Yildirim, G. | Attar, Rukset | Gulec-Yilmaz, S. | Duman, S. | İşbir, Turgay

Article | 2017 | Genetic Testing and Molecular Biomarkers21 ( 8 ) , pp.512 - 515

Aim: Chemokines and their receptors play an important role in tumor progression. In the current study, we aimed to determine the association between the CCR2 gene (+190 G/A) polymorphism and ovarian cancer severity. Methods: CCR2 (+190 G/A) genotyping was performed using real-time polymerase chain reaction for DNA isolated from blood samples from a cohort of patients with ovarian cancer (n = 44) and a control group (n = 45). Results: The CCR2 (+190 G/A) GG genotype frequencies for patients were significantly higher in the stage III-IV cancer group (p = 0.036), and A allele carriers were significantly higher in the stage I-II ovarian . . . cancer group. Conclusion: The CCR2 (+190 G/A) GG genotype may be a potential risk factor for the severe forms of ovarian cancer and the A allele may be a risk-reducing factor for severe ovarian cancer. © Mary Ann Liebert, Inc. 2017 Daha fazlası Daha az