The effects of PON1 gene Q192R variant on the development of uterine leiomyoma in Turkish patients

Aim: This study aimed to analyze the relation between uterine leiomyoma (ULM) patients and p.Q192R polymorphism. Materials and Methods: ULM patients (n=76) and healthy women (n=103) were recruited from the Yeditepe University, Department of Gynecology and Obstetrics. The genotype and allele distribution of p.Q192R was analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. Genotype and allele frequencies between study groups were calculated by the chisquare (?2) and Fischer's exact test. Results: The frequency of the B allele was lower in patients (p<0.001) and the AB genotype showed a decreased risk for ULM development (p<0.001). The variation was unrelated to ULM size and number. There was no significant difference between p.Q192R genotype frequencies and fibroid size and number. Conclusion: The heterogeneous AB genotype of PON1 p.Q192R variation could be recognized as a low-risk parameter for the development of ULM in Turkish women. © 2015, International Institute of Anticancer Research. All rights reserved.

Yazar Attar, Rukset
Atasoy, H.
Inal-Gültekin, G.
Timirci-Kahraman, Ö.
Güleç-Yilmaz, S.
Dalan, A.B.
İşbir, Turgay
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.11831/6535
Konu Başlıkları Cancer
Ethnicity
Paraoxanase
PON 192
Uterine benign tumor
Koleksiyonlar Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed
02- WoS İndeksli Yayınlar Koleksiyonu
03- Scopus İndeksli Yayınlar Koleksiyonu
05- PubMed İndeksli Yayınlar Koleksiyonu
Dergi Adı In Vivo
Cild 29
Dergi Sayısı 2
Sayfalar 243 - 246
Yayın Tarihi 2015
Eser Adı
[dc.title]
The effects of PON1 gene Q192R variant on the development of uterine leiomyoma in Turkish patients
Yazar
[dc.contributor.author]
Attar, Rukset
Yazar
[dc.contributor.author]
Atasoy, H.
Yazar
[dc.contributor.author]
Inal-Gültekin, G.
Yazar
[dc.contributor.author]
Timirci-Kahraman, Ö.
Yazar
[dc.contributor.author]
Güleç-Yilmaz, S.
Yazar
[dc.contributor.author]
Dalan, A.B.
Yazar
[dc.contributor.author]
İşbir, Turgay
Yayıncı
[dc.publisher]
International Institute of Anticancer Research
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: This study aimed to analyze the relation between uterine leiomyoma (ULM) patients and p.Q192R polymorphism. Materials and Methods: ULM patients (n=76) and healthy women (n=103) were recruited from the Yeditepe University, Department of Gynecology and Obstetrics. The genotype and allele distribution of p.Q192R was analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. Genotype and allele frequencies between study groups were calculated by the chisquare (?2) and Fischer's exact test. Results: The frequency of the B allele was lower in patients (p<0.001) and the AB genotype showed a decreased risk for ULM development (p<0.001). The variation was unrelated to ULM size and number. There was no significant difference between p.Q192R genotype frequencies and fibroid size and number. Conclusion: The heterogeneous AB genotype of PON1 p.Q192R variation could be recognized as a low-risk parameter for the development of ULM in Turkish women. © 2015, International Institute of Anticancer Research. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2020-03-18
Yayın Tarihi
[dc.date.issued]
2015
Açık Erişim Tarihi
[dc.date.available]
2020-03-18
Dil
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cancer
Konu Başlıkları
[dc.subject]
Ethnicity
Konu Başlıkları
[dc.subject]
Paraoxanase
Konu Başlıkları
[dc.subject]
PON 192
Konu Başlıkları
[dc.subject]
Uterine benign tumor
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0258851X
Yayının ilk sayfa sayısı
[dc.identifier.startpage]
243
Yayının son sayfa sayısı
[dc.identifier.endpage]
246
Dergi Adı
[dc.relation.journal]
In Vivo
Dergi Sayısı
[dc.identifier.issue]
2
Cild
[dc.identifier.volume]
29
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.11831/6535
Pubmed Id
[dc.identifier.pubmed]
PubMed ID: 25792652
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
64
20.03.2023 tarihinden bu yana
İndirme
1
20.03.2023 tarihinden bu yana
Son Erişim Tarihi
29 Eylül 2023 03:16
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Tıklayınız
genotype allele between patients variation development number frequencies polymorphism decreased unrelated showed significant difference reserved rights Research Anticancer Institute International Turkish fibroid parameter low-risk recognized heterogeneous Conclusion calculated (n=76) Department University Yeditepe recruited (n=103) healthy
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