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Risk assessment of allergen metals in cosmetic products

H. Sipahi | M. Charehsaz | Z. Güngör | O. Erdem | B. Soykut | C. Akay | A. Aydin

Article | 2015 | Journal of Cosmetic Science66 ( 5 ) , pp.313 - 323

Cosmetics are one of the most common reasons for hospital referrals with allergic contact dermatitis. Because of the increased use of cosmetics within the population and an increase in allergy cases, monitoring of heavy metals, especially allergen metals, is crucial. The aim of this study was to investigate the concentration of allergen metals, nickel (Ni), cobalt (Co), and chromium (Cr), in the most commonly used cosmetic products including mascara, eyeliner, eye shadow, lipstick, and nail polish. In addition, for safety assessment of cosmetic products, margin of safety of the metals was evaluated. Forty-eight makeup products were . . .purchased randomly from local markets and large cosmetic stores in Istanbul, Turkey, and an atomic absorption spectrometer was used for metal content determination. Risk assessment of the investigated cosmetic products was performed by calculating the systemic exposure dosage (SED) using Scientific Committee on Consumer Safety guideline. According to the results of this investigation in all the samples tested, at least two of the allergen metals, Ni and/or Co and/or Cr were detected. Moreover, 97% of the Ni-detected products, 96% of Cr- and 54% of Co-detected products, contained over 1 µg/g of this metals, which is the suggested ultimate target value for sensitive population and thereby can be considered as the possible allergen. On the basis of the results of this study, SED of the metals was negligible; however, contact dermatitis caused by cosmetics is most probably due to the allergen metal content of the products. In conclusion, to assess the safety of the finished products, postmarketing vigilance and routine monitoring of allergen metals are very important to protect public health. © 2015 Society of Cosmetic Chemists. All Rights Reserved Daha fazlası Daha az

Hyaluronic Acid/Chitosan Coacervate-Based Scaffolds

O. Karabiyik Acar | A.B. Kayitmazer | G. Torun Kose

Article | 2018 | Biomacromolecules19 ( 4 ) , pp.1198 - 1211

Effects of polycyclic aromatic hydrocarbon-containing oil mixtures on generation of reactive oxygen species and cell viability in MCF-7 breast cancer cells

B. Yılmaz | J. Ssempebwa | C.R. Mackerer | K.F. Arcaro | D.O. Carpenter

Article | 2007 | Journal of Toxicology and Environmental Health - Part A: Current Issues70 ( 13 ) , pp.1108 - 1115

Clarified slurry oil (CSO), and two crude oil samples, Belridge heavy crude oil (BHCO) and Lost Hills light crude oil (LHLCO), were examined for their ability to generate reactive oxygen species (ROS) in MCF-7 cells. Intracellular ROS and cell viability were determined in a flow cytometer using dihydroxyrhodamine 123 and propidium iodide, respectively. In experiments with short-term exposure, single-cell suspensions were loaded with the fluorescent probes and then treated with the oil samples (1 or 10 ppm). Measurements were made at 5, 15, 30, 60, and 90 min after addition of oil samples. In experiments with longer term exposure, pr . . .econfluent cell cultures were treated with oil samples for 6, 12, or 24 h prior to preparing single-cell suspensions. Both short-term and longer term treatment with oil samples resulted in elevated generation of reactive oxygen species (ROS). Cell cultures also were treated with benzo[a]pyrene, a polycyclic aromatic hydrocarbon detected in all three oil samples. Treatment with benzo[a]pyrene produced a significant increase in levels of ROS. The present findings suggest that oil samples with higher concentrations of polycyclic aromatic hydrocarbons may exert adverse effects on human mammary epithelial tissue through induction of oxidative stress. Copyright © Taylor & Francis Group, LLC Daha fazlası Daha az

