Parildar, H. | Serter, R. | Yeşilada, Erdem

Review | 2011 | Journal of the Pakistan Medical Association61 ( 11 ) , pp.1116 - 1120

This study reports a literature review aimed to analyse various studies related to the use of phytotherapy in diabetes mellitus in Turkey in order to provide additional information for healthcare professionals. The incidence of Diabetes Mellitus is rising and many of the diabetics frequently use herbal treatments along with modern medical treatment for glycaemic control and/or improve their well-being. Several electronic databases (such as Medline and Pubmed) were searched for 1990-2010 period (till May, 2010) and 33 related articles were analysed. Many studies-mostly animal trials- have been conducted in this field. Among the herbs . . . most-commonly used along with modern medical therapies and also in folkloric medicine, we searched for bitter melon, cinnamon, fenugreek, olive leaf, black seed and white mulberry. Studies conducted in this field have produced conflicting results and, the necessity to conduct randomized, placebo-controlled clinical human studies to develop new drugs from herbs, as in the case of metformin, still remains important. Besides, further studies are required to address the issues of standardization and quality control of existing preparations. More importantly, healthcare professionals caring for diabetic patients need to be aware of phytotherapy to incorporate phytomedicine into their practices and should undertake more responsibility in relation to these kind of therapies that are commonly-used throughout the world Daha fazlası Daha az

Bardakci Altan, H. | Akaydin, G. | Kirmizibekmez, H. | Yeşilada, Erdem

Article | 2014 | Turkish Journal of Pharmaceutical Sciences11 ( 3 ) , pp.245 - 254

Rosmarinic acid (RA), which is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid, is one of the most significant phenolic compound in the family Lamiaceae, which is restricted to the subfamily Nepetoideae, including Salvia species. Since various biological effects have been attributed to RA content of medicinal plants, has recently gained a great importance. We aimed to develop a rapid, simple and sensitive method for the quantitative determination of RA in extracts. The method was then practiced for comparative analysis of RA contents in seven Salvia species; S. candidissima, S. dichroantha, S. heldreichiana, S. sclarea, . . .S. tomentosa, S. triloba and as well as the official sage S. officinalis. The methanol extracts obtained from the aerial parts of the plant materials were submitted to chromatographic separation on silica gel 60 F254 HPTLC plates with toluene: ethyl acetate:formic acid (5:4:1) as mobile phase and the densitometric detection of RA was carried out at 330 nm by HPTLC. Method was then validated in terms of accuracy, precision, repeatability, reproducibility, linearity, limit of detection/quantification, sensitivity and specificity. The newly developed HPTLC method provides a powerful approach to estimate RA content which is a generally phytomarker in many plant extracts. © 2014, Turkish Pharmacists Association. All rights reserved Daha fazlası Daha az

Demir, A. | Mercanoglu Taban, B. | Aslan, M. | Yeşilada, Erdem | Aykut Aytac, S.

Article | 2009 | Pharmaceutical Biology47 ( 4 ) , pp.289 - 297

The objective of the present study was to investigate the in vitro antibacterial activity of the extracts and their fractions obtained from either the flowers or the leaves of Helichrysum plicatum DC. subsp. plicatum (Asteraceae), by studying inhibition of the growth of a dangerous food pathogen, Escherichia coli O157:H7. The antibacterial effects of the ethanol and water extracts of the flowers and leaves were examined first. Subsequently sub-extracts of the flower ethanol extract (FEE), which was found to be the most effective extract, were examined. As a result, the antibacterial effect of FEE was found to be stronger than that o . . .f the chloroform and ethyl acetate sub-extracts. This may due to synergistic activity of several components of the ethanol extract of the flowers. © 2009 Informa UK Ltd Daha fazlası Daha az

