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Bulunan: 540 Adet 0.001 sn
Koleksiyon [5]
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Yazar [20]
Yayın Türü [9]
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Yayıncı [20]
Dil [3]
Yazar Departmanı [1]
Non-abelian local reciprocity law

Ikeda, K.I. | Serbest, E.

Article | 2010 | Manuscripta Mathematica132 ( 1 ) , pp.19 - 49

Following our work on the generalized Fesenko reciprocity map, we construct the non-abelian local reciprocity map ?K(?) of a local field K as a certain isomorphism from the absolute Galois group GK of K onto a topological group ?K,Y(?) whose definition involves Fontaine-Wintenberger theory of field of norms, and build the non-abelian local class field theory over K in the sense of Fesenko and Koch. © Springer-Verlag 2010.

Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: Novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate ?-ester modifications

Maruoka, H. | Barrett, M.O. | Ko, H. | Tosh, D.K. | Melman, A. | Burianek, L.E. | Jacobson, K.A.

Article | 2010 | Journal of Medicinal Chemistry53 ( 11 ) , pp.4488 - 4501

The P2Y6 receptor is a cytoprotective G-protein-coupled receptor (GPCR) activated by UDP (EC50 = 0.30 µM). We compared and combined modifications to enhance P2Y6 receptor agonist selectivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate modifications such as ?,ß-methylene and extension of the terminal phosphate group into ?-esters of UTP analogues. The conformationally constrained (S)-methanocarba-UDP is a full agonist (EC 50 = 0.042 µM). 4-Methoxyimino modification of pyrimidine enhanced P2Y6, preserved P2Y2 and P2Y4, and abolished P2Y14 receptor potency, in the appropriate nucleotide. N . . . 4-Benzyloxy-CDP (15, MRS2964) and N4-methoxy-Cp 3U (23, MRS2957) were potent, selective P2Y6 receptor agonists (EC50 of 0.026 and 0.012 µM, respectively). A hydrophobic binding region near the nucleobase was explored with receptor modeling and docking. UTP-?-aryl and cycloalkyl phosphoesters displayed only intermediate P2Y6 receptor potency but had enhanced stability in acid and cell membranes. UTP-glucose was inactive, but its (S)-methanocarba analogue and N4-methoxycytidine 5'-triphospho-?-[1]glucose were active (EC50 of 2.47 and 0.18 µM, respectively). Thus, the potency, selectivity, and stability of pyrimidine nucleotides as P2Y6 receptor agonists may be enhanced by modest structural changes. © 2010 American Chemical Society Daha fazlası Daha az

Large motor unit territories by scanning electromyography in patients with juvenile myoclonic epilepsy

Goker, I. | Baslo, B. | Ertas, M. | Ulgen, Y.

Article | 2010 | Journal of Clinical Neurophysiology27 ( 3 ) , pp.212 - 215

Juvenile myoclonic epilepsy is a genetically inherited disorder characterized by myoclonic jerks and generalized seizures. It has been proposed that patients with juvenile myoclonic epilepsy have larger motor units (MUs) than normals by MU number estimation and macro electromyography techniques. In this study, an experimental setup for scanning electromyography was built to investigate electrophysiologic cross-sections of the MU territories in 9 patients with juvenile myoclonic epilepsy, 3 patients with spinal muscular atrophy, and 10 healthy volunteers. Scanning electromyography was performed on the biceps brachii muscle. For each . . .MU, three-dimensional maps of the MU territories were plotted. The length of MU cross-section and the maximum amplitude of each MU were measured from these maps and compared among the three groups of subjects. Like spinal muscular atrophy patients, patients with juvenile myoclonic epilepsy had significantly larger MU territories than normal controls. Copyright © 2010 by the American Clinical Neurophysiology Society Daha fazlası Daha az

The value of different washout parameters in the evaluation of renal transplants by technetium-99m-ethylene-l-l-dicysteine

Kanmaz, B. | Sayman, H.B. | Alan, N. | Devranoglu, G. | Nisli, S. | Sonmezoglu, K. | Uslu, I.

