Parmaksızoğlu, Fatih | Beyzadeoğlu, Tahsin

Article | 2004 | Acta Orthopaedica et Traumatologica Turcica38 ( 1 ) , pp.60 - 66

Amaç: El parmaklarının travmatik amputasyonlarmda kallus distraksiyonu ile falangeal uzatma uyguladığımız olguların sonuçları değerlendirildi. Çalışma planı: El parmaklarında travmatik amputasyon olan 13 erkek hastanın (ort. yaş 27.7; dağılım 12-43) 16 falanksı kallus distraksiyonu yöntemi ile uzatıldı. Uzatma tek taraflı dinamik eksternal fiksäsyon cihazı ile l mm/gün şeklinde uygulandı. Ortalama izlem süresi 42 ay (dağılım 12-80 ay) idi. Sonuçlar: Başparmaklarda ortalama 24 mm (dağılım 18-26 mm), diğer parmaklarda 21 mm (dağılım 18-26 mm) uzama sağlandı. Başparmaklarda oluşan yeni parmak boyu ile birinci web derinliği ve açıklığı . . .yeterli hale geldi ve elin uc-uc, uc-yan ve kaba kavramalarında fonksiyonel açıdan artış görüldü. Başparmak gücü, fleksör pollisis longusun katkısı ortadan kalktığı için, sağlam tarafın %65'ine karşılık gelecek şekilde, ortalama 7 kilogram (dağılım 5-9 kg) olarak ölçüldü. Diğer parmaklardaki uzama elin kullanım fonksiyonunu artırdı. İyileşme indeksi (l cm uzama için geçen ay sayısı), başparmaklarda ortalama 1.7 ay/cm (dağılım 1.6-2.1 ay/cm), diğer parmaklarda 1.6 ay/cm (dağılım 1.4-1.9 ay/cm) bulundu. Dört parmakta çivi dibi enfeksiyonu görüldü. Çıkarımlar: Başparmak distal falanks kayıplarında, baş parmak kısalığının yol açtığı fonksiyonel sorunların giderilmesinde, proksimal falanksa yapılan uzatma osteotomisi etkin bir rekonstrüksiyon yöntemidir. Diğer parmaklarda ise, ray rezeksiyon veya ray rezeksiyon ve transpozisyon yöntemini kabul etmeyen hastalarda uygulanabilir bir yöntemdir Objectives: We evaluated the results of lengthening of the phalanges by callus distraction in traumatic amputations of the fingers. Methods: We treated traumatic amputations of 16 fingers of 13 male patients (mean age 27.7 years; range 12 to 43 years) by callotasis of the phalanges. Callus distraction was performed with a rate of 1 mm/day using a unilateral dynamic external fixation device. The mean follow-up period was 42 months (range 12 to 80 months). Results: The mean lengthening was 24 mm (range 18 to 26 mm) and 21 mm (range 18 to 26 mm) for the thumbs and the other fingers, respectively. The achieved thumb length provided adequate depth and width of the first web space and enabled functional improvement in the ability of gripping, and pulp-to-pulp and pulp-to-side pinching, hi the absence of flexor pollicis longus, the mean strength of the thumbs was 7 kg (range 5 to 9 kg), amounting to 65% of the normal side. Lengthening of the other fingers resulted in improved functioning of the hand. The mean healing index (number of months per centimetre of lengthening) was 1.7 months/cm (range 1.6 to 2.1 months/cm) and 1.6 months/cm (range 1.4 to 1.9 months/cm) in the thumbs and the other fingers, respectively. Pin tract infections were observed in four phalanges. Conclusion: Callotasis of the proximal phalanx of the thumb is an effective reconstruction method to compensate for the loss of distal phalanx and to alleviate functional problems due to shortness. It may also be applied to the phalanges of the other fingers in patients who.,who do not accept ray resection with or without transposition Daha fazlası Daha az

Omeroglu, SN | Kirali, K | Mansuroglu, D | Goksedef, D | Balkanay, M | Ipek, G | Yakut, C

