Gurbuz, I | Demirci, B | Franz, G | Baser, KHC | Yesilada, E | Demirci, F

Article | 2013 | TURKISH JOURNAL OF BIOLOGY37 ( 1 ) , pp.114 - 121

Aerial parts of Daphne pontica were collected from Ilgaz-cankiri, and D. oleoides subsp. oleoides was collected from 2 different localities (Ayranci-Karaman and Ilgaz-Cankiri) in Turkey. The samples were subjected to hydrodistillation and microdistillation. The resulting volatile samples were analyzed both by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), respectively. The main components for D. pontica were identified as hexahydrofarnesyl acetone (8.6%), carvacrol (8.5%), dihydroedulane 11 (4.7%), (E)-geranyl acetone (4.6%), and thymol (4.5%), while nonacosane (42.5% and 27.2%), hexadecanoic acid (24.4% a . . .nd 20.0%), phytol (12.3%), and carvacrol (5.0%) were identified as the main components of D. oleoides subsp. oleoides obtained by hydrodistillation. Carvacrol (12.0%), thymol (7.7%), dihydroactinidiolide (7.2%), bicydosesquiphellandrene (5.5%), and (Z)-3-hexenal (4.1%) were the major components in D. pontica, while carvacrol (27.2% and 25.4%), nonacosane (24.6%), (Z)-3-hexenal (18.5% and 2.5%), decane (7.4%), hexahydrofarnesyl acetone (7.4% and 2.2%), hexanal (6.6% and 1.5%), heptacosane (6.1%), nonanal (5.6% and 1.9%), thymol (5.1% and 2.3%), and phytol (5.0%) were identified in the D. oleoides subsp. oleoides isolated by microdistillation, respectively. In addition, the volatile components were evaluated for their ability to scavenge 1,1-dipheny1-2-picrylhydrazyl (DPPH) radicals using a bioautographic thin layer chromatography (TLC) method, and the samples showed activity comparable with that of the tested standards, vitamins C and E Daha fazlası Daha az

Celep, E | Akyuz, S | Inan, Y | Yesilada, E

Article | 2018 | INDUSTRIAL CROPS AND PRODUCTS118 , pp.111 - 117

Despite the countless number of studies on phenolic compounds from herbal resources and their related bioactivities, their bioavailability factors are generally disregarded. The present study was performed in order to assess the potential bioavailability of major phenolics found in the aerial parts of Lavandula stoechas L. ssp. stoechas. To that end, a simulated human digestion method consisting of both gastric and intestinal phases was conducted. The total phenolic, phenolic acid and flavonoid contents were appraised together with high performance thin layer chromatography analysis of the two phenolic acids (rosmarinic acid and chl . . .orogenic acid) and two flavone glycosides (apigenin 7-glucoside and luteolin-7-O-beta-glucoside). On the other hand, antioxidant potentials of the samples were investigated using assays with different mechanisms such as free radical scavenging tests and metal-related activity tests. According to the results, flavone glycosides had lower bioavailability than phenolic acids, and antioxidant activities were altered due to in vitro gastrointestinal digestion Daha fazlası Daha az

Atay, I | Ilter, AZ | Bagatur, Y | Telci, D | Goren, AC | Kirmizibekmez, H | Yesilada, E

Conference Object | 2015 | PLANTA MEDICA81 ( 16 ) , pp.1512 - 1512

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Atay, I | Ilter, AZ | Bagatur, Y | Telci, D | Kirmizibekmez, H | Yesilada, E

Conference Object | 2015 | PLANTA MEDICA81 ( 16 ) , pp.1511 - 1511

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Gurbuz, I | Ozcelik, B | Karaaoglu, T | Yesilada, E

Conference Object | 2006 | PLANTA MEDICA72 ( 11 ) , pp.1004 - 1004

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Kirmizibekmez, H | Atay, I | Yesilada, E

Conference Object | 2008 | PLANTA MEDICA74 ( 9 ) , pp.1103 - 1103

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Bardakci, H | Akaydin, G | Kirmizibekmez, H | Yesilada, E

Conference Object | 2011 | PLANTA MEDICA77 ( 12 ) , pp.1270 - 1270

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Koksal, M | Gokhan, N | Kupell, E | Yesilada, E | Erdogan, H

Article | 2005 | ARCHIV DER PHARMAZIE338 ( 02.03.2020 ) , pp.117 - 125

The synthesis of a novel series of Mannich bases of 5-/6-acyl-5-methyl-2-benzoxazolinones has been described. The structures attributed to compounds 2a, 3a, 4a, 4b, 9a, 9b, 5a-5g, 6a-6g, 10a, 10g, 11a, 11g have been elucidated using IR and H-1 NMR spectroscopic techniques besides elemental analysis. The compounds have been evaluated for their in vivo analgesic and antiinflammatory activities using the p-benzoquinone-induced writhing test and the carrageenan hind paw oedema test in mice, respectively. In addition, the ulcerogenic effects of the compounds were determined. Among the tested derivatives most promising results were obtain . . .ed for the compounds bearing a 6-(4-chlorobenzoyl) at C-6 position and 2-/4-fluorophenyl at C-3 position of 2-benzoxazolinone ring (11c, 11d) Daha fazlası Daha az