Article | 2010 | Hellenic Journal of Nuclear Medicine13 ( 2 ) , pp.127 - 131

Technetium-99m-ethylene-l-l-dicysteine (99mTc-EC) is an agent with a potential for renal imaging. It is reported that EC uses the same tubular transporter system as orthohippurate (OIH) and mercaptoacetyltriglycine (MAG3) and that this agent has good imaging properties and higher renal clearance than MAG3. In this study we used 99mTc-EC to compare different washout parameters in renal transplanted patients. Sixty nine scans in 55 patients (38 males, 17 females) were performed with 99mTc-EC during the follow-up period after kidney transplantation. After bolus injection of 280MBq 99mTc-EC, 60x1sec and 29x1min images were taken in ante . . .rior position. Perfusions of transplanted kidneys were examined visually and perfusion indices (PI) were calculated according to Hilson's method. The semiquantitative washout parameters such as 20 and 30min to peak activity ratios and 20 and 30min to 3min activity ratios were calculated. The patients were clinically evaluated by nephrologists experienced in renal transplantation cases and followed-up by serum creatinine and blood urea nitrogen determinants which were checked every postoperative day until stabilized to a optimal level for each patient. Two standard deviations above the mean values derived from all cases with normal functioning transplanted kidneys were calculated for each method. Then, these values served as the threshold to differentiate the pathological cases respectively. Of the 69 total studies performed, we found 34 normal kidneys, 14 rejections, 19 acute tubular necrosis (ATN) and 2 cyclosporin A toxicity cases. The number of abnormal cases detected with 30/3min, 30/max, 20/3min and 20/max indices were 27, 26, 24, and 18, respectively. In conclusion, we strongly recommend in studying renal transplants to consider the activity at the 3 rd min post injection as a reference point instead of the time to maximum activity for washout index calculation. If, for any reason the time to maximum counts using 99mTc-(peak activity) is prefered, then the period of study should not be performed for less than 30min to achieve reliable results Daha fazlası Daha az

Structure of single-wall peptide nanotubes: In situ flow aligning X-ray diffraction

Castelletto, V. | Nutt, D.R. | Hamley, I.W. | Bucak, S. | Cenker, E. | Olsson, U.

Article | 2010 | Chemical Communications46 ( 34 ) , pp.6270 - 6272

The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A6K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into ß-sheet ribbons that wrap helically to form the nanotube wall. © 2010 The Royal Society of Chemistry.

Analyzing the Changes of Bosphorus Silhouette

Akdag, SG | Cagdas, G | Guney, C

Conference Object | 2010 | ECAADE 2010: FUTURE CITIES , pp.815 - 823

Due to improving technology and global competition today sky is the only limit for high towers of metropolitan areas. The increase in number of high rise has been ruining the silhouette of cities all over the world like Istanbul, whose identity and image have also been destroyed by skyscrapers dominating the seven slopes on which it was once built. The urbanization in Istanbul has somehow become homogenous and destructive over the topography. Despite of raising debates on the critical issue now and then, no analytical approach has ever been introduced. The research therefore, aims to analyze the change of Bosphorus silhouette caused . . . by the emergence of high rise blocks in Zincirlikuyu-Maslak route since it was defined as a Central Business District and a high rise development area by Bosphorus Conservation Law in 1991. ArcGIS Desktop software and its analyst extensions are used for mapping, analyzing and evaluating the urban development within years. The application is considered to be the initial step for a decision support system which will assist in assigning ground for high rise buildings in Istanbul Daha fazlası Daha az

Changes in corneal biomechanics in patients with keratoconus after penetrating keratoplasty

Yenerel, N.M. | Kucumen, R.B. | Gorgun, E.

