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Undrained shear strength and monotonic behavior of different nonplastic silts: Sand-like or clay-like?

M.M. Monkul | N.G. Aydin | B. Demirhan | M. Şahin

Article | 2020 | Geotechnical Testing Journal43 ( 3 )

The common assumption in geotechnical engineering research and practice has been that non-plastic silts behave sand-like, whereas, as silts become more plastic, they start to behave claylike. To date, there are practically no studies focusing solely on various nonplastic silts and their monotonic response, perhaps because of the solid belief that nonplastic silts behave sand-like in all aspects. A series of constant volume direct simple shear tests were conducted on three different nonplastic silts. Because the specimens were reconstituted to have loose grain structures, volumetrically contractive tendency was observed for all the s . . .ilts with relatively small effective stress friction angles. It was observed that Ko compression lines and critical state lines are parallel to each other for all three silts, which is considered to be a clay-like behavior in literature. It was shown that undrained shear strengths can be normalized with the effective vertical consolidation stress, which is also considered to be a clay-like behavior in literature. Normalized values are compared with the ones obtained for plastic silts compiled from previous studies. Normalized undrained shear strength values for plastic silts in literature were seen to be typically greater. Possible reasons such as density effect and strength anisotropy were discussed. Copyright © 2019 by ASTM International Daha fazlası Daha az

Comparison of tramadol versus tramadol with paracetamol for efficacy of postoperative pain management in lumbar discectomy: A randomised controlled study

N. Uztüre | H. Türe | Ö. Keskin | B. Atalay | Ö. Köner

Article | 2020 | International Journal of Clinical Practice74 ( 1 )

Purpose: Despite developments in the treatment of pain, the availability of new drugs or increased knowledge of pain management, postoperative pain control after different surgeries remains inadequate. We aimed to compare the postoperative analgesic efficacy of tramadol versus tramadol with paracetamol after lumbar discectomy. Design, Setting, Participants: Sixty patients undergoing lumbar discectomy were randomly assigned into two groups. Methods: Patients in Group T (n = 30) received tramadol (1 mg/kg), and patients in Group TP (n = 30) received tramadol (1 mg/kg) with paracetamol (1 g) 30 minutes before the end of surgery and par . . .acetamol was continued during the postoperative period at 6 hours intervals for the first 24 hours. Patient-controlled analgesia with tramadol was used during the postoperative period. Main Outcome Measures: Duration, postoperative pain scores, Ramsay sedation scores, analgesic consumption, and side effects were recorded in all patients during the postoperative period. Continuous random variables were tested for normal distribution using the Kolmogorov-Smirnov test, than Student's t-test was used for means comparisons between groups. For discrete random variables chi-square tests and McNemar test was used. Results: Demographic data, mean duration of anaesthesia and surgery were similar in both groups. Postoperative pain scores were significantly higher in Group T than Group TP at 5; 15; 20; and 30 minutes (P =.021, P =.004, P =.002, P =.018). Late postoperative pain scores were similar. Total tramadol consumption in Group T (106.12 ± 4.84 mg) was higher than Group TP (81.20 ± 2.53) during the 24 hours postoperative period. However, continuing the paracetamol at 6 hours interval did not change late postoperative pain scores. Conclusion: The administration of tramadol with paracetamol was more effective than tramadol alone for early acute postoperative pain therapy following lumbar discectomy. Therefore, while adding paracetamol in early pain management is recommended, continuing paracetamol for the late postoperative period is not advised. © 2019 John Wiley & Sons Lt Daha fazlası Daha az

Justifying privileged partnership with Turkey: an analysis of debates in the European Parliament

Türkeş-Kılıç, S.

Article | 2020 | Turkish Studies21 ( 1 ) , pp.29 - 55

This paper seeks to uncover what drives European Parliament (EP) discussions on a privileged partnership for Turkey. In line with Habermas’s Communicative Action Theory, it scrutinizes the justifications used by the Members of the European Parliament (MEPs) in the Plenary Sessions between 2005–2012, i.e. from the start of accession negotiations until the privileged partnership’s falling into disuse in EP discussions. The research reveals that the alleged benefits of privileged partnership in contrast to the costs of Turkey’s full membership constitute the backbone of the right-wing groups’ arguments whereas the objection to a privil . . .eged partnership is justified by MEPs from left-wing groups for being against the EU’s official commitments to Turkey. In disputing Turkey’s full membership, the members of the right-wing parties reconstruct a European identity in which Turkey is the constitutive other. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Role of rheology on the formation of Nanofibers from pectin and polyethylene oxide blends

Akinalan Balik, B. | Argin, S.

