Square wave voltammetric determination of valproic acid in pharmaceuticalPreparations
The electrochemical behavior of valproic acid (VAL) was investigated using square wave voltammetry, cyclicvoltammetry, and sampled direct current polarography and a new square wave voltammetric method was developed fordetermination of VAL in pharmaceutical preparations. VAL showed two reduction peaks at about {0.2 V and {0.8 V vs.Ag/AgCl 3 M KCl with a hanging mercury drop electrode in 0.05 M pH 3.3 Britton{Robinson (BR) buffer. These peakswere named peak I and peak II, respectively. The types of limiting current of both peaks were determined as diffusioncontrolled based on cyclic voltammetry studies. A linear calibration graph was obtained in the range 1.46104{1.0103M. The limit of detection (LOD) and limit of quanti cation (LOQ) were 1.09104M (21.05g/mL) and1.10104M (144.20g/mL), respectively. Recovery studies for the accuracy of the method were performed byadding known amounts of VAL and it was found to be 109.674.85%. The proposed method was successfully appliedto pharmaceutical products on the market.
| Yazar |
Acar, Ebru Türköz Onar, Atiye Nur |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.11831/5357 |
| Konu Başlıkları |
Mühendislik
Kimya |
| Koleksiyonlar |
Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed 04- TR-Dizin İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Turkish Journal of Chemistry |
| Cild | 40 |
| Dergi Sayısı | 1 |
| Sayfalar | 106 - 116 |
| Yayın Tarihi | 2016 |
| Eser Adı [dc.title] | Square wave voltammetric determination of valproic acid in pharmaceuticalPreparations |
| Yazar [dc.contributor.author] | Acar, Ebru Türköz |
| Yazar [dc.contributor.author] | Onar, Atiye Nur |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | The electrochemical behavior of valproic acid (VAL) was investigated using square wave voltammetry, cyclicvoltammetry, and sampled direct current polarography and a new square wave voltammetric method was developed fordetermination of VAL in pharmaceutical preparations. VAL showed two reduction peaks at about {0.2 V and {0.8 V vs.Ag/AgCl 3 M KCl with a hanging mercury drop electrode in 0.05 M pH 3.3 Britton{Robinson (BR) buffer. These peakswere named peak I and peak II, respectively. The types of limiting current of both peaks were determined as diffusioncontrolled based on cyclic voltammetry studies. A linear calibration graph was obtained in the range 1.46104{1.0103M. The limit of detection (LOD) and limit of quanti cation (LOQ) were 1.09104M (21.05g/mL) and1.10104M (144.20g/mL), respectively. Recovery studies for the accuracy of the method were performed byadding known amounts of VAL and it was found to be 109.674.85%. The proposed method was successfully appliedto pharmaceutical products on the market. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2020-03-18 |
| Yayın Tarihi [dc.date.issued] | 2016 |
| Açık Erişim Tarihi [dc.date.available] | 2020-03-18 |
| Dil [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Mühendislik |
| Konu Başlıkları [dc.subject] | Kimya |
| Haklar [dc.rights] | info:eu-repo/semantics/openAccess |
| ISSN [dc.identifier.issn] | 1300-0527 |
| ISSN [dc.identifier.issn] | 1303-6130 |
| Yayının ilk sayfa sayısı [dc.identifier.startpage] | 106 |
| Yayının son sayfa sayısı [dc.identifier.endpage] | 116 |
| Dergi Adı [dc.relation.journal] | Turkish Journal of Chemistry |
| Dergi Sayısı [dc.identifier.issue] | 1 |
| Cild [dc.identifier.volume] | 40 |
| Tek Biçim Adres [dc.identifier.uri] | http://www.trdizin.gov.tr/publication/paper/detail/TWpVMk1EVTBOQT09 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.11831/5357 |
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