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In this paper we present comparative expression, functional and pathway analysis of transcriptional profiling of a dysmorphic patient and its matched control using whole blood and fibroblast cells in an attempt to identify genetic changes in Dysmorphic disorders and developmental genes at large. Normalization was done by first finding an invariant set whose expression levels do not change significantly among the chips and then using this set to normalize raw probe values with a smoothing spline invariant set normalization method. Genes with significant change in expression were identified using the lower confidence bound of fold cha . . .nge and these genes were used to perform functional analyses within the context of Gene Ontology categories and biological pathwyas. Our results indicate that genes with altered expression levels are cell-type specific, activated biological categories are mostly developmental related such as skeletal and muscular system and genes dysregulated in both cell types effect cAMP dependent PKA pathway and consequently the CREB cycle
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Optical fibers which are the basic elements of the optical communication technology, that progressed rapidly during the recent years, have become the key element in many industrial applications. In this study, coupled optical waveguides which are in use in many areas such as directional couplers, sensors, multiplexers, amplifiers and filters, were analyzed. The impact of temperature on the performance of circularly bent, bare, weakly guiding, lossless, multimode and slab optical waveguides was investigated. The coupling between pair TE modes was observed to be higher than the coupling between other modes. Coupled optical waveguides . . .were analyzed in an ambient temperature of 100°C. The change in the modal propagation constant was observed to decrease as the ambient temperature increases
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In this paper we present comparative expression, functional and pathway analysis of transcriptional profiling of a dysmorphic patient and its matched control using whole blood and fibroblast cells in an attempt to identify genetic changes in Dysmorphic disorders and developmental genes at large. Normalization was done by first finding an invariant set whose expression levels do not change significantly among the chips and then using this set to normalize raw probe values with a smoothing spline invariant set normalization method. Genes with significant change in expression were identified using the lower confidence bound of fold cha . . .nge and these genes were used to perform functional analyses within the context of Gene Ontology categories and biological pathwyas. Our results indicate that genes with altered expression levels are cell-type specific, activated biological categories are mostly developmental related such as skeletal and muscular system and genes dysregulated in both cell types effect cAMP dependent PKA pathway and consequently the CREB cycle
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6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.