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Diagnostic value of BRCA1-associated protein-1, glucose transporter-1 and desmin expression in the discrimination between reactive mesothelial proliferation and malignant mesothelioma in tissues and effusions

Önder, S. | Özogul, E. | Koksal, D. | Sarinc Ulasli, S. | Firat, P. | Emri, S.

Article | 2019 | Cytopathology30 ( 6 ) , pp.592 - 600

Objective: The aim of this study was to investigate the utility of BRCA1-associated protein-1 (BAP1), glucose transporter (GLUT)-1 and desmin expression by immunohistochemistry in the discrimination between reactive and malignant mesothelial proliferations. Methods: A total of 88 biopsies and 30 effusions from mesothelioma cases were studied. Control groups were composed of 35 tissues and 30 cell blocks. The 88 mesothelioma cases were from 43 males and 45 females (mean age 56 years). Tumours were mostly localised to pleura (66/88, 75%) and of epithelioid histology (75/88, 85%). Cytology samples were from 17 males and 13 females (mea . . .n age 58 years), and 16 pleural and 14 peritoneal effusions. Twenty cytology cases had corresponding tissue biopsies. Results: BAP1 loss was detected in 61/88 (69%) tissues and in 20/30 (67%) cytology samples from mesothelioma with a specificity of 100% for both sampling methods. BAP1 loss was observed more frequently in pleural and biphasic tumours. GLUT-1 immunoreactivity was identified in 54/81 (67%) and 23/25 (92%) malignant tissues and effusions, and in 6/33 (18%) and 6/30 (20%) benign tissues and effusions, respectively. Desmin loss was observed in 74/80 (92%) malignant biopsy samples, 16/21 (76%) malignant effusions and 10/34 (29%) of benign tissues, but in none of the reactive effusions. Concordance rate of results between biopsy and cytology was as follows: BAP1 20/20 (100%); GLUT-1 13/18 (72%); and desmin 10/14 (71%). Conclusions: BAP1, GLUT-1 and desmin are useful markers in the discrimination between reactive and malignant mesothelial proliferations. BAP1 loss seems to be diagnostic for mesotheliomas both in biopsy and cytology samples. © 2019 John Wiley & Sons Lt Daha fazlası Daha az

'Stigma: The cul-de-sac of the double bind' the perspective of Turkiye; a phenomenological study

Yuksel, C. | Bingol, F. | Oflaz, F.

Article | 2014 | Journal of Psychiatric and Mental Health Nursing21 ( 8 ) , pp.667 - 678

The aim of this study was to explore and describe the stigmatization experienced by individuals with mental health problems (IMHP) and the relationships between stigmas associated with mental health problems, psychiatric diagnoses, treatments, and social environments and their consequences. Thirty-three IMHP were recruited from outpatient and day clinics at the psychiatry department of a university hospital within a 5-month time period for this qualitative, descriptive study. Data were gathered using a structured interview form with open-ended questions to explore the changes in everyday life experienced by IMHP during the course of . . . their illness. Data were analysed using the Colaizzi method of analysis. Our findings show that almost all IMHP were concerned about being stigmatized by others, society, their family, and health care professionals. Another concern that IMHP reported was self-stigmatization. Stigmatization serves as a barrier to treatment adherence and socialization in IMHP. Furthermore, stigmatization has a significant impact on the lives of IMHP, and methods of coping with stigmatization are commonly ineffective. However, stigmatization can be reduced by dealing with the illness, IMHP, their relatives, and professionals in an unprejudiced manner, © 2013 John Wiley & Sons Ltd Daha fazlası Daha az

Evidence for Financial Contagion in Endogenous Volatile Periods

Kilic, E. | Ulusoy, V.

Article | 2015 | Review of Development Economics19 ( 1 ) , pp.62 - 74

The objective of this study is to analyze cross-border contagious dynamics in both foreign exchange markets and stock exchange markets. Propagation is analyzed with respect to the transmission of excessive volatility that is endogenously determined. The contagion process is discussed in the context of financial systems, foreign direct investments and trade. Implementing a vector autoregressive-multivariate generalized autoregressive conditional heteroskedasticity (VAR-MGARCH) model, we show that country-specific turbulence in financial markets is able to create unanticipated financial contagion across countries. Diversified trade an . . .d financial relations decrease the risk of exposure to contagion from external markets. The world's largest economies, however, play a price-setter role, and diversification is of secondary importance. Asymmetric transmission of the empirically predicted contagion prevails in the latter case. © 2015 John Wiley & Sons Ltd Daha fazlası Daha az

A context-dependent view on the linguistic interdependence hypothesis: Language use and SES as potential moderators

Prevoo, M.J.L. | Malda, M. | Emmen, R.A.G. | Yeniad, N. | Mesman, J.

