Key Roles of Vitamins A, C, and E in Aflatoxin B1-Induced Oxidative Stress
Aflatoxins (Aspergillus flavus toxins) are one of the natural toxic molecules which are produced by a group of fungi called Aspergillus. Foods and drinks contaminated with aflatoxins cause global health and environmental problems. Today in many developing countries, these toxins are leading cause of some liver cancers and serious gastrointestinal problems. Aflatoxins, which are well known to be mutagenic, carcinogenic, hepatotoxic, and immunosuppressive, exert inhibitory effects on biological processes including DNA synthesis, DNA-dependent RNA synthesis, DNA repair, and protein synthesis. Aflatoxins B1 (AFB1) is the most widespread oxidative agent of the aflatoxins. Numerous diverse compounds and extracts have been reported to reduce the aflatoxins induced oxidative stress in the body. Most of these inhibitors including phenylpropanoids, terpenoids, alkaloids, and vitamins are originally derived from plants. Among these, being essential biomolecules, vitamins are used as coenzymes in very significant biological reactions. They also function as nonenzymatic antioxidative agents protecting the cells from oxidative stress-induced toxicity and transformation. This chapter reviews the mechanism of AFB1-induced oxidative stress and focuses on the protective effects of vitamins A, C, and E on reducing this stress. © 2011 Elsevier Inc.
| Yazar |
Alpsoy, L. Yalvac, M.E. |
| Yayın Türü | Book |
| Tek Biçim Adres | https://hdl.handle.net/20.500.11831/543 |
| Konu Başlıkları |
Aflatoxin B1
Oxidative stress Vitamins A, C, and E |
| Koleksiyonlar |
Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed 03- Scopus İndeksli Yayınlar Koleksiyonu 05- PubMed İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Vitamins and Hormones |
| Sayfalar | - |
| Yayın Tarihi | 2011 |
| Eser Adı [dc.title] | Key Roles of Vitamins A, C, and E in Aflatoxin B1-Induced Oxidative Stress |
| Yazar [dc.contributor.author] | Alpsoy, L. |
| Yazar [dc.contributor.author] | Yalvac, M.E. |
| Yayın Türü [dc.type] | book |
| Özet [dc.description.abstract] | Aflatoxins (Aspergillus flavus toxins) are one of the natural toxic molecules which are produced by a group of fungi called Aspergillus. Foods and drinks contaminated with aflatoxins cause global health and environmental problems. Today in many developing countries, these toxins are leading cause of some liver cancers and serious gastrointestinal problems. Aflatoxins, which are well known to be mutagenic, carcinogenic, hepatotoxic, and immunosuppressive, exert inhibitory effects on biological processes including DNA synthesis, DNA-dependent RNA synthesis, DNA repair, and protein synthesis. Aflatoxins B1 (AFB1) is the most widespread oxidative agent of the aflatoxins. Numerous diverse compounds and extracts have been reported to reduce the aflatoxins induced oxidative stress in the body. Most of these inhibitors including phenylpropanoids, terpenoids, alkaloids, and vitamins are originally derived from plants. Among these, being essential biomolecules, vitamins are used as coenzymes in very significant biological reactions. They also function as nonenzymatic antioxidative agents protecting the cells from oxidative stress-induced toxicity and transformation. This chapter reviews the mechanism of AFB1-induced oxidative stress and focuses on the protective effects of vitamins A, C, and E on reducing this stress. © 2011 Elsevier Inc. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2020-03-17 |
| Açık Erişim Tarihi [dc.date.available] | 2020-03-17 |
| Yayın Tarihi [dc.date.issued] | 2011 |
| Dil [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Aflatoxin B1 |
| Konu Başlıkları [dc.subject] | Oxidative stress |
| Konu Başlıkları [dc.subject] | Vitamins A, C, and E |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.11831/543 |
| Dergi Adı [dc.relation.journal] | Vitamins and Hormones |
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