Article | 2020 | Journal of Applied Polymer Science137 ( 3 ) , pp.29 - 55

Characterizing the parameters critical to the prediction of a successful electrospinning process from solution properties is essential, yet, not easy in the case of biopolymers. In this study, we attempted to present a broad perspective by simultaneously evaluating the effect of eight different parameters, namely zero shear viscosity, tip viscosity, elastic modulus, phase angle, cohesive energy, pH, conductivity, and surface tension, on the formation of smooth pectin nanofibers. Our results showed that (1) the viscosity of the solution is not an indication of jet formation, but once the jet is formed, high zero shear viscosity and h . . .igh tip viscosity are required to maintain a dominant whipping instability for smooth nanofiber formation and (2) while evaluating the elasticity of the spinning solutions, comparing only the elastic modulus values would be misleading, since low phase angle values are also necessary for pectin solutions to be electrospun into nonbeaded fibers. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48294. © 2019 Wiley Periodicals, Inc Daha fazlası Daha az

Affective theory of mind in human aging: is there any relation with executive functioning?

Yıldırım, E. | Soncu Büyükişcan, E. | Gürvit, H.

Article | 2020 | Aging, Neuropsychology, and Cognition27 ( 2 ) , pp.207 - 219

Theory of Mind (ToM) refers to the ability to make inferences on other’s mental or emotional states. Although there is evidence suggesting that impaired executive functions due to aging could have a negative impact on cognitive ToM, there is still controversy about the effect of age and age-related executive dysfunctions on affective ToM. To investigate affective ToM in healthy aging and its relationship with executive functions, we examined Reading Mind in the Eyes Test (RMET) performance and executive functions among young and older adults. There was no significant difference between age groups regarding their RMET scores. While a . . .ffective ToM was correlated to executive functioning within the younger group, short term memory was found to be associated with RMET performance among older participants. Furthermore, within the older group, women performed better than men. Our findings suggest a preserved ability of affective ToM in healthy aging, which appears to be independent of executive functioning. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Do We Build Similar Molecules for Comorbid Diseases? Tevarud in Drug Design, an Analysis for Depression and Inflammation

Bayram, FEO | Alradhwani, SAA | Tugcu, G | Sipahi, H

Article | 2020 | ACS MEDICINAL CHEMISTRY LETTERS11 ( 2 ) , pp.147 - 153

Tevarud designates two poets coincidently writing a same verse in the Ottoman Divan literature. This study aims to analyze the structural similarity of molecules independently designed for inflammation and depression to determine if coincidentally we are building similar molecules for comorbid diseases. For this purpose, a molecule library was first constituted with structures that were developed as anti-inflammatory (AI) and antidepressant (AD) agents these last decades. Then, the similarity of the structures was determined by calculating the Tanimoto and Cosine similarity coefficients for each AD/AI pair. The highest scores were o . . .btained for two theophylline derivatives: AD17 (for which some AI activity was found to be mentioned) and AI42. The study also pointed out the similarity of some AD coumarins with some AI flavonoids interestingly found to be highly similar to some AI coumarins and AD flavonoids, respectively. Thus, our investigation demonstrated that structures independently developed as AD and AI derivatives can present extremely high structural similarity, a finding that can suggest mechanistic interconnection for these comorbid diseases and also guide for the design of novel bioactive compounds Daha fazlası Daha az

On a group closely related with the automorphic langlands group

İkeda, K.İ.

Article | 2020 | Journal of the Korean Mathematical Society57 ( 1 ) , pp.21 - 59

The effects of macroprudential policies on managing capital flows

Uz Akdogan, I.

Article | 2020 | Empirical Economics58 ( 2 ) , pp.583 - 603

The implementation of macroprudential policies for improving a country’s financial stability has become more common in emerging markets. The aim of this paper is to analyse the effect of macroprudential policy on both capital flow volatility and price stability in emerging market economies. The analysis covers the Global Financial Crisis and post-crisis period. The effects of general macroprudential variables including leverage growth and credit growth and specific instruments, namely loan-to-value caps and reserve requirements on capital inflow, capital outflow and price stability have been tested. Propensity score matching techniq . . .ues have been used to measure the effectiveness of various macroprudential policy measures on capital flow volatility. Major findings indicate monetary policy instruments are effective in pursuing both monetary policy objectives and macroprudential objectives. Short-term capital account volatility is seen to respond to macroprudential policy instruments. Propensity score matching was only successfully implemented for capital volatility. Results show that increased measures for macroprudential policy are effective for capital outflow and, decreased measures for macroprudential policy are effective, to a lesser extent, for capital inflows. Furthermore, meaningful correlation between increased macroprudential measures during periods of tight monetary policy exists only for capital outflows. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature Daha fazlası Daha az

Sensitization of MDA-MBA231 breast cancer cell to docetaxel by myricetin loaded into biocompatible lipid nanoparticles via sub-G1 cell cycle arrest mechanism

Maroufi, N.F. | Vahedian, V. | Mazrakhondi, S.A.M. | Kooti, W. | Khiavy, H.A. | Bazzaz, R. | Sabzichi, M.

