Demirci, F | Demirci, B | Gurbuz, I | Yesilada, E | Baser, KHC

Article | 2009 | TURKISH JOURNAL OF BIOLOGY33 ( 2 ) , pp.129 - 136

The aerial parts of the endemic Achillea teretifolia Willd. and A. nobilis L. subsp. neilreichii (Kerner) Formanek collected from Beysehir were investigated for their essential oil compositions and several biological activities. The essential oils were analyzed both by gas chromatography (CC) and gas chromatography-mass spectrometry (GC-MS). The main components were identified as 1,8-cineole (34%), camphor (11%). terpinen-4-ol (8%), and alpha-thujone (5%) for A. teretifolia essential oil, while fragranyl acetate (32%), fragranol (24%), and beta-eudesmol (8%) for A. nobilis subsp. neilreichii essential oil, respectively. The essentia . . .l oils were also evaluated for their in vitro antimicrobial activity and their ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals using microdilution techniques as an index for the evaluation of antioxidant activity. Both essential oils were found to be effective against the tested human pathogenic microorganisms (MIC 0.5 to >2 mg/ml) and DPPH (IC(50) > 0.5 mg/ml) assay as compared to the references Daha fazlası Daha az

Yesilada, E

Article | 2015 | ETHNOPHARMACOLOGY , pp.356 - 362

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Aydemir, EA | Simsek, E | Imir, N | Gokturk, RS | Yesilada, E | Fiskin, K

Article | 2015 | PHARMACOGNOSY MAGAZINE11 ( 42 ) , pp.356 - 362

Background: Fabaceae family members are known to possess preventive and therapeutic potentials against various types of cancers. Objective: The aim of this study was to investigate the cytotoxic and apoptotic effects of hydroalcoholic extracts from the aerial parts and roots of an endemic Ebenus species; Ebenus boissieri Barbey in human lung cancer cell line. Materials and Methods: After treatment with hydroalcoholic extracts cytotoxic activities of both extracts were measured by 3-(4, 5-dimethylthiazolyl-2) -2,5-diphenyltetrazolium bromide assay, whereas caspase-3 activity, tumor necrosis factor-alpha (TNF-alpha) and interferon gam . . .ma (IFN-gamma) release were measured by enzyme linked immunosorbent assay. Results: According to in vitro assay results, the increase in all caspases activity suggested that extracts induce cells to undergo apoptosis. Especially, induction in caspase-3 activity was the most remarkable result of this study. Both aerial part and root extracts induced apoptosis by increasing caspase-3 activity, TNF-alpha and IFN-gamma release. When compared to their relative controls, the concentrations of both TNF-alpha and IFN-gamma in extract-treated groups were signi.cantly and dose dependently exalted. Conclusion: Taken together, our results indicate that the hydroalcoholic extracts of E. boissieri can be considered as a source of new anti-apoptotic and therefore anti-carcinogenic agent Daha fazlası Daha az

Celep, E | Aydin, A | Kirmizibekmez, H | Yesilada, E

Conference Object | 2011 | PLANTA MEDICA77 ( 12 ) , pp.1425 - 1426

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Tosun, A | Akkol, EK | Yesilada, E

Article | 2009 | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES64 ( 01.02.2020 ) , pp.56 - 62

n-Hexane and ethyl acetate extracts as well as coumarin derivatives obtained from the n-hexane extract of the aerial parts of Seseli gummiferum Pall. ex Sm. subsp. corymbosum (Boiss. & Heldr.) P.H. Davis (Apiaceae) were evaluated in vivo for their anti-inflammatory and antinociceptive activities. The n-hexane and ethyl acetate extracts of the species were shown to possess significant inhibitory activity against the carrageenan-induced hind paw edema and p-benzoquinone-induced writhing models in mice. Among the isolated coumarin derivatives; (-)-(3'S,4'S)-3'-acetoxy-4'-isovaleryloxy-3',4'-dihydroseselin (1), (-)-(3'S14 S)-3'-acetoxy- . . .4'-angeloyloxy-3'.4'-dihydroseselin (2),(+)-(3'S,4'S)-3'-hydroxy-4'-angeloyloxy-3',4'dihydroseselin (D-laserpitin) (3), (-)-(3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin (4), and osthole (5), only the 3'-acetoxy derivatives 1 and 2 were found to possess potent antinociceptive and anti-inflammatory activities, per os, without inducing any apparent acute toxicity as well as gastric damage, while all other compounds and extracts were found to be ineffective in the TPA-induced mouse ear edema model assay Daha fazlası Daha az

