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Fertility preserving surgical management of methotrexate-resistant cesarean scar pregnancy

Ficicioglu, C. | Attar, Rukset | Yildirim, G. | Cetinkaya, N.

Letter | 2010 | Taiwanese Journal of Obstetrics and Gynecology49 ( 2 ) , pp.211 - 213

[No abstract available]

Controlled ovarian hyperstimulation and repetead treatment failure in a patient of 45, X/46, XX

Yildirim, G. | Attar, Rukset | Akçin, O. | Fiçicioglu, C.

Article | 2010 | Turk Jinekoloji ve Obstetrik Dernegi Dergisi7 ( 2 ) , pp.149 - 152

It can be assumed a high incidence of chromosomal abnormality among the patients who underwent ICSI cycle after searching the current literature. The huge amount of these abnormalities consist of low grade mosaicism. Besides adequate follicular response, the rate of fertilization failure is high in these group. If pregnancy achieved, spontan abortion usually occurs. Oocyte donation can be most appropriate treatment choise in some selected patients.

The significance of the number of CGG repeats and autoantibodies in premature ovarian failure

Fiçicioglu, C. | Yildirim, G. | Attar, Rukset | Kumbak, B. | Yesildaglar, N.

Article | 2010 | Reproductive BioMedicine Online20 ( 6 ) , pp.776 - 782

The objective of this study was to determine whether there was a threshold for the number of CGG repeats in the FMR1 (fragile X) gene in premature ovarian ageing and premature ovarian failure and to investigate the association of this sequence with serum concentrations of anti-Müllerian hormone (AMH), inhibin B, anti-thyroid and anti-adrenal autoantibodies. In this prospective randomized controlled preliminary study, the number of triple CGG repeats and serum concentrations of FSH, AMH and aforementioned autoantibodies were evaluated in 79 women who were younger than 40 years old. FSH concentrations were between 12 and 50 IU/ml (pre . . .mature ovarian ageing) in 30 women and were higher than 50 IU/ml (premature ovarian failure) in nine women; FSH concentrations were normal in 40 women. All women whose FSH concentrations were higher than 12 IU/ml had CGG repeats greater than 30. No women whose FSH concentrations were normal had a repeat number above 30. There was no significant relationship between the levels of antibodies and either CGG repeat numbers or FSH concentrations. In conclusion, the number of CGG repeats between 30 and 40 might be used to predict premature ovarian ageing and premature ovarian failure in infertile women. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved Daha fazlası Daha az

Heterotopic pregnancy: A rare cause of acute abdomen. Report of a delayed case diagnosis and review of the literature

Yildirim, G. | Attar, Rukset | Ekci, B. | Fiçicioglu, C.

Article | 2008 | Journal of the Turkish German Gynecology Association9 ( 4 ) , pp.231 - 233

Heterotopic pregnancy is a potentially life threatining condition and an important cause of mortality and morbidity. Risk of heterotopic pregnancy is increased by assisted reproductive techniques (ART). We report such a case of heterotopic pregnancy after embryo transfer in a primary infertile 38-year old woman. Sixteen days after detection of intrauterine pregnancy by ultrasound, the patient was admitted to emergency service with severe abdominal pain. She underwent surgery and her preoperative diagnosis was undetermined intraperitoneal bleeding. Ruptured heterotopic pregnancy diagnosed after diagnostic laparotomy and salpingectomy . . . performed at the same procedure. Her postoperative status and the course of pregnancy was unremarkable. A healthy baby was delivered at 38 week of gestation without any further complication. Heterotopic pregnancy is an important cause of acute abdomen after embryo transfer. Although it's diagnosis and management is challenging, with proper diagnosis and treatment, potential risks can be minimized and concomitant intrauterine pregnancy can be preserved Daha fazlası Daha az

The effects of electromagnetic fields on the number of ovarian primordial follicles: An experimental study

Bakacak, M. | Bostanci, M.S. | Attar, Rukset | Yildirim, O.K. | Yildirim, G. | Bakacak, Z. | Han, A.

