Effect of hyperbaric oxygen therapy on bone prefabrication in rats

Sever, C. | Uygur, F. | Külahçi, Y. | Torun Köse, G. | Urhan, M. | Küçükodaci, Z. | Çayci, T.

Article | 2010 | Acta Orthopaedica et Traumatologica Turcica44 ( 5 ) , pp.403 - 409

Objectives: This experimental study aimed to create a prefabricated vascularized bone graft using the interconnected porous coralline hydroxyapatite ceramic by combining vascular bundle implantation, mesenchymal stem cells, and hyperbaric oxygen therapy (HBOT) administration in a rat model. Methods: Forty-five male Sprague-Dawley rats were divided into three groups, each containing 15 rats. The hydroxyapatite ceramics were vascularized by the superficial inferior epigastric artery and vein in all groups. These vessels passed through the hole of the hydroxyapatite blocks. In Group 2, mesenchymal stem cells were administered into the . . .hydroxyapatite. In Group 3, both mesenchymal stem cells and HBOT were administered. The presence and density of any new bone formation and neovascularization were evaluated by radiography, microangiography, scintigraphy, biochemical analysis, and histomorphometry. Results: Neovascularization and bone formation were significantly greater in Group 3, in which both mesenchymal stem cells and HBOT were applied, than the other groups. Conclusion: HBOT enhances neovascularization and osteogenesis, thus HBOT can provide optimal and faster prefabrication of a vascularized bone graft. © 2010 Turkish Association of Orthopaedics and Traumatology Daha fazlası Daha az

Venous thromboembolism prophylaxis in major orthopaedic surgery: A multicenter, prospective, observational study

Altintas, F. | Gurbuz, H. | Erdemli, B. | Atilla, B. | Ustaoglu, R.G. | Ozic, U. | Kinik, H.

Article | 2008 | Acta Orthopaedica et Traumatologica Turcica42 ( 5 ) , pp.322 - 327

Objectives: We investigated risk factors for venous thromboembolism (VTE), prophylaxis measures employed, and incidence of symptomatic deep venous thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing major orthopaedic surgery (MOS). Methods: An open, multicenter, prospective, observational study was conducted in 21 medical centers, comprising 899 patients. Of these, 316 patients (35.2%) underwent total hip arthroplasty (THA), 328 patients (36.5%) underwent total knee arthroplasty (TKA), and 255 patients (28.4%) underwent surgery for hip fractures (HF). Pharmacologic prophylaxis was employed in all the patients. Result . . .s: Risk factors for VTE were seen in 73.2% of the patents, the most common being obesity (72%) and prolonged immobilization (36.3%). Low-molecular-weight heparin (91.1%) and fondaparinux (8.9%) were used for prophylaxis, which was short-term in 273 patients (30.4%) and long-term in 626 patients (69.6%). Mechanical prophylaxis was performed with compression stockings in 610 patients (67.9%) and by intermittent pneumatic compression in 67 patients (7.5%). During three-months of follow-up, symptomatic DVT and PE were seen in eight (0.9%) and four patients (0.4%), respectively. Mortality occurred in 10 patients (1.1%). Complications of major and minor bleeding were seen in eight (0.9%) and 40 (4.5%) patients, respectively. Conclusion: Effective VTE prophylaxis is associated with low risk of clinically apparent DVT and PE in MOS. © 2008 Turkish Association of Orthopaedics and Traumatology Daha fazlası Daha az


Akman, B. | Şaylı, U. | Güven, M. | Altıntaş, F.

Letter | 2018 | Acta Orthopaedica et Traumatologica Turcica52 ( 4 ) , pp.326 - 327

[No abstract available]

Autosomal dominant inheritance of congenital dislocation of the hip in 16 members of a family

Ceylaner, G. | Ceylaner, S. | Ustunkan, F. | Inan, M.

Article | 2008 | Acta Orthopaedica et Traumatologica Turcica42 ( 4 ) , pp.289 - 291

The effect of genetic factors on hip dislocation, acetabular dysplasia, and developmental dysplasia of the hip (DDH) has long been recognized. In this report, we presented a large family that showed single gene inheritance for DDH. Pedigree analysis of a pregnant woman revealed a history of DDH in 16 members of the family. Although the pedigree showed autosomal dominant inheritance with reduced penetrance, the prevalence of DDH was considerably high, almost accounting for one-third of the family members, and skipping only one generation. Of 16 cases, three patients were diagnosed at our center. The remaining 13 patients were diagnos . . .ed at other centers. Dislocation was diagnosed very late in most of the family members, while four cases were diagnosed at birth. All family members were informed by a detailed clinical letter and recommended evaluation for DDH at every birth. © 2007 Türk Ortopedi ve Travmatoloji Dernegi Daha fazlası Daha az

The use of an absorbable collagen cover (NeuraWrap) improves patency of interpositional vein grafts

Bekler, H.I. | Rosenwasser, M.P. | Akilina, Y. | Bulut, G.