Kirmizibekmez, H | Atay, I | Kaiser, M | Yesilada, E | Tasdemir, D

Conference Object | 2011 | PLANTA MEDICA77 ( 12 ) , pp.1426 - 1426

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Olate, VR | Pertino, MW | Theoduloz, C | Yesilada, E | Monsalve, F | Gonzalez, P | Schmeda-Hirschmann, G

Article | 2012 | PLANTA MEDICA78 ( 4 ) , pp.362 - 367

Starting from the diterpene (4S, 9R, 10R) methyl 18-carboxy-labda-8,13(E)-dien-15-oate (PMD) and its 8(9)-en isomer [PMD 8(9)-en], 11 amides were prepared and assessed for a gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice. Basal cytotoxicity of the compounds was determined on the following human cell lines: normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). All compounds are described for the first time. At the single oral dose of 0.1mg/kg, compounds 1, 10, and 11 presented a strong gastroprotective effect, at least comparable with that of . . . the reference compound lansoprazole at 1mg/kg, reducing gastric lesions by 76.7, 67.7, and 77.2%, respectively. The leucyl amide methyl ester 3, tryptophanyl amide methyl ester 5, and benzyl amide 6 of PMD presented a selective basal cytotoxicity on Hep G2 cells with IC50 values of 136.8, 105.3, and 94.2 mu M, respectively, while the IC50 values towards AGS cells were 439.5, 928.0, and 937.3 mu M, respectively. The three compounds did not affect fibroblast viability with IC50 values > 1000 mu M. Compounds 7, 8, 10, and 11 showed no toxic effect against the three selected cell lines Daha fazlası Daha az

Tatli, II | Akdemir, ZS | Yesilada, E | Kupeli, E

Article | 2008 | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES63 ( 03.04.2020 ) , pp.196 - 202

The potential effects of flavonoids, phenylethanoid and neolignan glycosides from the aerial parts of Verbascum salviifolium Boiss. were studied in the p-benzoquinone-induced writhing reflex, for the assessment of the antinociceptive activity, and in carrageenan-and PGE1-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice, for the assessment of the anti-inflammatory activity. Through bioassay-guided fractionation and isolation procedures ten compounds from the aqueous extract of the plant, luteolin 7-O-glucoside (1), luteolin 3'-O-glucoside (2), apigenin 7-O-glucoside (3), chrysoeriol 7-O- . . .glucoside (4), beta-hydroxyacteoside (5), martynoside (6), forsythoside B (7), angoroside A (8), dehydrodiconiferyl alcohol-9'-O-beta-D-glucopyranoside (9) and dehydrodiconiferyl alcohol-9-O-beta-D-glucopyranoside (10), were isolated and their structures were elucidated by spectral techniques. Results have shown that 1, 2, 3 and 5 significantly inhibited carrageenan-induced paw edema at a 200 mg/kg dose, while 1, 2 and 5 also displayed anti-inflammatory activity against the PGE1-induced hind paw edema model. However, all the compounds showed no effect in the TPA-induced ear edema model. The compounds 1 and 2 also exhibited significant antinociceptive activity Daha fazlası Daha az

Tosun, A | Akkol, EK | Yesilada, E

Article | 2009 | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES64 ( 01.02.2020 ) , pp.56 - 62

n-Hexane and ethyl acetate extracts as well as coumarin derivatives obtained from the n-hexane extract of the aerial parts of Seseli gummiferum Pall. ex Sm. subsp. corymbosum (Boiss. & Heldr.) P.H. Davis (Apiaceae) were evaluated in vivo for their anti-inflammatory and antinociceptive activities. The n-hexane and ethyl acetate extracts of the species were shown to possess significant inhibitory activity against the carrageenan-induced hind paw edema and p-benzoquinone-induced writhing models in mice. Among the isolated coumarin derivatives; (-)-(3'S,4'S)-3'-acetoxy-4'-isovaleryloxy-3',4'-dihydroseselin (1), (-)-(3'S14 S)-3'-acetoxy- . . .4'-angeloyloxy-3'.4'-dihydroseselin (2),(+)-(3'S,4'S)-3'-hydroxy-4'-angeloyloxy-3',4'dihydroseselin (D-laserpitin) (3), (-)-(3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin (4), and osthole (5), only the 3'-acetoxy derivatives 1 and 2 were found to possess potent antinociceptive and anti-inflammatory activities, per os, without inducing any apparent acute toxicity as well as gastric damage, while all other compounds and extracts were found to be ineffective in the TPA-induced mouse ear edema model assay Daha fazlası Daha az