Cancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives
A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and 1H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
| Yazar |
Yarim, M. Koksal, M. Durmaz, I. Atalay, R. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.11831/2973 |
| Konu Başlıkları |
1-(4-chlorobenzhydryl)piperazine derivatives
Benzoyl chlorides Cancer Cell proliferation Cytotoxicity |
| Koleksiyonlar |
Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed 02- WoS İndeksli Yayınlar Koleksiyonu 03- Scopus İndeksli Yayınlar Koleksiyonu 05- PubMed İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | International Journal of Molecular Sciences |
| Cild | 13 |
| Dergi Sayısı | 7 |
| Sayfalar | 8071 - 8085 |
| Yayın Tarihi | 2012 |
| Eser Adı [dc.title] | Cancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives |
| Yazar [dc.contributor.author] | Yarim, M. |
| Yazar [dc.contributor.author] | Koksal, M. |
| Yazar [dc.contributor.author] | Durmaz, I. |
| Yazar [dc.contributor.author] | Atalay, R. |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and 1H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines. © 2012 by the authors; licensee MDPI, Basel, Switzerland. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2020-03-17 |
| Yayın Tarihi [dc.date.issued] | 2012 |
| Açık Erişim Tarihi [dc.date.available] | 2020-03-17 |
| Dil [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | 1-(4-chlorobenzhydryl)piperazine derivatives |
| Konu Başlıkları [dc.subject] | Benzoyl chlorides |
| Konu Başlıkları [dc.subject] | Cancer |
| Konu Başlıkları [dc.subject] | Cell proliferation |
| Konu Başlıkları [dc.subject] | Cytotoxicity |
| Haklar [dc.rights] | info:eu-repo/semantics/openAccess |
| ISSN [dc.identifier.issn] | 16616596 |
| Yayının ilk sayfa sayısı [dc.identifier.startpage] | 8071 |
| Yayının son sayfa sayısı [dc.identifier.endpage] | 8085 |
| Dergi Adı [dc.relation.journal] | International Journal of Molecular Sciences |
| Dergi Sayısı [dc.identifier.issue] | 7 |
| Cild [dc.identifier.volume] | 13 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.11831/2973 |
| Pubmed Id [dc.identifier.pubmed] | PubMed ID: 22942690 |
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