Article | 2010 | Acta Orthopaedica et Traumatologica Turcica44 ( 2 ) , pp.157 - 161

Objectives: Autologous interpositional vein grafts are used in peripheral arterial bypass procedures. Sudden exposure of vein grafts to arterial blood pressure is associated with increased wall tension leading to overdistension of the graft and changes in flow patterns. Overdistension of vein grafts often results in anastomotic leaks, thrombosis, and loss of patency. This study was designed to evaluate the use of a biodegradable collagen cover as a means of preventing overdistension of venous bypass grafts in a rat model. Methods: Twenty-two Sprague-Dawley female rats weighing 250-350 g were randomly assigned to two groups: study gr . . .oup (n= 15) and control group (n=7). In all the rats, a 10-mm segment of the left femoral vein was harvested and used as a graft in repair of a right femoral artery injury. Following this procedure, control rats remained untreated. After completion of the femoral artery repair in the study group, the graft was wrapped with a collagen cover of appropriate length (NeuraWrap Nerve Protector) and sutured to form a tube around the vein graft. At the end of the procedure, the intensity and duration of bleeding, and vessel patency were recorded and the proximal and distal arterial segments were examined by Doppler ultrasonography. All observations and measurements were repeated at 1 and 2 hours after surgery. After the second hour, all the rats were sacrificed and vein graft samples with the arterial portions were removed for histological study. Results: After removal of the vascular clamps of the control group, a sudden distension was observed in all the vein grafts. In this group, bleeding at the anastomosis site lasted for 1 to 3 minutes and was followed by ballooning of the grafts. In the study group, however, none of the samples exhibited distension and ballooning. There was no bleeding in 11 samples at all, and bleeding time was less than one minute in the remaining four samples. In the control group, only one graft was patent at two hours, one of the grafts was occluded after only three minutes. In the study group, all the grafts were patent and no thrombosis was noted. The mean blood flow velocity of the control group measured at 0 hour by Doppler ultrasonography was 0.93±0.33 cm/sec in the proximal artery, and 0.73±0.44 cm/sec in the distal artery. The mean blood flow velocities in the proximal and distal arteries of the study group were as follows, respectively: at 0 hour: 0.45±0.27 and 0.46±0.22 cm/sec; at 1 hour: 0.40±0.22 and 0.62±0.40 cm/sec; and at 2 hours: 0.55±0.22 and 0.64±0.37 cm/sec. Conclusion: Prevention of overdistension of vein grafts with the use of an external cover decreases anastomotic leaks, protects the intimal media, maintains blood flow, reduces the incidence of thrombosis, and thus provides a higher patency rate. © 2010 Turkish Association of Orthopaedics and Traumatology Daha fazlası Daha az

Subacromial space volume in patients with rotator cuff tear: The effect of surgical repair

Pepe, M. | Kocadal, O. | Gunes, Z. | Calisal, E. | Aksahin, E. | Aktekin, C.N.

Article | 2018 | Acta Orthopaedica et Traumatologica Turcica52 ( 6 ) , pp.419 - 422

Objective: The aim of this study was to evaluate the effect of the rotator cuff tear repair on subacromial space volume. Methods: We retrospectively identified 21 eligible patients (5 males and 16 females; mean age: 56.4 (range; 46–71) years) who had shoulder arthroscopy for unilateral full-thickness small to medium rotator cuff tear and normal controlateral shoulder joint. The mean follow-up time was 16.1 (range; 12–25) months. Preoperative and postoperative 1 year bilateral shoulder MRIs and Constant scores were reviewed. Subacromial volume was calculated by using Osirix software. Pre-, postoperative and healthy side (contralatera . . .l control group) subacromial volumes were recorded. Paired sample and t-tests were used to compare the pre- and postoperative groups. Independent sample t-tests were used to compare the healthy and pre- and postoperative groups. The correlation between the changes in the subacromial volume and the shoulder Constant score were analyzed using Pearson correlation analyses. Results: The mean subacromial volume of the preoperative group was 2.95 cm3 (range; 1.53–4.23) and the postoperative group was 3.59 cm3 (range; 2.12–4.84). The volume increase was statistically significant (p < 0.05). The mean subacromial volume of the control group was 3.93 cm3 (range; 2.77–5.03), and the difference between the preoperative group and the control group was statistically significant. There was no significant difference found between the postoperative group and the control group (p = 0.156). There was no significant correlation found between the volume and the constant score changes (r = 0.170, p = 0.515). Conclusion: The subacromial space volume significantly decreases in full-thickness rotator cuff tears smaller than 3 cm and the surgical repair increases the subacromial volume significantly. Level of evidence: Level IV; Diagnostic Study. © 2018 Turkish Association of Orthopaedics and Traumatolog Daha fazlası Daha az

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