Intestinal vaginoplasty: Seven years' experience of a tertiary center

A. Karateke | B. Haliloglu | O. Parlak | C. Cam | H. Coksuer

Article | 2010 | Fertility and Sterility94 ( 6 ) , pp.2312 - 2315

Objective: To investigate the long-term effects of intestinal vaginoplasty in cases with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Design: Prospective study. Setting: Division of Pelvic Reconstructive Surgery, Department of Gynecology and Obstetrics, at a women's and children disease education and research hospital. Patient(s): Between 2003 and 2009, 29 patients with MRKH syndrome underwent intestinal vaginoplasty. Intervention(s): Two of the patients were treated with ileal and 27 with sigmoid vaginoplasty. Main Outcome Measure(s): The age, marital status, associated anomalies, method used for bowel transposition (isoperistal . . .tic/antiperistaltic), type of abdominal incision, and intra- and postoperative complications were evaluated. Result(s): One of the patients for whom ileal vaginoplasty was performed had 40 cm ileal necrosis requiring bilateral ileostomy for 2 months. Introital stenosis was detected in 15 cases (79%) who were unmarried, while none of the married cases had introital stenosis. However, all patients responded to finger-dilatation. All married patients were sexually satisfied after operation. An intraluminal abscess developed in the proximal segment of the neovagina owing to stricture occurring above abdominoperineal tunnel 2 years after operation. In another patient who had a rudimentary uterine horn, hematometra developed 3 years after operation and treated with resection. Conclusion(s): In our experience, sigmoid vaginoplasty seems to be a favorable procedure which provides excellent long-term results for the patients with vaginal agenesis. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc Daha fazlası Daha az

Undrained shear strength and monotonic behavior of different nonplastic silts: Sand-like or clay-like?

M.M. Monkul | N.G. Aydin | B. Demirhan | M. Şahin

Article | 2020 | Geotechnical Testing Journal43 ( 3 ) , pp.2312 - 2315

The common assumption in geotechnical engineering research and practice has been that non-plastic silts behave sand-like, whereas, as silts become more plastic, they start to behave claylike. To date, there are practically no studies focusing solely on various nonplastic silts and their monotonic response, perhaps because of the solid belief that nonplastic silts behave sand-like in all aspects. A series of constant volume direct simple shear tests were conducted on three different nonplastic silts. Because the specimens were reconstituted to have loose grain structures, volumetrically contractive tendency was observed for all the s . . .ilts with relatively small effective stress friction angles. It was observed that Ko compression lines and critical state lines are parallel to each other for all three silts, which is considered to be a clay-like behavior in literature. It was shown that undrained shear strengths can be normalized with the effective vertical consolidation stress, which is also considered to be a clay-like behavior in literature. Normalized values are compared with the ones obtained for plastic silts compiled from previous studies. Normalized undrained shear strength values for plastic silts in literature were seen to be typically greater. Possible reasons such as density effect and strength anisotropy were discussed. Copyright © 2019 by ASTM International Daha fazlası Daha az

Evaluation of Surface Roughness Characteristics Using Atomic Force Microscopy and Inspection of Microhardness Following Resin Infiltration with Icon®

E.B. Gurdogan | D. Ozdemir-Ozenen | N. Sandalli

Article | 2017 | Journal of Esthetic and Restorative Dentistry29 ( 3 ) , pp.201 - 208

Objective: The aim of this study was to evaluate the surface roughness via atomic force microscopy (AFM) as well as to evaluate the microhardness values of Icon® in comparison with sound and demineralized enamel in a large subject group. Materials and Methods: Enamel samples were prepared from sound bovine incisors and randomly allocated into either AFM (n = 60) or microhardness (n = 60) groups. The AFM group was divided into control (n = 30) and Icon® (n = 30) subgroups. The microhardness group was also divided into three subgroups: control (n = 20), demineralization (n = 20) and Icon® (n = 20) groups. The demineralization and Icon . . .® subgroups were subjected to a demineralizing solution (pH: 4, 2 hours). Following the formation of shallow white spot lesions and application of the infiltrant, each sample was examined according to its parameter. Results: AFM images suggested that Icon® had a significantly rougher surface than the control group. When the AFM results were evaluated numerically, it was evident that the Icon® group possessed statistically higher Sa, Sq, mean height, and maximum deviation values compared to the control group. The mean Vickers hardness values of all groups were determined to be significantly different from one another. Hardness values in the demineralization group were determined to be significantly lower than the control and Icon® groups. No statistically significant difference was observed between mean Vickers hardness values for the contol and Icon® groups. Conclusions: The present in vitro study shows that more studies are required to improve the surface quality of this infiltrant material. Clinical Significance: The present in vitro study shows that the resin infiltration technique results in increased microhardness of demineralized enamel. However, it was observed that the infiltrant material creates a significantly rougher surface compared to healthy, untreated enamel. (J Esthet Restor Dent 29:201–208, 2017). © 2016 Wiley Periodicals, Inc Daha fazlası Daha az