Trifkovic, J. | Andric, F. | Ristivojevic, P. | Guzelmeric, E. | Yeşilada, Erdem

Article | 2017 | Journal of AOAC International100 ( 4 ) , pp.827 - 839

Honey is a precious natural product that is marketed with a wide range of nutritional and medicinal properties. However, it is also a product subjected to frequent adulteration through mislabeling and mixing with cheaper and lower-quality honeys and various sugar syrups. In that sense, honey authentication regarding its genuine botanical and geographical origins, as well as the detection of any adulteration, is essential in order to protect consumer health and to avoid competition that could create a destabilized market. Various analytical techniques have been developed to detect adulterations in honey, including measuring the ratio . . .s of stable isotopes (mostly 13C/12C) and the use of different spectroscopic, chromatographic, and electrochemical methods. This review aims to provide a cross-section of contemporary analytical methods used for the determination of honey authenticity in order to help the scientific community engaged in the field of honey chemistry make appropriate choices and select the best applications that should lead to improvements in the detection and elimination of fraudulent practices in honey manufacturing Daha fazlası Daha az

Küpeli Akkol, E. | Orhan, D.D. | Gürubüz, I. | Yeşilada, Erdem

Article | 2010 | Pharmaceutical Biology48 ( 3 ) , pp.253 - 259

Honey-bee pollen mix (HBM) formulation is claimed to be effective for the treatment of asthma, bronchitis, cancers, peptic ulcers, colitis, various types of infections including hepatitis B, and rheumatism by the herb dealers in northeast Turkey. In the present study, in vivo antinociceptive, anti-inflammatory, gastroprotective and antioxidant effects of pure honey and HBM formulation were evaluated comparatively. HBM did not show any significant gastroprotective activity in a single administration at 250mg/kg dose, whereas a weak activity was observed after three days of successive administration at 500mg/kg dose. On the other hand . . ., HBM displayed significant antinociceptive (p Daha fazlası Daha az

Gürbüz, İlhan | Yeşilada, Erdem

Article | 2008 | Turkish Journal of Biology32 ( 4 ) , pp.259 - 263

Equisetum telmateia bitkisinin topraküstü kısımları Türkiye’de halk arasında mide ağrısı ve peptik ülser dahil olmak üzere çeşitli hastalıkların tedavisinde halk ilacı olarak kullanılmaktadır. E. telmateia’nın iddia edilen antiülserojenik etkisini incelemek için toprak üstü kısımlarının sulu ve metanollü ekstreleri hazırlanmış ve sıçanlarda etanolle oluşturulan gastrik ülser modelinde incelenmiştir. Farmakolojik deneyler materyalin metanollü ve sulu ekstrelerinin her ikisinin de oral yolla uygulandığında bu ülser modeli üzerinde midede anlamlı bir koruma sağladığını (ülser önleme oranı sırasıyla %77,9 ve %100) göstermiştir (P 0,001) . . .. Her iki ekstrenin de aktif olması nedeniyle, materyalin %80 etanol ile ekstre edilmesi tercih edilmiş; ardından %80 etanol ekstresi kloroform ve suyla doyurulmuş n-bütanol ile daha ileri bir ayırıma tabi tutularak, kloroform, n-bütanol ve kalan su ekstreleri elde edilmiştir. %80 etanol ekstresi ve sıvı-sıvı ekstraksiyonla elde edilen ekstreler aynı in vivo deneysel ülser modeline uygulanmıştır. Tüm ekstreler bu model üzerinde istatistiksel olarak kuvvetli antiülserojenik etki göstermiş (P 0.001), ancak en belirgin etki kalan sulu ekstrede görülmüştür (ülser önleme oranı %98,2). Sonuç olarak bu çalışmayla E. telmateia’nın halk arasında peptik ülser üzerindeki kullanımı, sıçanlarda etanolle oluşturulan deneysel gastrik ülser modeli kullanılarak doğrulanmıştır. The aerial part of Equisetum telmateia Ehrh. is used against various conditions including stomachache and peptic ulcer in Turkish folk medicine. In order to prove the claimed anti-ulcerogenic potential of the plant, aqueous and methanol extracts were prepared from aerial parts of E. telmateia and investigated for their anti-ulcerogenic effect on ethanol-induced gastric ulcer model in rats. Pharmacological experiments clearly demonstrated that the oral administration of both methanol and aqueous extracts of Equisetum telmateia Ehrh. plant showed significant stomach protection (77.9% and 100% ulcer inhibition, respectively) against the applied model of ulcerogenesis (P < 0.001). Since both extracts were found significantly active, 80% ethanol was preferred for the extraction of the plant material and this crude methanolic extract was further fractionated by successive solvent extractions with chloroform and H2O saturated n-BuOH to obtain the chloroform and n-BuOH extracts as well as the remaining aqueous extract. The 80% ethanol extract and the solvent extracts were then submitted to pharmacological assay using the same in vivo experimental ulcer model. All the extracts statistically showed potent anti-ulcerogenic effect on this model (P < 0.001). However, the remaining aqueous extract was found prominent (98.2% ulcer inhibition). Consequently, folkloric utilization of E. telmateia on peptic ulcer has been confirmed in the present study by using ethanol-induced experimental ulcer model in rats Daha fazlası Daha az

