Attar, Rukset | Attar, E.

Article | 2015 | Women's Health11 ( 5 ) , pp.653 - 664

Endometriosis is defined as the presence of endometrial gland and stroma outside the uterine cavity. It is an estrogen-dependent disease and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia and infertility. The treatment of endometriosis is conservative or radical surgery, medical therapies or their combination. All currently used hormonally active treatments are effective in the treatment of endometriosis; however, the adverse effects of these hormonal treatments limit their long-term use. Moreover, recurrence rates are high after cessation of therapy, and the treatments have no benefit in endometriosis-associated . . .infertility. Therefore, researchers are working on new treatment modalities with improved side effects, mainly focusing on the molecular targets involved in etiopathogenesis of endometriosis. Here we summarized these novel treatments modalities. © 2015 Future Medicine Ltd Daha fazlası Daha az

Attar, Rukset | Yıldırım, Gazi | İnan, Yücel | Kızılkale, Özge | Karateke, Ateş

Article | 2013 | Journal of the Turkish-German Gynecological Association14 ( 4 ) , pp.242 - 245

Tek taraflı kapalı vajen ve aynı tarafta böbrek agenezisi ile birlikte di- delfik uterus nadir görülen bir durumdur. Genellikle menarj sonrasın- da görülen pelvik ağrı, dismenore, karın hacminde artış veya tek ta- raflı hematokolposa bağlı olarak ele gelen kitle şeklinde ortaya çıkar. Bu yazıda özellikle adet sırasında ortaya çıkan pelvik ağrı ve düzensiz adet kanaması şikayetleri ile başvuran 13 yaşındaki bir kız çocuğunun olgusunu sunduk. Hastaya pelvik ultrasonografi ve manyetik rezonans (MR) incelemesi yapıldı. Tek taraflı kapalı vajen ve aynı tarafta böb- rek agenezisi ile birlikte didelfik uterus tanısı konuldu. Tanı ve tedavi . . . amaçlı laparotomi yapıldı. İki ayrı hemiuterus, iki serviks ve sağ tarafta hematometra ve hematokolpos ile aynı tarafta böbrek agenezi tesbit edildi. Vaginal septum tamamen çıkartıldı ve Strassmann metroplas- tisi yapıldı. Ameliyat sonrasında hastanın bütün şikayetleri geçti ve bulguları tamamen kayboldu. Anatomik yapılardaki farklılığa, şikayet- lerin özgün olmamasına ve değişik şekillerde ortaya çıkmasına bağlı olarak bu konjenital anomalinin tanısı ve tedavisi güçtür. Dönemsel karın ağrısı ve abdominopelvik kitle ile başvuran bir kadında mutlaka bu bozuklukların da olabileceği düşünülmelidir. (J Turkish-German Gynecol Assoc 2013; 14: 242-5) Didelphic uterus with obstructed hemivagina and ipsilateral renal agenesis is a rare condition. It usually presents with pelvic pain fol- lowing the menarche, dysmenorrhoea, and an increase in abdomi- nal volume or a palpable mass due to unilateral haematocolpos. We present the case of a 13-year-old girl who referred with recurrent pel- vic pain, mainly at the time of menses, and irregular menstrual cycle complaints in this report. The patient underwent ultrasonography and magnetic resonance (MR) imaging of the pelvis was performed. The diagnosis was uterus didelphys with obstructed hemivagina and ipsi- lateral renal agenesia. Laparotomy was performed for diagnosis and treatment purposes. Two separated hemiuteri and two cervices with hematometra and hematocolpos on the right side and ipsilateral renal agenesis were detected. The vaginal septum was excised completely and Strassman metroplasty was performed. Her complaints were re- solved and she was absolutely asymptomatic after surgery. Diagnosis and management of this congenital anomaly is challenging due to the complexity of the anatomic structures, nonspecific complaints, and heterogenic presentation. These anomalies must always be consid- ered while working-up female patients presenting with episodic ab- dominal pain and abdominopelvic mass. (J Turkish-German Gynecol Assoc 2013; 14: 242-5) Key words Daha fazlası Daha az

Farooqi, A.A. | Khalid, S. | Tahir, F. | Sabitaliyevich, U.Y. | Yaylim, I. | Attar, Rukset | Xu, B.

