İyigündoğdu, Zeynep Ustaoğlu | Demirci, Selami | Baç, Nurcan | Şahin, Fikrettin

Article | 2014 | Turkish Journal of Biology38 ( 3 ) , pp.420 - 427

The present work involves development of stable antimicrobial materials containing silver- and zinc-ion-exchanged zeolites. Faujasite X and Linde type A zeolites were synthesized, and following ion exchange with Ag and Zn ions they were found to exhibit antimicrobial effects against bacteria (E. coli, P. aeruginosa, and S. aureus), yeast (C. albicans and C. glabrata), and fungi (A. niger and P. expansum). Zeolites-X and -A containing silver and zinc ions were then mixed with various coating materials, including paints and polypropylene, to develop antimicrobial composites. The long-term antimicrobial characteristics of zeolite-conta . . .ining composite materials were investigated by inoculating selected microorganisms onto the surface of the materials. The results indicated that the higher the zeolite concentration present in the composite, the more long-term antimicrobial activity was achieved. Silver-ion-exchanged zeolites were more effective against bacterial and candidal species, while zinc zeolites exhibited noticeable antifungal properties. Materials manufactured with metal-ion-exchanged zeolites would prevent microbial growth on surfaces, reducing cross-contamination and infection risk as well as the microbial degradation of products Daha fazlası Daha az

Demirci, Selami | Kaya, Mustafa Sarp | Doğan, Ayşegül | Kalay, Şaban | Altın, Nergis Özlem | Yarat, Ayşen | Şahin, Fikrettin

Article | 2015 | Turkish Journal of Biology39 ( 3 ) , pp.417 - 426

Secondary dental caries are one of the major reasons for restoration replacements. Incorporating antimicrobial properties into dental materials would limit the initiation and progression of dental caries. In the current study, dental composites having 1%, 5%, and 10% (w/w) sodium pentaborate pentahydrate were prepared and analyzed for their mechanical properties, degree of monomer conversion (DC) rate, antibacterial efects against Streptococcus mutans, and biocompatibility with human dental pulp stem cells (hDPSCs). Incorporation of boron into the composites signifcantly decreased fexural strength and DC in a dose-dependent manner, . . .but the value for 1% boron-containing composite still remained within acceptable levels. Compressive strength and diametral tensile strength were not found to be diferent from those of controls. Although no inhibition zone was detected in an agar-well difusion assay for any materials tested, signifcant bacterial growth inhibition was obtained in a direct contact test for boron-containing composites. Immunocytochemical and lineage-specifc gene expression analysis revealed that composites with boron content increased the osteogenic and odontogenic capacity of hDPSCs. Boron-containing dental composites showed promising results for future clinical applications, displaying nontoxic, osteogenic, and odontogenic-inducing characteristics with remarkable antibacterial activity against S. mutans, and are hence potentially able to prevent secondary caries Daha fazlası Daha az