Article | 2015 | Kaohsiung Journal of Medical Sciences31 ( 6 ) , pp.287 - 292

The aim of this study was to evaluate the effect of an electromagnetic field (EMF), generated close to the ovaries, on primordial follicles. A total of 16 rats were used in this study. The study group consisted of rats exposed to an EMF in the abdominal region for 15 min/d for 15 days. Both the study and control group were composed of eight rats. After the treatment period of 15 days, the ovaries of the rats were extracted, and sections of ovarian tissue were taken for histological evaluation. The independent samples t test was used to compare the two groups. In the study group, the means of the right and left ovarian follicle numbe . . .rs were 34.00 ± 10.20 and 36.00 ± 10.53, respectively. The average total ovarian follicle number was 70.00 ± 19.03. In the control group, the means of the right and left ovarian follicle numbers were 78.50 ± 25.98 and 71.75 ± 29.66, respectively, and the average total ovarian follicle number was 150.25 ± 49.53. The comparisons of the means of the right and left ovarian follicle numbers and the means of the total ovarian follicle numbers between the study and control groups indicated that the study group had significantly fewer follicles (p < 0.001, p = 0.011, and p = 0.002, respectively). This study found a significant decrease in the number of ovarian follicles in rats exposed to an EMF. Further clinical studies are needed to reveal the effects of EMFs on ovarian reserve and infertility. Copyright © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved Daha fazlası Daha az

Effects of aloevera gel on the induction of endometriosis and regression of endometrial explants in a rat model

Bostanci, M.S. | Bakacak, M. | Yildirim, O.K. | Yildirim, G. | Attar, Rukset | Ozkan, F. | Tolun, F.I.

Article | 2016 | Clinical and Experimental Obstetrics and Gynecology43 ( 4 ) , pp.529 - 533

Purpose of investigation: To evaluate the preventive and reducing effect of aloe vera gel on surgically-induced endometrial foci in rats. Materials and Methods: Twenty-four reproductive aged female non-pregnant, nulligravid Sprague-Dawley albino rats were used. The rats were randomly divided to three groups (Group 1: control. Group 2: Aloe vera endometriosis formation, and Group 3: Aloe vera endometriosis treatment). A peritoneal lavage using one-ml saline was taken at all the operations for determination of superoxide disinutase (SOD), malondialdehyde (MDA), and catalase (CAT). Forty-eight horns were implanted in 24 rats. Results: . . .All the implants were properly formed after implantation. In Group 3, before aloe vera application, the sum of the volumes was 87.2 ± 20.4 mm' and after treatment the volumes dropped to 28.9 ± 14.9 mm' (p = 0.01). As evaluation of aloe vera on the formation of endometriosis in the second operation in Group 2, the sum of the volumes was 2.9*1.4 mm3 and in Group 1, 118.9 ± 20.0 mm5 (/> = 0.001). Likewise, similar changes were observed in the histopatological scores. Conclusion: The application of aloe vera was seen to raise antioxidant levels in the peritoneal fluid and to reduce oxidative stress markers. Aloe vera is effective in the inhibition of formation and regression of endometriotic lesions Daha fazlası Daha az

The effects of different doses of melatonin treatment on endometrial implants in an oophorectomized rat endometriosis model

Cetinkaya, N. | Attar, Rukset | Yildirim, G. | Ficicioglu, C. | Ozkan, F. | Yılmaz, B. | Yesildaglar, N.

Article | 2015 | Archives of Gynecology and Obstetrics291 ( 3 ) , pp.591 - 598

Aims: To determine the effects of different doses of melatonin treatment on endometrial implants, the activity of antioxidant enzyme superoxide dismutase (SOD), the angiogenesis factor, the vascular endothelial growth factor (VEGF) and the waste metabolite product of lipid peroxidation malondialdehyde (MDA) in an oophorectomized rat endometriosis model.Methods: Thirty-two, female, non-pregnant, nulligravid Sprague–Dawley, albino rats were used in this prospective, randomized, controlled and experimental study. Endometriosis was surgically induced in oophorectomized rats, and estradiol treatment was started after the first operation . . .and continued till the end of the study. Second look, third look and necropsy operations were performed in the 2nd, 4th and 6th weeks. Mean volumes, histological scores and biochemical parameters were evaluated throughout the study.Results: The mean volumes of endometriotic foci were 98.8 mm3 ± 17.2 vs. 108.2 mm3 ± 17.5, 54.1 mm3 ± 15.6 vs. 25.8 mm3 ± 3.6, 42.8 mm3 ± 10.5 vs. 32.7 mm3 ± 6.0 and histopathological scores were 2.2 ± 0.2 vs. 1.7 ± 0.1, 2.6 ± 0.2 vs. 2.2 ± 0.2, 2.6 ± 0.1 vs. 2.7 ± 0.2 in the 10 vs. 20-mg/kg/day melatonin group at the end of the second, fourth and sixth weeks, respectively. When the groups were compared, no significant differences were seen in the histopathologic scores, SOD and VEGF levels between the groups. However, the endometriotic foci volumes were significantly decreased in both melatonin treatment groups with respect to the control group at the end of the fourth and sixth weeks. Moreover, the mean MDA levels were significantly lower in the control group than in the 10-mg/kg/day melatonin group at the end of the fourth and sixth weeks.Conclusion: Melatonin treatment resulted in the regression of endometriotic lesions in oophorectomized rats. Higher doses of melatonin treatment might be more effective in the regression of implants and improvement of histologic scores as well as in the precise evaluation of SOD, MDA and VEGF distributions in the rat experimental models. © 2014, Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

