Bayrak, F | Guneysu, T | Sevinc, D | Eroglu, E | Gemici, G | Mutlu, B | Degertekin, M

Conference Object | 2008 | ATHEROSCLEROSIS SUPPLEMENTS9 ( 1 ) , pp.165 - 165

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Tavli, V | Guven, B | Yilmazer, M | Mese, T | Oner, T | Demirpence, S

Conference Object | 2010 | INTERNATIONAL JOURNAL OF CARDIOLOGY140 , pp.165 - 165

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Ozgen, A

Article | 2015 | EUROPEAN JOURNAL OF RADIOLOGY84 ( 12 ) , pp.2593 - 2596

Objectives: To compare fat-saturated T2-weighted (FST2W) with contrast-enhanced fat-saturated T1-weighted (cFST1W) pulse sequences in magnetic resonance (MR) imaging of sacroiliac joints in diagnosis of active sacroiliitis associated with axial spondyloarthropathies. Materials and methods: MR examinations of 147 adult patients suspected for sacroiliitis were retrospectively analyzed. Signs of active inflammation, bone marrow edema/osteitis, capsulitis, enthesitis, and synovitis were noted both on FST2W and cFST1W images. Diagnosis of active sacroiliitis was made according to the Assessment in SpondyloArthritis international Society . . .(ASAS) definition. Results: Sixty three patients were diagnosed as having active sacroiliitis based on both FST2W images showing bone marrow edema and cFST1W images showing osteitis. All areas with osteitis seen on cFST1W images were also noted as having bone marrow edema on FST2W images while FST2W images revealed 4 additional areas of active bone marrow changes. Qualitative and quantitative analyses also revealed that FST2W images were superior in showing active bone marrow lesions, the hallmark of active sacroiliitis, while cFST1W images helped detecting enthesitis and/or capsulitis and were necessary for detecting synovitis. Conclusion: Although cFST1W images help detecting enthesitis and/or capsulitis and are necessary for detecting synovitis, FST2W sequence is superior in detecting active bone marrow lesions and therefore more valuable in diagnosing active sacroiliitis associated with axial spondyloarthropathies based on ASAS criteria. (C) 2015 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Topcuoglu, OM | Topcuoglu, ED | Altay, CM | Genc, S

Review | 2017 | EUROPEAN JOURNAL OF RADIOLOGY94 , pp.115 - 124

Objective: To emphasize the diverse diagnostic imaging findings of pediatric Behcet's disease and to define the fundamental imaging clues for pulmonary, vascular, gastrointestinal and central nervous system involvements of Behcet's disease in pediatric age group. We also aim to list the major imaging differences of Behcet's disease in childhood and adulthood. Conclusion: The diagnosis of pediatric Behcet's disease is challenging. Imaging can narrow the differential diagnosis by using some substantial clues and prevent diagnostic delays.

Cakmak, YO | Ekinci, G | Afsar, N | Cavdar, S

Conference Object | 2011 | NEUROSCIENCE RESEARCH71 , pp.115 - 124

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Gurbuz, I | Yesilada, E

Article | 2007 | JOURNAL OF ETHNOPHARMACOLOGY112 ( 2 ) , pp.284 - 291

The guaianolide type sesquiterpene lactones chlorojanerin, 13-acetyl solstitialin A and solstitialin A were identified as the anti-ulcerogenic components of the chloroform extract of the aerial parts of Centaurea solstitialis ssp. solstitialis (Asteraceae). In this study, these compounds were investigated by using various in vivo ulcer models in rats and mice. Chlorojanerin was shown to be significantly effective in preventing the induction of lesions by ethanol- (EtOH-) (both oral and subcutaneous administration), indomethacin-, indomethacin plus HCI/EtOH-, N-G-nitro-L-ar.-inine methyl ester plus EtOH, N-ethylmaleimide plus EtOH-, . . .water immersion and restraint stress, and serotonin, as well as inhibiting fitratable gastric acidity and acid output, and increasing gastric pH, but was ineffective in the prevention of ulcers induced by pyloric ligation, diethyldithiocarbamate, and cysteamine, and had no effect on gastric secretion volume or peptic activity. A mixture of 13-acetyl solstitialin A (95%) and solstitialin A (5%) was found to be significantly effective against EtOH-induced lesions on oral administration but was ineffective when administered subcutaneously. This mixture was also found to be effective in preventing lesions induced by EtOH, indomethacin, indomethacin plus HCl/EtOH, N-G-nitro-L-arginine methyl ester plus EtOH, N-ethylmateimide plus EtOH, water immersion and restraint stress, serotonin and cysteamine, as well as inhibiting fitratable gastric acidity and fitratable acid output, and gastric pH, but was found ineffective against the pyloric ligation-induced and diethyldithiocarbamate-induced ulcerogenesis models, as well as gastric secretion volume and peptic activity. On the other hand, active compounds did not show any toxic effect on acute toxicity (3 days administration) evaluation tests in mice. (c) 2007 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Guven, B | Yilmazer, MM | Mese, T | Tavli, V | Serdaroglu, E | Demirpence, S | Oner, T

