Hausott, B. | Kurnaz, I. | Gajovic, S. | Klimaschewski, L.

Conference Object | 2009 | Anatomical Record292 ( 12 ) , pp.1976 - 1985

Receptor tyrosine kinase activation by binding of neurotrophic factors determines neuronal morphology and identity, migration of neurons to appropriate destinations, and integration into functional neural circuits as well as synapse formation with appropriate targets at the right time and at the right place. This review summarizes the most important aspects of intraneuronal signaling mechanisms and induced gene expression changes that underlie morphological and neurochemical consequences of receptor tyrosine kinase activation in central and peripheral neurons. © 2009 Wiley-Liss, Inc.

Ozkul, F. | Barkana, D.E. | Demirbas, S.B. | Inal, S.

Conference Object | 2011 | IEEE International Conference on Rehabilitation Robotics , pp.1976 - 1985

In recent years, robot-assisted rehabilitation systems have been an active research area that can quantitatively monitor and adapt to patient progress, and ensure consistency during rehabilitation. In this work, an exoskeleton type robot-assisted rehabilitation system called RehabRoby is developed. A control architecture, which contains a high level controller and a low level controller, is designed for RehabRoby. Proprioceptive sense of healthy subjects has been evaluated during the execution of a task with RehabRoby. Additionally, usability of RehabRoby has been evaluated using a questionnaire. © 2011 IEEE.

Solaroglu, I. | Acar, F. | Bavbek, M. | Ture, U. | Beskonakli, E.

Conference Object | 2013 | World Neurosurgery79 ( 1 ) , pp.16 - 24

Although the history of neurosurgery in Anatolia goes back ten thousand years, modern surgery began in Turkey in 1890. Neurosurgery in Turkey began in the first half of the 20th century. However, general surgeons began applying neurosurgical techniques back in the late 19th century. Most of these applications included procedures for craniocerebral traumas and infections. Dr. Cemil Topuzlu (1868-1958) is the founder of modern surgery in Turkey. Dr. Abdulkadir Cahit Tuner became the first neurosurgeon with a degree in Turkey in 1923. The first neurosurgery department was established in Istanbul in 1923, and the first training program . . .began in the late 1940s. Currently there are almost 1200 neurosurgeons in Turkey and 75 training clinics at university hospitals and Training and Research Hospitals of the Ministry of Health provide neurosurgery training. The current state of neurosurgery in Turkey is parallel to that of the advanced Western countries. Apart from the application of neurosurgical procedures, there have been many scientific studies from Turkish neurosurgeons contributing to the total body of literature in neurosurgery Daha fazlası Daha az

Acar, E. | Bingos, C.A. | Bingol, H. | Bro, R. | Yener, B.

Conference Object | 2007 | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings , pp.4273 - 4276

With a goal of automating visual analysis of electroencephalogram (EEG) data and assessing the performance of various features in seizure recognition, we introduce a mathematical model capable of recognizing patient-specific epileptic seizures with high accuracy. We represent multi-channel scalp EEG using a set of features. These features expected to have distinct trends during seizure and non-seizure periods include features from both time and frequency domains. The contributions of this paper are threefold. First, we rearrange multi-channel EEG signals as a third-order tensor called an Epilepsy Feature Tensor with modes: time epoc . . .hs, features and electrodes. Second, we model the Epilepsy Feature Tensor using a multilinear regression model, i.e., Multilinear Partial Least Squares regression, which is the generalization of Partial Least Squares (PLS) regression to higher-order datasets. This two-step approach facilitates EEG data analysis from multiple electrodes represented by several features from different domains. Third, we identify which features are more significant for seizure recognition. Our results based on the analysis of 19 seizures from 5 epileptic patients demonstrate that multiway analysis of an Epilepsy Feature Tensor can detect (patient-specific) seizures with classification accuracy ranging between 77-96%. © 2007 IEEE Daha fazlası Daha az

Koyunluoglu, S. | Arslan-Alaton, I. | Eremektar, G. | Germirli-Babuna, F.