Article | 2015 | Language Learning65 ( 2 ) , pp.449 - 469

The linguistic interdependence hypothesis states that the development of skills in a second language (L2) partly depends on the skill level in the first language (L1). It has been suggested that the theory lacked attention for differential interdependence. In this study we test what we call the hypothesis of context-dependent linguistic interdependence. In order to do so, we examined child language use and socioeconomic status as two moderators in the relation between L1 vocabulary and L2 vocabulary growth in a sample of 104 5- and 6-year-old bilingual children with a Turkish background in the Netherlands. Relative child language us . . .e moderated the relation between L1 vocabulary and L2 vocabulary growth. Positive transfer was only present for children who used L1 more than L2. Socioeconomic status (SES) predicted growth in Dutch vocabulary but was not a moderator of linguistic interdependence, indicating that linguistic interdependence effects are similar across SES groups. The findings suggest the linguistic interdependence hypothesis is context-dependent and only valid under circumstances of more L1 use. © 2015 Language Learning Research Club, University of Michigan Daha fazlası Daha az

Effect of gestational diabetes mellitus on testis and pancreatic tissues of male offspring

Türk, G. | Rişvanlı, A. | Çeribaşı, A.O. | Sönmez, M. | Yüce, A. | Güvenç, M. | Yaman, M.

Article | 2018 | Andrologia50 ( 4 ) , pp.449 - 469

The purpose of this study was to determine the effect of gestational diabetes mellitus (GDM) on some reproductive characteristics, testicular and pancreatic oxidative status and pancreatic endocrine receptor densities of male offspring at post-pubertal stage. A total of 36 1-day-old Wistar Albino male offspring including 12 pups of nontreated mothers (control group), 14 pups of 40 mg/kg STZ-injected mothers (STZ-40 group) and 10 pups of 60 mg/kg STZ-injected mothers (STZ-60 group) were used. The offspring were euthanised on post-natal day 60, their blood, reproductive organs and pancreatic tissues were obtained and examined. When co . . .mpared with the control group, there was a significant decrease in body and absolute reproductive organ weights, serum testosterone level, testicular and pancreatic catalase activities, pancreatic glutathione level, epididymal sperm concentration of both STZ-40 and STZ-60 groups as well as in testicular glutathione level of only STZ-60 group. Significant increases were determined in testicular and pancreatic malondialdehyde level and glutathione peroxidase activity in both groups and in fasting serum glucose of only STZ-60 group in comparison with the control group. Although some histopathological damages were observed in testes of both STZ-40 and STZ-60 groups, there were no detectable differences between the groups in density of insulin, glucagon and somatostatin receptors in pancreas. In conclusion, GDM has negative effects on reproductive efficiency and testicular–pancreatic tissue oxidant/antioxidant balance of male offspring at post-pubertal stage. © 2018 Blackwell Verlag Gmb Daha fazlası Daha az

Pharmacotherapeutic agents used in temporomandibular disorders

B. Bal Kucuk | S. Tolunay Kaya | P. Karagoz Motro | K. Oral

Review | 2014 | Oral Diseases20 ( 8 ) , pp.740 - 743

Depending on the source and character, pharmacotherapy is one of the most commonly used methods to treat temporomandibular disorders in addition to the use of appliances, physiotherapy, behavioral therapy, and surgical interventions. To decide on the appropriate treatment approach for the treatment of temporomandibular disorders, pharmacotherapeutics should be understood in great detail. As for other pain treatments, pharmacotherapy can be used as a monotherapy or combined with other treatment options in temporomandibular disorders. The aim of the present review is to overview the primary analgesics and myorelaxants used in temporom . . .andibular disorders. © 2014 John Wiley & Sons A/S Daha fazlası Daha az

The Role of Anger in the Biased Assimilation of Political Information

Suhay, E. | Erisen, C.

