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Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/-catenin, JAK-STAT pathways, and microRNAs

Ozbey, U | Attar, R | Romero, MA | Alhewairini, SS | Afshar, B | Sabitaliyevich, UY | Farooqi, AA

Article | 2019 | JOURNAL OF CELLULAR BIOCHEMISTRY120 ( 2 ) , pp.1060 - 1067

Wealth of information gleaned from decades of high-impact research work; scientists have disentangled the complicated web of versatile regulators that underlie cancer development and progression. Use of structural biology approaches and functional genomics have helped us to gain new insights into complex nature of cancer, and it is now clear that genetic/epigenetic mutations, overexpression of oncogenes, inactivation of tumor suppressors, loss of apoptosis, and versatility of protein binding partners have contributory roles in carcinogenesis and metastatic spread. It is becoming progressively more understandable that reprogramming o . . .f gene expression during and nontranscriptional changes during cancer development and progression are initiated and controlled by deregulated signal transduction cascades, all of which collectively create an incalculable complexity. Data obtained through preclinical and clinical trials revealed that alterations in the targeted oncogenes and other downstream, and parallel pathways played a central role in the development of resistance against different therapeutics. Phytochemicals have regained limelight, and different natural products are currently being tested for efficacy in preclinical studies. Apigenin, a plant-derived flavonoid has considerable pharmacological value and is reportedly involved in the regulation of different signaling cascades. In this review, we have attempted to summarize rapidly evolving understanding of molecular biologists and pharmacologists about the potential of apigenin in the regulation of deregulated signaling pathways in different cancers. We have emphasized on the regulation of WNT/-catenin and janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways. We also comprehensively discuss how apigenin restored apoptosis in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant cancers. The review also gives a snapshot of microRNAs (miRNAs) that regulate wide-ranging biological processes, and it is now clear that each miRNA can control hundreds of gene targets. Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Moreover, apigenin-induced apoptotic rate was significantly higher when used in combination with miR-423-5p inhibitors or miR-138 mimics. Better comprehension of linear and integrated signaling pathways will be helpful in effective therapeutic targeting of deregulated signaling pathways to inhibit/prevent cancer Daha fazlası Daha az

Percentage and severity of periodontal diseases in Turkish adults aged 35+years, 2009-10

Ilhan, D | Oktay, I | Nur, B | Fisekcioglu, E | Lim, S | Lepkowski, JM | Ismail, AI

Article | 2017 | JOURNAL OF PUBLIC HEALTH DENTISTRY77 ( 4 ) , pp.325 - 333

Objective: This article presents data on the burden of periodontal diseases in Turkish adults aged 35 years or older. Methods: Within each region of Turkey, a rural and an urban area or city were selected in 2009-10 using a probability proportional to size method. In the selected towns, local officials who were familiar with their communities assisted in recruiting subjects. Loss of Attachment (LOA) was measured at six sites around each tooth present in the mouth, excluding third molars. Additionally, the Community Periodontal Index was used to assess the severity of periodontal diseases around 12 index teeth. Self-reported data on . . .key risk factors were also collected. Weights were computed using a raking ratio adjustment procedure and used in all analyses. Results: Almost all examined adults had some loss of periodontal attachment. The proportion of those with more than 3 mm LOA ranged from 43 percent in 35-44 year olds to 91 percent in those aged 65+ years. Among females, older age, low education status, smoking 11-40+ cigarettes a day, being employed, and presence of high number of missing tooth surfaces were associated with LOA>3 mm. Among males LOA >3 mm was associated with older age, use of alcohol, and unemployment. The CPI data did not yield the same associations with periodontal diseases and risk factors. Conclusions: Periodontal diseases in Turkish adults are highly prevalent. A tailored common risk factor health promotion program is recommended to reduce the burden of periodontal infection in Turkey Daha fazlası Daha az

Chemogenetics modulation of kisspeptin neuron activity and its role in anxiety behavior in mice

Eyuboglu, S | Agus, S | Baser, O | Atasoy, D | Yılmaz, B

Conference Object | 2017 | ACTA PHYSIOLOGICA221 , pp.154 - 156

Status epilepticus in the elderly

Yildrim, KA | Midi, I | Aykut-Bingol, C

Conference Object | 2015 | EUROPEAN JOURNAL OF NEUROLOGY22 , pp.239 - 239

Poly( amino acid)-based fibrous scaffolds modified with surface-pendant peptides for cartilage tissue engineering

Svobodova, J | Proks, V | Karabiyik, O | Koyuncu, ACC | Kose, GT | Rypacek, F | Studenovska, H


In this study, fibrous scaffolds based on poly(gamma-benzyl-L-glutamate) (PBLG) were investigated in terms of the chondrogenic differentiation potential of human tooth germ stem cells (HTGSCs). Through the solution-assisted bonding of the fibres, fully connected scaffolds with pore sizes in the range 20-400 mu m were prepared. Biomimetic modification of the PBLG scaffolds was achieved by a two-step reaction procedure: first, aminolysis of the PBLG fibres' surface layers was performed, which resulted in an increase in the hydrophilicity of the fibrous scaffolds after the introduction of N-5-hydroxyethyl-L-glutamine units; and second, . . . modification with the short peptide sequence azidopentanoyl-GGGRGDSGGGY-NH2, using the 'click' reaction on the previously modified scaffold with 2-propynylside-chains, was performed. Radio-assay of the I-125-labelled peptide was used to evaluate the RGD density in the fibrous scaffolds ( which varied in the range 10(-3) -10 pM/cm(2)). All the PBLG scaffolds, especially with density 90 +/- 20 fM/cm(2) and 200 +/- 100 fM/cm(2) RGD, were found to be potentially suitable for growth and chondrogenic differentiation of HTGSCs. Copyright (C) 2015 John Wiley & Sons, Ltd Daha fazlası Daha az

