Arama Sonuçları

Myeloperoxidase (MPO) is an enzyme which is a member of the haem-peroxidase superfamily and plays a role in production of reactive oxygen species. The most common polymorphism in the promoter region of MPO gene is -463 G/A. It was shown that carrying the GG genotype means increased activity of the gene approximately 2-3-fold compared to GA and AA genotypes. It was found that hyperglycaemia, modified oxidized proteins and increased advanced glycosylated end products (AGE) are related to oxidative stress in diabetes. Under the hyperglycaemic conditions, production of reactive oxygen radical is elevated in smooth muscle endothelial cel . . .ls, mesengial and tubular endothelial cells. Especially, elevated lipid oxidation plays an important role in pathogenesis of diabetic complications such as cardiovascular complications. We examined the MPO -463 G/A polymorphism by using the PCR-RFLP method in 145 type 2 diabetic patients and 151 healthy controls. We observed that the AA genotype and A allele were protective variants against type 2 diabetes and the GG genotype was a risk factor for diabetes. While we studied the relationship between genotypes and biochemical parameters, we found that patients with the A allele had decreased serum cholesterol, triglyceride, VLDL levels and body mass index. We suggest that the MPO gene has an important role in pathogenesis of type 2 diabetes because of the increased frequency of GG genotype, which is related to increased activity and oxidant capacity of MPO in the patients Daha fazlası Daha az

Association between apolipoprotein E genotypes and panic disorder in Turkish population

Article | 2018 | Nordic Journal of Psychiatry72 ( 7 ) , pp.477 - 483

Aim: In this study, we aimed to investigate possible interactions among the apolipoprotein E (ApoE) and panic disorder (PD), taking into account serum cholesterol levels and subfractions. Methods: ApoE genotyping was performed by real-time polymerase chain reaction in DNA samples of PD patient group (n = 45) and healthy control group (n = 50). The serum lipid levels, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) subfraction analysis were examined. Results: There was a significant difference of ApoE genotypes in patient and control groups. The E3/E3 genotypes lower whereas E4 allele carriers were significantly hig . . .her in PD group ApoE4allele carriers had 3.2-fold higher risk of PD. PD group had significantly lower LDL and HDL levels. In spite of the decreased levels of total LDL, antiatherogenic large LDL subgroup was significantly lower in a patient with PD. Antiatherogenic large HDL and Intermediate HDL levels were lower, while atherogenic small HDL subfraction was significantly higher in PD group. Furthermore, Apo E3/E3 genotype carriers had significantly higher large LDL, HDL, large HDL, intermediate HDL level, and also had highest HDL between all the groups. ApoE4 allele carriers while they had highest atherogenic small HDL level. Conclusion: E4 allele can be associated with PD as an eligible risk factor, the E3/E3 could be a risk-reducing factor for PD. Patients with PD not only had lower LDL and HDL levels but also they have higher atherogenic LDL and HDL subfractions. Also, E3/E3 genotype carriers had convenient but ApoE4 carriers had atherogenic plasma cholesterol levels and subfractions. © 2018, © 2018 The Nordic Psychiatric Association Daha fazlası Daha az

Relationship between MCP1 (-2518A > G) gene variants and ovarian cancer in Turkish population

Article | 2017 | CELLULAR AND MOLECULAR BIOLOGY63 ( 8 ) , pp.100 - 103

The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52). There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x(2)=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG geno . . .type and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer Daha fazlası Daha az

Evaluation of ER alpha and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women

Article | 2012 | MOLECULAR BIOLOGY REPORTS39 ( 6 ) , pp.6723 - 6730

https://hdl.handle.net/20.500.11831/6467

NAssociation of Estrogen Receptor alpha Gene Polymorphism with Bone Mineral Density and Body Mass Index in Turkish Postmenopausal Women

Kurt, O | Aydogan, HY | İşbir, Turgay | Uyar, M | Can, A

Conference Object | 2010 | DRUG METABOLISM REVIEWS42 , pp.254 - 254

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Filtreler

Koleksiyon [5]

Tam Metin [1]

Yazar [20]

Yayın Türü [3]

Konu Başlıkları [20]

Yayın Tarihi [11]

Dergi Adı [20]

Yayıncı [20]

Dil [1]

Yazar Departmanı [1]