Article | 2018 | Political Psychology39 ( 4 ) , pp.793 - 810

Political psychologists have established that politically motivated reasoning is a common phenomenon; however, the field knows comparatively less about the psychological mechanisms that drive it. Drawing on advances in the understanding of the relevance of emotion to political reasoning and behavior, we argue that anger likely plays a major role in motivating individuals to engage in the biased assimilation of political information—an evaluative bias in favor of information that bolsters one's views and against information that undercuts them. We test this proposition with two online studies, the second of which includes a quasi-rep . . .resentative sample of Americans. The studies support our expectations. Individuals felt more negative emotions toward arguments that undermined their attitudes and positive emotions toward arguments that confirmed them; however, anger was nearly alone in fueling biased reactions to issue arguments. © 2018 International Society of Political Psycholog Daha fazlası Daha az

The Effects of Different Cooking Methods on Some Quality Criteria and Mineral Composition of Beef Steaks

Oz, F. | Aksu, M.I. | Turan, M.

Article | 2017 | Journal of Food Processing and Preservation41 ( 4 ) , pp.793 - 810

Effects of different cooking methods (deep fat frying, hot plate, boiling, microwave, pan-frying with oil, pan-frying without fat or oil and oven cooking) on some quality criteria and mineral composition of steaks were investigated. Water content, pH, lipid oxidation (TBARS), color (L*, a*, b* values) and mineral composition of both raw and cooked samples were determined. Cooking methods had a significant effect (P < 0.01) on all the parameters analyzed except for some mineral content (Fe, Mn, Ni and Pb). It was determined that pH, TBARS, L* and b* values of the samples increased with cooking (P < 0.05), while water content, a* valu . . .es and all mineral contents analyzed decreased (P < 0.05). Losses in the amounts of Fe, Pb, S and Zn with cooking were less than 10%, while those of other minerals ranged between 13.6 and 21.1%. The lowest dry matter and cooking loss were determined in the samples pan-fried without fat or oil (P < 0.05. Practical Applications: Cooking is a procedure usually applied immediately before consumption of meat and meat products, and meat and meat products are usually eaten cooked except for the products especially raw eaten. The cooking of meat results in better aroma and also the cooked meat is tenderer compared to raw meat. In addition, if cooked properly, meat, more attractive and delicious when served hot, is easier to digest while almost sterile. However, cooking affects the nutritional value of meat due to changes in certain components. In addition, the cooking could result in a number of harmful chemical compounds. Quality properties and nutritional values of cooked meat can be dependent on cooking method. In the present study, the changes in meat cooked by common cooking methods and the differences between cooking methods were detected. © 2016 Wiley Periodicals, Inc Daha fazlası Daha az

Drift shell bifurcation near the dayside magnetopause in realistic magnetospheric magnetic fields

Wan, Y. | Sazykin, S. | Wolf, R.A. | Öztrük, M.K.

Article | 2010 | Journal of Geophysical Research: Space Physics115 ( 10 ) , pp.793 - 810

We study trapped energetic particles in the terrestrial magnetosphere undergoing drift shell bifurcation in the magnetic field lacking north-south and east-west symmetry. Drift shell bifurcation occurs near the dayside magnetopause, where, due to the solar wind compression, the field strength has a local maximum near the equatorial plane. As a result, a charged particle may become temporarily trapped in one of the hemispheres while traversing the region. Although this phenomenon has been known for a long time, only recently were the associated second invariant changes quantified for the magnetic field with north-south and east-west . . .symmetry. Here we show that if the magnetic field lacks such symmetry, the effect is more significant. We calculate changes to the second invariant of keV to MeV electrons in Tsyganenko magnetic fields with nonzero interplanetary magnetic field (IMF) BY component. The changes are on the order of the invariant itself, and thus, this effect is much larger than for the case of symmetric magnetic field (when the particle gyroradius is much less than the magnetospheric scale length). We also quantify the effect for different values of the solar wind dynamic pressure, IMF BZ component, and the Dst index with the Tsyganenko magnetic field T02. We find that Dst has no noticeable role, while larger solar wind ram pressure increases the second invariant changes. We verify our calculations by numerical integration of the guiding center drift equations and discuss properties of different versions of these equations. Copyright 2010 by the American Geophysical Union Daha fazlası Daha az

A system dynamics model for the analysis of clinical laboratory productivity

Gönül-Sezer, E.D. | Ocak, Z.

