The effect of indomethacin on hyperoxaluria-induced renal tubular epithelial injury

Objective: The aim of this study was to determine the effect of indomethacin, an anti-inflammatory agent, on apoptosis and crystal deposition developing as a consequence of tubular cell injury induced by hyperoxaluria in an animal model. Materials and methods: Fifty New Zealand rabbits were divided into 3 groups. The first 2 groups were fed with hyperoxaluric diet and Group 3 was the control group with no supplementary procedure or treatment. While the animals in Group 1 were given only hyperoxaluric diet, Group 2 animals was applied indomethacin in addition to the hyperoxaluric diet. Animals were sacrificed at the early (7th day) and late (28th day) periods and renal tis-sue specimens were sent for the pathological analysis of crystal deposition and apoptosis. Results: The presence and degree of crystal deposition were significantly less in the specimens obtained from indomethacin-treated group during both the early and late periods (p<0.001). Similarly, despite the evident tubular apoptosis in group receiving only hyperoxaluric diet; tubular apoptotic changes were limited in animals treated with additional indomethacin (p<0.001). Conclusion: As a result of cell injury developing due to hyperoxaluria, crystal deposition and apoptotic differences occur and the presence of ischemia increases both effects. At this point, in experimental model, indomethacin limits crystal deposition and apoptotic differences in the renal tissue.

Yazar Yencilek, F.
Erturhan, S.
Cangüven, Ö.
Erol, B.
Koyuncu, H.
Göktaş, C.
Sarica, K.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.11831/4913
Konu Başlıkları Hyperoxaluria
Indomethacin
Renal tubular injury
Koleksiyonlar Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed
03- Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Turk Uroloji Dergisi
Cild 35
Dergi Sayısı 4
Sayfalar 298 - 303
Yayın Tarihi 2009
Eser Adı
[dc.title]
The effect of indomethacin on hyperoxaluria-induced renal tubular epithelial injury
Yazar
[dc.contributor.author]
Yencilek, F.
Yazar
[dc.contributor.author]
Erturhan, S.
Yazar
[dc.contributor.author]
Cangüven, Ö.
Yazar
[dc.contributor.author]
Erol, B.
Yazar
[dc.contributor.author]
Koyuncu, H.
Yazar
[dc.contributor.author]
Göktaş, C.
Yazar
[dc.contributor.author]
Sarica, K.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The aim of this study was to determine the effect of indomethacin, an anti-inflammatory agent, on apoptosis and crystal deposition developing as a consequence of tubular cell injury induced by hyperoxaluria in an animal model. Materials and methods: Fifty New Zealand rabbits were divided into 3 groups. The first 2 groups were fed with hyperoxaluric diet and Group 3 was the control group with no supplementary procedure or treatment. While the animals in Group 1 were given only hyperoxaluric diet, Group 2 animals was applied indomethacin in addition to the hyperoxaluric diet. Animals were sacrificed at the early (7th day) and late (28th day) periods and renal tis-sue specimens were sent for the pathological analysis of crystal deposition and apoptosis. Results: The presence and degree of crystal deposition were significantly less in the specimens obtained from indomethacin-treated group during both the early and late periods (p<0.001). Similarly, despite the evident tubular apoptosis in group receiving only hyperoxaluric diet; tubular apoptotic changes were limited in animals treated with additional indomethacin (p<0.001). Conclusion: As a result of cell injury developing due to hyperoxaluria, crystal deposition and apoptotic differences occur and the presence of ischemia increases both effects. At this point, in experimental model, indomethacin limits crystal deposition and apoptotic differences in the renal tissue.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2020-03-18
Yayın Tarihi
[dc.date.issued]
2009
Açık Erişim Tarihi
[dc.date.available]
2020-03-18
Dil
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Hyperoxaluria
Konu Başlıkları
[dc.subject]
Indomethacin
Konu Başlıkları
[dc.subject]
Renal tubular injury
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
Alternatif Başlık
[dc.title.alternative]
Hiperoksalürinin neden oldugu renal tübüler epiteliyal hasar üzerine indometazinin etkisi
ISSN
[dc.identifier.issn]
13005804
Yayının ilk sayfa sayısı
[dc.identifier.startpage]
298
Yayının son sayfa sayısı
[dc.identifier.endpage]
303
Dergi Adı
[dc.relation.journal]
Turk Uroloji Dergisi
Dergi Sayısı
[dc.identifier.issue]
4
Cild
[dc.identifier.volume]
35
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.11831/4913
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
20.03.2023 tarihinden bu yana
İndirme
1
20.03.2023 tarihinden bu yana
Son Erişim Tarihi
29 Eylül 2023 14:41
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Tıklayınız
deposition crystal hyperoxaluric indomethacin animals tubular apoptosis apoptotic specimens groups injury hyperoxaluria periods developing presence differences Results degree analysis indomethacin-treated during obtained pathological significantly Objective limited Similarly tissue limits experimental effects increases ischemia despite result
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