Article | 2010 | Cornea29 ( 11 ) , pp.1247 - 1251

Purpose: To examine the biomechanical properties of keratoconic eyes following penetrating keratoplasty and to compare results with the biomechanical characteristics of manifest keratoconus, forme fruste keratoconus and normal eyes as measured with the Reichert ocular response analyzer (ORA). Methods: This retrospective analysis comprised a total of 169 eyes: 34 eyes with forme fruste keratoconus (group FF), 36 eyes with manifest keratoconus (Group KC), 36 eyes that have undergone penetrating keratoplasty (Group PK) and a control group of 63 normal eyes (Group N). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal com . . .pensated intraocular pressure, and Goldmann correlated intraocular pressure were measured by ORA. Central corneal thickness was calculated by the integrated handheld ultrasonic pachymeter of the ORA. The statistical analysis focused on CH and CRF changes among the 4 groups. Results: When compared with normal eyes, mean CH and CRF values were found significantly lower in all groups (P < 0.05). Mean CH values were 8.19 ± 1.49 mm Hg in Group KC, 9.21 ± 1.38 mm Hg in Group FF, 10.16 ± 1.93 mm Hg in Group PK, and 11.43 ± 1.52 mm Hg in normal eyes (Group N). Although there was not a significant difference in mean CH values between Groups PK and FF (P = 0.072), the difference was significant between Groups KC as well as FF and Groups KC and PK (P < 0.05). Mean CRF values were found as 6.79 ± 1.81 mm Hg (Group KC), 8.21 ± 1.64 mm Hg (Group FF), 9.94 ± 2.34 mm Hg (Group PK), and 11.53 ± 1.83 mm Hg in Group N. The difference was statistically significant among all groups (P < 0.05). Conclusions: Penetrating keratoplasty has a beneficial effect on corneal biomechanics in keratoconic eyes. CH and CRF parameters approach the range of normal eyes after corneal transplantation. Copyright © 2010 by Lippincott Williams & Wilkins Daha fazlası Daha az

An investigation of microstructure and mechanical properties of aluminum matrix composites reinforced with B4C particulates manufactured by powder metallurgy method

Güleryüz, L.F. | Ciblak, N. | Uzunsoy, D. | Ipek, R.

Conference Object | 2010 | Proceedings of the World Powder Metallurgy Congress and Exhibition, World PM 20104 , pp.1247 - 1251

Currently aluminum metal matrix composites (MMC) with particulate reinforcement and related manufacturing methods are among important research topics because of their low density, high specific stiffness, strength, and wear resistance. B4Cp/Al composites are commonly used materials for fabrication of light-weight functional components. Different percentage amounts of B4Cp (3wt%, 6wt%, and 9wt%) were added to the aluminum matrix and the composite materials were prepared at 823 °K under argon atmosphere. The X-ray diffraction (XRD) showed the formation of the phases such as Al, B4C and AlB2 in B4Cp/Al composites. The density of the co . . .mposite materials decreased from 2.5773 to 2.5270 g/cm3 with an increase in the amount of B4Cp addition. The optimum properties (hardness and compressive strength) were obtained by reinforcement with smallest B4C particles (size 22 µm). The present work was concentrated on the feasibility of the fabrication of B4Cp particulate reinforced aluminum MMCs by P/M technique Daha fazlası Daha az

Severe odynophagia in a patient developing after azithromycin intake: A case report

Akyuz, U. | Erzin, Y. | Yalniz, F.F. | Senkal, I.V. | Ekici, I.D. | Pata, C.

Article | 2010 | Cases Journal3 ( 2 ) , pp.1247 - 1251

Introduction: Drug-induced esophageal ulcers most commonly cause heartburn, midsternal pain and dysphagia. In our clinic azithromycin is a relative widely used antibiotic for respiratory tract infections and otitis media because of its activity against Haemophilus influenzae and atypical pathogens, and its ease of administration. After a thorough search in Pubmed the present case is the first one to report azithromycin-induced esophageal ulcer and associated symptoms in the literature. Case presentation: A 61-year-old Caucasian man was admitted to our endoscopy unit for the investigation of odynophagia and retrosternal pain of new o . . .nset. His past medical history was unremarkable but had used azithromycin 500 mg/d for three days in the previous week. An upper endoscopy revealed an extensive serpiginous midesophageal ulcer in the presence of a normal squamocolumnar junction and biopsies from the edges and center of the lesion disclosed no neoplasia or infectious causes but a dense acute inflammatory infiltrate. The patient was put on a liquid diet, sucralfate proton pump inhibitor treatment and was symptom-free within two weeks. After four weeks on therapy a repeated upper endoscopic control examination demonstrated normal findings. Conclusion: To our knowledge this is the first such a case of azithromycin -induced esophageal ulceration. We think that a little time taken by the physician to warn the patients for taking every oral drug with sufficient amount of water might prevent this kind of complications. © 2010 Akyuz et al; licensee BioMed Central Ltd Daha fazlası Daha az

Editorial comment

Kilickesmez, O.