Article | 2018 | International Transactions in Operational Research , pp.793 - 810

This study describes the initial stages of the development of a system dynamics (SD) model that will be used to simulate the dynamics of various factors that impact the productivity of clinical laboratories. Facing a staff capacity constraint, a clinical laboratory can undertake a number of strategies: (a) hiring new staff, (b) working overtime, or (c) doing both. In this preliminary research, we use a dynamic model to (a) study the impact of these strategies on laboratory productivity, including cost control, and (b) simulate the laboratory human resource utilization process. An SD approach is used for model development because it . . .enables modelers to understand and discuss complex problems by illuminating the relationships among the variables involved. We use a laboratory's test backlog and the test turnaround time as main productivity parameters for this preliminary study. We run the simulation for six months and study laboratory productivity performance behavior over this time period. © 2018 The Authors Daha fazlası Daha az

Comparison of combined antioxidants and thymoquinone in the prevention of testis ischemia – reperfusion injury

Erol, B. | Sari, U. | Amasyali, A.S. | Ozkanli, S. | Sogut, S. | Hanci, V. | Caskurlu, T.

Article | 2017 | Andrology5 ( 1 ) , pp.119 - 124

We aimed to compare the preventive effects of combined antioxidants (CA1, 2) with a single antioxidant drug (thymoquinone; TQ) on experimental testis Ischemia/Reperfusion (I/R) injury. Thirty-five adult male Wistar rats were divided into five groups of seven rats each: control, testis I/R, testis I/R + CA1, testis I/R + CA2, and testis I/R + TQ. After 1 h of testicular ischemia, reperfusion was achieved by detorsion for 4 h. Antioxidants were intraperitoneally administered for 30 min prior to reperfusion. All rats were sacrificed 4 h after reperfusion to evaluate the tissue levels of malondialdehyde (MDA) and total antioxidant statu . . .s (TAS) and the immunohistochemical evaluation of tissue inducible and endothelial nitric acid synthase (iNOS, eNOS) and apoptosis protease-activating factor 1 (APAF-1). MDA levels were lower and TAS values were higher in the I/R + antioxidant groups than in the I/R group (p Daha fazlası Daha az

Comparison of tramadol versus tramadol with paracetamol for efficacy of postoperative pain management in lumbar discectomy: A randomised controlled study

N. Uztüre | H. Türe | Ö. Keskin | B. Atalay | Ö. Köner

Article | 2020 | International Journal of Clinical Practice74 ( 1 ) , pp.119 - 124

Purpose: Despite developments in the treatment of pain, the availability of new drugs or increased knowledge of pain management, postoperative pain control after different surgeries remains inadequate. We aimed to compare the postoperative analgesic efficacy of tramadol versus tramadol with paracetamol after lumbar discectomy. Design, Setting, Participants: Sixty patients undergoing lumbar discectomy were randomly assigned into two groups. Methods: Patients in Group T (n = 30) received tramadol (1 mg/kg), and patients in Group TP (n = 30) received tramadol (1 mg/kg) with paracetamol (1 g) 30 minutes before the end of surgery and par . . .acetamol was continued during the postoperative period at 6 hours intervals for the first 24 hours. Patient-controlled analgesia with tramadol was used during the postoperative period. Main Outcome Measures: Duration, postoperative pain scores, Ramsay sedation scores, analgesic consumption, and side effects were recorded in all patients during the postoperative period. Continuous random variables were tested for normal distribution using the Kolmogorov-Smirnov test, than Student's t-test was used for means comparisons between groups. For discrete random variables chi-square tests and McNemar test was used. Results: Demographic data, mean duration of anaesthesia and surgery were similar in both groups. Postoperative pain scores were significantly higher in Group T than Group TP at 5; 15; 20; and 30 minutes (P =.021, P =.004, P =.002, P =.018). Late postoperative pain scores were similar. Total tramadol consumption in Group T (106.12 ± 4.84 mg) was higher than Group TP (81.20 ± 2.53) during the 24 hours postoperative period. However, continuing the paracetamol at 6 hours interval did not change late postoperative pain scores. Conclusion: The administration of tramadol with paracetamol was more effective than tramadol alone for early acute postoperative pain therapy following lumbar discectomy. Therefore, while adding paracetamol in early pain management is recommended, continuing paracetamol for the late postoperative period is not advised. © 2019 John Wiley & Sons Lt Daha fazlası Daha az

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