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Phenolic compounds from the aerial parts of Clematis viticella L. and their in vitro anti-inflammatory activities

H. Kırmızıbekmez | Y. İnan | R. Reis | H. Sipahi | A.C. Gören | E. Yeşilada

Article | 2019 | Natural Product Research33 ( 17 ) , pp.2541 - 2544

Phytochemical investigations on the EtOH extract of Clematis viticella led to the isolation of six flavonoid glycosides, isoorientin (1), isoorientin 3'-O-methyl ether (2), quercetin 7-O-?-L-rhamnopyranoside (3), quercetin 3,7-di-O-?-L-rhamnopyranoside (4), manghaslin (5) and chrysoeriol 7-O-ß-D-glucopyranoside (6), one phenylethanol derivative, hydroxytyrosol (7), along with three phenolic acids, caffeic acid (8), (E)-p-coumaric acid (9) and p-hydroxybenzoic acid (10). The structures of the isolates were elucidated on the basis of NMR and HR-MS data. All compounds were isolated from C. viticella for the first time. Compounds 7 and . . .8 showed significant anti-inflammatory activity at 100 µM by reducing the release of NO in LPS-stimulated macrophages comparable to positive control indomethacin. Compounds 3 and 7 exhibited anti-inflammatory activity through lowering the levels of TNF-? while 1, 3 and 5 decreased the levels of neopterin better than the positive controls. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Transit coordination with heterogeneous headways

Aksu, D.T. | Yilmaz, S.

Article | 2014 | Transportation Planning and Technology37 ( 5 ) , pp.450 - 465

We consider the transit coordination problem with heterogeneous headways. Timetables with heterogeneous headways improve coordination between transit lines and reduce transfer time for connecting passengers. Unfortunately, deviating from homogeneous headways impacts adversely on initial waiting times experienced prior to embarking on the initial vehicle of a trip. We focus on this trade-off between transfer waiting time and initial waiting time, which has not been explored previously, and develop a mathematical model to quantify the benefits of heterogeneous headways. We also propose a genetic algorithm (GA) to solve the transit coo . . .rdination problem with heterogeneous headways and demonstrate the benefit of heterogeneous headways based on two examples from the literature and one real-life example based on the rail transit network of Istanbul. Computational results suggest that the GA solves the transit coordination problem within a reasonable time and significant benefits can be achieved by adopting timetables with heterogeneous headways. © 2014 Taylor & Francis Daha fazlası Daha az

Knowledge management, innovation, and competitive advantage: is the relationship in the eye of the beholder?

Aydin, S. | Dube, M.

Article | 2018 | Knowledge Management Research and Practice16 ( 3 ) , pp.402 - 413

As countries like Turkey rapidly develop their technology sectors, there is significant interest in whether knowledge management (KM) can help companies gain competitive advantages. However, individual perceptions as to the effectiveness of KM or information systems, which ultimately determine company-wide usage, may vary by individual preferences, as well as by tasks and department. This study compares a sample of 61 survey responses from 61 firms operating in Turkey, to an auxiliary sample of 34 responses from a single firm. The populations of the responses for the two surveys were statistically the same. Furthermore, the response . . .s in the auxiliary survey provided similar relationships between the regression factors as the cross-company responses. This suggests a potential reinterpretation of cross-company survey results, and furthermore that KM and information technology measures for firms could be treated as distributions instead of single values. Perceptions also varied by employee turnover and workforce size. © 2018, © Operational Research Society 2018 Daha fazlası Daha az

Development and in vitro/in vivo evaluation of dihydroergotamine mesylate loaded maltodextrin-pullulan sublingual films

Esim, O. | Ozkan, C.K. | Kurbanoglu, S. | Arslan, A. | Tas, C. | Savaser, A. | Ozkan, Y.

