Altan-Atalay, A. | Kızılöz, B.K. | Dönger, İ. | Demiray, D.

Article | 2020 | Journal of Psychopathology and Behavioral Assessment

Rumination, which is a form of repetitive negative thinking, has been suggested as a variable associated with elevated risks for depression. Current research conceptualizes rumination as a dispositional entity but has neglected its more state-based forms, which may also be equally related to emotional disorders. Brief State Rumination Inventory (BSRI) is a psychometrically sound measure of state rumination, demonstrated to be sensitive to situational changes in rumination. The current study aims to examine the psychometric characteristics of the Turkish form of BSRI. Results of the first study replicated the single factor structure . . .of the original version of BSRI in a group of 192 Turkish speaking adults between ages 18 and 65. Moreover, the Turkish version of BSRI yielded satisfactory levels of internal consistency and construct validity indicated by significant associations with measures of repetitive negative thinking, avoidant coping, and psychological distress. Study 2 examined the sensitivity of BSRI to momentary changes in rumination to assess the criterion validity of the Turkish form of BSRI, by examining its sensitivity to a rumination induction procedure in 66 university students (39 women). Together, these results suggest that the Turkish version of BSRI is a psychometrically reliable tool which is appropriate for the assessment of state rumination in Turkish speaking populations. © 2020, Springer Science+Business Media, LLC, part of Springer Nature Daha fazlası Daha az

Topcuoglu, ED | Topcuoglu, OM | Oysu, AS | Bukte, Y

Article | 2020 | JOURNAL OF MAGNETIC RESONANCE IMAGING

Background Accumulation of macrocyclic gadolinium agents in children's brains remain to be determined. Purpose To demonstrate whether there is an intracranial macrocyclic gadolinium deposition after multiple contrast-enhanced MRI with gadoterate meglumine in a pediatric population. Study Type Retrospective case-control. Population In all, 45 children (age range: 5-17 years; mean, 13.7 +/- 3.4 years) for the study group and 45 healthy children (age range: 5-17 years; mean, 13.7 +/- 3.4 years) for the control group. Field Strength/Sequence T-1- and T-2-weighted axial images on a 1.5T scanner. Assessment Children with at least three en . . .hanced brain MRIs and an age- and sex-matched control group with an unenhanced brain MRIs were compared in terms of T-1 signal intensity (SI). All patients in the study group received gadoterate meglumine intravenously (0.1 mmol/kg). SI measurements were made by drawing six regions of interest (ROIs): dentate nuclei (DN), pons, globus pallidi (GP), frontal white matter (FWM), thalamus (T), clivus, and cerebrospinal fluid (CSF) for both groups on unenhanced T-1-weighted images. Statistical Tests Student's t-test was used for comparison of SI. The Pearson correlation was calculated for the correlation between the SI and the number of gadolinium administrations. Results A significant difference was detected between two groups for DN/CSF, pons/CSF, GP/CSF, thalamus/CSF, and FWM/CSF (P < 0.001, P < 0.001, P = 0.002, P = 0.002, P = 0.024, respectively). There was no significant difference between the two groups for clivus/CSF (P = 0.15). A good correlation between the number of gadoterate meglumine administrations and the SI for DN/CSF, pons/CSF, GP/CSF, and T/CSF (r = 0.80, r = 0.73, r = 0.91, and r = 0.90, respectively) was found. Data Conclusion A significant T-1 SI increase reflecting gadolinium retention in the brain was detected for children with at least three gadoterate meglumine administrations in this series. The number of administrations correlated well with the increased SI. Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019 Daha fazlası Daha az

Maroufi, N.F. | Vahedian, V. | Mazrakhondi, S.A.M. | Kooti, W. | Khiavy, H.A. | Bazzaz, R. | Sabzichi, M.

