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Ovarian cancer: Interplay of vitamin D signaling and miRNA action

Attar, Rukset | Gasparri, M.L. | Di Donato, V. | Yaylim, I. | Halim, T.A. | Zaman, F. | Farooqi, A.A.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 8 ) , pp.3359 - 3362

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added . . .regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine Daha fazlası Daha az

Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling

Rana, A. | Attar, Rukset | Qureshi, M.Z. | Gasparri, M.L. | Di Donato, V. | Ali, G.M. | Farooqi, A.A.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 19 ) , pp.8041 - 8046

In-depth analysis of how TRAIL signals through death receptors to induce apoptosis in cancer cells using high throughput technologies has added new layers of knowledge. However, the wealth of information has also highlighted the fact that TRAIL induced apoptosis may be impaired as evidenced by experimental findings obtained from TRAIL resistant cancer cell lines. Overwhelmingly, increasing understanding of TRAIL mediated apoptosis has helped in identifying synthetic and natural compounds which can restore TRAIL induced apoptosis via functionalization of either extrinsic or intrinsic pathways. Increasingly it is being realized that b . . .iologically active phytochemicals modulate TRAIL induced apoptosis, as evidenced by cell-based studies. In this review we have attempted to provide an overview of how different phytonutrients have shown efficacy in restoring apoptosis in TRAIL resistant cancer cells. We partition this review into how the TRAIL mediated signaling landscape has broadened over the years and how TRAIL induced signaling machinery crosstalks with autophagic protein networks. Subsequently, we provide a generalized view of considerable biological activity of coumarins against a wide range of cancer cell lines and how coumarins (psoralidin and esculetin) isolated from natural sources have improved TRAIL induced apoptosis in resistant cancer cells. We summarize recent updates on piperlongumine, phenethyl isothiocyanate and luteolin induced activation of TRAIL mediated apoptosis. The data obtained from pre-clinical studies will be helpful in translation of information from benchtop to the bedside Daha fazlası Daha az

The role of TWIST, SERPINB5, and SERPIN1 genes in uterine leiomyomas

Bostancı, Mehmet Süha | Bayram, Merih | Celtemen, Baran | Bakacak, Süleyman Murat | Kızılkale, Özge Yıldırım | Attar, Rukset | Ümit, Emin Bağrıaçık

Article | 2014 | Journal of the Turkish-German Gynecological Association15 ( 2 ) , pp.92 - 95

Objective: The aim of this study is investigate the role of the Twist homolog 1 (TWIST), serine peptidase inhibitor (SERPINB5), and plasminogen activator inhibitor 1 (SERPIN1) genes in uterine leiomyoma etiopathogenesis. Material and Methods: Twelve patients, aged between 39 and 58, and had a hysterectomy, were included in the study. The size of the leio- myomas was between 20 and 130 mm based on gross pathology after hysterectomy. Tissue samples were obtained from normal myometrium and leiomyoma (1 cm3) tissue of the uterus of the patients and stored at -86°C. Samples were divided to two groups after histopathological evaluatio . . .n of the uterus: normal myometrial tissues as control group (Group 1) and leiomyoma tissue as the study group (Group 2). The TWIST, SERPINB5, and SERPIN1 genes were studied for uterine leiomyoma etiopathogenesis. Results: TWIST gene expression was significantly higher in the uterine leiomyoma tissue (p<0.001). SERPINB5 and SERPIN1 gene expression was decreased in the uterine leiomyoma tissue, but the differences were not statistically significant. Conclusion: TWIST gene activity is significantly increased in leiomyoma tissue when compared to normal myometrium. In spite of the fact that the development of uterine leiomyomas is estrogen- and progesterone-dependent, myometrial cells could be triggered by the TWIST gene for uterine leiomyoma development. (J Turk Ger Gynecol Assoc 2014; 15: 92-5 Daha fazlası Daha az

Impact of transobturator tape procedure on female and their partner sexual function: it improves sexual function of couples

Narin, R. | Attar, Rukset | Narin, M.A. | Koyuncu, D. | Yencilek, E.

Article | 2014 | Archives of Gynecology and Obstetrics290 ( 5 ) , pp.913 - 917

Results: After TOT procedure, the mean value of IIQ-7 and UDI-6 questionnaires was lower than the mean scores that measured before treatment (p 

Recently emerging signaling landscape of Ataxia-telangiectasia mutated (ATM) kinase

Farooqi, A.A. | Attar, Rukset | Arslan, B.A. | Romero, M.A. | ul Haq, M.F. | Qadir, M.I.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 16 ) , pp.6485 - 6488

Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilize . . .d as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells Daha fazlası Daha az

TRAIL based therapy: Overview of mesenchymal stem cell based delivery and miRNA controlled expression of TRAIL

Attar, Rukset | Sajjad, F. | Qureshi, M.Z. | Tahir, F. | Hussain, E. | Fayyaz, S. | Farooqi, A.A.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 16 ) , pp.6495 - 6497

Rapidly increasing number of outstanding developments in the field of TRAIL mediated signaling have revolutionized our current information about inducing and maximizing TRAIL mediated apoptosis in resistant cancer cells. Data obtained with high-throughput technologies have provided finer resolution of tumor biology and now it is known that a complex structure containing malignant cells strictly coupled with a large variety of surrounding cells constitutes the tumor stroma. Utility of mesenchymal stem cells (MSCs) as cellular vehicles has added new layers of information. There is sufficient experimental evidence substantiating effici . . .ent gene deliveries into MSCs by retroviral, lentiviral and adenoviral vectors. Moreover, there is a paradigm shift in molecular oncology and recent high impact research has shown controlled expression of TRAIL in cancer cells on insertion of complementary sequences for frequently downregulated miRNAs. In this review we have attempted to provide an overview of utility of TRAIL engineered MSCs for effective killing of tumor and potential of using miRNA response elements as rheostat like switch to control expression of TRAIL in cancer cells Daha fazlası Daha az

Drugs from marine sources: Modulation of TRAIL induced apoptosis in cancer cells

Farooqi, A.A. | Attar, Rukset | Gasparri, M.L.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 20 ) , pp.9045 - 9047

There have been overwhelming advances in molecular oncology and data obtained through high-throughput technologies have started to shed light on wide ranging molecular mechanisms that underpin cancer progression. Increasingly it is being realized that marine micro-organisms and the biodiversity of plankton are rich sources of various anticancer compounds. Marine derived compounds play major roles in inducing apoptosis in cancer cells. More importantly, various agents have been noted to enhance TRAIL induced apoptosis in cancer cells by functionalizing intrinsic and extrinsic pathways. In this commentary, a list of marine derived com . . .pounds reported to induce apoptosis is discussed Daha fazlası Daha az

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