Investigation of Age-Related Changes in Oxidant and Antioxidant Status with mTOR Signal Pathway in Rat Liver Tissues

Yalcin, M | Yazihan, N | Ethemoglu, MS | Erdogan, CS | Kacar, M

Conference Object | 2018 | ACTA PHYSIOLOGICA225 , pp.52 - 52

The Relationship Between Lympadenopathy and HIf-1 Alpha Gene Polymorphism in Children

Yilmaz, S | Yoruk, A | Zemheri, E | Suakar, O | Imamova, N | Canizci, P | Kuskucu, A

Conference Object | 2018 | PEDIATRIC BLOOD & CANCER65 , pp.52 - 52

Approaches of patients receiving subcutaneous immunotherapy to anaphylaxis

Saricoban, HE | Karakoc-Aydiner, E

Conference Object | 2018 | ALLERGY73 , pp.849 - 849

Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'Similarities and differences'

Keles, S | Artac, H | Kara, R | Gokturk, B | Ozen, A | Reisli, I

Article | 2010 | PEDIATRIC ALLERGY AND IMMUNOLOGY21 ( 5 ) , pp.843 - 851

Transient hypogammaglobulinemia of infancy (THI) is characterized by recurrent infections and one or more reduced serum immunoglobulin (Ig) levels. Usually, this clinical picture resolves spontaneously by 3 yr of age. However, hypogammaglobulinemia persists until adolescence in some patients. In recent years, those patients have been classified as undefined/unclassified hypogammaglobulinemia (UCH). We aimed to evaluate the clinical and immunologic features of patients with THI and UCH considering age of recovery and to assess relationships between hypogammaglobulinemia, infections, and allergic manifestations. We reviewed the medica . . .l records of children followed with a diagnosis of hypogammaglobulinemia from 2001 to 2007. Patients with decreased levels (< 2 s.d.) of one or more major Ig isotypes (IgG, IgA, IgM) with normal antibody responses and lymphocyte subpopulations were included (n = 374). Those patients whose Igs normalized during the follow-up period were classified as THI and the others as UCH. The THI group consisted of 71 patients (27 females, 44 males) with a mean recovery age of 68.87 +/- 36.5 months. About 95% of patients with THI recovered before 10 yr of age. The UCH group consisted of 303 patients (105 females, 198 males) with a mean age at diagnosis of 52 +/- 42 months. The most common presenting manifestations in the THI and UCH groups were upper respiratory tract infections (URTIs), lower respiratory tract infections, and asthma (42%, 50%, and 52% in the THI group vs. 39%, 53%, and 55% in the UCH group, respectively). In the THI group, the prevalence of atopic disease was related to age and found to be increased markedly after 44 months. In all patients, the prevalence of asthma was independently and positively associated with family history of atopy and age, whereas it was negatively associated with recurrent URTIs. Patients with THI and UCH have similar clinical and immunologic features. The normalization of Igs may be delayed in a majority of the patients with hypogammaglobulinemia. This observation may be a contribution to the classical definition and diagnostic criteria for THI Daha fazlası Daha az

Current treatment of Helicobacter pylori infected children and adolescents in Europe: Interim Results of the new EuroPedHp Registry

Le Thi, T | Werkstetter, K | Cabral, J | Kotilea, K | Bontems, P | Pascual, MC | Koletzko, S

Conference Object | 2019 | HELICOBACTER24 , pp.843 - 851

Does Gadoterate Meglumine Cause Gadolinium Retention in the Brain of Children? A Case-Control Study

Topcuoglu, ED | Topcuoglu, OM | Oysu, AS | Bukte, Y

Article | 2020 | JOURNAL OF MAGNETIC RESONANCE IMAGING , pp.843 - 851

Background Accumulation of macrocyclic gadolinium agents in children's brains remain to be determined. Purpose To demonstrate whether there is an intracranial macrocyclic gadolinium deposition after multiple contrast-enhanced MRI with gadoterate meglumine in a pediatric population. Study Type Retrospective case-control. Population In all, 45 children (age range: 5-17 years; mean, 13.7 +/- 3.4 years) for the study group and 45 healthy children (age range: 5-17 years; mean, 13.7 +/- 3.4 years) for the control group. Field Strength/Sequence T-1- and T-2-weighted axial images on a 1.5T scanner. Assessment Children with at least three en . . .hanced brain MRIs and an age- and sex-matched control group with an unenhanced brain MRIs were compared in terms of T-1 signal intensity (SI). All patients in the study group received gadoterate meglumine intravenously (0.1 mmol/kg). SI measurements were made by drawing six regions of interest (ROIs): dentate nuclei (DN), pons, globus pallidi (GP), frontal white matter (FWM), thalamus (T), clivus, and cerebrospinal fluid (CSF) for both groups on unenhanced T-1-weighted images. Statistical Tests Student's t-test was used for comparison of SI. The Pearson correlation was calculated for the correlation between the SI and the number of gadolinium administrations. Results A significant difference was detected between two groups for DN/CSF, pons/CSF, GP/CSF, thalamus/CSF, and FWM/CSF (P < 0.001, P < 0.001, P = 0.002, P = 0.002, P = 0.024, respectively). There was no significant difference between the two groups for clivus/CSF (P = 0.15). A good correlation between the number of gadoterate meglumine administrations and the SI for DN/CSF, pons/CSF, GP/CSF, and T/CSF (r = 0.80, r = 0.73, r = 0.91, and r = 0.90, respectively) was found. Data Conclusion A significant T-1 SI increase reflecting gadolinium retention in the brain was detected for children with at least three gadoterate meglumine administrations in this series. The number of administrations correlated well with the increased SI. Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019 Daha fazlası Daha az

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