Article | 2020 | Naunyn-Schmiedeberg's Archives of Pharmacology393 ( 1 )

The harmful dose-dependent side effects of chemotherapy drugs have caused the discovery of novel perspective to evaluate chemotherapy protocols. In this study, the potential application of Compritol was investigated as a major scaffold into nanostructured lipid careers to highlight myricetin efficiency in treatment of breast cancer cells along with codelivery of docetaxel (DXT). Characterization of myricetin-loaded NLCs was carried out by measuring the particle size and zeta potential, using the scanning electron microscopy. MTT, DAPI staining, flow cytometric, and RT-PCR (real-time) assays were used to recognize novel formulation b . . .ehavior on cell cytotoxicity as well as recognizing molecular mechanism of formulation concerning apoptosis phenomenon. Myricetin-loaded NLCs reduced the cell viability from 50 ± 2.3 to 40 ± 1.3% (p < 0.05). Percentage of apoptosis improved with combination treatment of myricetin-loaded NLCs and DXT in the MDA-MBA231 breast cancer cells. Expression of antiapoptotic genes (survivin, Cyclin B1, and Mcl1) indicated a significant reduction in factor along with increment in proapoptotic factor Bax and Bid mRNA rates. Overall, our results represented that the NLC delivery system could be a promising strategy to enhance the effect of anticancer agents such as DXT on breast cancer. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature Daha fazlası Daha az

Yılmaz, H. | Cobandede, Z. | Yılmaz, D. | Cinkilic, A. | Çulha, Mustafa | Demiralay, E.C.

Article | 2020 | Talanta214

Potential degradation products (DPs), even in small concentrations, can cause changes in pharmacological and toxicological properties of a drug with a significant impact on product quality and safety. Thus, their stability and understanding of possible degradation mechanisms have a significant importance. Although liquid chromatography is the conventional technique used for forced degradation studies with excellent accuracy and reproducibility, the main disadvantages of the technique are being expensive and time-consuming. As a powerful technique, surface-enhanced Raman scattering (SERS) can be an alternative with its high sensitivi . . .ty, easy sample preparation and low cost. In this study, the degradation of both tofacitinib (TOF), a Janus kinase inhibitor, and methotrexate (MTX), an inhibitor of tetrahydrofolate dehydrogenase, are studied using SERS under hydrolytic, oxidative and thermal conditions using mesoporous silica coated silver nanoparticles (Si@AgNPs) as SERS substrates. The study demonstrated that the degradation of the tested drugs using Si@AgNPs as SERS substrates could be monitored through the spectral changes on SERS spectra of drugs under several degradation conditions. © 2020 Elsevier B.V Daha fazlası Daha az

Aklan, I. | Sayar Atasoy, N. | Yavuz, Y. | Ates, T. | Coban, I. | Koksalar, F. | Atasoy, D.

Article | 2020 | Cell Metabolism31 ( 2 ) , pp.313 - 32600000

Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nu . . .cleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia. © 2019 Elsevier Inc.Increased appetite is a key line of defense against hypoglycemia. Aklan et al. have identified an ascending pathway from the brainstem to the hypothalamus that is required for hypoglycemia-induced food intake. © 2019 Elsevier Inc Daha fazlası Daha az

Yilmaz, A. | Unal, G.

Article | 2020 | International Journal of Modern Physics C , pp.313 - 32600000

We propose a new method as an extension of the correlation dimension analysis by combining it with multiscale analysis taking into consideration the features in multiple time scales. We introduce and demonstrate multiscale correlation dimension analysis (MSCD) on several chaotic and stochastic time series in detail. We also study the choice of effective scaling filter as an alternative to the overlapping coarse-graining procedure we used for MSCD analysis and suggest the Gaussian filter according to its favorable performance and experiment it by assigning it for the second part of the study. Based on MSCD analysis, we further invest . . .igate CD and Hurst exponent relationship in multiscale on the same set of time series. We unveil a remarkable consistent patterns for the stochastic time series and describe it in a functional form. Consequently, the observed distinguishing patterns imply to opening up a new way of characterizing chaotic and stochastic time series. © 2020 World Scientific Publishing Company Daha fazlası Daha az

Farooqi, A.A. | Adylova, A. | Sabitaliyevich, U.Y. | Attar, Rukset | Sohail, M.I. | Yilmaz, S.

