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Folk medicine in selected towns of the Marmara subregion (Turkey)

Yeşılyurt, E.B. | Şımşek, I. | Tuncel, T. | Akaydın, G. | Yeşİlada, E.

Article | 2017 | Marmara Pharmaceutical Journal21 ( 1 ) , pp.132 - 148

In this study, 263 volunteers residing in the districts of Bilecik-Aşağıköy, Bilecik-Pazaryeri-Büyük Elmalı, Bursa-City Center, Edirne-Keşan-Kozköy, Edirne-Keşan and Edirne-İpsala participated into the research by using the face-to-face oral interview technique and the required information for the research was collected with the help of a questionary. In the light of the data taken from the survey, parts of the plants that are used as household remedy, aim of the usage and pattern of the preparation (decoction, infusion, poultice, ointment etc.) were documented inquisitively. All collected plant materials have been identified and de . . .posited at the Herbarium of Faculty of Education of Hacettepe University (HEF). In this study, 68 taxa belonging to 33 families were found to be used as household remedy. It was observed that the majority of these plants belonged to Rosaceae (10 taxa), Lamiaceae (8 taxa), Asteraceae (7 taxa) and Poaceae (4 taxa) families. Gastrointestinal system (46 remedies; 24,6%), respiratory system and chest diseases (41 remedies; 21,9%), urinary system (18 remedies; 9,6%), hemapoietic, immune system and cancer (18 remedies; 9,6%) remain most among 187 uses were documented as household remedy. © 2017, Marmara University. All rights reserved Daha fazlası Daha az

Clinical and phenomenological features in pediatric bipolar disorder

Coskun, M | Zoroglu, SS | Ozturk, M


Retrospective studies in adults with bipolar disorder have reported that as many as 60% experienced the onset of their bipolar disorder before 20 years of age, and 10-20% reported the onset before 10 years of age. These findings make childhood and adolescence onset bipolar disorder more relevant as early recognition and intervention in psychiatric disorders have been increasingly important. Today, despite there is no doubt on the existance of pediatric bipolar disorder, there remains significant controversy about clinical and phenomenological features of disorder in children and adolescents. This review article aims to present and d . . .iscuss clinical and phenomenological features of pediatric bipolar disorder in the light of current literature. We performed a search on Pubmed using keywords 'juvenile/pediatric bipolar disorder', 'bipolar disorder children/adolescents' and reviewed fulltext or abstracts of relevant articles. We also benefited from print books particularly the fourth edition of Lewis's Textbook of Child and Adolescent Psychiatry. (Anatolian Journal of Psychiatry 2010; 11:60-67 Daha fazlası Daha az

Models of Intervertebral Disc Degeneration

Guclu, B | Naderi, S

Review | 2011 | JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH28 ( 3 ) , pp.417 - 426

Degenerative disc disease is among the important causes of low back pain. This condition leads to serious clinical and economical consequences. There are many obscurities from the clinical point of view, requiring experimental models to highlight different aspect of this process. This study will review experimental models of intervertebral disc degeneration.

Effect of Neuromuscular Electrical Stimulation on Pain and Functional Parameters in Knee Osteoarthritis

Kulcu, DG | Yanik, B | Gulsen, G | Gokmen, D


Objective: To assess the effect of neuromuscular electrical stimulation (NMES) of quadriceps muscle on pain and functional level in knee osteoarthritis. Materials and Methods: Forty patients diagnosed as knee osteoarthritis participated in the study. Patients were randomized to two groups. First group received hotpack, ultrasound, transcutaneous electrical nerve stimulation (TENS) and isometric quadriceps exercises (control group), and second group received NMES of quadriceps muscle in addition to this therapy program. All patients were given treatment for 3 weeks, 5 sessions per week. Pain severity (VAS 0-10), Western Ontario McMas . . .ter Osteoarthritis Index (WOMAC), and duration of 50 m walking and stair climbing up and down were assessed before and after the treatment. Results: There were significant differences in NMES group regarding pain severity, walking duration, stair climbing up and down duration, WOMAC-pain stiffness and physical function scores between pre and post-treatment measurements (p=0.000, 0.008, 0.021, 0.002, 0.002, 0.001, respectively) and in control group regarding pain severity, WOMAC-pain and physical function scores (p=0.005, 0.021, 0.013, respectively). There was a significant difference between groups regarding percent change in 50 m walking duration (p=0.018). Conclusion: Isometric quadriceps exercises together with physical therapy interventions are effective in decreasing pain and improving functional level in knee osteoarthritis. Additive benefit, especially on walking was observed after adding NMES of quadriceps muscle to this therapy program. Turk J Phys Med Rehab 2009;55:111-5 Daha fazlası Daha az

