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Association of vitamin D receptor gene polymorphisms with colon cancer

Gündüz, M. | Cacina, C. | Toptaş, B. | Yaylim-Eraltan, I. | Tekand, Y. | İşbir, Turgay

Article | 2012 | Genetic Testing and Molecular Biomarkers16 ( 9 ) , pp.1058 - 1061

Objective: In this study, we investigated the association of two vitamin D receptor (VDR) polymorphisms BsmI and TaqI with colon cancer in a Caucasian population. Methods: The VDR gene polymorphisms BsmI and TaqI were detected by polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP)-genotyping assays by using endonucleases BsmI and TaqI, and an agarose gel electrophoresis technique in a series of 43 colon cancer patients and 42 healthy controls. Results: Allele frequencies and genotype distributions were found to be similar in both cases and controls. When homozygous carriers and heterozygotes were combine . . .d for each allele, alleles B and T were found to be more common in the control group (p=0.039, ?2=4.276, odds ratio [OR]=0.312, 95% confidence interval [CI]=0.100-0.973 and p=0.039, ?2=4.258, OR=0.254, 95% CI=0.064-1.000, respectively). When genotypes were analyzed as pairs, the Bb/TT variant was higher in the control group at a statistically high significance (p=0.001, ?2=11.854, OR=0.122, 95% CI=0.032-0.460). Conclusion: The alleles B and T and the genotype combination Bb/TT were found to be higher in the control group, and thus BsmI and TaqI polymorphisms of the VDR gene may be possible risk factors for colorectal carcinogenesis. © 2012 Mary Ann Liebert, Inc Daha fazlası Daha az

Association of the Cylin D1 G870A Polymorphism with Laryngeal Cancer: Are they Really Related?

Verim, A. | Ozkan, N. | Turan, S. | Korkmaz, G. | Cacina, C. | Yaylim, I. | İşbir, Turgay

Article | 2013 | Asian Pacific Journal of Cancer Prevention14 ( 12 ) , pp.7629 - 7634

Background: Cylin D1(CCDN1) is an important regulator of the cell cycle whose alterations are thought to be involved in cancer development. There have been many studies indicating CCDN1 amplification or overexpression in a variety of cancer types. In addition to gene amplification, the G870A polymorphism may be related with altered CCDN1 activity, and therefore with cancer development. This hypothesis has been tested in different cancer types but results have been contradictory. We therefore aimed to investigate any relationship between CCDN1 A870G genotypes and laryngeal squamous cell cancer development and progression. Materials a . . .nd Methods: A total of 68 Turkish patients with primary laryngeal squamous cell cancer and 133 healthy controls were enrolled. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to determine the CCDN1 genotypes. Results: No significant association was detected between CCDN1 genotypes and laryngeal squamous cell cancer (LxSCCa) development. Similarly CCDN1 genotypes were not related to clinical parameters of Lx SCCa. However, there was a very significant association between CCDN1 G allele and presence of perineural invasion (p= 0.003; OR: 1.464; CI% 1.073-1.999). CCDN1 G allele frequency was significantly higher in the individuals with perineural invasion (85.7%) when compared to those without (58.5%). The 2 patients who died of disease were both found to possess the GG genotype. Conclusions: These results pose a controversy in suggesting a protective role of the G allele against LxSCCa development and support the association of CCDN1 gene GG genotype with mortality in patients with LxSCCa Daha fazlası Daha az

DNA Repair Based Therapy in Oncology and Neurodegeneration

İşbir, Turgay | Gormus, U | Timirci-Kahraman, O | Ergen, A | Dalan, AB | Gulec-Yılmaz, S | Atasoy, H

Article | 2015 | ADVANCES IN DNA REPAIR , pp.405 - 412


Attar, R | Attar, E | Yaylim-Eraltan, I | Yılmaz-Aydogan, H | Agachan, B | İşbir, Turgay