Article | 2019 | Drug Development and Industrial Pharmacy45 ( 6 ) , pp.914 - 921

Dihydroergotamine mesylate (DHE), ergotamine derivative, has been offered for clinical use to stop or treat symptoms of an emerging migraine as injection for more than a half century. It is shown that bioavailability of DHE greatly changes between the subjects and up to 99% of the orally absorbed dose may be cleared by first pass metabolism. The aim of this study was to design and optimize DHE fast-dissolving sublingual films for migraine treatment. For this purpose pullulan and maltodextrin was chosen as film-forming polymers and propylene glycol as plasticizer. For optimization process Box Behnken design was used. The formed films . . . were free from air bubbles, cuttings, or cracks. Disintegration, mechanical strength and dissolution of films were compared. It is found that pullulan and maltodextrin formed films with the most desired properties at the concentration of 1.5% and 2%. The application of optimum formulation to rabbits showed that bioavailability of formulation is about 23.35% with a t max 20 min. Due to this fast onset of action and higher bioavailability than oral administration, it is suggested that the polymer combinations of pullulan and maltodextrin formed successful films and were considered as an alternative dosage form for DHE in migraine therapy. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Growth and physiology of basmati rice under conventional and water-saving production systems

Jabran, K. | Ullah, E. | Akbar, N. | Yasin, M. | Zaman, U. | Nasim, W. | Hussain, M.

Article | 2017 | Archives of Agronomy and Soil Science63 ( 10 ) , pp.1465 - 1476

Conventionally flooded rice (CFR) requires enormous water and labor inputs. Water scarcity aspires for cultivation of water-saving rice. Growth response and physiology of basmati rice genotypes under the water-saving production systems has not been reported yet. Studies were conducted for 2 years to compare the growth and physiology of three rice cultivars (Super Basmati, Basmati-2000 and Shaheen Basmati), under high (CFR), medium (alternate wetting and drying [AWD]) and low water input (aerobic rice [AR]) systems. Leaf area index, crop growth rate, leaf area duration and dry matter accumulation were higher for AR followed by AWD an . . .d CFR, respectively. Shaheen Basmati had a lower growth and relative water contents than Super Basmati and Basmati-2000, probably due to its shorter stature and shorter life cycle. Photosynthetic rate and stomatal conductance of rice cultivars in the different production were affected only at reproductive stage. Basmati-2000 grown as AR had the highest photosynthetic rate followed by the same cultivar under AWD. The results of this study provide us an idea that basmati cultivars can attain a high growth and development with low water input. This would be helpful to grow rice successfully under water-short rice-growing environments. © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Roles of glycine betaine in mitigating deleterious effect of salt stress on lettuce (Lactuca sativa L.)

Yildirim, E. | Ekinci, M. | Turan, M. | Dursun, A. | Kul, R. | Parlakova, F.

Article | 2015 | Archives of Agronomy and Soil Science61 ( 12 ) , pp.1673 - 1689

This study was conducted to evaluate the roles of glycine betaine (GB) in mitigating deleterious effect of salt stress on lettuce. Lettuce plants were subjected to two salinity (0 and 100 mmol l-1 NaCl) and four GB levels (0, 5, 10, 25 mmol l-1). Salinity resulted in a remarkable decrease in growth parameters, relative leaf water content and stomatal conductance. Plants subjected to salt stress exhibited an increase in membrane permeability (MP), lipid peroxidation (MDA), leaf chlorophyll reading value, H2O2 and sugar content. Exogenous foliar applications of GB reduced MP, MDA and H2O2 content in salt-stressed lettuce plants. Salt . . .stress increased Na and generally decreased other nutrient elements. GB reduced Na accumulation, but significantly increased other element contents under salinity conditions. The study showed that gibberellic acid (GA) and salicylic acid (SA) content in salt-stressed plants were lower than those of nonstressed plants. However, salinity conditions generally increased the abscisic acid content. GB treatments elevated the concentrations of GA, SA and indole acetic acid (IAA) at especially 10 and 25 mmol l-1 GB under salt stress conditions. It could be concluded that exogenous GB applications could ameliorate the harmful effects of salt stress in lettuce. © 2015 Taylor & Francis Daha fazlası Daha az

The effect of MDP-based primer on shear bond strength of various cements to two different ceramic materials

Pak Tunc, E. | Ozer, F. | Ayyildiz, S. | Ula, T.A. | Sen, D.