Article | 2020 | Naunyn-Schmiedeberg's Archives of Pharmacology393 ( 1 ) , pp.583 - 603

The harmful dose-dependent side effects of chemotherapy drugs have caused the discovery of novel perspective to evaluate chemotherapy protocols. In this study, the potential application of Compritol was investigated as a major scaffold into nanostructured lipid careers to highlight myricetin efficiency in treatment of breast cancer cells along with codelivery of docetaxel (DXT). Characterization of myricetin-loaded NLCs was carried out by measuring the particle size and zeta potential, using the scanning electron microscopy. MTT, DAPI staining, flow cytometric, and RT-PCR (real-time) assays were used to recognize novel formulation b . . .ehavior on cell cytotoxicity as well as recognizing molecular mechanism of formulation concerning apoptosis phenomenon. Myricetin-loaded NLCs reduced the cell viability from 50 ± 2.3 to 40 ± 1.3% (p < 0.05). Percentage of apoptosis improved with combination treatment of myricetin-loaded NLCs and DXT in the MDA-MBA231 breast cancer cells. Expression of antiapoptotic genes (survivin, Cyclin B1, and Mcl1) indicated a significant reduction in factor along with increment in proapoptotic factor Bax and Bid mRNA rates. Overall, our results represented that the NLC delivery system could be a promising strategy to enhance the effect of anticancer agents such as DXT on breast cancer. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature Daha fazlası Daha az

The gut microbiome in epilepsy

Şafak, B. | Altunan, B. | Topçu, B. | Eren Topkaya, A.

Article | 2020 | Microbial Pathogenesis139 , pp.583 - 603

The close relationship between epilepsy and autoimmune diseases and the fact that the cause of epilepsy is idiopathic in 60% of cases suggest that intestinal microbiota may play a role in the etiology of epilepsy. In this study, we analyzed and compared the intestinal microbiota composition of patients with idiopathic focal epilepsy (n = 30) and healthy volunteer group (n = 10) by 16s ribosomal DNA sequencing. Proteobacteria phylum was found to be higher in patients with epilepsy (25.4%) than in healthy volunteers group (1.5%). The genera of Campylobacter, Delftia, Haemophilus, Lautropia, Neisseria among Proteobacteria phylum were f . . .ound to be statistically significantly higher in patients with epilepsy than in healthy volunteers (p < 0.05). Fusobacteria phylum was detected in 10.6% of the patients with epilepsy but not in the healthy volunteer group. The genus of the Fusobacteria phylum was found as Leptotrichia and Fusobacterium. In our study, taxonomic drift and significant differences in the intestinal microbiota of patients with epilepsy according to healthy volunteer group showed that autoimmune mechanisms and inflammation may have a role in the etiology of epilepsy. Our data should be supported by other studies as to the role of the intestinal microbiome in the prevention and treatment of epilepsy. © 2019 Elsevier Lt Daha fazlası Daha az

A multi-national validity analysis of the self-perceived communication competence scale

Croucher, S.M. | Kelly, S. | Rahmani, D. | Burkey, M. | Subanaliev, T. | Galy-Badenas, F. | Jackson, K.

Article | 2020 | Journal of International and Intercultural Communication13 ( 1 ) , pp.1 - 12

The self-perceived communication competence (SPCC) measure has been used in over 50 published studies since 2000. McCroskey and McCroskey (1988. Self-report as an approach to measuring communication competence. Communication Research Reports, 5, 108–113. doi: 10.1080/08824098809359810) developed the measure to be used within the US college/university classroom. Despite its intended use, the measure is frequently used outside of the US and outside of the college/university setting without tests of measurement invariance. In fact, only four studies have performed tests of internal consistency on the measure since 2000, and each has fo . . .und poor fit. Therefore, the purpose of this study was to assess the utility of the measure outside of its intended population. The measure was utilized to survey respondents from 12 countries and failed to yield acceptable fit statistics in all samples, showing poor evidence of construct validity. © 2019, © 2019 National Communication Association Daha fazlası Daha az

Cellular Automata Tractography: Fast Geodesic Diffusion MR Tractography and Connectivity Based Segmentation on the GPU

Hamamci, A.

Article | 2020 | Neuroinformatics18 ( 1 ) , pp.25 - 41

Geodesic based tractography on diffusion magnetic resonance data is a method to devise long distance connectivities among the brain regions. In this study, cellular automata technique is applied to the geodesic tractography problem and the algorithm is implemented on a graphics processing unit. Cellular automaton based method is preferable to current techniques due to its parallel nature and ability to solve the connectivity based segmentation problem with the same computational complexity, which has important applications in neuroimaging. An application to prior-less tracking and connectivity based segmentation of corpus callosum f . . .ibers is presented as an example. A geodesic tractography based corpus callosum atlas is provided, which reveals high projections to the cortical language areas. The developed method not only allows fast computation especially for segmentation but also provides a powerful and intuitive framework, suitable to derive new algorithms to perform connectivity calculations and allowing novel applications. © 2019, Springer Science+Business Media, LLC, part of Springer Nature Daha fazlası Daha az

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