Yeşilada, Erdem

Article | 2009 | TSK Koruyucu Hekimlik Bülteni8 ( 3 ) , pp.259 - 262

Hekimlerin sıklıkla karşılaştıkları durumlardan birisi, hastaların allopatik tedavi yöntemleri dışındaki uygulamalara yönelmeleridir. Bu uygulamalar arasında en yaygını; bitkilerin toplum ve hastalar tarafından tedavi amacıyla kullanımıdır. Toplumun bu eğilimini maddi kazanca çevirme arzusundaki kişiler, bu tür uygulamaları medya ve reklam aracılığı ile sürekli gündemde tutmaya çabalarlar ve bu dünya genelinde çok yaygın bir durumdur. Bu girşimlerden toplumun etkilenmemesi mümkün değildir. Hekimlerin bitkisel uygulamalar karşısındaki tutumu nasıl olmalıdır? Yazıda bu soruya cevap aranmaktadır One of the frequent issues observed by m . . .edical doctors is the inclining of patients to applications other than allopathic therapies. The most common method among these applications is the usage of herbs for the purpose of therapy by patients and public. People who try to provide benefit from this incline of public, try to keep this kind of applications on agenda by the way of media and advertisements and this is a very common issue worldwide. It is impossible to be uninfluenced from these attempts. How should be the attitude of medical doctors for herbal therapeutic applications? The answer for this question is searched in this review Daha fazlası Daha az

Atay, İrem | Kırmızıbekmez, Hasan | Yeşilada, Erdem | Gören, Ahmet Ceyhan

Other | 2015 | Turkish Journal of Chemistry39 ( 1 ) , pp.34 - 41

Abstract: A new nonglycosidic iridoid, sambulin B (1), was isolated from the methanol extract of Sambucus ebulus L. leaves along with a recently reported new nonglycosidic iridoid, 10-O-acetylpatrinoside aglycone (sambulin A) (2); 2 flavonoids, isorhamnetin-3-O-eta-D-glucopyranoside (3) and isorhamnetin-3-O-rutinoside (4); and a mixture of 2 flavonoids (5), quercetin-3-O-eta-D-glucopyranoside and quercetin-3-O-eta-D-galactopyranoside. Their structures were elucidated by 1-D and 2-D nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) experiments.

Yeşilyurt, Emine Burcu | Şimşek, Işıl | Akaydın, Galip | Yeşilada, Erdem

Article | 2017 | Turkish Journal of Botany41 ( 1 ) , pp.47 - 62

The current study was carried out in selected districts of the Black Sea region of Turkey, in Trabzon (center), Çorum (İskilip town), Karabük (Yenice town), Amasya (Kapıkaya village), and Amasya (Belmebük village) in order to document the wild plants used by the local inhabitants, i.e. as a remedy or foodstuff or for other purposes. The data were collected from 352 individuals residing in these districts and volunteering to participate in the research through face-to-face interviewing. Depending on the data collected, the parts of the plants used, the purpose in using them, and the ways of preparation (simply cookin . . .g or decoction, infusion, poultice, ointment, etc.) were documented. Wild plants that are said to be used were collected with guidance from the informant and herbarium materials were prepared. All plant specimens collected were identified botanically and deposited at the Herbarium of the Faculty of Education of Hacettepe University (HEF). In the survey, the use of 72 plant taxa from 35 families was documented. Most of them belonged to the families Rosaceae (14 taxa), Lamiaceae (5 taxa), and Asteraceae (5 taxa). Among the 150 wild plant used in total, 106 were documented to be used in the treatment of several health problems. In descending order, these health problems were respiratory system disorders (25 remedies; 23.6%), dermatological disorders (21 remedies; 19.8%), gastro-intestinal disorders (20 remedies; 18.9%), endocrine and metabolic diseases (11 remedies; 10.4%), and urinary disorders (11 remedies; 10.4%), respectively Daha fazlası Daha az

