ye . . .ars. The subjects lacked basic knowledge about both menstruation and menopause. Most of the participants defined menopause as loss of fecundity, increased weight, and loss of beauty. The most important concern voiced was men's own sexual life. None of the men had heard about treatment modalities available for menopause. Conclusion: Interventions are needed to increase men's awareness regarding menopause in order to help these men to be able to better support their spouses so that they can both have a smooth transition into postmenopausal years Daha fazlası Daha az

Prosthetic rehabilitation of maxillary dentoalveolar defects with fixed dental prostheses: Two clinical reports

Canpolat, C. | Özkurt-Kayahan, Z. | Kazazoglu, E.

Article | 2014 | Journal of Prosthetic Dentistry112 ( 3 ) , pp.418 - 422

Traumatic injuries or congenital malformations may cause soft and hard tissue defects resulting in the loss of alveolar bone and attached mucosa. Restoring the defective area presents a challenge for clinicians. The prosthetic rehabilitation of 2 patients with maxillary dentoalveolar defects with 2 different prosthetic designs is presented. The esthetic and functional requirements of the patients were fulfilled.

Small bowel mucosal damage in familial Mediterranean fever: Results of capsule endoscopy screening

Demir, A. | Akyüz, F. | Göktürk, S. | Evirgen, S. | Akyüz, U. | Örmeci, A. | Gül, A.

Article | 2014 | Scandinavian Journal of Gastroenterology49 ( 12 ) , pp.1414 - 1418

Objective. Familial Mediterranean fever (FMF) is the most common form of autoinflammatory diseases. We aimed to evaluate the small bowel mucosa by capsule endoscopy (CE) in FMF patients for investigation of other possible causes of abdominal pain. Material and methods. The study group consisted of 41 patients with FMF. A standard questionnaire was used to record the gastrointestinal symptoms, other clinical findings, Mediterranean fever gene (MEFV) mutations, and history of medications including non-steroidal anti-inflammatory drugs (NSAIDs). Gastroscopy, colonoscopy and small bowel CE were performed in all patients, and biopsies we . . .re taken from terminal ileum and duodenum. Results. The mean age of the patients was 34 ± 11 years, 63% of them were female, and 76.5% of them were carrying MEFV exon 10 mutations. Only one patient used NSAIDs in addition to colchicine. In endoscopic investigations, gastric erosion was detected in only one patient, and no significant findings were detected in colonoscopy. CE showed small bowel mucosal defects in 44% (erosions in 26.8%, ulcer in 17.1%) and edema in 29.3% of the patients. Most (64%) of the ulcer and erosions were localized to jejunum, and only 24% were in ileum. Mitotic changes as an indirect finding of colchicine toxicity were not different from the changes observed in samples of independent group of patients with irritable bowel syndrome. Conclusion. Mucosal defect was observed in half of the FMF patients, which may be associated with underlying inflammation or chronic colchicine exposure. Detection of nonspecific chronic inflammation without mitotic changes supports that mucosal defects may be associated with the autoinflammatory process. © 2014 Informa Healthcare Daha fazlası Daha az

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