Article | 2018 | Food and Chemical Toxicology119 , pp.98 - 105

Research over decades has progressively explored pharmacological actions of bitter gourd (Momordica charantia). Biologically and pharmacologically active molecules isolated from M. charantia have shown significant anti-cancer activity in cancer cell lines and xenografted mice. In this review spotlight was set on the bioactive compounds isolated from M. charantia that effectively inhibited cancer development and progression via regulation of protein network in cancer cells. We summarize most recent high-quality research work in cancer cell lines and xenografted mice related to tumor suppressive role-play of M. charantia and its bioac . . .tive compounds. Although M. charantia mediated health promoting, anti-diabetic, hepatoprotective, anti-inflammatory effects have been extensively investigated, there is insufficient information related to regulation of signaling networks by bioactive molecules obtained from M. charantia in different cancers. M. charantia has been shown to modulate AKT/mTOR/p70S6K signaling, p38MAPK-MAPKAPK-2/HSP-27 pathway, cell cycle regulatory proteins and apoptosis-associated proteins in different cancers. However, still there are visible knowledge gaps related to the drug targets in different cancers because we have not yet developed comprehensive understanding of the M. charantia mediated regulation of signal transduction pathways. To explore these questions, experimental platforms are needed that can prove to be helpful in getting a step closer to personalized medicine. © 2018 Elsevier Lt Daha fazlası Daha az

Attar, Rukset | Agachan, B. | Kucukhuseyin, O. | Toptas, B. | Attar, E. | İşbir, Turgay

Article | 2010 | Molecular Biology Reports37 ( 1 ) , pp.369 - 374

Endometriosis is regarded as a complex trait, in which genetic and environmental factors contribute to the disease phenotype. We investigated whether the interleukin (IL) 1beta (+3953) polymorphism is associated with the severity of endometriosis. Diagnosis of endometriosis was made on the basis of laparoscopic findings. Stage of endometriosis was determined according to the Revised American Fertility Society classification. 118 women were enrolled in the study. 78 women didnot have endometriosis, 6 women had stage I, 3 had stage II, 13 had stage III and 18 had stage IV endometriosis. Polymerase Chain Reaction (PCR), Restriction Fra . . .gment Length Polymorphism (RFLP), and agarose gel electrophoresis techniques were used to determine the IL 1beta (+3953) genotype. Frequencies of the IL-1beta (+3953) genotypes in the control group were: CC, 0.397; TT, 0.115; CT, 0.487. Frequencies of the IL-1beta (+3953) genotypes in cases were: CC, 0.375; TT, 0.225; CT, 0.400. We found a 2.22 fold increase in TT genotype in the endometriosis group. However, the difference was not statistically significant (P > 0.05). We also observed an increase in the frequency of IL-1beta (+3953) T allele in the endometriosis group. However, the difference was not statistically significant. We also investigated the association between IL-1beta (+3953) polymorphism and the severity of endometriosis. The frequencies of CC+CT genotypes in stage I, III and IV endometriosis patients were 83.3, 84/6 and 72.2%, respectively; and TT genotypes were 16.7, 15.4 and 27.8%, respectively. We observed a statistically insignificant increase in TT genotype in stage IV endometriosis (P > 0.05). We suggest that IL-1beta (+3953) polymorphism is not associated with endometriosis in Turkish women. © 2009 Springer Science+Business Media B.V Daha fazlası Daha az

Baykal, C. | Al, A. | Ugur, M.G. | Çetinkaya, N. | Attar, Rukset | Arioglu, P.

Article | 2008 | European Journal of Gynaecological Oncology29 ( 1 ) , pp.76 - 79

https://hdl.handle.net/20.500.11831/764

Attar, Rukset | Gasparri, M.L. | Di Donato, V. | Yaylim, I. | Halim, T.A. | Zaman, F. | Farooqi, A.A.

