Sarfaraz, L. | Mian, S.A. | Karadeniz, E.E. | Zali, M.R. | Qureshi, M.S.
Book Part | 2018 | Contributions to Management Science , pp.691 - 693
Iran, Pakistan, and Turkey are the founding members of the Economic Cooperation Organization (ECO), established in 1985, to promote economic, technical, and cultural cooperation among the member states. The three countries share borders and have marked similarities in numerous cultural, religious, and traditional values. With a combined population of over 320 million and economies ranging from factor-driven to efficiency-driven, countries of Iran, Pakistan and Turkey, comprise more than half of the MENA region population. This project envisages a comparative study of women entrepreneurship in Iran, Pakistan, and Turkey using qualita . . .tive as well as quantitative approaches. Women entrepreneurship in these countries are studied from both domestic and international perspectives. © Springer International Publishing AG, part of Springer Nature 2018
İlsever, M. | Ünsalan, Cem
Book Part | 2012 | SpringerBriefs in Computer Science ( 9781447142546 ) , pp.71 - 72
Two dimensional change detection methods are used extensively in image processing and remote sensing applications. In this study, we focused on these methods and their application to satellite images. We grouped change detection methods (based on the way they process data) under four categories as: pixel based, texture based, transformation based, and structural. © 2012, Cem Ünsalan.
Altan-Atalay, A. | Kızılöz, B.K. | Dönger, İ. | Demiray, D.
Article | 2020 | Journal of Psychopathology and Behavioral Assessment , pp.71 - 72
Rumination, which is a form of repetitive negative thinking, has been suggested as a variable associated with elevated risks for depression. Current research conceptualizes rumination as a dispositional entity but has neglected its more state-based forms, which may also be equally related to emotional disorders. Brief State Rumination Inventory (BSRI) is a psychometrically sound measure of state rumination, demonstrated to be sensitive to situational changes in rumination. The current study aims to examine the psychometric characteristics of the Turkish form of BSRI. Results of the first study replicated the single factor structure . . .of the original version of BSRI in a group of 192 Turkish speaking adults between ages 18 and 65. Moreover, the Turkish version of BSRI yielded satisfactory levels of internal consistency and construct validity indicated by significant associations with measures of repetitive negative thinking, avoidant coping, and psychological distress. Study 2 examined the sensitivity of BSRI to momentary changes in rumination to assess the criterion validity of the Turkish form of BSRI, by examining its sensitivity to a rumination induction procedure in 66 university students (39 women). Together, these results suggest that the Turkish version of BSRI is a psychometrically reliable tool which is appropriate for the assessment of state rumination in Turkish speaking populations. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
L. Sarfaraz | S.A. Mian | E.E. Karadeniz | M.R. Zali | M.S. Qureshi
Book Part | 2018 | Contributions to Management Science , pp.639 - 648
Book Part | 2012 | SpringerBriefs in Computer Science ( 9781447142546 ) , pp.57 - 70
In this chapter, we provide experimental results obtained from all change detection methods considered in this study. We first explain the data set used in the experiments. Then, we provide performance results in tabular form for each change detection method in detail. © 2012, Cem Ünsalan.
Maroufi, N.F. | Vahedian, V. | Mazrakhondi, S.A.M. | Kooti, W. | Khiavy, H.A. | Bazzaz, R. | Sabzichi, M.
