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Cancer stem cells in metastasis therapy

Aydemir Çoban, E. | Şahin, Fikrettin

Book Part | 2018 | Advances in Experimental Medicine and Biology1089 , pp.97 - 113

Tumors consists of subpopulation of cells in which each subtype has contributes to tumor progression. Specifically one subtype known as cancer stem cells are associated with the initiation, progression, resistance to conventional therapies and metastasis. Metastasis is leading cause of cancer related deaths. Overall it is important to consider cancer as a whole in which a mutated cell proliferating indefinitely and forming its hierarchy consisting of subgroups with different molecular signatures. To be able to target this disease we need to evaluate every step including initiation, progression, survival, angiogenesis and finally mig . . .ration and repopulation. Cancer stem cells do play vital roles in each step however when metastasis can be stopped or eliminated we talk about saving a life or improving its quality. Considering how deeply these cancer stem like cells affect the tumor life and metastasis it is crucial to develop effective strategies against them. Metastatic cascade can also be directed by membrane derived vesicles specifically exosomes. Several studies show the role of exosomes in mediating cellular migration and pre-metastatic niche formation. During this chapter we wanted to explain in detail how the metastasis occur in tumor and how cancer stem cells contribute into the development of metastatic cascade and possibly suggest therapeutic approaches against cancer stem cells. © Springer Nature Switzerland AG 2018 Daha fazlası Daha az

Intra-arterial Ultra-low-Dose CT Angiography of Lower Extremity in Diabetic Patients

Özgen, A. | Sanioğlu, S. | Bingöl, U.A.

Article | 2016 | CardioVascular and Interventional Radiology39 ( 8 ) , pp.1165 - 1169

Purpose: To image lower extremity arteries by CT angiography using a very low-dose intra-arterial contrast medium in patients with high risk of developing contrast-induced nephropathy (CIN). Materials and Methods: Three cases with long-standing diabetes mellitus and signs of lower extremity atherosclerotic disease were evaluated by CT angiography using 0.1 ml/kg of the body weight of contrast medium given via 10-cm-long 4F introducer by puncturing the CFA. Images were evaluated by an interventional radiologist and a cardiovascular surgeon. Density values of the lower extremity arteries were also calculated. Findings in two cases wer . . .e compared with digital subtraction angiography images performed for percutaneous revascularization. Blood creatinine levels were followed for possible CIN. Results: Intra-arterial CT angiography images were considered diagnostic in all patients and optimal in one patient. No patient developed CIN after intra-arterial CT angiography, while one patient developed CIN after percutaneous intervention. Conclusion: Intra-arterial CT angiography of lower extremity might be performed in selected patients with high risk of developing CIN. Our limited experience suggests that as low as of 0.1 ml/kg of the body weight of contrast medium may result in adequate diagnostic imaging. © 2016, Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Daha fazlası Daha az

Management of blood donation system: Literature review and research perspectives

Baş, S. | Carello, G. | Lanzarone, E. | Ocak, Z. | Yalçındağ, S.

Conference Object | 2016 | Springer Proceedings in Mathematics and Statistics169 , pp.121 - 132

2nd International Conference on Health Care Systems Engineering, HCSE 2015 -- 27 May 2015 through 29 May 2015 -- -- 181519

Mesenchymal Stem Cells as Regulators of Carcinogenesis

Hayal, T.B. | Kıratlı, B. | Şişli, H.B. | Şahin, Fikrettin | Doğan, A.

Book Part | 2019 | Advances in Experimental Medicine and Biology1144 , pp.147 - 166

Mesenchymal Stem Cells (MSCs) are adult stem cells; isolated from various body parts including bone marrow, adipose tissue and dental tissue, have been characterized well and used in regenerative medicine applications. The promising potential of MSCs makes them great candidates in many disorders. It has been well known in the literature that MSCs interact with cancer cells and regulate the carcinogenesis process at different stages. The dual role of MSCs in cancer progression should be clearly identified at the physiological and molecular level to identify clinical potential in cancer treatment. The promoting or suppressive role of . . .MSCs in cancer is controlled by various growth factors, cytokines and chemokines which affect the cell proliferation, angiogenesis and metastasis. Although many studies have been conducted to explore MSC-cancer cell interactions, it is still unclear how MSCs communicate with cancer cells and tumor microenvironment. Further studies are required to investigate secreted factors and paracrine effects, tumor stroma environment, molecular regulators and downstream pathways that are involved in MSC-cancer interaction loop. MSC type, cancer type and stage specific phenotypic and transcriptomic profile changes should be identified in detail to improve clinical use of MSCs in cancer either as a target or as a tool. In the current book chapter, we review the literature to summarize current information about the MSC-cancer cell interactions in terms of soluble factors, angiogenesis, metastasis and drug resistance. The role of MSCs in tumor progression or suppression was discussed based on the current literature. © 2018, Springer Nature Switzerland AG Daha fazlası Daha az

Basic properties of the non-abelian global reciprocity map

İkeda, K.İ.