Article | 2014 | Asian Pacific Journal of Cancer Prevention15 ( 8 ) , pp.3359 - 3362

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added . . .regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine Daha fazlası Daha az

Yildirim, G. | Attar, Rukset | Akçin, O. | Fiçicioglu, C.

Article | 2010 | Turk Jinekoloji ve Obstetrik Dernegi Dergisi7 ( 2 ) , pp.149 - 152

It can be assumed a high incidence of chromosomal abnormality among the patients who underwent ICSI cycle after searching the current literature. The huge amount of these abnormalities consist of low grade mosaicism. Besides adequate follicular response, the rate of fertilization failure is high in these group. If pregnancy achieved, spontan abortion usually occurs. Oocyte donation can be most appropriate treatment choise in some selected patients.

Fiçicioglu, C. | Yildirim, G. | Attar, Rukset | Kumbak, B. | Yesildaglar, N.

Article | 2010 | Reproductive BioMedicine Online20 ( 6 ) , pp.776 - 782

The objective of this study was to determine whether there was a threshold for the number of CGG repeats in the FMR1 (fragile X) gene in premature ovarian ageing and premature ovarian failure and to investigate the association of this sequence with serum concentrations of anti-Müllerian hormone (AMH), inhibin B, anti-thyroid and anti-adrenal autoantibodies. In this prospective randomized controlled preliminary study, the number of triple CGG repeats and serum concentrations of FSH, AMH and aforementioned autoantibodies were evaluated in 79 women who were younger than 40 years old. FSH concentrations were between 12 and 50 IU/ml (pre . . .mature ovarian ageing) in 30 women and were higher than 50 IU/ml (premature ovarian failure) in nine women; FSH concentrations were normal in 40 women. All women whose FSH concentrations were higher than 12 IU/ml had CGG repeats greater than 30. No women whose FSH concentrations were normal had a repeat number above 30. There was no significant relationship between the levels of antibodies and either CGG repeat numbers or FSH concentrations. In conclusion, the number of CGG repeats between 30 and 40 might be used to predict premature ovarian ageing and premature ovarian failure in infertile women. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved Daha fazlası Daha az

Yıldırım, Gazi | Attar, Rukset | Akçin, Oya | Fıçıcıoğlu, Cem

Article | 2010 | Türk Jinekoloji ve Obstetrik Derneği Dergisi7 ( 2 ) , pp.149 - 152

Literatür tarandığında ICSI yapılacak olan bayanlarda kromozom anomali sıklığının arttığı söylenebilir. Bu düşük dereceli cinsiyet kromozomu bozukluklarının büyük bir kısmını düşük dereceli mozaisizmler oluşturur. 45,X/46,XX mozaisizmi olan bayanlarda yeterli oosit elde edilebilse bile bunlarda total fertilizasyon başarısızlığı ihtimali yükselir. Gebelik sağlananlarda ise spontan düşük riski artar. Seçilmiş hastalarda oosit donasyon programları uygun bir yaklaşım olabilir. It can be assumed a high incidence of chromosomal abnormality among the patients who underwent ICSI cycle after searching the current literature. The huge amount . . .of these abnormalities consist of low grade mosaicism. Besides adequate follicular response, the rate of fertilization failure is high in these group. If pregnancy achieved, spontan abortion usually occurs. Oocyte donation can be most appropriate treatment choise in some selected patients Daha fazlası Daha az

Agachan, B. | Attar, Rukset | Isbilen, E. | Aydogan, H.Y. | Sozen, S. | Gurdol, F. | İşbir, Turgay

Article | 2010 | Journal of Interferon and Cytokine Research30 ( 9 ) , pp.673 - 676