Better glycemic control with insulin premix 50/50 TID compared to insulin premix 70/30 BID

Aydin, H. | Demir, H. | Şienkal, I.V. | Yalniz, F.F. | Ayrilmaz, A.

Article | 2010 | Turkish Journal of Endocrinology and Metabolism14 ( 3 ) , pp.60 - 65

Objective: Since only a small proportion of diabetics achieve optimal glycemic targets, intensification of treatment with insulin is needed in most of the cases. Application of insulin lispro premix 50/50 TID provides better glycemic control compared to human insulin premix 70/30 and comparable results reported with basal-bolus insulin regimen. The aim of this study was to determine the effect of insulin lispro premix 50/50 TID (Group 1, n=60) in comparison with insulin aspart premix 70/30 (Group 2, n=62). Materials and Methods: Type 2 diabetic patients, who were started on insulin treatment for the first time, were screened retrosp . . .ectively. Change in A1C levels, 4-point self-monitored blood glucose measurements and rate of hypoglycemia within a 3-month period were recorded. Results: Basal A1C levels were higher (p=0.002) and the rate of improvement was greater in patients of Group 1 than in Group 2 patients (p=0.0006). There was no difference between the patients in achieving target A1C level and in the rate of hypoglycemia. A greater decrease in postprandial blood glucose level was achieved in patients of Group 1 ( Daha fazlası Daha az

Investigation of lsepamicin, Chloramphenicol and Minocycline Sensitivity in Carbapenem-Resistant Enterobacteriaceae

Karakullukcu, A | Borsa, BA | Kuskucu, MA | Bakir, E | Taner, Z | Ozalp, VC | Aygun, G

Article | 2018 | KLIMIK JOURNAL31 ( 1 ) , pp.50 - 55

Objective: In this study, we aimed to determine the resistance mechanisms of carbapenem-resistant Enterobacteriaceae (CRE), and evaluate the prospective alternative treatment options. Methods: Between October 2014 and July 2015, rectal swabs routinely obtained from hospitalized patients were included in the study. The isolated Gram-negative enteric bacteria were identified to the species level by using standard conventional microbiological methods. Determined carbapenem resistance in enteric bacteria was confirmed by using meropenem Etest (R) (bioMerieux, Marcy l'Etoile, France), and the resistance mechanisms were investigated with . . .MAST-ID (TM) Discs (Mast Diagnostics Ltd, Bootle, Merseyside, UK). Antibiotic susceptibilities of the CRE were determined by disk diffusion method using isepamicin, chloramphenicol, and minocycline disks (Oxoid, Basingstoke, Hampshire, UK). Results: Of the 3,323 rectal swabs sent to the laboratory during the study period, totally 84 (2.5%) CRE were isolated with one strain from each patient. Of the 84 CRE, 74 (88%) were Klebsiella pneumoniae and 10 (12%) were Escherichia coli. Among the 84 CRE, 66 (78.5%) with OXA-48, 11 (13.1%) with OXA48 + metallo-beta-lactamase (MBL), 1 (1.2%) with only MBL and 1 (1.2%) with AmpC + porin loss were detected, none of the strains were positive for KPC. In 5 (6%) strains, none of the resistance mechanisms were found. Of the 84 CRE, 80 (95.2%), 77 (91.6%) and 14 (16.6%) were found to be susceptible to isepamicin, chloramphenicol and minocycline, respectively. Conclusions: The OXA-48 type, endemic in Turkey, was also the most commonly detected carbapenemase in the study. It has been observed that isepamicin and chloramphenicol can be the potential antibiotics in the treatment of KDE-related infections Daha fazlası Daha az

Novel diagnostic autoantibodies in rheumatoid arthritis

Yanik, B. | Külcü, D.G.