Conference Object | 2010 | INTERNATIONAL JOURNAL OF CARDIOLOGY140 , pp.284 - 291

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Orhan, I | Kiipeli, E | Terzioglu, S | Yesilada, E

Article | 2007 | JOURNAL OF ETHNOPHARMACOLOGY114 ( 1 ) , pp.32 - 37

Calluna vulgaris L. (Ericaceae) is used for the treatment of various inflammatory ailments in traditional medicines. In order to evaluate this ethnobotanical information, its anti-inflammatory and antinociceptive activities were studied using in vivo experimental models in mice. The ethanolic extract of the plant was first fractionated into five extracts; namely, n-hexane, chloroform, ethyl acetate (EtOAc), n-butanol, and water fractions. Among them, the EtOAc Fr. was found to be the most effective and was further subjected to bioassay-guided fractionation and isolation procedures. After successive column chromatography applications . . ., on Sephadex LH-20 and silica gel, a component, which is responsible for the above-mentioned activities of this species of Turkish origin, was isolated and its structure was elucidated as kaempferol-3-O-beta-D-galactoside, a common flavonol derivative by means of spectral techniques. (C) 2007 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Aslan, M | Orhan, DD | Orhan, N | Sezik, E | Yesilada, E

Article | 2007 | JOURNAL OF ETHNOPHARMACOLOGY109 ( 1 ) , pp.54 - 59

Helichrysum species (Asteraceae) are widely found in Anatolia. Decoction prepared from the capitulums of Helichrysum plicatum ssp. plicatum is used to alleviate the symptoms of diabetes mellitus in folk medicine. In the present study, the hypoglycaemic and antioxidant potential of Helichrysum plicatum ssp. plicatum was evaluated by using in vivo methods in normal and streptozotocin-induced-diabetic rats. After the oral administration of water and ethanolic extracts at doses of 500 mg/kg body weight prepared from the capitulums of plant, blood glucose levels were monitored at specific intervals. Tolbutamide was used as a reference dr . . .ug at a dose of 100 mg/kg. The experimental data indicated that water and ethanol extracts of capitulums demonstrate significant antihyperglycaemic and antioxidant activity in streptozotocin-induced rats which confirmed the folkloric utilization. In order to assess the role of polyphenolic components in the relevant activity, phenolic and flavonoid contents of each extract were also determined in terms of total phenols: 113.5 +/- 8.6 mg (gallic acid equivalent/l g extract) and total flavanoids 50.5 +/- 1.9 mg (quercetin equivalent/l g extract) for ethanol extract, total phenols: 75.9 +/- 3.7, flavonoids: 31.5 +/- 2.3 for water extract using Folin-Ciocalteu reagent. (c) 2006 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Guzelmeric, E | Helvacioglu, S | Hamitoglu, M | Aydin, A | Yesilada, E

Conference Object | 2017 | TOXICOLOGY LETTERS280 , pp.54 - 59

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Ergenoglu, MU | Yerebakan, H | Koner, O | Ozveren, O | Kalangos, A | Demirsoy, E

Conference Object | 2011 | INTERNATIONAL JOURNAL OF CARDIOLOGY147 , pp.54 - 59

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Terzioglu, G | Ormeci, B | Turksoy, O | Sayman, C | Cinar, N | Ozturk, GA | Demirel, GY

Article | 2017 | MECHANISMS OF AGEING AND DEVELOPMENT167 , pp.24 - 29

Alzheimer's disease (AD) may be associated with mitochondrial defects. The aim of the present study was to investigate changes in mitochondrial abundance in peripheral lymphocytes of early and late stage AD patients. We analysed levels of mitochondrial DNA (mtDNA) and mean fluorescence intensity (MFI) of the mitochondria- specific antibody 113-1 in CD4(+), CD8(+), CD19(+) and CD56(+ )peripheral lymphocytes of early and late stage AD by quantitative real-time PCR and flow cytometry, respectively. In early stage AD, the levels of mtDNA were significantly decreased in CD4(+), CD19(+) and CD56(+) peripheral lymphocytes while the MFI of . . .113-1 staining was significantly decreased in CD4(+) and CD19(+ )cells. Thus, CD4(+) and CD19(+) peripheral lymphocytes of early stage AD patients exhibit mitochondrial depletion, as seen both at the level of DNA and protein Daha fazlası Daha az