Comparison of follicular fluid and serum cytokine concentrations in women undergoing assisted reproductive treatment with GnRH agonist long and antagonist protocols

Ficicioglu, C. | Kumbak, B. | Akcin, O. | Attar, Rukset | Yildirim, G. | Yesildaglar, N.

Article | 2010 | Gynecological Endocrinology26 ( 3 ) , pp.181 - 186

Background. This study investigated whether follicular fluid (FF) and serum (S) concentrations of cytokines in women undergoing assisted reproductive treatment (ART) were different in GnRH antagonist cycles compared to agonist long ones. Methods. A retrospective clinical study was performed at a University ART center. A total of 85 women who underwent ART either with agonist long (n=34) or antagonist protocol (n=51) were analyzed. FF and serum samples were collected at the time of oocyte retrieval and measured for interleukin (IL)- 1ß, IL-6, IL-8, IL-12, tumor necrosis factor (TNF)-? by the enzyme-linked immunosorbent assay (ELISA) . . .technique, using commercially available kits and nitric oxide (NO) by the nitrate/nitrite colorimetric assay. The results were compared between GnRH antagonist and agonist cycles. Results. No significant difference was found in the FF concentrations of those cytokines between the two protocols. The serum values were also similar in the two groups except IL-6 (14.3±4.8 vs. 20.5±12.2 pg/ml; p=0.008) and NO (1.4±1.1 vs. 2.2±1.9 µm; p=0.038) levels which were found to be significantly lower in antagonist cycles. Conclusions. There is no significant difference in follicular microenvironment in terms of IL-1ß, IL-6, IL-8, IL-12, TNF-?, and NO levels between agonist long and antagonist cycles. However, serum IL-6 and NO levels were lower in women given antagonists. © 2010 Informa UK Ltd Daha fazlası Daha az

Comparision of reproductive outcome of the women with hypogonadotropic hypogonadism and tubal factor infertility

Yildirim, G. | Ficicioglu, C. | Attar, Rukset | Akcin, O. | Tecellioglu, N.

Article | 2010 | Clinical and Experimental Obstetrics and Gynecology37 ( 2 ) , pp.120 - 122

Objective: To evaluate the outcome of women with hypogonadotropic hypogonadism (HH) undergoing in-vitro fertilization (IVF). Materials and Methods: Data from 13 cycles of ten hypogonadotropic patients treated with in vitro fertilization from the period January 2006 to January 2008 were analyzed and compared with treatment results from 20 patients with tubal factor infertility (TI). All patients underwent ovarian hyperstimulation for IVF/ICSI at the same center. HH patients initiated the treatment by receiving daily injections of hMG. The patients in the control group were given the same dosage of recombinant FSH. Results: Demographi . . .c characteristics of the patients were comparable. Mean duration of stimulation was 13 days in the HH group and nine days in the TI group; the difference was significant (p < 0.001). Significantly more gonadotropins were used for the stimulation of HH patients (p < 0.05). Peak serum E2 concentration was found to be higher in the TI group. We evaluated the proportion of metaphase II (MII) oocytes to total oocytes retrieved in HH patients and found the number was similar to the TI group. Despite that fertilization and implantation rates were similar in both groups, the cancellation rate was higher in the HH group (23.1% vs 0). However pregnancy and live birth rates were similar. Conclusions: The present study showed that HH women undergoing IVF/ICSI are good responders. The treatment of HH women with IVF/ICSI did not increase multiple pregnancies and OHSS rates over the TI group Daha fazlası Daha az

The protective effect of G-CSF on experimental ischemia/reperfusion injury in rat ovary

Bostancı, M.S. | Bakacak, M. | İnanc, F. | Yaylalı, A. | Serin, S. | Attar, Rukset | Yildirim, G.