Conference Object | 2006 | Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering41 ( 9 ) , pp.1873 - 1886

The effect of ozonation on the biodegradability and acute toxicity of two frequently used textile dye assisting chemicals, namely natural tannin (NT) having an initial chemical oxygen demand (COD0) of 1195 mg L -1; initial total organic carbon (TOC0) of 342 mg L -1; initial 5th-day biochemical oxygen demand (BOD5,0) of 86 mg L-1; initial ultraviolet absorbance at 280 nm wavelength (UV280,0) of 32.2 cm-1; initial ultraviolet absorbance at 254 nm wavelength (UV254,0) of 19.35 cm-1 and synthetic tannin (ST); with a COD0 of 465 mg L-1; TOC0 of 155 mg L-1; BOD5,0 of 6 mg L-1; UV 280,0 of 11.78 cm-1; UV254,0 of 13.74 cm -1 was investigate . . .d. Synthetic wastewater bearing these tannin formulations was individually prepared and subjected to ozonation at varying doses (500 and 1000 mg h-1), and pHs (3.5 and 7.0) to elucidate the effect of ozone dose and pH on oxidation efficiency. Changes in the environmental sum parameters chemical oxygen demand (COD), total organic carbon (TOC), 5th-day biochemical oxygen demand (BOD5), ultraviolet absorbance at 280 nm wavelength (UV280) and ultraviolet absorbance at 254 nm wavelength (UV254), the latter two representing the aromaticity and double bonds of the studied textile tannins, respectively, were monitored during the course of ozonation. In the second part of the study, the biodegradability and acute toxicity of the raw and pre-ozonated textile tannins were evaluated in terms of the BOD 5 parameter and an activated sludge inhibition test, respectively. Results indicated no significant changes in acute toxicity for NT, whereas the inhibitory effect of ST could be completely eliminated after 40 min ozonation at a rate of 1000 mg h-1 (i.e., at a specific ozone dose of 1.4 mg O3 (mg COD0)-1 and a pH of 3.5. In conclusion, pre-ozonation appeared to be potential pretreatment option to achieve complete detoxification and a fair biodegradability improvement of the otherwise refractory synthetic tannin. Copyright © Taylor & Francis Group, LLC Daha fazlası Daha az

Karapolat, H.U. | Kurtaiç, Y. | Tur, B.S. | Demirsoy, N. | Özyemişci Taşkiran, Ö. | Sarp, Ü. | Güzel, R.

Conference Object | 2012 | European Journal of Physical and Rehabilitation Medicine48 ( 2 ) , pp.223 - 230

Background. Although it is known that cardiopulmonary rehabilitation (CPR) reduces mortality and morbidity, it is not widely implemented as is in Turkey. One factor might be lack of demand since the levels of knowledge and awareness among patients who are eligible for CPR seem to be insufficient. Aim. It is aimed to investigate the level of awareness and knowledge of CPR among patients with cardiopulmonary problems. Design. Cross-sectional survey study Setting. Outpatient Methods. Knowledge regarding CPR was assessed by questionnaires given to 690 patients recruited in seven university hospitals and six training and research hospita . . .ls in which either comprehensive or limited CPR services are available. Population. Patients who have cardiopulmonary problems Results. Of the patients, 34.7% were given information on CPR by healthcare staff, and 25.3% reported that their source of information was physicians. Although 49-9% of the patients knew that they needed to exercise for their cardiac/pulmonary problems, only 23.4% and 32.1% of those were aware that fast walking and climbing stairs, respectively, would not pose a risk to their cardiac/pulmonary health. The majority of the patients believed that activities of daily living, which comprise the most important component of exercise-based CPR, were harmful for their cardiopulmonary health. We found that 31.1% of the patients exercised regularly. During their stay at the hospital, certain kinds of exercises were suggested to 62.7% of the patients, and 34.7% of these patients performed various exercises. Of the patients who were given detailed information on cardiopulmonary rehabilitation, 69% stated that they would be willing to participate in a similar program. Conclusion. Although nearly half of the patients stated that they needed CR, it was observed that the ratio of patients who had true knowledge of CPR was low among patients. It is imperative to furnish patients with information on CPR, both in the field of PMR and throughout Turkey, and to put more effort into running those services effectively. Furthermore, we should make an effort to increase the level of liaison between patients and physicians and other healthcare professionals who participate in the treatment of cardiac/pulmonary patients Daha fazlası Daha az

Canbay, F. | Levent, V.E. | Serbes, G. | Goren, S. | Aydin, N.