Review | 2020 | Gene737 , pp.313 - 32600000

There has always been a quest to search for synthetic and natural compounds having premium pharmacological properties and minimum off-target and/or side effects. Therefore, in accordance with this approach, scientists have given special attention to the molecules having remarkable ability to target oncogenic protein network, restore drug sensitivity and induce apoptosis in cancer cells. The mechanisms through which general anesthetics modulated wide-ranging deregulated cell signaling pathways and non-coding RNAs remained unclear. However, rapidly accumulating experimentally verified evidence has started to resolve this long-standing . . . mystery and a knowledge about these important molecular targets has surfaced and how these drugs act at the molecular level is becoming more understandable. In this review we have given special attention to available evidence related to ability of propofol to modulate Wnt/ß-catenin, JAK/STAT and mTOR-driven pathway. Excitingly, great strides have been made in sharpening our concepts related to potential of propofol to modulate non-coding RNAs in different cancers. Collectively, these latest findings offer interesting, unexplored opportunities to target deregulated signaling pathways to induce apoptosis in drug-resistant cancers. © 2020 Elsevier B.V Daha fazlası Daha az

Şişli, H.B. | Hayal, T.B. | Seçkin, S. | Şenkal, S. | Kıratlı, B. | Şahin, Fikrettin | Doğan, A.

Book Part | 2020 | Advances in Experimental Medicine and Biology1237 , pp.17 - 28

The identification of human embryonic stem cells and reprogramming technology to obtain induced pluripotent stem cells from adult somatic cells have provided unique opportunity to create human disease models, gene editing strategies and cell therapy options. Development of pluripotent stem cells from somatic cells and genomic manipulation tools enabled to use site specific nucleases in the cell therapy research. Identification of efficient gene manipulation, safe differentiation and use will provide a novel strategy to treat many diseases in the near future. Current available registered clinical trials clearly indicate the need for . . .pluripotent stem cell and gene therapy treatment options. Although gene editing based pluripotent stem cell research is a popular field for research worldwide, improvement of clinical approaches for treatment still remains to be investigated. In this review, we summarized the current situation of gene editing based pluripotent cell therapy developments and applications in clinics. © Springer Nature Switzerland AG 2019 Daha fazlası Daha az

Ozkaya, M. | Erata, F.

Article | 2020 | Information and Software Technology121 , pp.17 - 28

Context: Software architecture viewpoints modularize the software architectures in terms of different viewpoints that each address a different concern. Unified Modeling Language (UML) is so popular among practitioners for modeling software architectures from different viewpoints. Objective: In this paper, we aimed at understanding the practitioners’ UML usage for the modeling of software architectures from different viewpoints. Method: To this end, 109 practitioners with diverse profiles have been surveyed to understand practitioners’ UML usage for six different viewpoints: functional, information, concurrency, development, deployme . . .nt, and operational. Each viewpoint has been considered in terms of a set of software models that can be created in that viewpoint. Results: The survey includes 35 questions for different viewpoint models, and the results lead to interesting findings. While the top popular viewpoints for the UML-based software architecture modeling are the functional (96%) and information (99%) viewpoints, the least popular one is the operational viewpoint that is considered by 26% of the practitioners. The top popular UML modeling tool is Enterprise Architect regardless of the viewpoints considered. Concerning the software models that can be created in each viewpoint, UML's class diagram is practitioners’ top choice for the functional structure (71%), data structure (85%), concurrency structure (75%), software code structure (34%), and system installation (39%), and system support (16%) models; UML's sequence diagram is the top choice for the data lifecycle models (47%); UML's deployment diagram for the physical structure (71%), mapping between the functional and physical components (53%), and system migration (21%) models; UML's activity diagram for the data flow (65%), software build and release processes (20–22%), and system administration (36%) models; UML's component diagram for the mapping between the functional and concurrent components (35%), software module structure (47%), and system configuration (21%) models; and UML's package diagram for the software module structure (47%) models. © 2020 Elsevier B.V Daha fazlası Daha az

Akinalan Balik, B. | Argin, S.