Conference Object | 2015 | Springer Proceedings in Mathematics and Statistics98 , pp.45 - 92

6th World Conference on 21st Century Mathematics, WC 2013 -- 6 March 2013 through 9 March 2013 -- -- 122289

Efficient simulations for a Bernoulli mixture model of portfolio credit risk

Başoğlu, İ. | Hörmann, W. | Sak, H.

Article | 2018 | Annals of Operations Research260 ( 01.02.2020 ) , pp.113 - 128

We consider the problem of calculating tail loss probability and conditional excess for the Bernoulli mixture model of credit risk. This is an important problem as all credit risk models proposed in literature can be represented as Bernoulli mixture models. Thus, we deviate from the efficient simulation of credit risk literature in that we propose an efficient simulation algorithm for this general Bernoulli mixture model in contrast to previous works that focus on specific credit risk models like CreditRisk+ or Credit Metrics. The algorithm we propose is a combination of stratification, importance sampling based on cross-entropy, an . . .d inner replications using the geometric shortcut method. We evaluate the efficiency of our general method considering three different examples: CreditRisk+ and two of the latent variable models, the Gaussian and the t-copula model. Numerical results suggest that the proposed general algorithm is more efficient than the benchmark methods for these specific models. © 2016, Springer Science+Business Media New York Daha fazlası Daha az

Blow up of solutions of second order semilinear parabolic equations under robin boundary conditions

Kalantarova, J. | Polat, M.

Conference Object | 2016 | Springer Proceedings in Mathematics and Statistics155 , pp.211 - 224

We considered initial boundary value problems for semilinear heat equation with a nonlinear source term under the Robin boundary conditions. Sufficient conditions for the finite-time blow up of solutions with negative initial energy and arbitrary positive initial energy are obtained. © Springer International Publishing Switzerland 2016.

Cytoglobin inhibits migration through PI3K/AKT/mTOR pathway in fibroblast cells

Demirci, S. | Doğan, A. | Apdik, H. | Tuysuz, E.C. | Gulluoglu, S. | Bayrak, O.F. | Şahin, Fikrettin

Article | 2018 | Molecular and Cellular Biochemistry437 ( 01.02.2020 ) , pp.133 - 142

Cell proliferation and migration are crucial in many physiological processes including development, cancer, tissue repair, and wound healing. Cell migration is regulated by several signaling molecules. Identification of genes related to cell migration is required to understand molecular mechanism of non-healing chronic wounds which is a major concern in clinics. In the current study, the role of cytoglobin (CYGB) gene in fıbroblast cell migration and proliferation was described. L929 mouse fibroblast cells were transduced with lentiviral particles for CYGB and GFP, and analyzed for cell proliferation and migration ability. Fibroblas . . .t cells overexpressing CYGB displayed decreased cell proliferation, colony formation capacity, and cell migration. Phosphorylation levels of mTOR and two downstream effectors S6 and 4E-BP1 which take part in PI3K/AKT/mTOR signaling declined in CYGB-overexpressing cells. Microarray analysis indicated that CYGB overexpression leads to downregulation of cell proliferation, migration, and tumor growth associated genes in L929 cell line. This study demonstrated the role of CYGB in fibroblast cell motility and proliferation. CYGB could be a promising candidate for further studies as a potential target for diseases related to cell migration such as cancer and chronic wound treatment. © 2017, Springer Science+Business Media, LLC Daha fazlası Daha az

On the use of cross impact analysis for enhancing performance in primary school education

Pedamallu, C.S. | Ozdamar, L. | Weber, G.-W.

Conference Object | 2014 | Springer Proceedings in Mathematics and Statistics73 , pp.521 - 538

International Conference on Modeling, Optimization and Dynamics, ICMOD 2010 and 5th Bioeconomy Conference 2012 -- 5 July 2010 through 7 July 2010 -- -- 117169

Styles and style-stretching: How are they related to successful learning?

Griffiths, C. | İnceçay, G.