Preeclampsia complicates 10% of pregnancies in developing countries. It is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. It has been suggested that maladaptation of the maternal immune response during pregnancy might be a causal factor for preeclampsia. According to immune maladaptation hypothesis, preeclampsia is due to an inappropriate regulation of normally Th2-deviated maternal immune responses, leading to a shift toward harmful Th1 immunity. Several studies indicate that monocyte chemotactic protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) are involved in Th1 and Th2 immunity. I . . .n this study, we investigated the association between MCP-1 A-2518G and CCR2-V64I polymorphisms and preeclampsia. One hundred eighty preeclamptic pregnant women and 145 healthy controls were included in the study. We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia. © Mary Ann Liebert, Inc Daha fazlası Daha az

Yıldırım, Gazi | İnan, Yücel | Çomunoğlu, Nil | Attar, Rukset | Çetinkaya, Nilüfer | Yılmaz, Canan | Fıçıcıoğlu, Cem

Article | 2010 | Fırat Tıp Dergisi15 ( 3 ) , pp.152 - 154

Endometriozis tam olarak anlaşılamamış bir hastalıktır. Sıklıkla pelvik bölgede lökalizedir, fakat endometriozisin görüldüğü yerler, özellikle ekstragenital yerleşimli olanlarda, oldukça değişkendir. Bu durum tanıyı güçleştirir ve tedavinin gecikmesine neden olur. Zaman zaman ekstrapelvik yerleşimli endometriozise rastlanır. Biz burada, sezaryen skarında gelişen bir endometriyosiz vakası sunduk ve bu hastalığın fizyopatolojisine tekrar dikkat çekmek istedik. Endometriosis is still a poorly understood disease. Endometriosis is frequently seen within pelvic region. But, its presentation is highly variable, particularly in extragenital . . . sites, making diagnosis difficult and potentially delaying treatment. Sometimes extrapelvic endometriosis can be seen. We presented a cesarean scar endometriosis case and with this case report discussed pathophysiology of the disease Daha fazlası Daha az

Farooqi, A.A. | Attar, Rukset | Qureshi, M.Z. | Fayyaz, S. | Sohail, M.I. | Sabitaliyevich, U.Y. | Alaaeddine, N.

Article | 2018 | Cellular and Molecular Biology64 ( 15 ) , pp.1 - 6

Based on the exciting insights gleaned from decades of ground-breaking research, it has become evident that deregulated signaling pathways play instrumental role in cancer development and progression. Interestingly discovery of non-coding RNAs has revolutionized our understanding related to transcription, post-transcription and translation. Modern era has witnessed landmark discoveries in the field of molecular cancer and non-coding RNA biology has undergone tremendous broadening. There has been an exponential growth in the list of publications related to non-coding RNAs and overwhelmingly increasing classes of non-coding RNAs are a . . .dding new layers of complexity to already complicated nature of cancer. Regulation of TGF/SMAD signaling by miRNAs and LncRNAs has opened new horizons for therapeutic targeting of TGF/SMAD pathway. In this review we have set spotlight on central role of LncRNAs in modulation of TGF/ SMAD pathway. Major proportion of the available evidence is underlining positive role of LncRNAs in contextual regulation of TGF/SMAD pathway. LncRNAs are vital to these regulatory networks because they provide a background support to make the TGF/SMAD mediated intracellular signaling more smooth or make transduction cascade more flexible in response to cues from extracellular environment. Therefore, in accordance with this notion, MALAT1, OIP5-AS1, MIR100HG, HOTAIR, ANRIL, PVT1, AFAP1-AS1, SPRY4-IT, ZEB2NAT, TUG1 and Lnc-SNHG1 have been reported to positively regulate TGF/SMAD signaling. In this review, we have focused on the regulation of TGF/SMAD signaling by LncRNAs and how these non-coding RNAs can be therapeutically exploited. Short-interfering RNA (siRNA) and natural products are currently being tested for efficacy against different LncRNAs. Nanotechnological strategies to efficiently deliver LncRNA-targeting siRNAs are also currently being investigated in different cancers. © 2018 by the C.M.B. Association. All rights reserved Daha fazlası Daha az