Article | 2020 | Journal of Applied Polymer Science137 ( 3 ) , pp.17 - 28

Characterizing the parameters critical to the prediction of a successful electrospinning process from solution properties is essential, yet, not easy in the case of biopolymers. In this study, we attempted to present a broad perspective by simultaneously evaluating the effect of eight different parameters, namely zero shear viscosity, tip viscosity, elastic modulus, phase angle, cohesive energy, pH, conductivity, and surface tension, on the formation of smooth pectin nanofibers. Our results showed that (1) the viscosity of the solution is not an indication of jet formation, but once the jet is formed, high zero shear viscosity and h . . .igh tip viscosity are required to maintain a dominant whipping instability for smooth nanofiber formation and (2) while evaluating the elasticity of the spinning solutions, comparing only the elastic modulus values would be misleading, since low phase angle values are also necessary for pectin solutions to be electrospun into nonbeaded fibers. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48294. © 2019 Wiley Periodicals, Inc Daha fazlası Daha az

O. Kaya | E. Orhan | M. Sapmaz-Metin | Y. Topçu-Tarladaçalışır | Ö. Gündüz | B. Aydın

Article | 2020 | Dermatologic Therapy33 ( 1 ) , pp.17 - 28

After burns, protecting tissues by medicines in the zone of stasis reduces the width and depth of injury. This study's goal was to reduce burned tissue damage in the zone of stasis using epidermal growth factor (EGF). Forty-eight Wistar rats were separated into three groups. In all groups, the burn procedure was applied following the comb burn model. In Group 1, no postburn treatment was administered. In Group 2, physiological saline solution (0.3 cc) was injected intradermally and in Group 3, EGF (0.3 cc) was injected intradermally into stasis zone tissues after the burn procedure. Surviving tissue rates were 24.0% in Group 1, 25.3 . . .% in Group 2, and 70.2% in Group 3. The average numbers of cells stained with Nrf2, HO-1, and the number of apoptotic cells were 230, 150, and 17.5 in Group 1, 230, 145, and 15.0 in Group 2, and 370, 230, and 0 in Group 3, respectively. Values in Group 3 were found to be statistically significantly different than those of Groups 1 and 2; there was no difference between Groups 1 and 2. This study shows that EGF protects zone of stasis tissue from burn damage. © 2019 Wiley Periodicals, Inc Daha fazlası Daha az

Selvi-Kuvvetli, S. | Turan, B.S. | Bayrak, G.D. | Noyan, A.

Article | 2020 | Pediatric Dental Journal , pp.17 - 28

Objective: To evaluate the effects of administration of 1 mg·kg-1 propofol before the end of surgery on the haemodynamic values and incidence of emergence delirium in paediatric dental patients retrospectively. Methods: Ninety-seven children aged between 2 and 12 who were treated under general anaesthesia in Yeditepe University Faculty of Dentistry were included. Midazolam for premedication and intravenous propofol for induction and isoflurane for maintenance of anaesthesia were used. One mg·kg-1 propofol was administered before extubation and 15 min before the end of surgery. The monitorized haemodynamic values including heart rate . . ., oxygen saturation in periferic circulation, CO2 in expirium and body temperature were collected from patient files. The level of emergence delirium was measured using the Pediatric Anaesthesia Emergence Delirium Scale. Results: Thirty-nine girls and fifty-eight boys (5.21 ± 2.32) were investigated. A statistically significant increase was found in the mean heart rate during induction and end of intubation. Expired CO2 significantly increased after the end of intubation and decreased at the end of anaesthesia. According to the Pediatric Anaesthesia Emergence Delirium Scale none of the patients were scored as emergence delirium and 52,78% of the children were scored as 0. Conclusions: When administration of single dose of propofol is used for the prevention of Emergence Delirium, constant monitoring of expired CO2 values during and after the end of intubation is essential. It can be suggested that administration of a single dose of 1 mg·kg-1 propofol prevents emergence delirium in paediatric dental patients; nevertheless this finding should be confirmed with prospective clinical trials. © 2020 Japanese Society of Pediatric Dentistr Daha fazlası Daha az