The effects of intra-articular levobupivacain versus levobupivacain plus magnesium sulfate on postoperative analgesia in patients undergoing arthroscopic meniscectomy: A prospective randomized controlled study

Objective: The aim of this study was to compared the effectiveness of intraarticular levobupivacain withlevobupivacain and magnesium sulfate.Methods: In this prospective randomized double blinded study, 96 patients (67 male, 29 female; agerange: 18e65 years) with ASA (American Society of Anesthesiologist) score I and II, who had undergonearthroscopic meniscectomy operation, were divided to 3 groups that had postoperative analgesia withintra-articular saline injection (control group), levobupivacain injection (L group) or levobupivacain andmagnesium sulfate injection (LM group). Patients were compared with postoperative VAS (Visual AnalogScore) score during rest and activity, opioid analgesic need, non-opioid analgesic need and othermedication needs.Results: Postoperative VAS scores during rest and activation at early postoperative period were signiŞcantly lower at LM group when compared with L group and lower than control group at all time periods.Opioid analgesic need, non-opioid analgesic need and other medication needs for non-pain symptomswere lower at LM group when compared with L and control groups at all time periods.Conclusion: Intraarticular magnesium sulfate plus Levobupivacain injection is a safe and effectivemethod for post operative pain management after arthroscopic meniscectomy.Keywords: Intra-articular injection, Magnesium sulfate, Levobupivacain, Postoperative analgesia, Chondrocyte apoptosis, Pain management, Arthroscopic menisectomyLevel of Evidence: Level I, Therapeutic study© 2017 Turkish Association of Orthopaedics and Traumatology. Publishing services by Elsevier B.V. This isan open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).