Demir, A | Taban, BM | Aslan, M | Yesilada, E | Aytac, SA

Article | 2009 | PHARMACEUTICAL BIOLOGY47 ( 4 ) , pp.289 - 297

The objective of the present study was to investigate the in vitro antibacterial activity of the extracts and their fractions obtained from either the flowers or the leaves of Helichrysum plicatum DC. subsp. plicatum (Asteraceae), by studying inhibition of the growth of a dangerous food pathogen, Escherichia coli O157:H7. The antibacterial effects of the ethanol and water extracts of the flowers and leaves were examined first. Subsequently sub-extracts of the flower ethanol extract (FEE), which was found to be the most effective extract, were examined. As a result, the antibacterial effect of FEE was found to be stronger than that o . . .f the chloroform and ethyl acetate sub-extracts. This may due to synergistic activity of several components of the ethanol extract of the flowers Daha fazlası Daha az

Atay, I | Kirmizibekmez, H | Goren, AC | Yesilada, E

Article | 2015 | TURKISH JOURNAL OF CHEMISTRY39 ( 1 ) , pp.34 - 41

A new nonglycosidic iridoid, sambulin B (1), was isolated from the methanol extract of Sambucus ebulus L. leaves along with a recently reported new nonglycosidic iridoid, 10-O-acetylpatrinoside aglycone (sambulin A) (2); 2 flavonoids, isorhamnetin-3-O-beta-D-glucopyranoside (3) and isorhamnetin-3-O-rutinoside (4); and a mixture of 2 flavonoids (5), quercetin-3-O-beta-D-glucopyranoside and quercetin-3-O-beta-D-galactopyranoside. Their structures were elucidated by 1-D and 2-D nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) experiments.

Atay, I | Ilter, AZ | Bagatur, Y | Telci, D | Goren, AC | Kirmizibekmez, H | Yesilada, E

Conference Object | 2015 | PLANTA MEDICA81 ( 16 ) , pp.1512 - 1512

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Ozer, G | Guzelmeric, E | Sezgin, G | Ozyurek, E | Arslan, A | Sezik, E | Yesilada, E

Article | 2018 | JOURNAL OF CHEMICAL METROLOGY12 ( 1 ) , pp.79 - 88

In this study, it was aimed to qualify the rhizome samples of butcher's broom (Ruscus aculeatus L.) gathered from various populations distributed naturally in The Marmara Region of Anatolia (Asian part of Turkey) based on the methods described in European Pharmacopoeia. For this purpose, rhizomes were sampled from 18 divers populations; namely, 6 from Istanbul, 4 from Bursa, 4 from Adapazari, 2 from Balikesir and 2 from Canakkale. For qualitative analysis HPTLC method was used in order identify ruscogenin and stigmasterol and these were determined in all samples. For quantitative analysis, concentrations of total ruscogenin (mixture . . . of neoruscogenin and ruscogenin) were analyzed by HPLC technique. According to The European Pharmacopoeia, Butcher's broom rhizomes should contain at least 1% ruscogenins and the rhizome samples obtained from Bahcekoy, Biga, Karacabey, Poyrazlar, Gonen and Kanlica were found consistent with this limit. For pilot field cultivation trial, rhizome sections were prepared from the selected rhizome samples by cutting carefully from their knuckles. The sections then were planted in the nursery under 3 different crown closures with three replications (one of which to serve control). However, it was observed that the survival ratio of seedlings, which was 1% in the first year in the nursery, declined even further in the 2nd and 3rd years, and finally the seedlings dried up, neither developed a root system nor formed a rhizome. Consequently, further cultivation studies should be carried out under suitable climatic conditions and soil compositions by directly planting the rhizomes Daha fazlası Daha az

Kirmizibekmez, H | Atay, I | Kaiser, M | Yesilada, E | Tasdemir, D

Conference Object | 2009 | PLANTA MEDICA75 ( 9 ) , pp.904 - 905

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Gurbuz, I | Ozcelik, B | Karaaoglu, T | Yesilada, E

Conference Object | 2006 | PLANTA MEDICA72 ( 11 ) , pp.1004 - 1004

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Kirmizibekmez, H | Bardakci, H | Yesilada, E | Hohmann, J

Conference Object | 2011 | PLANTA MEDICA77 ( 12 ) , pp.1342 - 1343

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