Article | 2004 | TEXAS HEART INSTITUTE JOURNAL31 ( 3 ) , pp.240 - 245

In this prospective study, the long-term effect of posterior leaflet extension with glutaraldehyde-preserved autologous pericardium and associated mitral valve commissurotomy was investigated in patients with mixed mitral valve disease of rheumatic origin. Mitral commissurotomy and posterior leaflet extension using a pericardial patch were performed in 25 patients from 1 January 7994 through 31 December 1995 for mixed mitral valve disease. Preoperatively, no patient had chordal rupture or papillary muscle dysfunction. Four patients had left atrial thrombosis. The mean age was 35.7 +/- 15.4 years. Associated procedures were tricuspid . . . annuloplasty in 4 patients, aortic annuloplasty in 3, aortic and tricuspid annuloplasty in 1, and aortic homograft replacement in 1. There were no early deaths. One patient died 2 years after surgery due to noncardiac causes. Mitral valve area increased from 1.53 +/- 0.63 cm(2) to 2 +/- 0.33 cm(2) (P = 0.09), and left atrial diameter decreased from 5.8 +/- 1 cm to 4.86 +/- 1.27 cm (P = 0.07) after 6.1 +/- 0.7 years (range, 5.5 to 71 years). Mitral insufficiency was reduced significantly, from grade 2.65 +/- 0.9 to grade 1.2 +/- 0.9 (P = 0. 007). Functional capacity improved in all patients (New York Heart Association functional class, 3 +/- 0.58 preoperatively vs 1.44 +/- 0.82 postoperatively; P = 0.001). Three patients required reoperation and valve replacement. This type of reconstruction may be a good alternative for patients who are not able to use anticoagulant therapy. Long-term results of this technique are acceptable; however, the risk of reoperation is an important disadvantage in these young patients Daha fazlası Daha az

Vickers, E.R. | Kasza, A. | Kurnaz, I.A. | Seifert, A. | Zeef, L.A.H. | O'Donnell, A. | Sharrocks, A.D.

Article | 2004 | Molecular and Cellular Biology24 ( 23 ) , pp.10340 - 10351

Members of the ternary complex factor (TCF) subfamily of the ETS-domain transcription factors are activated through phosphorylation by mitogen-activated protein kinases (MAPKs) in response to a variety of mitogenic and stress stimuli. The TCFs bind and activate serum response elements (SREs) in the promoters of target genes in a ternary complex with a second transcription factor, serum response factor (SRF). The association of TCFs with SREs within immediate-early gene promoters is suggestive of a role for the ternary TCF-SRF complex in promoting cell cycle entry and proliferation in response to mitogenic signaling. Here we have inv . . .estigated the downstream gene regulatory and phenotypic effects of inhibiting the activity of genes regulated by TCFs by expressing a dominantly acting repressive form of the TCF, Elk-1. Inhibition of ternary complex activity leads to the downregulation of several immediate-early genes. Furthermore, blocking TCF-mediated gene expression leads to growth arrest and triggers apoptosis. By using mutant Elk-1 alleles, we demonstrated that these effects are via an SRF-dependent mechanism. The antiapoptotic gene Mcl-1 is identified as a key target for the TCF-SRF complex in this system. Thus, our data confirm a role for TCF-SRF-regulated gene activity in regulating proliferation and provide further evidence to indicate a role in protecting cells from apoptotic cell death Daha fazlası Daha az

Sinmazişik, G. | Tirakyali, G. | Gülmez, T. | Akesi, S.

Conference Object | 2004 | Key Engineering Materials264-268 ( III ) , pp.2067 - 2070

For the In-Ceram™ system, the core needs to be sintered on a special plaster model and fired two times, first for 6 hours and then 2 more hours. In the fabrication of single piece jacket crowns with VITA In-Ceram™ sprint system, this time is reduced to 40 minutes. In this study by using the VITA In-Ceram™ sprint system, the pontic and crowns were prepared separately and these were connected to each other by a second sintering and glass infiltration procedure in order to decrease the firing time. The effects of this procedure on the fracture strength of the bridge prosthesis were investigated by 4-point bending tests on standard samp . . .les representing the pontic and crowns of a bridge prosthesis. Three different sample groups were prepared for the 4-point bending tests : a control group consisting of monolithic samples, a second group comprising separate samples with a connect distance of 1.5 mm and a third one having a connect distance of 1 mm. Whereas the control group had better bending strength values,there were no statistically significant differences between the strength values of the specimens of the other two groups. Scanning Electron Microscopy investigations were carried out to examine the fracture surfaces of the bending specimens Daha fazlası Daha az

Köse, G.T. | Hasirci, V.

