Yeşılyurt, E.B. | Şımşek, I. | Tuncel, T. | Akaydın, G. | Yeşİlada, E.

Article | 2017 | Marmara Pharmaceutical Journal21 ( 1 ) , pp.132 - 148

In this study, 263 volunteers residing in the districts of Bilecik-Aşağıköy, Bilecik-Pazaryeri-Büyük Elmalı, Bursa-City Center, Edirne-Keşan-Kozköy, Edirne-Keşan and Edirne-İpsala participated into the research by using the face-to-face oral interview technique and the required information for the research was collected with the help of a questionary. In the light of the data taken from the survey, parts of the plants that are used as household remedy, aim of the usage and pattern of the preparation (decoction, infusion, poultice, ointment etc.) were documented inquisitively. All collected plant materials have been identified and de . . .posited at the Herbarium of Faculty of Education of Hacettepe University (HEF). In this study, 68 taxa belonging to 33 families were found to be used as household remedy. It was observed that the majority of these plants belonged to Rosaceae (10 taxa), Lamiaceae (8 taxa), Asteraceae (7 taxa) and Poaceae (4 taxa) families. Gastrointestinal system (46 remedies; 24,6%), respiratory system and chest diseases (41 remedies; 21,9%), urinary system (18 remedies; 9,6%), hemapoietic, immune system and cancer (18 remedies; 9,6%) remain most among 187 uses were documented as household remedy. © 2017, Marmara University. All rights reserved Daha fazlası Daha az

Kirca Yilmaz, Ş. | Acuner, I.Ç. | Strommenger, B. | Bek, Y. | Witte, W.

Article | 2014 | Mikrobiyoloji Bulteni48 ( 1 ) , pp.14 - 27

The increase in the prevalence of epidemic strains of methicillin resistant Staphylococcus aureus (MRSA) in hospitals and community requires special attention of infection control. The aim of this study was to determine the pathogenic phenotype (i.e. infectivity and resistotype) and genotypic character-istics (i.e. PFGE-pulsotyping, SLST-spa typing, MLST-sequence typing, eBURST-clonal complex detection algorithm) of clinical MRSA isolates in the Central Blacksea region of Turkey, in order to understand their short- and long-term epidemiological and evolutionary dynamics, and to investigate any probable presence of a significant clus . . .tering. This prospective study included consecutive but non-repetitive 48 MRSA isolates (of them 18 were colonized strains and 30 were causes of nosocomial infection) and seven methicillin-susceptible S.aureus (MSSA, all were isolated from nosocomial infection), collected between December 2006-February 2007 period from hospitalized patients. Identification of the isolates were performed by Vitek-2 automated system (BioMérieux, USA), and in vitro antimicrobial susceptibility testing by broth microdilution method and Vitek-2 automated system. The MRSA isolates found susceptible to erythromycin (n= 10) were further investigated for the presence of ermA gene by the PCR method. All the strains were typed by spa-typing and PFGE-pulsotyping methods. Among the isolates with different spa-types, representatives were selected (3 MRSA, 7 MSSA) and typed with MLST typing method. Among the isolates with different spa-types, representatives with different antimicrobial susceptibility patterns were selected (n= 8), and SCCmec types were determined by the multiplex PCR method. Antimicrobial resistance patterns of the isolates were digitized to get standardized antimicrobial resistance phenotypes. Clustering of MRSA isolates in pattern groups on the basis of discriminatory characteristics, namely infectivity, phenotype and genotype were statistically analyzed with specific inclusion and exclusion criteria. As a result, three different antimicrobial resistance phenotypes were found in MSSA isolates, whereas 13 were identified in MRSA isolates. In MSSA isolates, seven different PFGE-pulsotypes were detected, as compared to 14 pulsotypes in MRSA isolates. Among MRSA isolates, 10 sporadic strains with single PFGE-pulsotypes were detected. All MRSA isolates, with two exceptions (t459, t632), were of t030 spa-type; in the MLST analysis of the representatives of different spa-types (n= 3), a single type of MLST-clonal complex (CC8) and single MLST-sequence type (ST239) were identified. Each of the seven MSSA isolates yielded different spa-types, MLST-clonal complex types and MLST-sequence types (t777-ST5-CC5; t660-ST25-CC5; t153-ST34-CC30; t015-ST45-CC45; t267-ST97-CC97; t377-ST360-CC8; t084-ST15-C15). In the statistical analysis of 38 non-sporadic MRSA isolates, the isolates in Group-13 (n= 16; infectious, resistotype 14, pulsotype 4; antimicrobial resistance score= 24) displayed significant infectivity-phenotype-genotype clustering (p< 0.001). In 27 of the MRSA isolates, decreased susceptibility to teicoplanin (MIC= 4 µg/mL) was detected. Although, global MRSA isolates belonging to MLST-CC8, MLST-ST239, t030 spa-type were usually expected to be resistant to erythromycin, 10 such strains were erythromycin susceptible. However, ermA gene was found in six of these 10 strains, leading to a conclusion that the ermA gene of these isolates might be dysfunctional due to a point mutation or deletion. Selected representatives of MRSA isolates with different antimicrobial susceptibility patterns (n= 8) were detected to be SCCmec type III. In conclusion, S.aureus isolates in the patient population of our hospital representing the Central Blacksea region showed statistically significant clustering in infectivity, antimicrobial resistance phenotype and clonal genotype (p< 0.001). The dominant MRSA clone was ST239 which was one of the five major pandemic MRSA clones. Nosocomial MSSA isolates displayed long-term clonal diversity. This study produced regional evolutionary-epidemiological data that may support further regional, national and international long-term surveillance studies of S.aureus strains Daha fazlası Daha az