Prenatal karyotypes of fetuses conceived by intracytoplasmic sperm injection

E.A. Jozwiak | U. Ulug | A. Mesut | H.F. Erden | M. Bahçeci

Article | 2004 | Fertility and Sterility82 ( 3 ) , pp.628 - 633

To evaluate the rate of chromosomal abnormalities in babies conceived by intracytoplasmic sperm injection (ICSI). Retrospective case-control analysis. Private IVF center. One thousand one hundred thirty-six karyotype results obtained from fetuses conceived by ICSI. Amniocentesis and prenatal karyotyping. Presence of normal and abnormal chromosomal configurations. Abnormal karyotypes were detected in 17 (1.5%) of 1,136 fetuses. Eight (0.7%) of these were from singleton and nine (0.8%) from twin pregnancies. There was no difference in the autosomal chromosome structure or the number or structure of sex chromosomes in karyotyped fetuse . . .s of singleton and twin pregnancies. However, abnormal numbers of autosomal chromosomes were more frequent in singletons (2.3%) than in twins (1.1%). There was also no difference in the frequency of chromosomal aberrations between ICSI groups in which ejaculated spermatozoa (1.9%) and testicular spermatozoa (1.5%) were used. There was no difference in the frequency of chromosomal aberrations between fetuses for whom ICSI was used because of male factors (1.8%) compared with babies for whom ICSI was also the choice of assisted fertilization method for other types of infertility factors (0.9%). Sperm source does not influence the karyotype of babies conceived by ICSI. By comparing our results with previously reported data from natural pregnancies, we show that ICSI babies carry a significantly increased risk of an abnormal karyotype. However, the increased risk is similar among the different infertility groups. © 2004 by American Society for Reproductive Medicine Daha fazlası Daha az

Phenolic compounds from the aerial parts of Clematis viticella L. and their in vitro anti-inflammatory activities

H. Kırmızıbekmez | Y. İnan | R. Reis | H. Sipahi | A.C. Gören | E. Yeşilada

Article | 2019 | Natural Product Research33 ( 17 ) , pp.2541 - 2544

Phytochemical investigations on the EtOH extract of Clematis viticella led to the isolation of six flavonoid glycosides, isoorientin (1), isoorientin 3'-O-methyl ether (2), quercetin 7-O-?-L-rhamnopyranoside (3), quercetin 3,7-di-O-?-L-rhamnopyranoside (4), manghaslin (5) and chrysoeriol 7-O-ß-D-glucopyranoside (6), one phenylethanol derivative, hydroxytyrosol (7), along with three phenolic acids, caffeic acid (8), (E)-p-coumaric acid (9) and p-hydroxybenzoic acid (10). The structures of the isolates were elucidated on the basis of NMR and HR-MS data. All compounds were isolated from C. viticella for the first time. Compounds 7 and . . .8 showed significant anti-inflammatory activity at 100 µM by reducing the release of NO in LPS-stimulated macrophages comparable to positive control indomethacin. Compounds 3 and 7 exhibited anti-inflammatory activity through lowering the levels of TNF-? while 1, 3 and 5 decreased the levels of neopterin better than the positive controls. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

The effect of vitamin C on ischemia reperfusion injury because of prolonged tourniquet application with reperfusion intervals