Conference Object | 2004 | Advances in Experimental Medicine and Biology553 , pp.317 - 329

[No abstract available]

Başgut, B. | Ademoglu, F. | Gürsoy, G. | Çakici, I. | Abacioglu, N.

Article | 2004 | Fabad Journal of Pharmaceutical Sciences29 ( 3 ) , pp.127 - 132

The aim of the present study was to investigate the effect of melatonin on the isolated rat anococcygeus muscle (RAM). The RAM was isolated as described by Gillespie 1971. The muscles were mounted in an organ bath containing modified Krebs-Henseleit solution at 37°C and, changes in the tension due to the precontractile agents and melatonin were measured by isometric force displacement transducers. Although cumulative addition of melatonin (10 -10-10-3 M) produced no effect on the basal tone of the anococcygeus muscle, it caused an inhibitory action on the muscle pre-contracted by KCl (70 mM) and phenylephrine (1.7×10-6 M). In the so . . .dium fluoride (NaF) (3×10-3 M)-precontracted muscles, melatonin (10-5-10-3 M)-induced maximum relaxation was found higher than that obtained in phenylephrine or KCl-precontracted RAM. Incubation with phorbol myristate acetate (PMA (10-10-10-4 M) an activator of protein kinase C) produced no effect on the resting or precontracted muscle. In conclusion, the inhibitory effect of melatonin might be related to the G-protein mediated pathways, but not to protein kinase C Daha fazlası Daha az

Ghodoossi, L. | Egrican, N.

Article | 2004 | Energy Conversion and Management45 ( 6 ) , pp.811 - 828

https://hdl.handle.net/20.500.11831/2229

Saritas, O | Oner, MA

Article | 2004 | TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE71 ( 01.02.2020 ) , pp.27 - 65

This paper proposes a new systems approach to foresight studies. The paper will first indicate the complex and conflicting nature of long-term decision-making process. Then, the need for systems approach will be highlighted by the analysis of 1995 UK Delphi survey results and the scenarios of 2000 UK foresight scenarios. The paper proposes two methodologies, namely Integrated Management Model (IMM) and Roadmapping, in order to overcome challenges introduced by the multidimensional characteristics and complex nature of foresight studies. Based on systemic approach, HAM offers a useful way of developing long-term normative policies an . . .d strategies and their transformations into actions by considering necessary changes in organizational structures and behaviors. In addition, roadmapping is used to capture, manipulate and manage information to decrease complexity in the foresight by constructing roadmaps. In the paper, IMM and roadmapping are employed first to analyze UK foresight results and then to develop a new methodology to formulate Delphi events and scenarios for the successful implementation of foresight. This paper also promotes the integrated use of foresight techniques such as scenarios and Delphi rather than one for another. (C) 2003 Elsevier Inc. All rights reserved Daha fazlası Daha az

Guner, ES | Watanabe, M | Hashimoto, N | Kadosaka, T | Kawamura, Y | Ezaki, T | Masuzawa, T

Article | 2004 | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY54 , pp.1649 - 1652

Previously, a novel, fast-growing spirochaete was isolated from the hard tick Hyalomma aegyptium, which infests tortoises (Testudo graeca), by using Barbour-Stoenner-Kelly (BSK) II medium; the tick samples were taken from the Istanbul area in northwestern Turkey [Goner et al. (2003). Microbiology 149, 2539-2544]. Here is presented a detailed characterization of the spirochaete. Electron microscopy revealed that strain IST7(T) is morphologically similar to other spirochaetes of the genus Borrelia and possesses 15 to 16 flagellae that emerge from both polar regions. PFGE analysis revealed the genome to comprise a linear chromosome of . . .approximately 1 Mb; two large linear plasmids of approximately 145 and 140 kb, and several small plasmids ranging from 50 to 20 kb in size were also found. The 16S rRNA gene sequence of this Borrelia isolate exhibited 99.4 to 99(.)8% identity with other strains isolated from H. aegyptium and less than 99 similarity with those of other Borrelia species. A phylogenetic tree, generated from 16S rRNA gene sequences, demonstrated that the spirochaete isolates from H. aegyptium clustered together and branched off from both Lyme-disease-related and relapsing-fever-associated Borrelia species. A single copy of the rrs gene was detected in the genome of strain IST7(T) by Southern hybridization. DNA-DNA hybridization results showed that strain IST7(T) was distinct from Lyme-disease-related Borrelia, Borrelia burgdorferi and the relapsing-fever-associated species Borrelia hermsii. The G+C content of strain IST7(T) is 30.0 mol%. From these genetic features, a novel Borrelia species, Borrelia turcica sp. nov., is proposed; the type strain is IST7(T) (=JCM 11958(T)=DSM 16138(T)) Daha fazlası Daha az