Midilli, K. | Yilmaz, G. | Türkoglu, S. | Iskanova, B. | Ergin, S. | Yarimcam, F. | Altaş, K.

Article | 2010 | Mikrobiyoloji Bulteni44 ( 3 ) , pp.405 - 413

Human bocavirus (HBoV) which was described in 2005 by molecular techniques, is a member of Parvoviridae. The role of HBoV is being questioned in acute respiratory diseases (ARD) in many recent studies. The aim of this study was to determine the presence of HBoV DNA in the respiratory specimens of patients with ARD. A total of 155 throat swab and/or washing specimens from 76 children and 79 adults with ARD were examined. HBoV DNA was investigated by single step in-house polymerase chain reaction (PCR) using NS1 primers (5- 'TATGGCCAAGGCAATCGTCCAAG-3', 5'-GCC GCGTGAACATGAGAAA-CAG-3') which amplify the 290 base pair region of NS1 gene . . .located between nucleotides 1545-1835 of prototype HBoV st1 strain. HBoV DNA was detected in 5 (6.5%) of 76 children and 2 (2.5%) of 79 adults. Three sequenced samples showed 100% homology with the reference sequences. This study in which HBoV DNA was detected in children and adults with ARD, is the first HBoV prevalence study in Turkey. Larger scale prospective clinical and molecular studies are required to explain the association between HBoV and respiratory disease Daha fazlası Daha az

Zahmacioglu, O. | Dinç, G. | Naderi, S.

Article | 2009 | Turkish Neurosurgery19 ( 3 ) , pp.308 - 314

The modern age of psychosurgery can be said to have started with Moniz and Lima. Freeman and Watts subsequently revised and popularised the lobotomy procedure. Moniz shared the 1949 Nobel Prize for medicine or physiology for his discovery of the therapeutic value of leucotomy in certain psychoses, which accelerated the worldwide popularisation of lobotomy, particularly during the years from 1948 to 1953. In Turkey, psychosurgical interventions were first performed in the early 1950s, and were applied in almost 400 cases. These operations gradually ceased after the discovery and worldwide clinic applications of a modern antipsychotic . . . drug named Chlorpromazine in 1950s, paralleling a similar trend in other countries. Our paper reviews the clinical, psychometric and histopathological results of psychosurgery performed in Turkey in the 1950s Daha fazlası Daha az

Ertaş, G. | Kozan, Ö. | Degertekin, M. | Kervan, Ü. | Aksoy, M. | Koç, O. | Göktekin, Ö.

