Effect of hyperbaric oxygen therapy on bone prefabrication in rats
Objectives: This experimental study aimed to create a prefabricated vascularized bone graft using the interconnected porous coralline hydroxyapatite ceramic by combining vascular bundle implantation, mesenchymal stem cells, and hyperbaric oxygen therapy (HBOT) administration in a rat model. Methods: Forty-five male Sprague-Dawley rats were divided into three groups, each containing 15 rats. The hydroxyapatite ceramics were vascularized by the superficial inferior epigastric artery and vein in all groups. These vessels passed through the hole of the hydroxyapatite blocks. In Group 2, mesenchymal stem cells were administered into the hydroxyapatite. In Group 3, both mesenchymal stem cells and HBOT were administered. The presence and density of any new bone formation and neovascularization were evaluated by radiography, microangiography, scintigraphy, biochemical analysis, and histomorphometry. Results: Neovascularization and bone formation were significantly greater in Group 3, in which both mesenchymal stem cells and HBOT were applied, than the other groups. Conclusion: HBOT enhances neovascularization and osteogenesis, thus HBOT can provide optimal and faster prefabrication of a vascularized bone graft. © 2010 Turkish Association of Orthopaedics and Traumatology.
| Yazar |
Sever, C. Uygur, F. Külahçi, Y. Torun Köse, G. Urhan, M. Küçükodaci, Z. Çayci, T. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.11831/5996 |
| Konu Başlıkları |
Bone grafting
Hydroxyapatite ceramic Hyperbaric oxygen therapy Rat |
| Koleksiyonlar |
Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed 02- WoS İndeksli Yayınlar Koleksiyonu 03- Scopus İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Acta Orthopaedica et Traumatologica Turcica |
| Cild | 44 |
| Dergi Sayısı | 5 |
| Sayfalar | 403 - 409 |
| Yayın Tarihi | 2010 |
| Eser Adı [dc.title] | Effect of hyperbaric oxygen therapy on bone prefabrication in rats |
| Yazar [dc.contributor.author] | Sever, C. |
| Yazar [dc.contributor.author] | Uygur, F. |
| Yazar [dc.contributor.author] | Külahçi, Y. |
| Yazar [dc.contributor.author] | Torun Köse, G. |
| Yazar [dc.contributor.author] | Urhan, M. |
| Yazar [dc.contributor.author] | Küçükodaci, Z. |
| Yazar [dc.contributor.author] | Çayci, T. |
| Yayıncı [dc.publisher] | Turkish Association of Orthopaedics and Traumatology |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Objectives: This experimental study aimed to create a prefabricated vascularized bone graft using the interconnected porous coralline hydroxyapatite ceramic by combining vascular bundle implantation, mesenchymal stem cells, and hyperbaric oxygen therapy (HBOT) administration in a rat model. Methods: Forty-five male Sprague-Dawley rats were divided into three groups, each containing 15 rats. The hydroxyapatite ceramics were vascularized by the superficial inferior epigastric artery and vein in all groups. These vessels passed through the hole of the hydroxyapatite blocks. In Group 2, mesenchymal stem cells were administered into the hydroxyapatite. In Group 3, both mesenchymal stem cells and HBOT were administered. The presence and density of any new bone formation and neovascularization were evaluated by radiography, microangiography, scintigraphy, biochemical analysis, and histomorphometry. Results: Neovascularization and bone formation were significantly greater in Group 3, in which both mesenchymal stem cells and HBOT were applied, than the other groups. Conclusion: HBOT enhances neovascularization and osteogenesis, thus HBOT can provide optimal and faster prefabrication of a vascularized bone graft. © 2010 Turkish Association of Orthopaedics and Traumatology. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2020-03-18 |
| Yayın Tarihi [dc.date.issued] | 2010 |
| Açık Erişim Tarihi [dc.date.available] | 2020-03-18 |
| Dil [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Bone grafting |
| Konu Başlıkları [dc.subject] | Hydroxyapatite ceramic |
| Konu Başlıkları [dc.subject] | Hyperbaric oxygen therapy |
| Konu Başlıkları [dc.subject] | Rat |
| Haklar [dc.rights] | info:eu-repo/semantics/openAccess |
| ISSN [dc.identifier.issn] | 1017995X |
| Yayının ilk sayfa sayısı [dc.identifier.startpage] | 403 |
| Yayının son sayfa sayısı [dc.identifier.endpage] | 409 |
| Dergi Adı [dc.relation.journal] | Acta Orthopaedica et Traumatologica Turcica |
| Dergi Sayısı [dc.identifier.issue] | 5 |
| Cild [dc.identifier.volume] | 44 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.11831/5996 |
27
1
29 Eylül 2023 03:16
Tıklayınız