Article | 2017 | Journal of Adhesion Science and Technology31 ( 10 ) , pp.1142 - 1150

The aim of this study was to determine the effect of 10-methacryloyloxydecyl dihydrogen phosphate (MDP)-based primer on the shear bond strengths of thermally aged self-adhesive and conventional adhesive resin cements and zinc phosphate cement to zirconia and lithium disilicate substructures. Sixty zirconia (Z) and 60 lithium disilicate (L) disk specimens were cut from ceramic blocks. Each group was divided into six subgroups (n = 10). Half of the specimens of each ceramic group were treated with primer (P) and the other half was remained untreated. Three types of cement were applied: zinc phosphate cement [(ZPC) (Hoffmann Harmonic S . . .hades)]; self-adhesive resin cement [(SAC) (RelyX U200)]; conventional adhesive resin cement [(CAC) (C&B)]. The specimens were subjected to thermal aging procedure for 1 week under 37 °C water bath. Shear bond strength (SBS) was determined using a universal testing machine at a crosshead speed of 1 mm/min. Data were analyzed with three-way (ANOVA). Pairwise comparisons and interactions between groups were analyzed by using Tukey’s simultaneous confidence intervals. There was no significant difference between the SBS values of SAC-Z (11,47 ± 0,47) and SAC-ZP (11,39 ± 0,42) (p > 0.05). However, the SBS values of SAC-L (12.34 ± 0,55) and SAC-LP (12,50 ± 0,49) were significantly higher than those of SAC-Z and SAC-ZP (p Daha fazlası Daha az

Efficacy of multi-mode adhesive systems on dentin wettability and microtensile bond strength of resin composite

Arhun, N. | Halacoglu, D.M. | Ozduman, Z.C. | Tuncer, D.

Article | 2018 | Journal of Adhesion Science and Technology32 ( 21 ) , pp.2405 - 2418

Purpose: To evaluate the wetting ability and the microtensile bond strength of adhesive systems in various depths of dentin. Materials and Method: 48 extracted human molars cut in half in buccolingual direction. Buccal and lingual surfaces were used to obtain deep (n = 48) and superficial (n = 48) dentin. Groups were divided into 4 subgroups: Self-etch (CSE), etch&rinse (SB), multi-mode self-etch (SAU) and multimode etch&rinse (EAU) adhesive systems. 3 consecutive contact-angle measurements were obtained: T0- 3 µl drop of distilled water on dentin; T1-Droplet of the adhesive; T2- Distilled water after polymerization of the adhesive. . . . After composite build-ups, microtensile measurements were performed. Contact angle data were analysed with analysis of variance for repeated measures. Bond strength data were analyzed by repeated measures analysis of variance, comparisons were made according to the logarithmic values (p Daha fazlası Daha az

Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation

G. Renda | B. Korkmaz | M. Kılıç | M.K. Duman | H. Kırmızıbekmez

Article | 2018 | Natural Product Research32 ( 16 ) , pp.1902 - 1910

The present study was undertaken to evaluate the in vivo analgesic activities of the extracts prepared from the aerial parts and roots of Scrophularia kotscyhana and to isolate the bioactive metabolites from the most active extract. Analgesic activities of all extracts and subextracts at the doses of 5, 10 and 30 mg/kg (i.p.) were examined using hot plate test in mice. Among the tested extracts, MeOH extract prepared from the aerial parts and the n-butanol subextract prepared thereof displayed the best analgesic activity at all doses. Phytochemical studies on n-butanol subextract led to the isolation of two new iridoid glycosides as . . . an inseparable mixture, 8-O-acetyl-4'-O-(E)-(p-coumaroyl)-harpagide (1) and 8-O-acetyl-4'-O-(Z)-(p-coumaroyl)-harpagide (2) along with five known secondary metabolites, ß-sitosterol 3-O-ß-glucopyranoside (3), apigenin 7-O-ß-glucopyranoside (4), apigenin 7-O-rutinoside (5), luteolin 7-O-ß-glucopyranoside (6) and luteolin 7-O-rutinoside (7). The iridoid mixture (1 and 2), 3 and 4 elicited significant inhibition of pain at 5 mg/kg dose. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Dynamic programming and mixed integer programming based algorithms for the online glass cutting problem with defects and production targets

Durak, B. | Aksu, D.T.

Article | 2017 | International Journal of Production Research55 ( 24 ) , pp.7398 - 7411

In flat glass manufacturing, glass products of various dimensions are cut from a glass ribbon that runs continuously on a conveyor belt. Placement of glass products on the glass ribbon is restricted by the defects of varying severity located on the ribbon as well as the quality grades of the products to be cut. In addition to cutting products, a common practice is to remove defective parts of the glass ribbon as scrap glass. As the glass ribbon moves continuously, cutting decisions need to be made within seconds, which makes this online problem very challenging. A simplifying assumption is to limit scrap cuts to those made immediate . . .ly behind a defect (a cut-behind-fault or CBF). We propose an online algorithm for the glass cutting problem that solves a series of static cutting problems over a rolling horizon. We solve the static problem using two methods: a dynamic programming algorithm (DP) that utilises the CBF assumption and a mixed integer programming (MIP) formulation with no CBF restriction. While both methods improve the process yield substantially, the results indicate that MIP significantly outperforms DP, which suggests that the computational benefit of the CBF assumption comes at a cost of inferior solution quality. © 2017 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

Botulinum toxin for the treatment of bruxism

Tinastepe, N. | Küçük, B.B. | Oral, K.

Article | 2015 | Cranio - Journal of Craniomandibular Practice33 ( 4 ) , pp.292 - 299

Aims: Botulinum toxin, the most potent biological toxin, has been shown to be effective for a variety of disorders in several medical conditions, when used both therapeutically and cosmetically. In recent years, there has been a rising trend in the use of this pharmacological agent to control bruxing activity, despite its reported adverse effects. The aim of this review was to provide a brief overview to clarify the underlying essential ideas for the use of botulinum toxin in bruxism based on available scientific papers. Methodology: An electronic literature search was performed to identify publications related to botulinum toxin an . . .d its use for bruxism in PubMed. Hand searching of relevant articles was also made to identify additional studies. Results: Of the eleven identified studies, only two were randomized controlled trials, compared with the effectiveness of botulinum toxins on the reduction in the frequency of bruxism events and myofascial pain after injection. The authors of these studies concluded that botulinum toxin could be used as an effective treatment for reducing nocturnal bruxism and myofascial pain in patients with bruxism. Conclusion: Evidence-based research was limited on this topic. More randomized controlled studies are needed to confirm that botulinum toxin is safe and reliable for routine clinical use in bruxism. © W. S. Maney & Son Ltd Daha fazlası Daha az

Decay of solutions and structural stability for the coupled Kuramoto-Sivashinsky–Ginzburg-Landau equations

Çelebi, O.A. | Kalantarov, V.K.

Article | 2015 | Applicable Analysis94 ( 11 ) , pp.2342 - 2354

We show that solutions of the initial boundary value problem for the coupled system of Kuramoto-Sivashinsky and Ginzburg-Landau (KS–GL) equations continuously depend on parameters of the system, and under some restrictions on parameters all solutions of initial boundary value problem for KS–GL equations tend to zero as (Formula presented.) with an exponential rate. © 2014 Taylor & Francis.

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