B.T. Ulug | F.B. Aksungar | O. Mete | F. Tekeli | N. Mutlu | B. Calik

Article | 2009 | Annals of Plastic Surgery62 ( 2 ) , pp.194 - 199

We examined the effect of vitamin C on muscle injury distal to the tourniquet which was applied for 4 hours with 10- and 20-minute reperfusion intervals after 2 hours of tourniquet. Sixty-four Sprague-Dawley rats were allocated to 4 randomized groups. After 2 hours tourniquet, 10- and 20-minutes of reperfusion were allowed to half of each group respectively. Afterward an additional 2 hours compression was applied. Except the control group the animals received vitamin C intravenously, before the first tourniquet in Group I, at the reperfusion interval in Group II, and at both times in Group III. Malondialdehyde levels were measured i . . .n blood and the tibialis anterior muscle. The muscle was histopathologically examined. The data was evaluated statistically. The effects of timing and the dose of vitamin C on ischemia reperfusion injury remain controversial and there was no statistical difference between 10- and 20-minute reperfusion intervals. But the blood malondialdehyde levels showed that vitamin C has a positive effect on the muscle injury caused by ischemia-reperfusion. © 2009 by Lippincott Williams & Wilkins Daha fazlası Daha az

Anti-immigration attitudes and the opposition to European integration: A critical assessment

C Kentmen-Cin | C Erisen

Article | 2017 | EUROPEAN UNION POLITICS18 ( 1 ) , pp.3 - 25

The aim of this overview is to critically examine the state of research on the relationship between anti-immigrant attitudes and attitudes toward European integration. We argue that the two most commonly used measures of anti-immigrant attitudes do not fully capture perceived threats from immigrants and opinion about different immigrant groups. Future research should pay more attention to two particular issues: first, scholars could employ methodological techniques that capture the underlying constructs associated with attitudes and public opinion; second, researchers could differentiate between groups within the overall immigrant p . . .opulation. This overview identifies themes in the literature while drawing attention to the need for more research on the behavioral underpinnings of anti-immigrant attitudes and public opinion on European integration Daha fazlası Daha az

Brevibacterium siliguriense sp. nov., a facultatively oligotrophic bacterium isolated from river water

A. Kumar | I.A. Ince | A. Kati | R. Chakraborty

Article | 2013 | International Journal of Systematic and Evolutionary Microbiology63 ( PART2 ) , pp.511 - 515

A Gram-positive-staining, rod-shaped, facultatively oligotrophic bacterial strain, designated MB18T, was isolated from a water sample collected from the River Mahananda at Siliguri (26° 44' 23.20' N, 88° 25' 22.89' E), West-Bengal, India. On the basis of 16S rRNA gene sequence similarity, the closest relative of this strain was Brevibacterium epidermidis NCDO 2286T (96% similarity). The DNA G+C content of strain MB18T was 64.6 mol%. Chemotaxonomic data [MK-8(H2) as the major menaquinone, galactose as the sole cell-wall sugar, meso-diaminopimelic acid as the diagnostic cell-wall diamino acid, phosphatidylglycerol and diphosphatidylgl . . .ycerol as constituents of the polar lipids, anteiso-C15: 0, anteiso-C17: 0 and iso-C15: 0 as the major fatty acids] supported the affiliation of strain MB18T to the genus Brevibacterium. The results of DNA G+C content, 16S rRNA gene sequence analysis and biochemical and physiological analyses allowed genotypic and phenotypic differentiation of strain MB18T from its nearest neighbour B. epidermidis. The isolate therefore represents a novel species, for which the name Brevibacterium siliguriense sp. nov. is proposed; the type strain is MB18T (=DSM 23676T=LMG 25772T). © 2013 IUMS Daha fazlası Daha az

Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator

F. Brellier | K. Hostettler | H.-R. Hotz | C. Ozcakir | S.A. Çöloglu | D. Togbe | R. Chiquet-Ehrismann

Article | 2011 | FEBS Letters585 ( 6 ) , pp.913 - 920

We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpressio . . .n such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved Daha fazlası Daha az

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