Conference Object | 2009 | IUBMB LIFE61 ( 3 ) , pp.371 - 372

Apolipoprotein E Genotypes in Patients with Prostate Cancer

Yencilek, F. | Yilmaz, S.G. | Yildirim, A. | Gormus, U. | Altinkilic, E.M. | Dalan, A.B. | İşbir, Turgay

Article | 2016 | Anticancer research36 ( 2 ) , pp.707 - 711

BACKGROUND: Apolipoprotein E (ApoE) is a potential inhibitor of cell proliferation, immune regulation and modulation of cell growth and differentiation; it also has a substantial role in antioxidant activity. ApoE has a potential role in prostate cancer progression.MATERIALS AND METHODS: ApoE genotyping was performed using real-time polymerase chain reaction (RT-PCR) for blood samples from a group of patients with prostate cancer (n=68) and a control group (n=78).RESULTS: The frequency of the E3/E3 genotype was significantly higher in patients compared to controls (p=0.004). E3/E3 genotype carriers were 3.6-fold more likely to be pa . . .tients than controls (odds ratio=3.67, 95% confidence interval=1.451-9.155; p=0.004). Additionally, the patients with E3/E3 genotype had significantly higher Gleason score (p=0.017), and more patients with this genotype had a Gleason score higher than 7 (p=0.007). Individuals carrying the E4 allele were significantly more common in the control group (p=0.006). The frequency of the E3/E4 genotype was found to be significantly higher in controls compared to patients (p=0.007), and patients were significantly less likely to have this genotype than controls (odds ratio=0.89, 95% confidence interval=0.833-0.967, p=0.007). Individuals carrying the E2/E3 genotype had a significantly lower Gleason score (p=0.049)-all of the patients with this genotype had a Gleason score lower than 7 (p=0.024).CONCLUSION: E3/E3 genotype may be a potential risk factor for prostate cancer and high Gleason scoring. The E4 allele maybe a risk-reducing factor for prostate cancer. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved Daha fazlası Daha az

Tumor Necrosis Factor-Alpha (TNF-alpha-308G > A) Polymorphism in High-grade Gliomas

Ozdogan, S | Yaltirik, CK | Yılmaz, SG | Kaya, M | Duzkalir, AH | Demirel, N | İşbir, Turgay

Article | 2018 | IN VIVO32 ( 2 ) , pp.287 - 289

Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligo-dendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-alpha -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There . . . were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities Daha fazlası Daha az


Attar, R | Agachan, B | Kucukhuseyin, O | Toptas, B | Ergen, HA | Attat, E | İşbir, Turgay

Conference Object | 2009 | IUBMB LIFE61 ( 3 ) , pp.372 - 372


Findik, O | Eruyar, AT | Kunt, AT | Yılmaz, SG | Isbir, S | Parlar, H | İşbir, Turgay

Conference Object | 2016 | THROMBOSIS RESEARCH141 , pp.372 - 372

Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cance

Yılmaz, SG | Yencilek, F | Yildirim, A | Yencilek, E | İşbir, Turgay

Article | 2017 | IN VIVO31 ( 2 ) , pp.205 - 208

Background: Prostate cancer is one of the most common solid tumors and the second leading cause of the death due to malignancy in men. Caspase 9 (CASP9) is a member of the intrinsic pathway and plays a central role in the apoptosis. Patients and Methods: Genotyping of the CASP9 (rs1052576) polymorphism were performed using real-time polymerase chain reaction for blood samples of prostate cancer patients (n=69) and controls (n=76). Results: There were no significant differences between the groups in the frequency of CASP9 genotypes (chi 2 = 1.363; p=0.506). Patients with CASP9 (rs1052576) CT genotype were 12.8 fold higher in patholog . . .ical stage of pT2a compared to any other stages of cancer (OR=0.078, 95% CI= 0.009-0.062; p=0.004). Also TT genotype carriers were 11.3 times lower in pathological stage of pT2a (OR=11.33, 95% CI= 2.39-53.748; p=0.000). C allele carriers were 11.36 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.088, 95% CI= 0.019-0.418; p=0.002). Conclusion: CASP9 (rs1052576) C allele was decreasing the risk for pathological stage of patients with prostate cancer and also CT genotype had positive impact on pathological stage of patients with prostate cancer. CASP9 (rs1052576) TT genotype was seemed to be associated with higher risk of pathological stage. Those results implicated that CASP9 variations could be associated with severity of prostate cancer Daha fazlası Daha az