Akaydın, Galip | Şimşek, Işıl | Arıtuluk, Zekiye Ceren | Yeşilada, Erdem

Article | 2013 | Turkish Journal of Biology37 ( 2 ) , pp.230 - 247

This survey was carried out by face-to-face oral interviews with 379 inhabitants who agreed to be interviewed in selected localities of the Mediterranean region: Hatay (İskenderun and Narlıca), İçel (Erdemli, Tarsus, and Silifke), and Isparta (Sav). The current study was conducted to document the ethnobotanical uses of plants. In the first step of the study, demographic profiles of the informants were evaluated. Subsequently, they were asked to state whether the plants were used for therapeutic or other purposes; then detailed information, i.e. local names, parts used, methods of preparation (decoction, infusion, poultice, oi . . .ntment, etc.) was recorded; and finally the plant materials were collected for authentication. All collected plant materials have been identified and deposited at the Herbarium of Faculty of Education of Hacettepe University (HEF). In the survey, uses of 88 plant taxa from 39 plant families were documented. Plant species from the families Rosaceae, Asteraceae, and Lamiaceae were reported to be the most frequently utilized. Among the 152 plant remedies documented, 38 remedies (25.0%) for gastrointestinal disorders, 30 remedies (19.7%) for respiratory ailments, and 18 remedies (11.8%) for urinary problems were the most frequently recorded Daha fazlası Daha az

Celep, E. | Aydin, A. | Yeşilada, Erdem

Article | 2012 | Food and Chemical Toxicology50 ( 9 ) , pp.3329 - 3335

This study was designed in order to investigate in vitro antioxidant potentials of 80% methanolic extracts prepared from three edible fruits, Cornus mas L., Diospyros kaki L., Laurocerasus officinalis Roem. For this purpose, 8 different tests were performed including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radical scavenging tests, ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), metal-chelating capacity, determination of total antioxidant capacity, ß-carotene bleaching test in a linoleic acid emulsion system and trolox equivalent antioxidant capacity. In addition, for evaluating t . . .he phenolic profile, total phenolic, flavonoid and proanthocyanidin contents were measured spectrophotometrically. Among the three fruits analyzed, Diospyros kaki L. showed the highest activity in all tests, except ß-carotene bleaching test. Whereas, neither of three fruits showed metal-chelating activity. Also, a good correlation was found between the phenolic content and antioxidant parameters. © 2012 Elsevier Ltd Daha fazlası Daha az

Süntar, I. | Akkol, E.K. | Keles, H. | Yeşilada, Erdem | Sarker, S. | Baykal, T.

Article | 2014 | Records of Natural Products8 ( 2 ) , pp.93 - 109

Ethnobotanical surveys revealed that Daphne oleoides Schreber has been used against rheumatic pain and for wound healing in Turkish folk medicine. The aim of the present study is to verify the folkloric assertion of D. oleoides ssp. oleoides (DOO) by bioassay-guided fractionation procedures leading to determination of the active component(s) and to elucidate the activity mechanisms of the isolated compounds. The wound healing activity of the methanol extract, its subextracts, fractions and isolates was evaluated by using two different in vivo wound healing experimental techniques. Anti-inflammatory and antioxidant activities of the . . .test materials were also evaluated. For the determination of the activity mechanisms, the isolated compounds were screened for hyaluronidase, collagenase and elastase enzyme inhibitory activities. The methanolic extract of DOO was found to possess potent wound healing activity. This extract was then subjected to successive solvent extractions with n-hexane, dichloromethane, ethyl acetate (EtOAc) and n-butanol. EtOAc subextract yielded three compounds, quercetin 3-O-glucoside, triumbellin and rutarensin by using chromatographic separation techniques. The experimental study revealed that D. oleoides subsp. oleoides methanolic extract possesses significant wound healing effect and quercetin 3-O-glucoside was determined as the active component responsible from the activity. © 2014 ACG Publications. All rights reserved Daha fazlası Daha az