Review | 2008 | Romatizma23 ( 3 ) , pp.97 - 99

Early diagnosis and early treatment can prevent joint damage in rheumatoid arthritis (RA); but the lack of appropriate diagnostic criteria hinders early diagnosis. There are not many disease-specific serological markers for the diagnosis of the disease. Highly sensitive and specific markers are needed in the early stages of the disease. The autoantibodies which probably play an importanat role in the pathogenesis of RA and have increasingly been examined in recent years, will be reviewed, discussed, and examples given of the work done.

Saccharomyces cerevisiae Fungemia in an elderly patient following probiotic treatment

Eren, Z. | Gürol, Y. | Sönmezoglu, M. | Eren, H.Š. | Çelik, G. | Kantarci, G.

Article | 2014 | Mikrobiyoloji Bulteni48 ( 2 ) , pp.351 - 355

Saccharomyces cerevisiae, known as baker's yeast, is also used as a probiotic agent to treat gastroenteritis by modulating the endogenous flora and immune system. However, since there have been increasing reports of fungemia due to S.cerevisiae and its subspecies S.boulardii, it is recommended that probiotics should be cautiously used in immunosuppressed patients, people with underlying diseases and low-birth weight babies. To emphasize this phenomenon, in this report, a case of S.cerevisiae fungemia developed in a patient given probiotic treatment for antibiotic-associated diarrhea, was presented. An 88-year-old female patient was . . .admitted to our hospital with left hip pain, hypotension, and confusion. Her medical history included hypertension, chronic renal failure, left knee replacement surgery, and recurrent urinary tract infections due to neurogenic bladder. She was transferred to the intensive care unit with the diagnosis of urosepsis. After obtaining blood and urine samples for culture, empirical meropenem (2 × 500 mg) and linezolid (1 × 600 mg) treatment were administered. A central venous catheter (CVC) was inserted and after one day of inotropic support, her hemodynamic parameters were stabilized. The urine culture obtained on admission yielded extended-spectrum betalactamase-producing Klebsiella pneumoniae and Escherichia coli. Urine culture was repeated after three days and no bacteria were isolated. On the 4th day of admission she developed diarrhea. Toxin A/B tests for Clostridium difficile were negative. To releive diarrhea, S.boulardii (Reflor 250 mg capsules, Sanofi Aventis, Turkey) was administered twice a day, without opening capsules. Two days later, her C-reactive protein (CRP) level increased from 23.2 mg/L to 100 mg/L without fever. Her blood culture taken from the CVC yielded S.cerevisiae. Linezolid and meropenem therapies were stopped on the 13th and 14th days, respectively, while prophylactic fluconazole therapy was replaced with caspofungin 1 × 50 mg on the fifth day. After seven days of therapy CRP and serum creatinine levels decreased to 9.1 mg/L and 1.2 mg/dl, respectively; and she was discharged from the hospital with improvement. The probiotic capsules were used unopen, thus, it was proposed that S.cerevisiae fungemia originated from translocation from the intestinal mucosa. Since it was not possible to investigate the molecular genetics of the strain isolated from the blood culture and the strain present in the probiotic, a definite conclusion about the origin of the strain could not be reached. It was thought that old age and underlying disease of the patient were the related predisposing factors for S.cerevisiae fungemia. This case emphasized that clinicians should be cautious in case of probiotic application eventhough in encapsulated form, even in immunocompetent patients with a history of long-term hospital stay and use of broad-spectrum antimicrobials since there may be a risk of S.cerevisiae fungemia development Daha fazlası Daha az

From Correct Words to Correct Care: Usage of The Term Pressure Sore Among Turkish Nurses

Unver, S | Yildirim, M | Akyolcu, N | Kanan, N


The cross-infection control in dental practice: Evaluation of patient attitude and susceptibility

Özkurt, Z. | Tomruk, C.Ö. | Gürsoy, H. | Dölekoglu, S. | Kazazoglu, E.