The CYBA A649G Polymorphism Frequency in Coronary Heart Disease Patients

Gultekin, GI | Kahraman, OT | Hekimoglu, BT | Kucukhuseyin, O | Ceviz, AB | Dalan, AB | İşbir, Turgay

Conference Object | 2015 | ACTA PHYSIOLOGICA215 , pp.100 - 100

Paraoxonase-1 192/55 polymorphisms and the risk of lung cancer in a Turkish population

Aksoy-Sagirli, P. | Cakmakoglu, B. | İşbir, Turgay | Kaytan-Saglam, E. | Kizir, A. | Topuz, E. | Berkkan, H.

Article | 2011 | Anticancer Research31 ( 6 ) , pp.2225 - 2229

Aim: The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population. Materials and Methods: A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192/55 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Distribution of PONl 192 R (+) genotype was found to be significantly higher in patients with LC compared to the controls (odds ratio: 1.497, 95% . . . confidence interval: 1.034-2.166). This difference was especially noteworthy in patients with small cell carcinoma and squamous cell carcinoma. Conclusion: This is the first case-control study on the association between PON1 polymorphisms and LC susceptibility in a Turkish population. Our results suggest that PON1 192 polymorphsim is associated with an increased risk of LC in the Turkish population and may be a useful genetic marker for small cell and squamous cell carcinoma Daha fazlası Daha az

Comparison of Lipid Profiles with AP0A1 MspI Polymorphism in Obese Children with Hyperlipidemia

Toptas, B | Gormus, U | Ergen, A | Gurkan, H | Kelesoglu, F | Darendeliler, F | İşbir, Turgay

Article | 2011 | IN VIVO25 ( 3 ) , pp.425 - 430

Background: Obesity is a multifactorial, chronic disorder leading. to adverse metabolic effects on plasma lipid levels. Apolipoprotein AI (Apo AI) is the major structural component of high-density lipoprotein (HDL) and is involved in the esterification of cholesterol as a cofactor of lecithin-cholesterol acyltransferase (LCAT) and thus plays a major role in cholesterol efflux from peripheral cells. The APOA1 gene is associated with changes in lipid metabolism. A common gene polymorphism described in the APOA1 promoter region consists of the exchange of guanine (G) for adenine (A) at a position -75 bp upstream of the transcription or . . .igin. The relationship between lipid levels in obese children and the APOA1 MspI polymorphisms, was examined. Materials and Methods: Three separate groups were included, the patient group of obese children with hyperlipidemia; the obese control group (control group I) consisted of obese children without hyperlipidemia: and the healthy control group (control group II) contained healthy children with neither hyperlipidemia nor obesity. The related gene segments were amplified by polymerase chain reaction and determined different patterns were determined using denaturating gradient gel electrophoresis and positive results were confirmed automatic sequence analysis. All the results were analyzed by Proseq and BioEdit computer programmes. Results: The A allele was found to be more frequent in control group I compared to the patient group (p=0.035). Very low-density lipoprotein (VLDL), LDL and triglyceride (TG), levels were statistically higher in the patients carrying the GA genotype than in control group I. and body mass index (BMI), VLDL and TG levels were statistically higher than in control group II (p0.05). Additionally, according to the -75 GA genotypes, those in control group I with the GA genotype had elevated total cholesterol levels compared to those with the GG genotype ( Daha fazlası Daha az

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