Article | 2012 | Turk Kardiyoloji Dernegi Arsivi40 ( 5 ) , pp.414 - 418

Objectives: The Stent for Life (SFL) project's main mission is to increase the use of primary percutaneous coronary intervention (PCI) in more than 70% of all acute ST segment elevation myocardial infarction (STEMI) patients. Previous to the SFL project, thrombolysis was the dominant reperfusion strategy since a low percentage of acute STEMI patients had access to primary PCI in our country. In this study, we present the main barriers of access to primary PCI in the centers that were involved with the SFL project. Study design: Patients with acute STEMI admitted to the centers that were involved in the SFL project between 2009 and 2 . . .011 were included in the analysis. Results: Since the inception of the SFL project, the primary PCI rate has reached over 90% in SFL pilot cities. In the last 5 years, the number of ambulances and emergency stations has increased. Since the collaboration with 112 Emergency Service, a great majority of cases were reached via the emergency medical system. The mean door-to-balloon time for the pilot cities was 54.72±43.66 minutes. Conclusion: After three years of the SFL project, primary PCI has emerged as the preferred reperfusion strategy for patients with STEMI in pilot cities. © 2012 Türk Kardiyoloji Dernegi Daha fazlası Daha az

İşler, S. | Sezik, E.

Article | 2019 | Yuzuncu Yil University Journal of Agricultural Sciences29 ( 3 ) , pp.476 - 488

Our aim is to clarify the species used for production of salep, production methods of orchids in Altınova region of Haskoy and Bulanık districts of Muş province. The orchids species were collected from Muş province, Hasköy district around Altınova town and around Bulanık district. Moreover, our research showed that salep is collected from Diyarbakır as well. The methods and the species used to obtain salep in these areas were determined. Segmentary tubers collected from Muş province, Hasköy district around Altınova town and around Bulanık district belong to Dactylorhiza umbrosa, Dactylorhiza iberica. As for The round tubers, they ar . . .e Anacamptis palustris, Orchis pseudolaxiflora, Anacamptis coriophora. In the area, 7 orchids species were determined. The species belong to 4 orchids genera. Two of the species are rhizomatous. Every year millions of orchids are being destructed to obtain salep. This destruction especially endangers the salep species growing in meadows. © 2019, Centenary University. All rights reserved Daha fazlası Daha az

Göncü, E.K. | Aktan, Ş. | Atakan, N. | Başkan, E.B. | Erdem, T. | Koca, R. | Utaş, S.

Article | 2016 | Turkderm Deri Hastaliklari ve Frengi Arsivi50 ( 3 ) , pp.82 - 98

Background and Design: Albeit an easily recognized disease, urticaria features many diverse approaches which rationalize the need for an algorithm for the diagnosis, classification, etiopathogenesis, diagnostic evaluation and therapeutic approach. Therefore, authors from Dermatoallergy Working Group of the Turkish Society of Dermatology and the Turkish Dermatoimmunology and Allergy Association aimed to create an urticaria guideline for the diagnosis, treatment and followup of urticaria. Materials and Methods: Each section of the guideline has been written by a different author. The prepared sections were evaluated in part by e-mail . . .correspondence and have taken its final form after revision in the last meeting held by the participation of all authors. Results: The guideline includes the description, classification, pathophysiology as well as diagnosis and treatment of urticaria. Urticaria is classified into two main types: acute urticaria and chronic urticaria while chronic urticaria is further subdivided into spontaneous urticaria and inducible urticaria. The first step of treatment includes standard doses of H1-blockers. In patients who do not respond to the first step, antihistamine dose is increased up to four times; if unsuccessful, another second-generation antihistamine is given in the same dose. In antihistamine-resistant cases, introduction of omalizumab is required. Omalizumab dose may be increased in patients failing to respond to the standard dose. In patients unresponsive to omalizumab, cyclosporine-A may be given. Routine diagnostic tests are not recommended in acute urticaria. In chronic urticaria, erythrocyte sedimentation rate, differential blood count and C-reactive protein testing are the only investigations that are needed routinely. Conclusion: Chronic urticaria is a disease that can be challenging for the physician in terms of treatment and follow-up. Depending on evidence-based data (and individual experiences), this guideline will have a leading role in the diagnosis and treatment of urticaria and help the physician to overcome the challenges in the management Daha fazlası Daha az