Hizel, C. | Gök, S. | Sardaş, S. | Bernard-Gallon, D. | Maugard, C. | Genç, E.
Conference Object | 2009 | Current Pharmacogenomics and Personalized Medicine7 ( 4 ) , pp.297 - 301
Pharmacogenetics has its roots in the 1950s with pioneering studies of monogenic variations in drug metabolism and pharmacokinetics. With the availability of high-throughput genomics technologies and the completion of the Human Genome Project in 2003, we are now in the postgenomics era. This transition is increasingly marked with study of polygenic and multifactorial traits such as common complex human diseases as well as pharmacodynamic differences among populations. Changes that emerge from postgenomics medicine are not, however, limited to seismic shifts in scale and scope of pharmacogenetics research. Importantly, many low- and . . .middle-income countries (LMICs) of the South, Asia-Pacific, Eastern Mediterranean and the Middle-East are becoming notable contributors with rapid globalization of science and increasing access to genomics technologies. This brings about, in parallel, an acute demand for regional capacity building in LMICs so that the future evaluation and implementation of postgenomics technologies in personalized medicine take place in an integrated, sustainable and equitable manner. With this overarching vision, we herein report the founding of the Istanbul Working Group in Personalized Medicine (IWG-PM, represented by the authors of this report) that was inaugurated as a component of the 2nd Symposium on Personalized and Predictive Medicine held in Istanbul, sponsored by the Yeditepe University, and the Turkish Scientific and Technological Research Council (TUB?TAK) (10-12 September, 2009). While highlighting the applications of personalized medicine in oncology, psychiatry, nutrition, infectious diseases, occupational health, genetic testing and systems biology, the symposium also raised challenging questions in the context of LMICs. How can we best evaluate the promises, intended and unintended impacts of personalized medicine and enabling technologies in the context of Turkey, and the LMICs more generally? IWG-PM is a small but significant and necessary step to initiate regional capacity building in Turkey. We trust that the IWG-PM initiative may also provide a constructive example to further develop capacity in other LMICs in the Eastern Mediterranean region. © 2009 Bentham Science Publishers Ltd
Agaoglu, A. | Ciblak, N. | Safak, K.K.
Conference Object | 2010 | ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis, ESDA20103 , pp.693 - 701
This work addresses the optimization of the workspace of a six degrees of freedom parallel manipulator. In this study, The topology of the manipulator is composed of three xy-tables, symmetrically positioned on a circle on a base plane, connected by three legs to a moving platform. Kinematic composition of the manipulator is introduced and kinematic diagram is illustrated. Orientation workspace is investigated using three different orientation representations. XYZ fixed angles representation is selected considering the benefits of its visualization are considered. By using this representation, the orientation workspace is modeled an . . .d kinematic circuits of the manipulator are explored. First, optimization is performed without slider limitations. A result table is obtained based on the user defined parameters. Secondly, optimization is performed under slider limitations. The maximal orientation capability is optimized using numerical analysis. The optimized configuration of the manipulator indicates that a 330% increase in orientation capability is achieved, compared to the old configuration. © 2010 by ASME
Ince, R. | Alper, F.M.P. | Yukselici, M.H. | Asikoglu, A. | Allahverdi, C.
Conference Object | 2012 | International Conference on Oxide Materials for Electronic Engineering, OMEE 2012 , pp.75 - 76
Non-linear optical properties of weakly confined CdTe nanocrystals in a glass matrix were studied by electro-modulation spectroscopy. Copper electrodes of about 10 nm thick were deposited on both sides of glass samples of thickness 0.8 mm by physical vapor deposition. Optical transmission spectra of the samples were recorded under dc high voltage applied to the electrodes. The absorption band is observed to broaden. This is most likely caused by state filling. © 2012 IEEE.
Erden, O | Koner, O | Temur, S | Menda, F | Bilgen, S
Conference Object | 2012 | BRITISH JOURNAL OF ANAESTHESIA108 , pp.301 - 301
Baser, O | Yavuz, Y | Bilgin, VA | Cebecioglu, U | Eyuboglu, S | Atasoy, D | Yılmaz, B
Conference Object | 2017 | ACTA PHYSIOLOGICA221 , pp.79 - 79
Baser, M | Sofu, A | Ozcan, E | Korachi, M | Ekinci, FY
Conference Object | 2012 | NEW BIOTECHNOLOGY29 , pp.79 - 79
Demir, O | Biyikli, E | Lazoglu, I | Kucukaksu, S
Conference Object | 2010 | INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS33 ( 7 ) , pp.470 - 470
Sabuncuoglu, S | Eken, A | Ozgunes, H | Aydin, A | Orhan, H
Conference Object | 2010 | DRUG METABOLISM REVIEWS42 , pp.138 - 139