Article | 2010 | International Braz J Urol36 ( 1 ) , pp.26 - 27

[No abstract available]

Solution of initial value problems of Cauchy-Kovalevsky type in the space of generalized monogenic functions

Yüksel, U. | Çelebi, A.O.

Article | 2010 | Advances in Applied Clifford Algebras20 ( 2 ) , pp.427 - 444

This paper deals with the initial value problem of the type, where t ? R0+ is the time, x ? Rn+1 is a generalized monogenic function and the operator L, acting on a Clifford-algebra-valued function, with real-valued components uB(t, x), is defined by, We formulate sufficient conditions on the coefficients of the operator L under which L transforms generalized monogenic functions again into generalized monogenic functions. For such an operator the initial value problem (0.1) is solvable for an arbitrary generalized monogenic initial function u0 and the solution is also generalized monogenic for each t. © 2010 Birkhäuser / Springer Ba . . .sel AG, Switzerland Daha fazlası Daha az

Postmodernizmin cadısı: Diamanda Galas

Tezgör, Hilmi

Article | 2010 | YEDİ: SANAT, TASARIM VE BİLİM DERGİSİ0 ( 4 ) , pp.79 - 84

Bu makalede, şov ile performans arasındaki, günümüzde iyice bulanıklaşan alanda sahiciliğiyle bir performans sanatçısı olarak öne çıkan Diamanda Galas’ın, müziğini edebiyat ve performans ile buluştururken politik tavrından da asla ödün vermeyişi üzerinde durulacaktır. Kendisi için “auteur” (yazar) nitelemesini tercih eden, üç buçuk oktavlık soprano Diamanda Galas, sesini kıyımlara uğrayanların, yurtlarından kovulan halkların, işkence görenlerin, ezilen kadınların, fahişelerin, toplumdan dışlanan eşcinsellerin, AIDS hastalarının yanında, onların lehine bir silah gibi kullanıyor; özgürlük kavramına vurgu yaparak bizzat direnişin ve ka . . .rşı koyuşun sesine dönüşüyor. Blues, gospel, caz, klasik müzik, folk, rembetiko ve rock etkili müziğinde ölüm, hastalık, kötülük, adaletsizlik gibi karanlık temaları daha çok kullanan Galas, Baudelaire, Artaud, Nerval, Pasolini, Genet, Poe, Celan, Adonis, Michaux, Vallejo gibi yazar ve şairlerin metinlerinden de yararlanıyor. Bu makale, günümüz sanatında başkaldırının en güçlü kadın seslerinden biri olan Diamanda Galas’ın özgünlüğünü ve önemini vurgulamayı amaçlamaktadır. This article will focus on Greek/American avant-garde artist Diamanda Galas and her uncompromising political attitude while her music meets performance and literature. While the boundaries between a show and a performance are blurring, Galas is also an important performance artist. Diamanda Galas has a voice range of three and a half octaves and she prefers the term &#8216;auteur&#8217; for herself. She turns her great voice to a weapon for the sake of oppressed, expelled, tortured, externalized, ill-fated people, for the victims of holocausts, genocides and plagues and for the outsiders. She insists on the term &#8216;freedom&#8217; and speaks, shouts and screams for their resistance. Her music, influenced by blues, gospel, jazz, classical music, folk, rembetiko and rock has its dark themes like death, illness, evil and injustice. It also uses texts by marginal writers, poets and artists like Baudelaire, Artaud, Nerval, Pasolini, Genet, Poe, Celan, Adonis, Michaux and Vallejo. This article aims to stres the originality and importance of Diamanda Galas, one of the strongest voices of revolt in today&#8217;s art Daha fazlası Daha az

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