Article | 2016 | Archives of Gynecology and Obstetrics293 ( 4 ) , pp.789 - 795

Objective: This experimental study was designed to evaluate the effect of granulocyte colony-stimulating factor (G-CSF) in ovarian ischemia and ischemia/reperfusion (I/R) injury. Study design: Forty-eight female adult Sprague–Dawley albino rats were divided into six groups as Group 1: sham, Group 2: torsion, Group 3: detorsion, Group 4: sham + G-CSF, Group 5: torsion + G-CSF, and Group 6: detorsion + G-CSF. Except for Groups 1 and 4, all groups underwent adnexal torsion bilaterally for 3 h. Adnexal detorsion was applied to Groups 3 and 6 for 3 h after a 3-h torsion period. The intraperitoneal injection of G-CSF (100 IU/kg) was admin . . .istered 30 min previously in Group 4, 5 and 6. At the end of the study process the animals were euthanized and their ovaries were removed for histopathological and biochemical analysis. Total oxidant status (TOS), total antioxidative status and oxidative stress index (OSI) concentrations were determined and compared. Histopathological examination of ovaries was performed for the presence of interstitial edema, congestion, hemorrhage and loss of cohesion to determine tissue damage. Results: In Group 3, 4, 5 and 6, TOS, OSI and total histopathological scores of ovarian tissue were higher than in the sham group (p Daha fazlası Daha az

The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study

Yildirim, G. | Attar, Rukset | Ozkan, F. | Kumbak, B. | Ficicioglu, C. | Yesildaglar, N.

Article | 2010 | Fertility and Sterility93 ( 6 ) , pp.1787 - 1792

Objective: To determine the effects of letrozole and melatonin on surgically induced endometriosis in a rat endometriosis model. Design: Prospective, randomized, controlled, experimental study. Setting: Experimental Research Center of Yeditepe University (YUDETAM). Animal(s): Thirty female, nonpregnant, nulligravid Wistar-Hannover albino rats. Intervention(s): Surgical induction of endometriosis, administration of estrogen for 2 weeks, and laparotomy; administration of letrozole or melatonin for 2 weeks after induction of endometriosis, and laparotomy; administration of estrogen for 2 weeks and necropsy. Main Outcome Measure(s): The . . . volume and histopathologic scores of endometriotic foci, and levels of superoxide dismutase, catalase, and malondialdehyde in the peritoneal fluid. Result(s): The mean volumes of the endometriotic foci were 99.6 ± 18.8 mm3, 21.5 ± 7.4 mm3, and 29.2 ± 17.5 mm3, and histopathologic scores were 2.5 ± 0.7, 2.0 ± 0.8, and 1.7 ± 0.9 in the melatonin group at the end of the second, fourth, and sixth weeks, respectively. The mean volumes of the endometriotic foci were 75.9 ± 26.3 mm3, 29.8 ± 14.7 mm3, and 121.2 ± 35.1 mm3 and the histopathologic scores were 2.5 ± 0.5, 2.2 ± 0.8, and 2.7 ± 0.4 in the letrozole group at the end of the second, fourth, and sixth weeks, respectively. In the melatonin group, peritoneal fluid superoxide dismutase and catalase levels increased statistically significantly. Conclusion(s): Melatonin caused more pronounced regression of endometriotic foci when compared with letrozole in a rat model. After the cessation of melatonin treatment, the recurrence rate was lower than that observed after the cessation of letrozole treatment. © 2010 American Society for Reproductive Medicine Daha fazlası Daha az

Exposure to industrially polluted water resulted in regressed endometriotic lesions and enhanced adhesion formation in a rat endometriosis model: a preliminary study

Yesildaglar, N. | Yildirim, G. | Attar, Rukset | Karateke, A. | Ficicioglu, C. | Yılmaz, B.

Article | 2010 | Fertility and Sterility93 ( 5 ) , pp.1722 - 1724

The effects of water collected from an industrially polluted river in a rat model with surgically induced endometriosis were investigated in this preliminary study. Exposure to industrially polluted water resulted in regressed endometriotic lesions and enhanced adhesion formation. © 2010 American Society for Reproductive Medicine.

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