Article | 2016 | Journal of Psycholinguistic Research45 ( 3 ) , pp.599 - 613

Although the learning style construct has aroused much interest over the years, questions remain regarding basic issues such as definition, the validity and/or reliability of various measurement instruments, and the relationship between learning style and successful learning. Furthermore, although maintaining stylistic flexibility is recommended by many authors, few studies have attempted to relate the style-stretching concept to successful learning. This study therefore attempted to address these questions. According to results, conducted among 106 Turkish university students, using an original instrument constructed using elements . . . from established questionnaires, a small group of styles was significantly correlated with exam results, accounting for about a quarter of the variance (considered a large effect size in social science). In addition, higher-scoring students reported a more eclectic range of styles, suggesting more willingness to style-stretch, while lower-scoring students reported a more limited range. Pedagogical implications as well as areas for ongoing research are suggested. © Springer Science+Business Media New York 2015 Daha fazlası Daha az

Bronchial Artery Embolization with Large Sized (700–900 µm) Tris-acryl Microspheres (Embosphere) for Massive Hemoptysis: Long-Term Results (Clinical Research)

Kucukay, F. | Topcuoglu, O.M. | Alpar, A. | Altay, Ç.M. | Kucukay, M.B. | Ozbulbul, N.I.

Article | 2018 | CardioVascular and Interventional Radiology41 ( 2 ) , pp.225 - 230

Purpose: To investigate the safety, efficacy and long-term results of bronchial artery embolization with microsphere particles (Embosphere® Microspheres, BioSphere Medical, Rockland, MA) 700–900 µm in size for massive hemoptysis. Methods: One hundred and seventy-four patients (94 female, 80 male; mean age 39.4 ± 5.7) who had bronchial artery embolization for massive hemoptysis between January 2010 and October 2015 were incorporated in the study. Patients had hemoptysis with a mean volume of 525 ± 150 mL (median 500 mL, range 300–1200 mL) over a 24-h period. Underlying pathologies included bronchial artery hypertrophy due to bronchie . . .ctasis (56.3% [98/174]), lung cancer (29.9% [52/174]), tuberculosis (10.3% [18/174]) and the rest remained idiopathic (3.4% [6/174]). Mean bronchial artery diameter before the intervention was 3.8 ± 1.5 mm (median 4 mm, range 3.1–7.5 mm). Median follow-up period was 56 months (range 10–82 months). Primary objectives were the technical and clinical success. Results: Technical success was 100%. Clinical success for preventing massive hemoptysis was 91.9% (160/174). There was no procedure-related mortality or morbidities. Minor complications such as chest pain were observed in nine patients (5.0%). Recurrent hemoptysis (8.1%) was observed within 6 months in 14 patients, ten of whom were treated with a second embolization session and the remaining four with a total of three embolization sessions. Conclusion: Bronchial artery embolization for massive hemoptysis with Embosphere particles 700–900 µm in size is a safe and effective method with high technical and clinical success rates. Long-term results are excellent. © 2017, Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Daha fazlası Daha az

Evaluation of Sexual Dysfunction in Males with Diabetes

Yıldız, H. | Bölüktaş, R.P.

Article | 2015 | Sexuality and Disability33 ( 2 ) , pp.187 - 205

This study was conducted in order to determine the prevalence of sexual dysfunction and factors affecting sexual dysfunction (SD) in male patients with diabetes. Diabetes is a public health problem. Erectile dysfunction (ED) is seen in nearly half of all males who have had diabetes for more than 10 years. Erectile dysfunction, metabolic and psychological factors are involved in the emergence. A descriptive was conducted and questionnaire was used in this study. Data was gathered via general knowledge form which consists of socio-demographic characteristics and risk factors, International Index of Erectile Function, Quality of Life S . . .cale (SF-36), Beck Depression Inventory, Coopersmith Self-Esteem Scale, and Body Image Scale. SD was determined in 48 % of our cases. The most affected domain among the cases was erectile function (33.1 %) and intercourse satisfaction (29.1 %), and the least affected domain was sexual desire (6.3 %). Most of the male cases with ED had mild and moderate ED (42.6 %). Factors affecting SD’s included age, education level, obesity, hypertension, retinopathy, vasculopathy, nephropathy, diabetic foot, HBA1C and LDL levels, diabetes duration, drugs used. All quality of life subgroups scores were lower in male patients with SD than patients without SD except for pain. Depression and body image scores were lower in male patients with SD. SD’s are affected by both metabolic and psychosocial factors. Sexual dysfunction in men with diabetes should be routinely evaluated. © 2015, Springer Science+Business Media New York Daha fazlası Daha az

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