Bayrakçeken, Fuat

Article | 2004 | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy60 ( 13 ) , pp.3033 - 3036

High resolution S0 › Sn and T1 › Tn electronic absorptions and B-type delayed fluorescence of 1,2,7,8-dibenzanthracene in polymethylmethacrylate (PMMA) were experimentally observed by flash and laser flash photolysis technique. Dibenzanthracene molecules were excited in a two-step process. In the first step, an excited singlet is created, which undergoes intersystem crossing to triplet state, then T-T absorption creates an excited triplet dibenzanthracene molecule, which returns to the first excited singlet level by intersystem crossing. The re-created first excited singlet of dibenzanthracene decays back to the ground state by emit . . .ting B-type of delayed fluorescence, which was observed at the same emission band of prompt (normal) fluorescence, and R-, E-, P-types of delayed fluorescences. For normal fluorescence, S1 state is decaying to S0 ground state. For E- and P-type of delayed fluorescences, T 1 state is decaying to S0 via S1 state, and for B-type of delayed fluorescence, T2 state is decaying to S 0 via S1 state. © 2004 Elsevier B.V. All rights reserved Daha fazlası Daha az

Kurnaz, I.A.

Article | 2004 | Biotechnology and Bioengineering88 ( 7 ) , pp.890 - 900

Immediate early gene activation upon mitogenic activation occurs through the serum response element (SRE), which makes the delineation of the upstream pathways a powerful means to engineer cellular responses. The malfunctioning of this system leads to a variety of disorders, ranging from neurological disorders such as Coffin-Lowry syndrome (RSK2 mutations) to cancer (c-fos mutations). We therefore investigated the SRE activation mechanism in a typical mammalian cell. Mitogenic signaling uses the mitogen-activated protein kinase (MARK) module through increased binding of the ternary complex factor (TCF), such as Elk-1, to the promote . . .r DNA (the SRE element) and subsequent transcriptional activation, as well as through activation of a histone kinase, such as the MAPK-activated protein kinase (MAPKAP-K) ribosomal S6 kinase (RSK2). This computational model uses the biochemical simulation environment GEPASI 3.30 to investigate three major models of interaction for Elk-1 and RSK2, and to study the effect of histone acetyl transferase (HAT) recruitment in each of these models on the local chromatin modifications in the presence and absence of MAPK activation. We show that the quickest response on the chromatin can be achieved in the presence of a preformed complex of RSK2, Elk-1 and HAT, with HAT being activated upon dissociation from the complex upon activation of the MAPK cascade. This study presents critical components in the pathway that can be targeted for engineering of specific inhibitors or activators of the system. © 2004 Wiley Periodicals, Inc Daha fazlası Daha az

Ünsalan, Cem | Boyer, K.L.

Article | 2004 | IEEE Transactions on Geoscience and Remote Sensing42 ( 4 ) , pp.907 - 919

We introduce a set of measures based on straight lines to assess land development levels in high-resolution (1 m) panchromatic satellite images. Most urban areas locally (such as in a 400 × 400 m2 area) exhibit a preponderance of straight-line features, generally appearing in fairly simple quasi-periodic organizations. Wilderness and rural areas produce line structures in more random spatial arrangements. We use this observation to perform an initial triage on the image to restrict the attention of subsequent more computationally intensive analyses. Statistical measures based on straight lines guide the analysis. We base these measu . . .res on length, contrast, orientation, periodicity, and location. On these, we trained and tested parametric and non-parametric classifiers. These tests were for a two-class problem (urban versus rural). However, because our ultimate goal is to extract residential regions, we then extended these ideas to address the detection of suburban regions. To do so, some use of spatial coherence is required; suburban regions are especially difficult to detect. Therefore, we introduce a decision system to perform suburban region classification via an overlapping voting method for consensus discovery. Our data were taken from regions all around the world, which underscores the robustness of our approach. Based on extensive testing, we can report very promising results in distinguishing developed areas Daha fazlası Daha az