Article | 2020 | Naunyn-Schmiedeberg's Archives of Pharmacology393 ( 1 ) , pp.57 - 70
The harmful dose-dependent side effects of chemotherapy drugs have caused the discovery of novel perspective to evaluate chemotherapy protocols. In this study, the potential application of Compritol was investigated as a major scaffold into nanostructured lipid careers to highlight myricetin efficiency in treatment of breast cancer cells along with codelivery of docetaxel (DXT). Characterization of myricetin-loaded NLCs was carried out by measuring the particle size and zeta potential, using the scanning electron microscopy. MTT, DAPI staining, flow cytometric, and RT-PCR (real-time) assays were used to recognize novel formulation b . . .ehavior on cell cytotoxicity as well as recognizing molecular mechanism of formulation concerning apoptosis phenomenon. Myricetin-loaded NLCs reduced the cell viability from 50 ± 2.3 to 40 ± 1.3% (p < 0.05). Percentage of apoptosis improved with combination treatment of myricetin-loaded NLCs and DXT in the MDA-MBA231 breast cancer cells. Expression of antiapoptotic genes (survivin, Cyclin B1, and Mcl1) indicated a significant reduction in factor along with increment in proapoptotic factor Bax and Bid mRNA rates. Overall, our results represented that the NLC delivery system could be a promising strategy to enhance the effect of anticancer agents such as DXT on breast cancer. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature
Book Part | 2012 | SpringerBriefs in Computer Science ( 9781447142546 ) , pp.23 - 34
This chapter deals with change detection methods based on color or multispectral space transformations. They are based on Principal Component Analysis (PCA), Kauth-Thomas transformation, vegetation indices, and color invariants. © 2012, Cem Ünsalan.
E. Karadeniz | A. Özçam
Book Part | 2018 | Contributions to Management Science , pp.433 - 448
Entrepreneurship is an important process in regional economic development. However, there is no dedicated research to determinants of entrepreneurship in relation to all regions of Turkey. The main objective of chapter is to find the extent to which the level of entrepreneurial activity varies between regions in Turkey. This chapter also contributes to the field of entrepreneurship studies by presenting, for the first time, the entrepreneurship data of women over the regions of Turkey and by analyzing the regional variations with respect to gender in the early stage of entrepreneurial activity. Our findings support the fact that the . . . entrepreneurial activity in the West Marmara, the Mediterranean, the West Black Sea and the West, Southeast and the Central Anatolia Regions, are no different from the base Region of Istanbul. The general entrepreneurship pursuit in Aegean, the East Marmara, the East Black Sea, the Northeast Anatolia and the Central East Anatolia Regions are found to be about 2% lower compared to the Region of Istanbul, on the average. On the other hand, the likelihood of being an entrepreneur among women is highest in the Aegean Region which is 9.4%. This likelihood is even higher than that in the Region of Istanbul which is 8.1%. Hence, the probability of being a woman entrepreneur ranges from 5.8 to 10.6% in Turkey. When the same probabilities are considered at the age of 45, they are lower and range from 5.4 to 9.7%. Moreover, while the entrepreneurial attitudes, i.e. fear of failure in starting business, and education have a negative effect, the perceptions on start-up opportunities and believed to have knowledge, skill and experience have a positive effect on the probability of being an entrepreneur. The data used in this study were collected by means of the national adult population Survey (APS) from the Global Entrepreneurship monitor (GEM) project conducted in Turkey covering the years of 2006–2015 (except for the year of 2009). The dataset consisting of 56,142 interviews with a representative sample of adults (18–64Â years old) covering 12 regions. © Springer International Publishing AG, part of Springer Nature 2018
Hacınlıyan, A. | Kandıran, E.
