Ozturk, M.A. | Kalayci, M. | Oyan, B.

Letter | 2013 | Clinics and Research in Hepatology and Gastroenterology37 ( 5 )

[No abstract available]

Fayyaz, S. | Javed, Z. | Attar, Rukset | Farooqi, A.A. | Yaylim, I. | Ahmad, A.

Review | 2019 | Seminars in Cancer Biology58 , pp.56 - 64

Large-scale sequencing methodologies have helped us identify numerous genomic alterations and we have started to scratch the surface of many new targets for treatment of cancer and the associated predictive biomarkers. TRAIL (TNF-related apoptosis-inducing ligand) is a highly appreciated anti-cancer molecule because of its ability to selectively target cancer cells. However, confluence of information suggests that cancer cells develop resistance against TRAIL-based therapeutics. It is being realized that overexpression of anti-apoptotic proteins and inactivation of pro-apoptotic proteins significantly impairs TRAIL triggered apoptos . . .is, particularly in clinical settings. Re-balancing of pro-and anti-apoptotic proteins and upregulation of death receptors with functionally active extrinsic and intrinsic apoptotic pathways are necessary to sensitize cancer cells to TRAIL based therapeutics. microRNAs (miRNAs) are involved in regulation of myriad of molecular processes and characterized into oncogenic and tumor suppressor miRNAs. Accumulating data has identified miRNAs which positively or negatively regulate TRAIL mediated signaling in cancer cells, helping us understand different steps at which TRAIL-mediated apoptotic signaling can be targeted. Here, we assess the status of our understanding of the mechanisms related to miRNA regulation of TRAIL mediated signaling, as well as the existing gaps therein, and discuss the challenges and opportunities that will help us get closer to personalized medicine. © 2019 Elsevier Lt Daha fazlası Daha az

Gurol, Y | Romano, E | Coskun, FT | Bicer, S | Celik, G

Article | 2017 | EGYPTIAN PEDIATRIC ASSOCIATION GAZETTE65 ( 2 ) , pp.31 - 32

Objective: Even though mixed bacterial-viral infections are very common in other respiratory tract conditions such as acute otitis media and pneumonia, concurrent GAS-influenza virus pharyngotonsillitis is generally not considered. We share our experience of mixed infection of GAS and influenza in children with this report. Methods: The rapid antigen test for streptococcus group A (Quidel, USA) was applied to the throat samples. The throat samples were also cultured in sheep blood agar at 37 degrees C for 24 h incubation. The rapid antigen test for influenza (Quidel, USA) was applied to the nasal samples at the same time. Results: B . . .etween January and April 2016, among 541 children, 11 cases had concurrent influenza and GAS; 3 cases with influenza B and 8 cases with influenza A. Conclusion: There is a number of data alerting the clinicians about bacterial coinfections because of the rapid progression to severe illnesses. (C) 2017 The Egyptian Pediatric Association. Production and hosting by Elsevier B.V Daha fazlası Daha az

Bayrak, A.B. | Bayrakçeken, Fuat | Sevinç, P.C. | Karaaslan, I.S.

Article | 2007 | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy67 ( 03.04.2020 ) , pp.582 - 585

The ultraviolet absorption and emissions as well as Stokes and anti-Stokes Raman scatterings of spectroscopically pure 5H-dibenzo(a,d)cycloheptene-5-ol were investigated by flash and laser-flash photolysis technique in solution at room temperature and at 77 K. The whole spectrum, absorption, excitation, prompt and delayed fluorescence, T-T absorption spectra were recorded photographically and photoelectrically in the ultraviolet and visible region and phosphorescence spectrum, Stokes, anti-Stokes scatterings were recorded at 77 K. © 2006 Elsevier B.V. All rights reserved.