Article | 2011 | Cumhuriyet Dental Journal14 ( 2 ) , pp.106 - 112

Objectives: The aim of this study was to evaluate the attitude and susceptibility of the patients who attended to Yeditepe University Faculty of Dentistry, about the cross-infection control. Methods: A questionnaire was designed to obtain information about cross-infection control in dental practices. The study population included 450 patients (277 female, 173 male) who attended to Yeditepe University Faculty of Dentistry, in December 2010. The questionnaire collected data on socio-demographic characteristics, expectations from dentists about wearing of gloves, mask, protective cap and glass, changing and renewing of these materials, . . . and infection control procedures before treatment. Descriptive statistical methods and Chi-square test were used to analyze data. An alpha level of 0.05 was used for all statistical analyses. Results: 100% of the patients expected from dentist to wear gloves, 98.9% of them expected to wear mask, 73% of them expected to wear protective cap, and 67.1% of them expected to wear protective glass. The 50.5% of the female respondents stated that all patients should wear protective glass, and this ratio is higher than male patients (37.6%) ( Daha fazlası Daha az

Oral squamous cell papilloma: a case report

Ozener, HO | Kuru, L | Kuru, B

Article | 2015 | CLINICAL AND EXPERIMENTAL HEALTH SCIENCES5 ( 2 ) , pp.140 - 144

Oral squamous cell papilloma (OSCP) is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass. OSCP is usually associated with human papilloma virus. Although any surface of the oral cavity can be affected, the sites of predilection for localization of the lesions include the tongue, lip and soft palate. In this report, treatment and histological findings of a local gingival enlargement at the vestibular side of the upper right central tooth of a 10 year-old systemically healthy girl are presented. The lesion was asymptomatic and had shown a slow growth. Solitary, exoph . . .ytic lesion was clinically soft, pink-white in color and appeared as cauliflower. Dental and periodontal tissues were radiographically normal. One month after scaling and root planing, under local anesthesia the lesion was excised and this was followed by the use of Nd: YAG laser (1064 nm, 20 Hz, 3 W) to control bleeding, minimize pain and scarring in post-operative period, and provide sterilization. Macroscopic examination revealed that the lesion was 1.1x0.5x0.2 cm(3) in size, yellow in colour and had a rough surface, while histological examination showed multi-layer connective tissue underlying the squamous epithelium, numerous rete pegs and spinous cell proliferation at the papillary and OSCP was diagnosed. There was no evidence of viral cytopathic effect or malignancy of the lesion. No recurrence was observed during the 4-year follow-up period. Daha fazlası Daha az

Effect of honey supplementation on total antioxidant capacity of herbal teas

Ş. Özdatli | H. Sipahi | M. Charehsaz | A. Aydin | E. Yeşilada

Article | 2014 | Marmara Pharmaceutical Journal18 ( 3 ) , pp.147 - 152

Scientific researchers have revealed that antioxidant components in herbal teas and honey would be beneficial for the health and may help to reduce the risk of development of acute and chronic diseases. However, possible changes in the antioxidant capacity of herbal teas by the addition of honey as a sweetener have not been investigated in detail yet. The aim of this study was to determine the total antioxidant capacity (TOAC) of 9 different mixed or pure herbal teas marketed in Turkey and then possible changes in the TOAC value of these tea samples after addition of either flower or pine honey. For 100 ml tea which is equivalent to . . . a cup of tea, the highest TOAC value was observed in melissa, black tea and white tea and these were followed by green tea > sage > echinacea > daisy > ginger > linden, respectively. The antioxidant activity of these tea samples increased by the addition of both flowers and pine honeys and 7 g of honey exerted higher activity than 3 g of honey. Higher antioxidant activity was observed in some herbal tea samples (melissa, sage, linden, chamomile, lemon ginger) by the addition of pine honey, whereas in some teas (echinacea, black, white and green teas) flower honey supplementation has been found to be more effective. In conclusion, our study suggests that addition of honey to herbal tea increase its antioxidant activity significantly and drinking herbal tea with honey at least once a day may protect the body against the harmful effects of free radicals. However, further studies are required to understand the protective mechanisms of this combination. © 2014, Marmara University. All rights reserved Daha fazlası Daha az

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