Conference Object | 2015 | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS2015-November , pp.6026 - 6029

Due to the inherent time-varying characteristics of physiological systems, most biomedical signals (BSs) are expected to have non-stationary character. Therefore, any appropriate analysis method for dealing with BSs should exhibit adjustable time-frequency (TF) resolution. The wavelet transform (WT) provides a TF representation of signals, which has good frequency resolution at low frequencies and good time resolution at high frequencies, resulting in an optimized TF resolution. Discrete wavelet transform (DWT), which is used in various medical signal processing applications such as denoising and feature extraction, is a fast and di . . .scretized algorithm for classical WT. However, the DWT has some very important drawbacks such as aliasing, lack of directionality, and shift-variance. To overcome these drawbacks, a new improved discrete transform named as Dual Tree Complex Wavelet Transform (DTCWT) can be used. Nowadays, with the improvements in embedded system technology, portable real-time medical devices are frequently used for rapid diagnosis in patients. In this study, in order to implement DTCWT algorithm in FPGAs, which can be used as real-time feature extraction or denoising operator for biomedical signals, a novel hardware architecture is proposed. In proposed architecture, DTCWT is implemented with only one adder and one multiplier. Additionally, considering the multi-channel outputs of biomedical data acquisition systems, this architecture is capable of running N channels in parallel. © 2015 IEEE Daha fazlası Daha az

Köse, G.T. | Hasirci, V.

Conference Object | 2004 | Advances in Experimental Medicine and Biology553 , pp.317 - 329

[No abstract available]

Güler, N. | Yumuk, P.F. | Ilguy, D. | Olgac, V. | Greer, J.

Conference Object | 2005 | Journal of Oral and Maxillofacial Surgery63 ( 8 ) , pp.1201 - 1205

[No abstract available]

Küçükaksu, S.

Conference Object | 2007 | Artificial Organs31 ( 11 ) , pp.789 - 791

[No abstract available]

Kenar, H. | Kose, G.T. | Hasirci, V.

Conference Object | 2010 | Journal of Materials Science: Materials in Medicine21 ( 3 ) , pp.989 - 997

The heart does not regenerate new functional tissue when myocardium dies following coronary artery occlusion, or if it is defective. Ventricular restoration involves excising the infarct and replacing it with a cardiac patch to restore the heart to a more healthy condition. The goal of this study was to design and develop a clinically applicable myocardial patch to replace myocardial infarcts and improve long-term heart function. A basic design composed of 3D microfibrous mats that house mesenchymal stem cells (MSCs) was developed from human umbilical cord matrix (Wharton's Jelly) cells aligned in parallel to each other mimicking th . . .e native myocardium. Poly(3-hydroxybutyrate- co-3-hydroxyvalerate) (PHBV), poly(L-D,L-lactic acid) (P(L-D,L)LA) and poly(glycerol sebacate) (PGS) were blended and electrospun into aligned fiber mats with fiber diameter ranging between 1.10 and 1.25 µm. The micron-sized parallel fibers of the polymer blend were effective in cell alignment and cells have penetrated deep within the mat through the fiber interstices, occupying the whole structure; 8-9 cell layers were obtained. Biodegradable macroporous tubings were introduced to serve as nutrient delivery route. It was possible to create a thick myocardial patch with structure similar to the native tissue and with a capability to grow. © 2009 Springer Science+Business Media, LLC Daha fazlası Daha az

Bayrak, F. | Kahveci, G. | Mutlu, B. | Degertekin, M. | Demirtaş, E.

Conference Object | 2007 | Anadolu Kardiyoloji Dergisi7 ( SUPPL. 1 ) , pp.178 - 181

Objective: Few data exist regarding the prognostic value of QT dispersion in hypertrophic cardiomyopathy (HCM). In this study, we prospectively investigated the association between baseline QT dispersion and clinical course of HCM. Methods: Overall, 101 patients with asymmetric septal hypertrophy (59 men, mean age 45±16 years, range 13-74 years) were included in the study and were followed up for 595±367 days for clinical endpoints defined as cardiac death and hospitalization due to worsening in heart failure symptoms. QRS duration, QT interval, and JT interval were manually measured on 12-lead electrocardiogram (ECG). QT dispersion . . . and corrected QT dispersion were calculated accordingly. The ECG findings of the patients with and without clinical endpoints were compared. Results: Twenty-nine patients experienced clinical endpoints (3 sudden deaths, 26 hospitalizations due to worsening heart failure). The measurements of QT, JT and QRS intervals were all comparable between the two groups (p>0.05 for all). QT dispersion and corrected QT dispersion were significantly different between patients with and without clinical endpoints (64±30 ms vs. 83±18 ms and 71±33 ms vs. 90±18 ms, respectively, p=0.001 for both). Corrected QT dispersion >80 ms detected patients with clinical endpoints with sensitivity and specificity of 79% and 75%, respectively. Patients with corrected QT dispersion Daha fazlası Daha az