Conference Object | 2019 | Springer Proceedings in Complexity , pp.149 - 158
Lyapunov exponents characterize the rate of approach or recession of nearby trajectories in a dynamical system defined by differential equations or maps. They are usually taken as indicators of chaotic behavior. The density of orbits in the state space or equivalently, the Poincare map is usually taken as another such indicator. Although these indicators usually give correct results, there are instances in which they can lead to confusing or misleading information. For instance, a system of three linear differential equations can have three positive eigenvalues ?i leading to a solution ?it. The Wolf-Benettin algorithm  would repo . . .rt three positive Lyapunov exponents, in spite of the fact that the system is not chaotic. Another example is the Khomeriki model  or even the usual Bloch equations that would report a spectrum of all negative Lyapunov exponents but produce completely full state space plots, if the AC field is sufficiently strong. We will consider the class of systems proposed by Sprott  consisting of three-dimensional ODE’s with at most two quadratic nonlinearities as examples. Many of them obey two scenarios one of which is Lorenz model like behavior where an unstable linearized fixed point is surrounded by two stable fixed points so that the unstable fixed-point leads to a throw and catch behavior. The other is Rössler-like behavior whereas the system moves away from a weakly unstable linearized fixed point, nonlinear terms return it to equilibrium with a spiral out catch in mechanism. Since the presence of an attractor may involve structural stability, these two mechanisms are expected to produce different spatial extents for the attractor. Although Lyapunov exponents indicate time dependent behavior, spatial extent would complement this as a spatial measure of localization, thus complementing the Lyapunov exponents that characterize horizon of predictability. Direct numerical simulation and where feasible, the normal form approach will be used to investigate selected examples of the three degree of freedom systems. © Springer Nature Switzerland AG 2019
Yılmaz, B. | Terekeci, H. | Sandal, S. | Kelestimur, F.
Review | 2019 | Reviews in Endocrine and Metabolic Disorders , pp.149 - 158
Endocrine Disrupting Chemicals (EDCs) are a global problem for environmental and human health. They are defined as “an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action”. It is estimated that there are about 1000 chemicals with endocrine-acting properties. EDCs comprise pesticides, fungicides, industrial chemicals, plasticizers, nonylphenols, metals, pharmaceutical agents and phytoestrogens. Human exposure to EDCs mainly occurs by ingestion and to some extent by inhalation and dermal uptake. Most EDCs are lipophilic and bioaccumulate in the adipose tissue, thus they have a very long ha . . .lf-life in the body. It is difficult to assess the full impact of human exposure to EDCs because adverse effects develop latently and manifest at later ages, and in some people do not present. Timing of exposure is of importance. Developing fetus and neonates are the most vulnerable to endocrine disruption. EDCs may interfere with synthesis, action and metabolism of sex steroid hormones that in turn cause developmental and fertility problems, infertility and hormone-sensitive cancers in women and men. Some EDCs exert obesogenic effects that result in disturbance in energy homeostasis. Interference with hypothalamo-pituitary-thyroid and adrenal axes has also been reported. In this review, potential EDCs, their effects and mechanisms of action, epidemiological studies to analyze their effects on human health, bio-detection and chemical identification methods, difficulties in extrapolating experimental findings and studying endocrine disruptors in humans and recommendations for endocrinologists, individuals and policy makers will be discussed in view of the relevant literature. © 2019, Springer Science+Business Media, LLC, part of Springer Nature
Şişli, H.B. | Hayal, T.B. | Seçkin, S. | Şenkal, S. | Kıratlı, B. | Şahin, Fikrettin | Doğan, A.
Book Part | 2020 | Advances in Experimental Medicine and Biology1237 , pp.17 - 28
The identification of human embryonic stem cells and reprogramming technology to obtain induced pluripotent stem cells from adult somatic cells have provided unique opportunity to create human disease models, gene editing strategies and cell therapy options. Development of pluripotent stem cells from somatic cells and genomic manipulation tools enabled to use site specific nucleases in the cell therapy research. Identification of efficient gene manipulation, safe differentiation and use will provide a novel strategy to treat many diseases in the near future. Current available registered clinical trials clearly indicate the need for . . .pluripotent stem cell and gene therapy treatment options. Although gene editing based pluripotent stem cell research is a popular field for research worldwide, improvement of clinical approaches for treatment still remains to be investigated. In this review, we summarized the current situation of gene editing based pluripotent cell therapy developments and applications in clinics. © Springer Nature Switzerland AG 2019
Editorial | 2012 | SpringerBriefs in Computer Science ( 9781447142546 ) , pp.17 - 28
[No abstract available]