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Chronic Manipulation of Arcuate Kisspeptin Neurons in A(1-42) Induced Mouse Model of Alzheimer's Disease

Agus, S | Eyuboglu, S | Solak, H | Bilgin, VA | Yavuz, Y | Akkaya, H | Yılmaz, B

Conference Object | 2018 | NEUROENDOCRINOLOGY107 , pp.9 - 10

Identification of cardiogenic factors modulated during neonatal cardiac regeneration

Kocabas, F | Aslan, GS | Arbatli, S | Akgol, S | Aksoz, M | Turan, RD | Yılmaz, B

Conference Object | 2018 | CARDIOVASCULAR RESEARCH114 , pp.9 - 10

Interaction of the mTERT telomerase catalytic subunit with the c-Abl tyrosine kinase in mouse granulosa cells

Yaba, A | Agus, S | Yildirim, E | Erdogan, CS | Yılmaz, B

Article | 2020 | JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION , pp.9 - 10

Context: Oocyte and granulosa cells (GCs) have bidirectional communication and GCs play an important role in folliculogenesis and proliferation of GCs is very important for the development of ovulatory follicle. DNA double-strand breaks activate c-Abl protein tyrosine kinase and c-Abl has a functional role in repairement of DNA and control of telomere. Objective: In this study, we hypothesized that c-Abl has a regulative role on mTERT in mouse ovarian granulosa cells (GCs) and we aimed to detect c-Abl and mTERT interaction in mouse primary culture of GCs. Materials and methods: Mouse ovarian granulosa cell were cultured and siRNA-me . . .diated knockdown approach was used to knockdown c-Abl expression. Results: We showed c-Abl and mTERT immunolocalization in vivo and in vitro mouse GCs. c-Abl and mTERT were constitutively expressed in mouse granulosa cells and c-Abl presented more intense expression in granulosa cells than mTERT expression. The interaction of the c-Abl-mTERT is supported by the exhibition that c-Abl siRNA knockdown cells show decreased mTERT expression. We also present an interaction between c-Abl and mTERT by immunoprecipitation. In addition, our results indicated that the down-regulation of c-Abl was also accompanied by reduced expression of proliferating cell nuclear antigen (PCNA) in GCs. Conclusions: We suggest that mTERT may associate with the c-Abl in mouse GCs and the interactions between c-Abl and mTERT suggest a role for c-Abl in the regulation of telomerase function and proliferation in mouse granulosa cells Daha fazlası Daha az

Children with first urinary tract infection

Yılmaz, B | Vitrinel, A | Akin, Y | Erdag, GC | Agzikuru, T | Comert, S | Sadikoglu, S

Conference Object | 2008 | ACTA PAEDIATRICA97 , pp.214 - 214

Effects of cholesterol and docosahexaenoic acid on cell viability and (Ca2+)(i) levels in acutely isolated mouse thymocytes

Sandal, S | Tuneva, J | Yılmaz, B | Carpenter, DO

Article | 2009 | CELL BIOCHEMISTRY AND FUNCTION27 ( 3 ) , pp.155 - 161

We investigated the effects of lipids oil thymocyte function. The effects of application of cholesterol or docosahexaenoic acid (DHA). a C22, omega-3 (n-3) polyunsaturated fatty acid (PUFA), on viability and intracellular calcium concentrations of acutely isolated mouse thymocytes were investigated using flow cytometry. Cholesterol (100 mu M) caused significant cell death after 30-60 min whether or not calcium was present in the medium. Cell death was associated with an elevation of intracellular calcium whether or not calcium was present in the extracellular medium. However, the elevation of calcium concentration was not responsibl . . .e for the cell death since calcium levels in the presence of ionomycin rose higher without significant cell death. DHA had similar actions but was more potent, causing significant cell death and elevation of calcium concentration within 5 min at 1 mu M. In the absence of extracellular calcium 1 mu M DHA caused 100% cell death within 15 min. Linolenic acid, a C18 omega-3 fatty acid also Caused cytotoxicity at low concentrations whether or not albumin was present, but omega-6 or saturated C22 fatty acids were much less effective. These observations demonstrate that thymocyte viability is very sensitive to acute exposure to low concentrations of omega-3 fatty acids. Copyright (c) 2009 John Wiley & Soils, Ltd Daha fazlası Daha az

Pinealectomy alters IFN-gamma and IL-10 levels in primary thymocyte culture of rats

Sahin, Z | Sandal, S | Yılmaz, B | Bulmus, O | Ozdemir, G | Kutlu, S | Kelestimur, H

Article | 2018 | CELLULAR AND MOLECULAR BIOLOGY64 ( 14 ) , pp.25 - 30

Melatonin, produced mainly by the pineal gland, has an immunomodulatory role. However, the effects of the pineal gland and/or melatonin on thymus cytokine levels such as interferon-gamma (IFN-gamma), interleukin (IL)-4, and IL-10 are not well known. Twenty-one male Wistar rats (220-250 gr) were randomly divided into three groups (n=7): intact control, sham, and pinealectomy. Primary thymocyte cultures were prepared from each group and dispensed into well plates as Control, DMSO (or vehicle), Sham-pinealectomy, Pinealectomy, Pinealectomy+10 mu M melatonin, and Pinealectomy+100 mu M melatonin. IFN-gamma, IL-4, and IL-10 concentrations . . . were measured in the thymocytes (as nonstimulated and Concanavalin A-stimulated) after 24 h. IFN-gamma levels significantly increased and IL-10 levels significantly decreased in both media prepared from pinealectomized rats. There was no significant difference between the groups in terms of IL-4. In the pinealectomy+100 mu M melatonin group, IFN-gamma and IL-10 levels did not differ from the pinealectomy group. However, the dose of 100 mu M melatonin caused a decrease in levels of IFN-gamma in both thymocyte media and an increase in the concentration of IL-10 in Concanavalin A-stimulated thymocytes. In conclusion, pineal gland and or melatonin affect IFN-gamma and IL-10 levels in the thymus gland Daha fazlası Daha az

Synaptic Pharmacology of Orexigenic Arcagrp -> PVN Connection

Yavuz, Y | Ates, T | Atasoy, NS | Atasoy, D | Yılmaz, B

Conference Object | 2018 | NEUROENDOCRINOLOGY107 , pp.10 - 10

Thermodynamic analysis of human respiratory (diaphragm) skeletal muscles

Catak, J | Ozilgen, M | Yılmaz, B

Conference Object | 2018 | EUROPEAN RESPIRATORY JOURNAL52 , pp.10 - 10

Comparison of Bioactivity of Dioxins in Breast Milk with Body Mass Index in Lactating Mothers

Agus, S | Atasayan, O | Sandal, S | Mete, F | Eyuboglu, S | Yılmaz, B

Conference Object | 2016 | ACTA PHYSIOLOGICA218 , pp.61 - 61

Effect of c-Abl gene silencing by siRNA on proliferation of mouse granulosa cells

Yaba, A | Agus, S | Eyuboglu, S | Demir, N | Yılmaz, B

Conference Object | 2015 | ACTA PHYSIOLOGICA215 , pp.44 - 44

Effects of Agomelatineon Penicillin-Induced Epilepsy with Electrocorticogram and Blood Pressure

Ethemoglu, SM | Seker, B | Kutlu, S | Yılmaz, B

Conference Object | 2016 | ACTA PHYSIOLOGICA218 , pp.8 - 9

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